1,456 results on '"ion mobility"'
Search Results
2. Instability analysis of perovskite solar cells via short-circuit impedance spectroscopy: A case study on NiOx passivation.
- Author
-
Almora, Osbel, López-Varo, Pilar, Escalante, Renán, Mohanraj, John, Marsal, Lluis F., Olthof, Selina, and Anta, Juan A.
- Subjects
PEROVSKITE analysis ,SOLAR cells ,SURFACE recombination ,LEWIS bases ,IMPEDANCE spectroscopy ,ION mobility - Abstract
Perovskite solar cells (PSCs) continue to be the "front runner" technology among emerging photovoltaic devices in terms of power conversion efficiency and versatility of applications. However, improving stability and understanding their relationship with their ionic–electronic transport mechanisms continue to be challenging. In this work, a case study of NiO
x -based inverted PSCs and the effect of different interface passivating treatments on device performance is presented. Impedance spectroscopy (IS) measurements in short-circuit conditions were performed under different illumination intensities, as well as bias-stress operational stability tests under constant illumination intensity. Surface treatments that involved bulky Lewis bases resulted in better and more stable performance. In contrast, acidic anion donors could induce both an initial performance decrease with a characteristic three-arcs impedance Nyquist plot and a subsequent instability during light exposure. Drift–diffusion simulations suggest strong modifications of surface recombination at the interface with the hole transport material, and for the ion concentration and mobilities in the perovskite. Importantly, capacitance and resistance are shown to peak maximum and minimum values, respectively, around mobile ion concentration (Nion ) of 1016 and 1017 cm−3 . These features relate to the transition from a drift-, for low Nion below a threshold value, to a diffusion-dominated transport in the bulk of the perovskite, for high Nion beyond the threshold value. Our results introduce a general route for characterization of instability paths in PSCs via IS performed under short-circuit conditions. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
3. Electrophoresis of ions and electrolyte conductivity: From bulk to nanochannels.
- Author
-
Vinogradova, Olga I. and Silkina, Elena F.
- Subjects
CONDUCTIVITY of electrolytes ,ELECTROPHORESIS ,ION mobility ,IONIC mobility ,IONS ,ION mobility spectroscopy ,ELECTROLYTE solutions - Abstract
When electrolyte solutions are confined in micro- and nanochannels their conductivity is significantly different from those in a bulk phase. Here we revisit the theory of this phenomenon by focusing attention on the reduction in the ion mobility with the concentration of salt and a consequent impact to the conductivity of a monovalent solution, from bulk to confined in a narrow slit. We first give a systematic treatment of electrophoresis of ions and obtain equations for their zeta potentials and mobilities. The latter are then used to obtain a simple expression for a bulk conductivity, which is valid in a concentration range up to a few molars and more accurate than prior analytic theories. By extending the formalism to the electrolyte solution in the charged channel the equations describing the conductivity in different modes are presented. They can be regarded as a generalization of prior work on the channel conductivity to a more realistic case of a nonzero reduction of the electrophoretic mobility of ions with salt concentration. Our analysis provides a framework for interpreting measurements on the conductivity of electrolyte solutions in the bulk and in narrow channels. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
4. Capturing the interactions in the BaSnF4 ionic conductor: Comparison between a machine-learning potential and a polarizable force field.
- Author
-
Lian, Xiliang and Salanne, Mathieu
- Subjects
MACHINE learning ,SOLID electrolytes ,IONIC interactions ,ION mobility ,IONIC mobility ,SOLID state batteries - Abstract
BaSnF
4 is a prospective solid state electrolyte for fluoride ion batteries. However, the diffusion mechanism of the fluoride ions remains difficult to study, both in experiments and in simulations. In principle, ab initio molecular dynamics could allow to fill this gap, but this method remains very costly from the computational point of view. Using machine learning potentials is a promising method that can potentially address the accuracy issues of classical empirical potentials while maintaining high efficiency. In this work, we fitted a dipole polarizable ion model and trained machine learning potential for BaSnF4 and made comprehensive comparisons on the ease of training, accuracy and efficiency. We also compared the results with the case of a simpler ionic system (NaF). We show that contrarily to the latter, for BaSnF4 the machine learning potential offers much higher versatility. The current work lays foundations for the investigation of fluoride ion mobility in BaSnF4 and provides insight on the choice of methods for atomistic simulations. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
5. High-resolution ion mobility based on traveling wave structures for lossless ion manipulation resolves hidden lipid features.
- Author
-
Reardon, Allison R., May, Jody C., Leaptrot, Katrina L., and McLean, John A.
- Subjects
IONIC mobility ,ION mobility ,IONIC structure ,ION acoustic waves ,RF values (Chromatography) ,LIPIDOMICS ,ION mobility spectroscopy - Abstract
High-resolution ion mobility (resolving power > 200) coupled with mass spectrometry (MS) is a powerful analytical tool for resolving isobars and isomers in complex samples. High-resolution ion mobility is capable of discerning additional structurally distinct features, which are not observed with conventional resolving power ion mobility (IM, resolving power ~ 50) techniques such as traveling wave IM and drift tube ion mobility (DTIM). DTIM in particular is considered to be the "gold standard" IM technique since collision cross section (CCS) values are directly obtained through a first-principles relationship, whereas traveling wave IM techniques require an additional calibration strategy to determine accurate CCS values. In this study, we aim to evaluate the separation capabilities of a traveling wave ion mobility structures for lossless ion manipulation platform integrated with mass spectrometry analysis (SLIM IM-MS) for both lipid isomer standards and complex lipid samples. A cross-platform investigation of seven subclass-specific lipid extracts examined by both DTIM-MS and SLIM IM-MS showed additional features were observed for all lipid extracts when examined under high resolving power IM conditions, with the number of CCS-aligned features that resolve into additional peaks from DTIM-MS to SLIM IM-MS analysis varying between 5 and 50%, depending on the specific lipid sub-class investigated. Lipid CCS values are obtained from SLIM IM (
TW(SLIM) CCS) through a two-step calibration procedure to align these measurements to within 2% average bias to reference values obtained via DTIM (DT CCS). A total of 225 lipid features from seven lipid extracts are subsequently identified in the high resolving power IM analysis by a combination of accurate mass-to-charge, CCS, retention time, and linear mobility-mass correlations to curate a high-resolution IM lipid structural atlas. These results emphasize the high isomeric complexity present in lipidomic samples and underscore the need for multiple analytical stages of separation operated at high resolution. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
6. Fast and broad-coverage lipidomics enabled by ion mobility-mass spectrometry.
- Author
-
Cai, Yuping, Chen, Xi, Ren, Fandong, Wang, Hongmiao, Yin, Yandong, and Zhu, Zheng-Jiang
- Subjects
LIQUID chromatography-mass spectrometry ,ION mobility ,MOLECULAR structure ,LIPIDOMICS ,LIPID metabolism ,ION mobility spectroscopy - Abstract
Aberrant lipid metabolism has been widely recognized as a hallmark of various diseases. However, the comprehensive analysis of distinct lipids is challenging due to the complexity of lipid molecular structures, wide concentration ranges, and numerous isobaric and isomeric lipids. Usually, liquid chromatography-mass spectrometry (LC-MS)-based lipidomics requires a long time for chromatographic separation to achieve optimal separation and selectivity. Ion mobility (IM) adds a new separation dimension to LC-MS, significantly enhancing the coverage, sensitivity, and resolving power. We took advantage of the rapid separation provided by ion mobility and optimized a fast and broad-coverage lipidomics method using the LC-IM-MS technology. The method required only 8 minutes for separation and detected over 1000 lipid molecules in a single analysis of common biological samples. The high reproducibility and accurate quantification of this high-throughput lipidomics method were systematically characterized. We then applied the method to comprehensively measure dysregulated lipid metabolism in patients with colorectal cancer (CRC). Our results revealed 115 significantly changed lipid species between preoperative and postoperative plasma of patients with CRC and also disclosed associated differences in lipid classes such as phosphatidylcholines (PC), sphingomyelins (SM), and triglycerides (TG) regarding carbon number and double bond. Together, a fast and broad-coverage lipidomics method was developed using ion mobility-mass spectrometry. This method is feasible for large-scale clinical lipidomic studies, as it effectively balances the requirements of high-throughput and broad-coverage in clinical studies. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
