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The PLOS Medicine editors and the Maternal Health Task Force announce a new call for papers on the theme of “maternal health is women's health.”

Economics

With climate change as prototype example, this paper analyzes the implications of structural uncertainty for the economics of low-probability, high-impact catastrophes. Even when updated by Bayesian learning, uncertain structural parameters induce a critical “tail fattening” of posterior-predictive distributions. Such fattened tails have strong implications for situations, like climate change, where a catastrophe is theoretically possible because prior knowledge cannot place sufficiently narrow bounds on overall damages. This paper shows that the economic consequences of fat-tailed structural uncertainty (along with unsureness about high-temperature damages) can readily outweigh the effects of discounting in climate-change policy analysis., Economics

Questions of the effectiveness of economic policy reform are inseparable from the political economy factors responsible for distortionary policies in the first place. Distortionary policies are more likely to be adopted where politicians face fewer constraints. Hence reform should have modest effects in societies where the political system already imposes strong constraints, and in societies with weak constraints, because it does not alter the underlying political economy. Reform should be most effective in societies with intermediate constraints. Furthermore, effective reform in one dimension may lead to deterioration in others, as politicians address the underlying demands through other means—a phenomenon we call the seesaw effect. We report evidence that central bank reforms reduced inflation in countries with intermediate constraints but had no or little effect where constraints were strong or weak. We also present evidence consistent with the seesaw effect: in countries where central bank reform reduces inflation, government expenditure tends to increase., Economics

Economics

Economics

Fifty years after a paper linked sea-floor magnetic stripes and continental drift, Naomi Oreskes explains its legacy as a lesson in achieving scientific consensus., History of Science

Since its founding a decade ago, Environmental Health has received more than one thousand manuscripts. Last year marked the first time we published over 100 articles. The journal web site currently receives over 60,000 unique visitors every month, and the steady increase suggests that the number will soon exceed 100,000 monthly. Individual articles are usually accessed several thousand times within a few years of publication, the highest number for a single paper being close to 100,000. The access numbers suggest that the journal has a reach that goes much beyond narrow academic circles as represented by numbers of citations in scholarly journals. To further the goal of reaching the wider public health community and linking to environmental health promotion, we ask prospective Environmental Health authors to highlight the findings that are new or different along with the implications for future research and in terms of prevention of environmental hazards.

The hereditary breast and ovarian cancerpredisposition genes BRCA1 and BRCA2 account for the lion’s share of heritable breast cancer risk in the human population. Loss of function of either gene results in defective homologous recombination (HR) and triggers genomic instability, accelerating breast tumorigenesis. A longstanding hypothesis proposes that BRCA1 and BRCA2 mediate HR following attempted replication across damaged DNA, ensuring error-free processing of the stalled replication fork. A recent paper describes a new replication fork protective function of BRCA2, which appears to collaborate with its HR function to suppress genomic instability.

The most important and illuminating early writing on Brown v. Bd. of Education is a nine-page essay by Charles Black. Black memorably shows that segregation was a crucial part of a racial caste system. At the same time, he cuts through legal abstractions that made it difficult to answer the question whether the Court’s decision was sufficiently “neutral.” At the same time, Black’s argument suffers from two serious problems: formalism and institution-blindness. Black writes as if his interpretation of the equal protection clause can be simply read off the clause, and he does not engage the complex institutional problems that were raised by the Court’s decision. Nonetheless, the legal culture needs more voices like Black’s.

Stephen M. Kosslyn is Professor of Psychology at Harvard University and an Associate Psychologist in the Department of Neurology at the Massachusetts General Hospital. He received his B.A. in 1970 from UCLA and his Ph.D. from Stanford University in 1974, both in psychology, and taught at Johns Hopkins, Harvard, and Brandeis Universities before joining the Harvard Faculty as Professor of Psychology in 1983. His work focuses on the nature of visual mental imagery and high-level vision, as well as applications of psychological principles to visual display design. He has published over 125 papers on these topics, co-edited five books, and authored or co-authored five books. His books include Image and Mind (1980), Ghosts in the Mind's Machine (1983), Wet Mind: The New Cognitive Neuroscience (with 0. Koenig, 1992), Elements of Graph Design (1994), and Image and Brain: The Resolution of the Imagery Debate (1994). Dr. Kosslyn has received numerous honors, including the National Academy of Sciences Initiatives in Research Award, is currently on the editorial boards of many professional journals, and has served on several National Research Council committees to advise the government on new technologies., Psychology