7. Commemoration.
- Author
-
Hakonen, Pertti and Krusius, Matti
- Subjects
LOW temperature physics ,CONDENSED matter physics ,QUANTUM field theory ,ENERGY levels (Quantum mechanics) ,ACOUSTICS ,ION mobility - Abstract
The Journal of Low Temperature Physics published a memorial issue commemorating the life and work of Alexander Fedorovich Andreev, a renowned low-temperature physicist known for his contributions to superconductivity and superfluidity. Andreev's research on Andreev reflection and bound states at interfaces has had a lasting impact on the field. The issue includes articles that build on Andreev's legacy, covering topics such as superconductors, superfluids, quantum crystals, and topological materials, showcasing the breadth of his influence on low-temperature quantum physics. [Extracted from the article]
- Published
- 2024
- Full Text
- View/download PDF
8. Application of Ion Mobility Mass Spectrometry in Food Analysis.
- Author
-
SI Bo, GU Yating, YANG Chen, LU Yongling, and LÜ Lishuang
- Subjects
ION mobility spectroscopy ,LIQUID chromatography-mass spectrometry ,ELECTRIC charge ,MASS spectrometry ,ION mobility - Abstract
Ion mobility spectroscopy is a technique to characterize compounds based on the differences in the migration of sample ions under the combined action of electric field and air flow. Ions can be separated according to their quantity of electric charge, mass, size and shape. Meanwhile, the collision cross section of the ions can also be calculated to obtain chemical compound structural information, which has shown excellent performance in separating isomers of substances. In recent years, a variety of ion mobility technologies combined with mass spectrometry technology have emerged, and been widely used in food, biology, medicine, environment and other fields. In this paper, the types and working principles of ion mobility spectroscopy are introduced, the advantages and disadvantages of various types of instruments are analyzed, and the application of ion mobility spectrometry, liquid chromatography and mass spectrometry multidimensional combination in analyzing and identifying nutritive and active ingredients and chemical hazards in food is reviewed. The application prospect and development trend of this technology are also prospected. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
9. Investigating Anion Effects on Metal Ion Binding Interactions With Amyloid β Peptide by Ion Mobility Mass Spectrometry.
- Author
-
Zhang, Jingwei, Phetsanthad, Ashley, and Li, Lingjun
- Subjects
ION mobility spectroscopy ,BICARBONATE ions ,SOLUTION (Chemistry) ,ALZHEIMER'S disease ,COORDINATE covalent bond ,ELECTROSPRAY ionization mass spectrometry ,ION mobility - Abstract
The study of metal ion's role in the biological processes of Alzheimer's disease has spurred investigations into the coordination chemistry of amyloid beta peptide and its fragments. Nano‐electrospray ionization mass spectrometry (nESI‐MS) has been utilized to examine the stabilization of bound anions on multiprotein complexes without bulk solvent. However, the effects of anions on metal ion binding interactions with amyloid beta peptide have not been explored. This study directly examined metal‐peptide complexes using nESI‐MS and investigated the effects of various anions on the binding ratio and stability of these complexes from ammonium salt solutions. The results indicate that different anions have distinct effects on the binding ratio and stability of various metal‐peptide complexes. Of these, the bicarbonate ion exhibits the highest binding ratios for metal‐peptide complexes, while binding ratios for these complexes in phosphate are comparatively low. Our results suggest that acetate, formate, bicarbonate, and phosphate have weak affinities and act as weak stabilizers of the metal‐peptide complex structure in the gas phase. Intriguingly, chloride and sulfate act as stabilizers of the metal‐peptide complex in the gas phase. The rank order determined from these data is substantially different from the Hofmeister salt series in solution. Although this outcome was anticipated due to the reduced influence of anions and water solvation, our findings correlate well with expected anion binding in solution and emphasize the importance of both hydration layer and anion‐metal‐peptide binding effects for Hofmeister‐type stabilization in solution. This approach proved useful in examining the interactions between metal ions and amyloid beta peptide, which are relevant to Alzheimer's disease, using direct ESI‐MS. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
10. The molecular picture of the local environment in a stable model coacervate.
- Author
-
Baksi, Atanu, Zerze, Hasan, Agrawal, Aman, Karim, Alamgir, and Zerze, Gül H.
- Subjects
MOLECULAR dynamics ,ADENOSINE triphosphate ,IONIC mobility ,DEIONIZATION of water ,ION mobility - Abstract
Complex coacervates play essential roles in various biological processes and applications. Although substantial progress has been made in understanding the molecular interactions driving complex coacervation, the mechanisms stabilizing coacervates against coalescence remain experimentally challenging and not fully elucidated. We recently showed that polydiallyldimethylammonium chloride (PDDA) and adenosine triphosphate (ATP) coacervates stabilize upon their transfer to deionized (DI) water. Here, we perform molecular dynamics simulations of PDDA-ATP coacervates in supernatant and DI water, to understand the ion dynamics and structure within stable coacervates. We found that transferring the coacervates to DI water results in an immediate ejection of a significant fraction of small ions (Na
+ and Cl− ) from the surface of the coacervates to DI water. We also observed a notable reduction in the mobility of these counterions in coacervates when in DI water, both in the cluster-forming and slab simulations, together with a lowered displacement of PDDA and ATP. These results suggest that the initial ejection of the ions from the coacervates in DI water may induce an interfacial skin layer formation, inhibiting further mobility of ions in the skin layer. Transferring coacervates based on polydiallyldimethylammonium chloride and adenosine triphosphate into deionized water has been experimentally demonstrated to stabilize them against coalescence. Here, molecular modeling and simulations are used to study the coacervation and stabilization of the relevant polyelectrolyte mixture, systematically investigating the structural and dynamic properties that lead to stability. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
11. Quasi-solid-state plasticized chitosan biopolymer electrolyte with enhanced Mg2+ ion mobility for next-generation Mg ion battery.
- Author
-
Helen, P. Adlin, Selvin, P. Christopher, and Sakthivel, P.
- Subjects
CONDUCTIVITY of electrolytes ,GLASS transition temperature ,ION mobility ,PLASTIC crystals ,IONIC conductivity ,POLYELECTROLYTES - Abstract
Developing electrolytes with high Mg
2+ ion mobility and compatibility with magnesium electrodes is of the utmost importance for the development of next-generation magnesium ion batteries. Here, we report the findings related to the physicochemical properties of the quasi-solid state chitosan biopolymer electrolyte prepared with a highly polar plastic crystal succinonitrile plasticizer. The prepared biopolymer electrolytes exhibited ionic conductivity in the order of 10−2 S cm−1 which is very much comparable to the conductivity of a liquid electrolyte used in commercial batteries. Besides, the prepared electrolyte shows decreased crystallinity ( χ c ) and glass transition temperature (Tg ) values, widened electrochemical window (2.5 V), good transference number ( t Mg 2 + ~0.6), reduced activation energy Ea (25 kJ mol−1 ), and increased dielectric values (ε). These results confirm the enhanced Mg2+ ion kinetics owing to the addition of SCN with high dissociate property and oxidative stability. Furthermore, the interfacial stability of the best-conducting chitosan biopolymer electrolyte is evaluated using CV analysis against Mg electrodes (vs. Mg/Mg2+ ). Also, a prototype Mg battery is constructed using the prepared electrolyte, MoO3 cathode, and Mg metal anode which showed an initial specific capacity of 277 mAh g−1 analyzed through galvanostatic charge/discharge studies. Therefore, in light of the results, we believe that adding succinonitrile to polymer electrolytes could be a practical approach to enhancing the electrochemical properties suitable for magnesium ion batteries. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
12. New strategy for boosting cathodic performance of low temperature solid oxide fuel cells via chlorine doping.
- Author
-
Xu, ShaoHua, Qiu, Hao, Jiang, Shanshan, Jiang, Jingjing, Wang, Wei, Xu, Xiaomin, Kong, Wei, Chivurugwi, Tanaka Dennis, Proskurin, Arkadii, Chen, Daifen, and Su, Chao
- Subjects
ION mobility ,OXYGEN reduction ,IONIC mobility ,POWER density ,LOW temperatures - Abstract
To enhance the performance and widespread use of solid oxide fuel cells (SOFCs), addressing the low-temperature (< 650 °C) electrochemical performance and operational stability issues of cathode materials is crucial. Here, we propose an innovative approach to enhance oxygen ion mobility and electrochemical performance of perovskite oxide by substituting some oxygen sites with chlorine anions. The designed SrTa
0.1 Fe0.9 O3-δ-x Clx (x = 0.05 and 0.10) exhibits improved performance compared to SrTa0.1 Fe0.9 O3-δ (STF). SrTa0.1 Fe0.9 O2.95-δ Cl0.05 (STFCl0.05) shows the lowest area-specific resistance (ASR) value on Sm0.2 Ce0.8 O1.9 (SDC) electrolyte. At 600 °C, STFCl0.05 achieves an ASR value of 0.084 Ω·cm2 , and a single cell with STFCl0.05 reaches a higher peak power density (PPD) value (1143 mW·cm-2 ) than that with STF (672 mW·cm-2 ). Additionally, besides exhibiting excellent oxygen reduction reaction (ORR) activity at lower temperatures, the STFCl0.05 cathode demonstrates good CO2 tolerance and operational stability. Symmetrical cell operation lasts for 150 h, and single cell operation endures for 720 h without significant performance decline. The chlorine doping approach effectively enhances ORR activity and stability, making STFCl0.05 a promising cathode material for low-temperature SOFCs. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
13. Evaluating the generalizability of graph neural networks for predicting collision cross section.
- Author
-
Engler Hart, Chloe, Preto, António José, Chanana, Shaurya, Healey, David, Kind, Tobias, and Domingo-Fernández, Daniel
- Subjects
GRAPH neural networks ,DNA fingerprinting ,MOLECULAR shapes ,MOLECULAR size ,CHEMICAL models ,ION mobility - Abstract
Ion Mobility coupled with Mass Spectrometry (IM-MS) is a promising analytical technique that enhances molecular characterization by measuring collision cross-section (CCS) values, which are indicative of the molecular size and shape. However, the effective application of CCS values in structural analysis is still constrained by the limited availability of experimental data, necessitating the development of accurate machine learning (ML) models for in silico predictions. In this study, we evaluated state-of-the-art Graph Neural Networks (GNNs), trained to predict CCS values using the largest publicly available dataset to date. Although our results confirm the high accuracy of these models within chemical spaces similar to their training environments, their performance significantly declines when applied to structurally novel regions. This discrepancy raises concerns about the reliability of in silico CCS predictions and underscores the need for releasing further publicly available CCS datasets. To mitigate this, we introduce Mol2CCS which demonstrates how generalization can be partially improved by extending models to account for additional features such as molecular fingerprints, descriptors, and the molecule types. Lastly, we also show how confidence models can support by enhancing the reliability of the CCS estimates. Scientific contribution We have benchmarked state-of-the-art graph neural networks for predicting collision cross section. Our work highlights the accuracy of these models when trained and predicted in similar chemical spaces, but also how their accuracy drops when evaluated in structurally novel regions. Lastly, we conclude by presenting potential approaches to mitigate this issue. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
14. Is the E/Z Iminium Ratio a Good Enantioselectivity Predictor in Iminium Catalysis?
- Author
-
Hellinghuizen, Matthijs A., Franceschi, Pietro, and Roithová, Jana
- Subjects
ION mobility ,MASS spectrometry ,IONIC mobility ,SPECTROMETRY ,CATALYSIS - Abstract
Developing new enantioselective reactions is an important part of chemical discovery but requires time and resources to test large arrays of potential reaction conditions. New techniques are required to analyse many different reactions quickly and efficiently. Mass spectrometry is a high‐throughput method; when combined with ion‐mobility spectrometry, this technique can monitor diastereomeric reaction intermediates and thus be a handle to study enantioselective reactions. Through this technique and others, it was noted before that in the organocatalytic 1,4‐addition to α,β‐unsaturated aldehydes, the abundance of initial diastereomeric intermediates correlates strongly to that of the final enantiomeric products. This work determines isomeric abundance for various catalysts and aldehydes and uses it to predict the enantiomeric excess of two control reactions. The prediction matches well for one reaction but does not predict the obtained results for the second. This finding confirms that the E/Z ratio of the iminium intermediates can be used as a predictor for some reactions, but the kinetics of the following steps can dramatically change the true enantioselectivity. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
15. Ultrafast Proteomics.
- Author
-
Fedorov, Ivan I., Protasov, Sergey A., Tarasova, Irina A., and Gorshkov, Mikhail V.
- Subjects
BIOLOGICAL systems ,PEPTIDES ,MASS spectrometry ,MASS measurement ,ARTIFICIAL intelligence ,ION mobility ,PROTEOMICS - Abstract
Current stage of proteomic research in the field of biology, medicine, development of new drugs, population screening, or personalized approaches to therapy dictates the need to analyze large sets of samples within the reasonable experimental time. Until recently, mass spectrometry measurements in proteomics were characterized as unique in identifying and quantifying cellular protein composition, but low throughput, requiring many hours to analyze a single sample. This was in conflict with the dynamics of changes in biological systems at the whole cellular proteome level upon the influence of external and internal factors. Thus, low speed of the whole proteome analysis has become the main factor limiting developments in functional proteomics, where it is necessary to annotate intracellular processes not only in a wide range of conditions, but also over a long period of time. Enormous level of heterogeneity of tissue cells or tumors, even of the same type, dictates the need to analyze biological systems at the level of individual cells. These studies involve obtaining molecular characteristics for tens, if not hundreds of thousands of individual cells, including their whole proteome profiles. Development of mass spectrometry technologies providing high resolution and mass measurement accuracy, predictive chromatography, new methods for peptide separation by ion mobility and processing of proteomic data based on artificial intelligence algorithms have opened a way for significant, if not radical, increase in the throughput of whole proteome analysis and led to implementation of the novel concept of ultrafast proteomics. Work done just in the last few years has demonstrated the proteome-wide analysis throughput of several hundred samples per day at a depth of several thousand proteins, levels unimaginable three or four years ago. The review examines background of these developments, as well as modern methods and approaches that implement ultrafast analysis of the entire proteome. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
16. Single ion mobility monitoring (SIM2) stitching method for high-throughput and high ion mobility resolution chiral analysis.
- Author
-
Chalet, Clément, Rathahao-Paris, Estelle, and Alves, Sandra
- Subjects
AMINO acid analysis ,ION mobility ,IONIC mobility ,MASS spectrometry ,ION analysis - Abstract
Chiral analysis is of high interest in many fields such as chemistry, pharmaceuticals and metabolomics. Mass spectrometry and ion mobility spectrometry are useful analytical tools, although they cannot be used as stand-alone methods. Here, we propose an efficient strategy for the enantiomer characterization of amino acids (AAs) using non-covalent copper complexes. A single ion mobility monitoring (SIM
2 ) method was applied on a TIMS-ToF mass spectrometer to maximize the detection and mobility separation of isomers. Almost all of the 19 pairs of proteinogenic AA enantiomers could be separated with at least one combination with the chiral references L-Phe and L-Pro. Furthermore, we extended the targeted SIM2 method by stitching several mobility ranges, in order to be able to analyze complex mixtures in a single acquisition while maintaining high mobility resolution. Most of the enantiomeric pairs of AAs separated with the SIM2 method were also detected with this approach. The SIM2 stitching method thus opens the way to a more comprehensive chiral analysis with TIMS-ToF instruments. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
17. Why are nH-perfluoroalkanoate ions more mobile than expected? Implications for identifying an emerging environmental pollutant.
- Author
-
Jobst, Karl J., Penney, Chloe, and Burgers, Peter C.
- Subjects
EMERGING contaminants ,ION mobility ,IONIC mobility ,IONS ,CARBOXYLIC acids - Abstract
nH-Perfluoroalkyl carboxylic acids (nH-PFCAs) are emerging pollutants. Their identification by ion mobility is frustrated by the nH-PFCAs having unexpectedly small collision cross sections (CCS). Theory and experiment agree that this is because nH-PFCA ions undergo internal hydrogen bridging, and this insight will help guide the creation of more accurate methods for pollutant identification. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
18. Halide ions doped SrMnO3 for chemical looping oxidative dehydrogenation of ethane.
- Author
-
Xing, Zifan, Chen, Haitao, Mao, Min, Liang, Xiaocen, Song, Da, Li, Yang, Long, Tao, Chen, Xiaoli, and He, Fang
- Subjects
OXIDATIVE dehydrogenation ,ION mobility ,CHEMICAL industry ,IONIC mobility ,CELL size - Abstract
The chemical looping oxidative dehydrogenation (CL‐ODH) of ethane represents a highly effective approach for converting ethane into the value‐added product ethylene. This investigation focused on the synthesis of SrMnO3 and its halide ions doped derivatives (SrMnO3Cl and SrMnO3Br) through the sol‐gel method. The performance of these perovskites, employed as oxygen carriers in CL‐ODH of ethane, was explored. The results unveiled several advantageous outcomes arising from the incorporation of halide ions (Cl− and Br−) with larger radius into the oxygen sites of the SrMnO3 perovskite. Halide ions doping notably induced cell volume expansion and enhanced lattice fringe spacing. Furthermore, it contributed to elevated oxygen vacancy concentration, increased Mn4+/Mn3+ molar ratio, and improved oxygen ions mobility within the bulk lattice. Fixed‐bed experiments demonstrated that these redox catalysts, doped with halide ions, exhibited outstanding activity and stability during cycling tests, exhibiting enhanced both ethylene selectivity and yield in CL‐ODH of ethane. In summary, the introduction of halide ions into SrMnO3 emerges as a promising strategy for enhancing the performance of CL‐ODH in ethane conversion for SrMnO3 based oxygen carriers. © 2023 Society of Chemical Industry and John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
19. Traveling waves in a model of calcium ions influx via mechanically stimulated membrane channels.
- Author
-
Kazmierczak, Bogdan and Volpert, Vitaly
- Subjects
CALCIUM ions ,ION mobility ,CALCIUM channels ,EXTRACELLULAR space ,ACTOMYOSIN ,CALCIUM - Abstract
We consider the problem of existence and properties of pulse solutions to a system of equations modeling fast calcium waves in long cells. These waves have the speed up to 1000 μ$$ \upmu $$m/s. They propagate via the inflow of calcium ions from the extracellular space through the mechanically stimulated membrane channels. The channels open due to mechano‐chemical interaction, in which stretching of the cell's membrane at a point opens the calcium channels at neighboring points due to the forces exerted by the actomyosin network. The existence of homoclinic solutions is based on the celebrated exchange lemma, which cannot be applied straightforwardly due to some specificities of the model equations. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
20. Simultaneous Determination of Contezolid and Its Metabolite M2 in Human Plasma and Cerebrospinal Fluid by Ultra-High-Performance Liquid Chromatography – Tandem Mass Spectrometry (UHPLC-MS/MS).
- Author
-
Xie, Chufei, Zhang, Dongjie, Wu, Lei, Shi, Guangzhi, Wang, Hailin, Cao, Yanmei, Bian, Xiaohe, Wang, Wenjing, Zhao, Lichun, and Mei, Shenghui
- Subjects
LIQUID chromatography-mass spectrometry ,TANDEM mass spectrometry ,CEREBROSPINAL fluid ,LIQUID chromatography ,MATRIX effect ,CENTRAL nervous system ,ION mobility ,MASS transfer coefficients - Abstract
This study established a simple, rapid, and sensitive ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method for the simultaneous quantification of contezolid and its major metabolite M2 in human plasma and cerebrospinal fluid (CSF). We used isotope-labeled internal standards (IS) along with protein precipitation to efficiently eliminate impurities. The ion transition was m/z 409.1 → 269.1 for contezolid, m/z 414.1 → 269.0 for contezolid-d5, m/z 445.1 → 385.1 for M2, and m/z 450.2 → 390.1 for M2-d5. The flow rate was 0.4 mL/min with a run time of 2.5 min. Validation results demonstrated that the calibration range was 10–5000 ng/mL for contezolid, and 5–2500 ng/mL for M2 in plasma and CSF. Both analytes exhibit excellent linear relationships (all R
2 ≥ 0.99). Intra- and inter-batch accuracy and precision for all quality control (QC) levels were within ± 15%, including the lower limit of quantification (LLOQ). The recoveries of contezolid and M2 were 92.60–100.4% and 92.26–99.61% in plasma and 93.33–99.19% and 91.31–98.21% in CSF, respectively. The matrix effects for contezolid and M2 were 97.20–110.3% and 98.27–105.47% in plasma and 105.25–112.99% and 103.35–109.84% in CSF, respectively. The coefficients of variation (CV%) were ≤ 12.58%. Conteozolid and M2 remained stable in plasma and CSF. This study has established a simple and accurate method for determining contezolid and M2 in human plasma and CSF, making it a valuable tool for monitoring the efficacy of central nervous system (CNS) drugs. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
21. Development of a cyclic ion mobility spectrometry‐mass spectrometry‐based collision cross‐section database of permethylated human milk oligosaccharides.
- Author
-
Habibi, Sanaz C., Bradford, Victoria R., Baird, Sophie C., Lucas, Shadrack Wilson, Chouinard, Christopher D., and Nagy, Gabe
- Subjects
LIQUID chromatography-mass spectrometry ,ION mobility ,MASS spectrometry ,BREAST milk ,IONIC mobility ,ION mobility spectroscopy - Abstract
Human milk oligosaccharides (HMOs) are an important class of biomolecules responsible for the healthy development of the brain‐gut axis of infants. Unfortunately, their accurate characterization is largely precluded due to a variety of reasons – there are over 200 possible HMO structures whereas only 10s of these are available as authentic analytical standards. Furthermore, their isomeric heterogeneity stemming from their many possible glycosidic linkage positions and corresponding α/β anomericities further complicates their analyses. While liquid chromatography coupled to tandem mass spectrometry remains the gold standard for HMO analyses, it often times cannot resolve all possible isomeric species and thus warrants the development of other orthogonal approaches. High‐resolution ion mobility spectrometry coupled to mass spectrometry has emerged as a rapid alternative to condensed‐phase separations but largely has remained limited to qualitative information related to the resolution of isomers. In this work, we have assessed the use of permethylation to improve both the resolution and sensitivity of HMO analyses with cyclic ion mobility separations coupled with mass spectrometry. In addition to this, we have developed the first‐ever high‐resolution collision cross‐section database for permethylated HMOs using our previously established calibration protocol. We envision that this internal reference database generated from high‐resolution cyclic ion mobility spectrometry‐mass spectrometry will greatly aid in the accurate characterization of HMOs and provide a valuable, orthogonal, approach to existing liquid chromatography–tandem mass spectrometry‐based methods. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
22. Differentiation of regioisomers of sulfobenzoic acid by traveling‐wave ion mobility mass spectrometry.
- Author
-
Zhang, Jinxin, Kumar, Meenu, Pinto, Spencer, Samarasinghe, Ishira, and Attygalle, Athula B.
- Subjects
DAUGHTER ions ,ION traps ,IONS spectra ,MASS spectrometers ,ISOMERS ,ION mobility ,ION mobility spectroscopy - Abstract
An ion mobility mass spectrometry (IM‐MS) investigation using a Synapt G2 mass spectrometer was conducted to separate anions generated from the three regioisomers of sulfobenzoic acid. The results revealed that the differences in arrival time distributions (ATDs) were inadequate to differentiate the isomers unambiguously. However, the ATD profiles of the product ions, generated by fragmenting the respective mass‐selected m/z 201 precursor ions in the Trap region of the three‐compartment traveling‐wave ion guide of the Synapt G2 mass spectrometer, were distinctly different, enabling definitive differentiation of the isomers. An arrival‐time peak for an ion of m/z 157 resulting from the loss of CO2 from the respective precursors was common to all three mobilograms. However, only the profile recorded from the para‐isomer exhibited a unique arrival‐time peak for an ion of m/z 137, originating from an SO2 loss. Such a peak corresponding to an SO2 loss was absent in the ATD profiles of the ortho‐ and meta‐isomers. Additionally, the mobilogram of the meta‐isomer displayed a unique peak at 3.42 ms. Based on its product ion spectrum, this peak was attributed to the bisulfite anion (m/z 81; HSO3ˉ). Previously, this meta‐isomer specific m/z 81 ion had been proposed to originate from a two‐step process involving the intermediacy of an m/z 157 ion formed by CO2 loss. However, our detailed tandem mass spectrometric experiments suggest that the m/z 81 is not a secondary product but rather an ion that originated from a direct elimination of a benzyne derivative from the m/z 201 precursor ion. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
23. Structural Principles of Ion-Conducting Mineral-like Crystals with Tetrahedral, Octahedral, and Mixed Frameworks.
- Author
-
Pushcharovsky, Dmitry and Ivanov-Schitz, Alexey
- Subjects
IONIC conductivity ,ION mobility ,SOLID electrolytes ,ISOMORPHISM (Crystallography) ,IONIC mobility - Abstract
Materials with high ion mobility are widely used in many fields of modern science and technology. Over the last 40 years, they have thoroughly changed our world. The paper characterizes the structural features of minerals and their synthetic analogs possessing this property. Special attention is paid to the ionic conductors with tetrahedral (zincite- and wurtzite-like), octahedral (ilmenite-like), and mixed (NASICON-like) frameworks. It is emphasized that the main conditions for fast ionic transport are related to the size and positions occupied by a mobile ion, their activation energy, the presence and diameter of conduction channels running inside the structure, isomorphic impurities, and other structural peculiarities. The results of the studies of solid electrolytes are dispersed in different editions, and the overview of new ideas related to their crystal structures was the focus of this paper. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
24. Functionality of zirconium nanofiller on structural and ionic properties of PVDF -co-HFP blended with PMMA nanocomposite polymer electrolytes.
- Author
-
Kundana, N., Reddy, V. Madhusudhana, Venkatapathy, M., and Neeraja, V.
- Subjects
POLYMETHYLMETHACRYLATE ,ION mobility ,IONIC conductivity ,POLYMER films ,IONIC mobility ,POLYELECTROLYTES - Abstract
PVDF-co HFP blended PMMA complexed with Mg(CF
3 SO3 )2 polymer electrolytes were synthesized using the solution casting process, zirconium nanofiller of 20 nm has been distributed with various concentrations. Utilising electronic Impedance Spectroscopy from 1Hz to 10MHz at various temperatures, the sample's electrical properties are investigated. The dielectric permittivity values of real (ε'), imaginary (ε"), electric modulus (M' and M"), and relaxation time are used to analyse the sample's dielectric behaviour. The thermal behaviour of composite polymer electrolytes Disseminated with Zirconium nanofiller are changed tremendously. The ionic conduction of nano composite polymer electrolyte films has been improved by one order of magnitude by the addition of nano filler, and the extreme ionic conductivity (0.3434 x 10−3 Scm−1 ) is perceived for 8 wt % of ZrO2 dispersed in PVDF-co-HFP, PMMA & Mg(CF3 SO3 )2 polymer electrolyte system. The growth in conductivity is ascribed to an increase in disconnection of ions and conception of large number of conducting paths for ion mobility by the addition of nano sized ZrO2 . [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
25. Bond dissociation energies for Fe2+, Fe2O+, and Fe2O2+ clusters determined through threshold photodissociation in a cryogenic ion trap.
- Author
-
Marlton, Samuel J. P., Liu, Chang, Watkins, Patrick, Buntine, Jack T., and Bieske, Evan J.
- Subjects
ION traps ,ION mobility spectroscopy ,IRON clusters ,METAL clusters ,PHOTODISSOCIATION ,ION mobility ,ELECTRON affinity ,HEAT of formation - Abstract
Understanding and controlling the chemical behavior of iron and iron oxide clusters requires accurate thermochemical data, which, because of the complex electronic structure of transition metal clusters, can be difficult to calculate reliably. Here, dissociation energies for Fe 2 + , Fe
2 O+ , and Fe 2 O 2 + are measured using resonance enhanced photodissociation of clusters contained in a cryogenically cooled ion trap. The photodissociation action spectrum of each species exhibits an abrupt onset for the production of Fe+ photofragments from which bond dissociation energies are deduced for Fe 2 + (2.529 ± 0.006 eV), Fe2 O+ (3.503 ± 0.006 eV), and Fe 2 O 2 + (4.104 ± 0.006 eV). Using previously measured ionization potentials and electron affinities for Fe and Fe2 , bond dissociation energies are determined for Fe2 (0.93 ± 0.01 eV) and Fe 2 − (1.68 ± 0.01 eV). Measured dissociation energies are used to derive heats of formation Δf H0 ( Fe 2 + ) = 1344 ± 2 kJ/mol, Δf H0 (Fe2 ) = 737 ± 2 kJ/mol, Δf H0 ( Fe 2 − ) = 649 ± 2 kJ/mol, Δf H0 (Fe2 O+ ) = 1094 ± 2 kJ/mol, and Δf H0 ( Fe 2 O 2 + ) = 853 ± 21 kJ/mol. The Fe 2 O 2 + ions studied here are determined to have a ring structure based on drift tube ion mobility measurements prior to their confinement in the cryogenic ion trap. The photodissociation measurements significantly improve the accuracy of basic thermochemical data for these small, fundamental iron and iron oxide clusters. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
26. Mechanism of monovalent and divalent ion mobility in Nafion membrane: An atomistic simulation study.
- Author
-
Paspureddi, Akhilesh, Zhang, Zidan, Ganesan, Venkat, Sharma, Mukul M., and Katz, Lynn E.
- Subjects
NAFION ,IONIC mobility ,MONOVALENT cations ,MOLECULAR dynamics ,ION mobility spectroscopy ,ION mobility ,WATER purification ,POLYMERS - Abstract
Polymer cation exchange membranes (CEMs) are widely used in water treatment processes. The fundamental factors that control the separation and selectivity of cations with different valences in CEMs are not fully understood. In this study, we use atomistic molecular dynamics simulations to investigate the underlying molecular mechanisms that control the mobility of cations with different valences in Nafion membranes. Our results indicate structural differences in binding of monovalent and divalent cations, which gives rise to differences in ion diffusion in Nafion. Monovalent cations are shown to be "territorially" bound, i.e., bound while partially hydrated, to the fixed charge groups whereas divalent cations are shown to be "site" bound, i.e., bound while fully dehydrated, to the charge groups on the polymer. This difference in binding structure gives rise to differences in transport characteristics of cations in Nafion. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
27. Gas‐phase ion mobility of protonated aldehydes in helium measured using a selected ion flow‐drift tube.
- Author
-
Gnioua, Maroua Omezzine, Španěl, Patrik, and Spesyvyi, Anatolii
- Subjects
ION mobility ,IONIC mobility ,CHEMICAL ionization mass spectrometry ,DENSITY functionals ,ION migration & velocity ,ION-molecule collisions - Abstract
Rationale: In soft chemical ionization mass spectrometry, analyte ions are produced via ion–molecule reactions in the reactor. When an electric field E is imposed, the ion drift velocity vd determines the reaction time and the effective ion temperature. Agreement between experimental ion mobilities and theoretical predictions confirms the accuracy of the ion residence time measurement procedure. Methods: A selected ion flow‐drift tube (SIFDT), an instrument with a chemical ionization source, was used to produce protonated aldehydes and selectively inject them into the resistive glass drift tube filled with He. Arrival‐time distributions of ions were obtained using the Hadamard modulation. Reduced ion mobilities were then obtained at a pressure of 2 hPa in the E/N range of 5–15 Td. Theoretical ion mobility values were calculated using two methods: hard‐sphere approximation and trajectory modelling. Results: The measured mobilities of three saturated and three unsaturated protonated aldehydes do not show substantial variation across the studied E/N range. Effective temperatures calculated using the Wannier formula from measured gas temperatures ranged from 300 to 315 K. Experimentally obtained values of the near‐zero‐ E/N‐reduced ion mobilities agree with both methods of calculations typically within ±3% standard deviation (maximum ±5%). Conclusions: The experimental SIFDT values of reduced mobilities in He of protonated aldehyde molecules generated from a chemical ionization source are in close agreement with two different theoretical methods based on the density functional theory calculations of ion geometries and partial atomic charges. Besides its fundamental importance, the ion mobility results validate the correct operation of the drift tube reactor and the ion residence time measurement procedure. Diffusion losses can also be determined from these results. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
28. Pharmacokinetic study of Q808 in rhesus monkey using liquid chromatography-tandem mass spectrometry.
- Author
-
Ning Xiao, Xiang Li, Wei Li, Jialin Zhao, Yingnan Li, and Limei Wang
- Subjects
RHESUS monkeys ,LIQUID chromatography-mass spectrometry ,PHARMACOKINETICS ,ORAL drug administration ,LIQUID-liquid extraction ,MASS transfer coefficients ,ION mobility - Abstract
Background: Q808 is a novel antiepileptic agent currently in development. In this study, we established and validated a LC-MS/MS method for the quantification of Q808 in Rhesus monkey plasma. Furthermore, we applied this method to investigate the pharmacokinetics of Q808 in Rhesus monkeys. Methods: Samples containing diazepam as an internal standard (IS) were subjected to liquid-liquid extraction (LLE) and separated using a Zorbax Extend C18 column. The detection of Q808 and IS was performed using multiple reaction monitoring mode (MRM), specifically monitoring precursor-to-product ion transitions at m/z 297.9 to 213.9 and m/z 285.2 to 193.1 for Q808 and IS, respectively. For the pharmacokinetic study of Q808, a total of 30 healthy Rhesus monkeys (half male and half female) were administered single oral doses, single IV doses, or multiple oral doses of Q808. Blood samples were collected at predetermined time points for subsequent pharmacokinetic analysis. Results: The developed LC-MS/MS method exhibited linearity within the concentration range of 1.5-750 ng/mL with intra-day precision ≤8.3% and inter-day precision ≤14.6%. Additionally, accuracy was found to be ≤3.4%. In the pharmacokinetic study involving single oral doses of Q808 in Rhesus monkeys, Q808 was absorbed with a median time to peak plasma concentration ranging from 4.50-6.00 h and was eliminated with a terminal elimination half-life (t
1/2 ) between 9.34-11.31 h. No definitive conclusion regarding linear pharmacokinetic characteristics could be drawn. The absolute bioavailability was determined as 20.95%, indicating limited systemic exposure after oral administration. Multiple dosing did not result in significant accumulation based on an accumulation factor Rac value of 1.31. Conclusion: We have successfully developed and validated a rapid yet sensitive LC-MS/MS method for quantifying levels of Q808 in rhesus monkey plasma for the first time. The determination method and pharmacokinetic characteristics of Q808 in rhesus monkey support the next steps in drug development. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
29. Tuning Ion Mobility in Lithium Argyrodite Solid Electrolytes via Entropy Engineering.
- Author
-
Lin, Jing, Schaller, Mareen, Indris, Sylvio, Baran, Volodymyr, Gautam, Ajay, Janek, Jürgen, Kondrakov, Aleksandr, Brezesinski, Torsten, and Strauss, Florian
- Subjects
IONIC conductivity ,ION mobility ,SOLID electrolytes ,IONIC mobility ,NUCLEAR magnetic resonance spectroscopy ,ENTROPY - Abstract
The development of improved solid electrolytes (SEs) plays a crucial role in the advancement of bulk‐type solid‐state battery (SSB) technologies. In recent years, multicomponent or high‐entropy SEs are gaining increased attention for their advantageous charge‐transport and (electro)chemical properties. However, a comprehensive understanding of how configurational entropy affects ionic conductivity is largely lacking. Herein we investigate a series of multication‐substituted lithium argyrodites with the general formula Li6+x[M1aM2bM3cM4d]S5I, with M being P, Si, Ge, and Sb. Structure‐property relationships related to ion mobility are probed using a combination of diffraction techniques, solid‐state nuclear magnetic resonance spectroscopy, and charge‐transport measurements. We present, to the best of our knowledge, the first experimental evidence of a direct correlation between occupational disorder in the cationic host lattice and lithium transport. By controlling the configurational entropy through compositional design, high bulk ionic conductivities up to 18 mS cm−1 at room temperature are achieved for optimized lithium argyrodites. Our results indicate the possibility of improving ionic conductivity in ceramic ion conductors via entropy engineering, overcoming compositional limitations for the design of advanced electrolytes and opening up new avenues in the field. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
30. Tuning Ion Mobility in Lithium Argyrodite Solid Electrolytes via Entropy Engineering.
- Author
-
Lin, Jing, Schaller, Mareen, Indris, Sylvio, Baran, Volodymyr, Gautam, Ajay, Janek, Jürgen, Kondrakov, Aleksandr, Brezesinski, Torsten, and Strauss, Florian
- Subjects
IONIC conductivity ,ION mobility ,SOLID electrolytes ,IONIC mobility ,NUCLEAR magnetic resonance spectroscopy ,ENTROPY - Abstract
The development of improved solid electrolytes (SEs) plays a crucial role in the advancement of bulk‐type solid‐state battery (SSB) technologies. In recent years, multicomponent or high‐entropy SEs are gaining increased attention for their advantageous charge‐transport and (electro)chemical properties. However, a comprehensive understanding of how configurational entropy affects ionic conductivity is largely lacking. Herein we investigate a series of multication‐substituted lithium argyrodites with the general formula Li6+x[M1aM2bM3cM4d]S5I, with M being P, Si, Ge, and Sb. Structure‐property relationships related to ion mobility are probed using a combination of diffraction techniques, solid‐state nuclear magnetic resonance spectroscopy, and charge‐transport measurements. We present, to the best of our knowledge, the first experimental evidence of a direct correlation between occupational disorder in the cationic host lattice and lithium transport. By controlling the configurational entropy through compositional design, high bulk ionic conductivities up to 18 mS cm−1 at room temperature are achieved for optimized lithium argyrodites. Our results indicate the possibility of improving ionic conductivity in ceramic ion conductors via entropy engineering, overcoming compositional limitations for the design of advanced electrolytes and opening up new avenues in the field. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
31. Effect of buffer on direct lithium extraction from Tibetan brine by formed titanium-based lithium ion sieves.
- Author
-
Tang, Chunmei, Zhang, Lin, Li, Jiayu, Yue, Huihui, Sun, Wenjun, Cui, Qun, and Wang, Haiyan
- Subjects
LITHIUM ions ,TIBETANS ,SALT ,SIEVES ,ADSORPTION capacity ,FLUOROETHYLENE ,ION mobility ,BORON isotopes - Abstract
The adsorption performance of titanium-based lithium ion sieves for Li
+ through H+ –Li+ exchange is greatly limited by the pH value of brine. To improve the adsorption capacity of HTO-P (formed titanium-based lithium ion sieves) for Li+ , the adsorption characteristics and dynamic performance in Tibetan brine–NaHCO3 (NaHCO3 as a buffer added into the brine used) were studied. The addition of NaHCO3 reduces the aggregation of H+ and maintains the pH value at ∼7.5, which also accelerates the mass transfer rate of Li+ in the initial adsorption stage. Compared with Tibetan brine, the equilibrium adsorption capacity and recovery ratio of HTO-P for Li+ in Tibetan brine–NaHCO3 increase by 60% and 70%, respectively, and the adsorption equilibrium time is shortened by one-third. Moreover, the dynamic saturated adsorption capacity of HTO-P for Li+ reaches 14.25 mg g−1 in Tibetan brine–NaHCO3 . This work provides a basis for the direct lithium adsorption and extraction process from salt lake brines. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
32. Evaluation and comparison of liquid chromatography/high‐resolution mass spectrometry platforms for the separation and characterization of ginsenosides from the leaves of Panax ginseng.
- Author
-
Li, Xiaohang, Zou, Yadan, Cheng, Huizhen, Ding, Mengxiang, Yang, Yang, Hong, Lili, Xiong, Ying, Zhang, Min, Li, Xue, Chen, Qinhua, Wang, Hongda, Cui, Yuanwu, and Yang, Wenzhi
- Subjects
ION mobility ,RF values (Chromatography) ,LIQUID chromatography ,GINSENOSIDES ,INFORMATION sharing - Abstract
The measurement of data repeatability in small‐molecule metabolites acquired within and among different liquid chromatography‐mass spectrometry (LC‐MS) platforms is crucial for data sharing or data transfer in natural products research. This work was designed to investigate and evaluate the separation and detection performance of three commercial high‐resolution LC‐MS platforms (e.g., Agilent 6550 QTOF, Waters Vion IM‐QTOF, and Thermo Scientific Orbitrap Exploris 120) using 68 ginsenoside references and the extract of Panax ginseng leaf. The retention time (tR), measured on these three platforms (under the same chromatography condition), showed good stability in different concentration tests, and within/among different instruments for both intra‐day and inter‐day precision examinations. Correlation in tR of ginsenosides was also highly determined on these three platforms. In spite of the different mass analyzers involved, these three platforms gave the accurate mass determination ability, especially enhanced resolution gained because of the ion mobility (IM) separation facilitated by IM‐quadrupole time‐of‐flight. The current study has systematically evaluated the separation and MS detection performance enabled by three high‐resolution LC‐MS platforms taking ginsenosides as the template, and the reported findings can benefit the researchers for the selection of analytical platforms and the purpose of data sharing or data transfer. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
33. Exploring ion mobility mechanisms in poly indolequinone polymers: a case study on black soldier fly melanin.
- Author
-
Ambrico, M, Mostert, A B, Ambrico, P F, Phua, J, Mattiello, S, and Gunnella, R
- Subjects
HERMETIA illucens ,MELANINS ,ION mobility ,IONIC mobility ,PHYSICAL mobility ,POLYMERS - Abstract
Black soldier fly (BSF) melanin is a new supply of the brown-black pigment eumelanin. Given that eumelanin is a model bioelectronic material for applications such as medical devices and sensors, understanding BSF melanin's electrical properties is important to confirm its viability as an advanced material. Presented here is a systematic, hydration dependent alternating current study of BSF melanin utilising both H
2 O and D2 O vapours. There is a clear difference between the vapours, enabling a thorough analysis including Nyquist plots with model circuit analysis, broad band dielectric spectroscopic modelling as well as applying the Trukhan model to understand free ion concentration and mobility changes as a function of hydration. We find that BSF melanin behaves similarly to previous reports on synthetic systems, and the analysis here sheds additional light on potential charge transport changes. Significantly, a key finding is that there are two different mobility mechanisms for ion transport depending on hydration. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
34. Effect of NASCION-Type ceramic dispersion in PAN/ PVA-based blend polymer electrolyte: A structural, thermal, and electrical study.
- Author
-
Kumar, Dharmendra, Mukherjee, Shweta, and Das, Avirup
- Subjects
POLYMER blends ,POLYACRYLONITRILES ,POLYELECTROLYTES ,CERAMICS ,DISPERSION (Chemistry) ,ION mobility ,DIELECTRIC properties ,SOLID electrolytes - Abstract
Solid flexible separators having adequate ion conductivity at ambient temperature along with good thermal and voltage stability are potential candidates for separators in all solid-state ion batteries. In the present work, zirconium and niobium-doped Li
1.3 Al0.3 Ti1.7 (PO4 )3 ceramic particles have been incorporated into a polyvinyl alcohol (PVA) and polyacrylonitrile (PAN)-based blend that served as a flexible matrix to create a flexible polymer–ceramic framework and have been examined for conductivity, dielectric properties, voltage stability, thermal stability, and electrochemical performance. The flexible polymer–ceramic framework shows high thermal stability, improved conductivity, and a high-voltage window. Optimized dc conductivity of 9.8 × 10−5 S cm−1 has been observed among all investigated samples, with an improved voltage stability of 4.94 V. Further, the Trukhan model has been used to understand the effect of filler loading on ion migration properties. The optimized solid polymer electrolyte (SPE) shows improved ion mobility (μ) of 5.13 × 10−2 cm2 V−1 s, number density (n) = 2.39 × 1015 cm³, and diffusion coefficient (D) of 2.09 × 10−3 cm² s−1 . It also shows a very high specific capacitance of ~10−4 Fg−1 , excellent cycling stability, and 93.75% capacity retention after 100 cycles. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
35. Effect of dynamic exclusion and the use of FAIMS, DIA and MALDI-mass spectrometry imaging with ion mobility on amyloid protein identification.
- Author
-
Aguilan, Jennifer T., Lim, Jihyeon, Racine-Brzostek, Sabrina, Fischer, Joshua, Silvescu, Cristina, Cornett, Shannon, Nieves, Edward, Mendu, Damodara Rao, Aliste, Carlos-Madrid, Semple, Stacia, Angeletti, Ruth, Weiss, Louis M., Cole, Adam, Prystowsky, Michael, Pullman, James, and Sidoli, Simone
- Subjects
ION mobility spectroscopy ,TANDEM mass spectrometry ,PROTEOMICS ,ION mobility ,LIQUID chromatography-mass spectrometry ,AMYLOID - Abstract
Amyloidosis is a disease characterized by local and systemic extracellular deposition of amyloid protein fibrils where its excessive accumulation in tissues and resistance to degradation can lead to organ failure. Diagnosis is challenging because of approximately 36 different amyloid protein subtypes. Imaging methods like immunohistochemistry and the use of Congo red staining of amyloid proteins for laser capture microdissection combined with liquid chromatography tandem mass spectrometry (LMD/LC–MS/MS) are two diagnostic methods currently used depending on the expertise of the pathology laboratory. Here, we demonstrate a streamlined in situ amyloid peptide spatial mapping by Matrix Assisted Laser Desorption Ionization–Mass Spectrometry Imaging (MALDI-MSI) combined with Trapped Ion Mobility Spectrometry for potential transthyretin (ATTR) amyloidosis subtyping. While we utilized the standard LMD/LC–MS/MS workflow for amyloid subtyping of 31 specimens from different organs, we also evaluated the potential introduction in the MS workflow variations in data acquisition parameters like dynamic exclusion, or testing Data Dependent Acquisition combined with High-Field Asymmetric Waveform Ion Mobility Spectrometry (DDA FAIMS) versus Data Independent Acquisition (DIA) for enhanced amyloid protein identification at shorter acquisition times. We also demonstrate the use of Mascot's Error Tolerant Search and PEAKS de novo sequencing for the sequence variant analysis of amyloidosis specimens. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
36. Enhancing Electrochemical Characteristics of Li‐Metal Electrodes: The Impact of Pre‐Treatment via CO2 Gas Reaction.
- Author
-
Kim, Yeji, Maldonado Nogales, Paul, Lee, Changhee, and Jeong, Soon‐Ki
- Subjects
ELECTRODES ,IONIC mobility ,METALLIC surfaces ,ALUMINUM-lithium alloys ,ION mobility ,METALLIC films - Abstract
Regulation of the surface film characteristics of Li‐metal is a pivotal strategy for augmenting the electrochemical performance of Li‐metal batteries. This investigation elucidates a straightforward approach to surface film modification, namely, pre‐treatment via a CO2 gas reaction, and its subsequent impact on the electrochemical attributes of Li‐metal electrodes. Analysis of the topography and composition of the Li metal surfaces revealed the transformation of the surface film into a more uniform layer enriched with inorganic compounds, including Li2CO3 and Li2O, by pre‐treatment. This pre‐treatment process significantly enhances the electrochemical properties, such as cyclability and overpotential, in Li/Li symmetric cells, primarily because of the formation of an improved solid‐electrolyte interphase (SEI) derived from the altered surface film on Li metal electrodes. The reformed SEI significantly increases the mobility of Li ions through the interphase, thereby attenuating the impedance associated with Li‐ion migration within the SEI. This resistance attenuation is instrumental in alleviating the overpotentials, thereby significantly refining the electrochemical plating and stripping dynamics of Li metal electrodes. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
37. ProPept-MT: A Multi-Task Learning Model for Peptide Feature Prediction.
- Author
-
He, Guoqiang, He, Qingzu, Cheng, Jinyan, Yu, Rongwen, Shuai, Jianwei, and Cao, Yi
- Subjects
PEPTIDES ,DEEP learning ,IONIC mobility ,PEARSON correlation (Statistics) ,ION mobility ,DAUGHTER ions ,RF values (Chromatography) - Abstract
In the realm of quantitative proteomics, data-independent acquisition (DIA) has emerged as a promising approach, offering enhanced reproducibility and quantitative accuracy compared to traditional data-dependent acquisition (DDA) methods. However, the analysis of DIA data is currently hindered by its reliance on project-specific spectral libraries derived from DDA analyses, which not only limits proteome coverage but also proves to be a time-intensive process. To overcome these challenges, we propose ProPept-MT, a novel deep learning-based multi-task prediction model designed to accurately forecast key features such as retention time (RT), ion intensity, and ion mobility (IM). Leveraging advanced techniques such as multi-head attention and BiLSTM for feature extraction, coupled with Nash-MTL for gradient coordination, ProPept-MT demonstrates superior prediction performance. Integrating ion mobility alongside RT, mass-to-charge ratio (m/z), and ion intensity forms 4D proteomics. Then, we outline a comprehensive workflow tailored for 4D DIA proteomics research, integrating the use of 4D in silico libraries predicted by ProPept-MT. Evaluation on a benchmark dataset showcases ProPept-MT's exceptional predictive capabilities, with impressive results including a 99.9% Pearson correlation coefficient (PCC) for RT prediction, a median dot product (DP) of 96.0% for fragment ion intensity prediction, and a 99.3% PCC for IM prediction on the test set. Notably, ProPept-MT manifests efficacy in predicting both unmodified and phosphorylated peptides, underscoring its potential as a valuable tool for constructing high-quality 4D DIA in silico libraries. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
38. Using mass spectrometry‐based methods to understand amyloid formation and inhibition of alpha‐synuclein and amyloid beta.
- Author
-
Wagner, Wesley J. and Gross, Michael L.
- Subjects
AMYLOID ,AMINO acid separation ,ALPHA-synuclein ,PROTEIN fractionation ,DEUTERIUM ,HYDROGEN-deuterium exchange ,ION mobility - Abstract
Amyloid fibrils, insoluble β‐sheets structures that arise from protein misfolding, are associated with several neurodegenerative disorders. Many small molecules have been investigated to prevent amyloid fibrils from forming; however, there are currently no therapeutics to combat these diseases. Mass spectrometry (MS) is proving to be effective for studying the high order structure (HOS) of aggregating proteins and for determining structural changes accompanying protein–inhibitor interactions. When combined with native MS (nMS), gas‐phase ion mobility, protein footprinting, and chemical cross‐linking, MS can afford regional and sometimes amino acid spatial resolution of the aggregating protein. The spatial resolution is greater than typical low‐resolution spectroscopic, calorimetric, and the traditional ThT fluorescence methods used in amyloid research today. High‐resolution approaches can struggle when investigating protein aggregation, as the proteins exist as complex oligomeric mixtures of many sizes and several conformations or polymorphs. Thus, MS is positioned to complement both high‐ and low‐resolution approaches to studying amyloid fibril formation and protein–inhibitor interactions. This review covers basics in MS paired with ion mobility, continuous hydrogen‐deuterium exchange (continuous HDX), pulsed hydrogen‐deuterium exchange (pulsed HDX), fast photochemical oxidation of proteins (FPOP) and other irreversible labeling methods, and chemical cross‐linking. We then review the applications of these approaches to studying amyloid‐prone proteins with a focus on amyloid beta and alpha‐synuclein. Another focus is the determination of protein–inhibitor interactions. The expectation is that MS will bring new insights to amyloid formation and thereby play an important role to prevent their formation. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
39. Metal adduction in mass spectrometric analyses of carbohydrates and glycoconjugates.
- Author
-
Gass, Darren T., Quintero, Ana V., Hatvany, Jacob B., and Gallagher, Elyssia S.
- Subjects
GLYCOCONJUGATES ,GLYCANS ,CARBOHYDRATES ,ADDUCTION ,ION mobility ,METALS ,IMPACT ionization - Abstract
Glycans, carbohydrates, and glycoconjugates are involved in many crucial biological processes, such as disease development, immune responses, and cell–cell recognition. Glycans and carbohydrates are known for the large number of isomeric features associated with their structures, making analysis challenging compared with other biomolecules. Mass spectrometry has become the primary method of structural characterization for carbohydrates, glycans, and glycoconjugates. Metal adduction is especially important for the mass spectrometric analysis of carbohydrates and glycans. Metal‐ion adduction to carbohydrates and glycoconjugates affects ion formation and the three‐dimensional, gas‐phase structures. Herein, we discuss how metal‐ion adduction impacts ionization, ion mobility, ion activation and dissociation, and hydrogen/deuterium exchange for carbohydrates and glycoconjugates. We also compare the use of different metals for these various techniques and highlight the value in using metals as charge carriers for these analyses. Finally, we provide recommendations for selecting a metal for analysis of carbohydrate adducts and describe areas for continued research. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
40. 磷酸铁锰锂材料的合成方法及 结构改性的研究进展.
- Author
-
苏宝才, 张勤, 谢元健, 蔡平雄, and 潘远凤
- Subjects
ELECTRIC conductivity ,ION mobility ,ENERGY density ,IONIC mobility ,HIGH voltages - Abstract
Copyright of Inorganic Chemicals Industry is the property of Editorial Office of Inorganic Chemicals Industry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
- Full Text
- View/download PDF
41. Validity of LiPON Conductivity Determined by Impedance Spectroscopy.
- Author
-
Rudy, Alexander, Novozhilova, Alena, and Egorova, Julia
- Subjects
ELECTRIC double layer ,ELECTRIC conductivity ,DEBYE length ,ION mobility ,ELECTRIC fields - Abstract
A hypothesis that the generally accepted value of the LiPON conductivity should be attributed to the absorption and displacement currents is substantiated. The reason is a small contribution of the drift current due to field screening by the electric double layer. The basis for this assumption is the measurement of the LiPON absorption capacitance, according to which its dielectric constant is about 10
6 . An alternative equivalent circuit containing a non-ideal absorption element is proposed and its impedance is calculated. It is shown that the Bode diagrams of the alternative circuit approximate the experimental curves well. Parameters and the magnitude of electric field screening are calculated based on a proposed model of a double electric layer. Considering the screening effect, the drift conductivity of LiPON is obtained, which is in good agreement with the data on lithium concentration and ion mobility. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
42. Recent advances in gas phase unfolding: Instrumentation and applications.
- Author
-
Matney, Rowan and Gadkari, Varun V.
- Subjects
ION mobility spectroscopy ,ION mobility ,ENERGY futures ,BIOMOLECULES ,MASS spectrometry ,STRUCTURAL stability ,RESEARCH personnel - Abstract
Broader adoption of native mass spectrometry (MS) and ion mobility‐mass spectrometry (IM‐MS) has propelled the development of several techniques which take advantage of the selectivity, sensitivity, and speed of MS to make measurements of complex biological molecules in the gas phase. One such method, collision induced unfolding (CIU), has risen to prominence in recent years, due to its well documented capability to detect shifts in structural stability of biological molecules in response to external stimuli (e.g., mutations, stress, non‐covalent interactions, sample conditions etc.). This increase in reported CIU measurements is enabled partly due to advances in IM‐MS instrumentation by vendors, and also innovative method development by researchers. This perspective highlights a few of these advances and concludes with a look forward toward the future of the gas phase unfolding field. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
43. Detecting Trace Amounts of Peroxides and Ammonium Nitrate in Fingerprints by Ion Mobility Spectrometry.
- Author
-
Buryakov, T. I. and Buryakov, I. A.
- Subjects
AMMONIUM nitrate ,ION mobility spectroscopy ,ION mobility ,HEXAMETHYLENEDIAMINE ,LACTIC acid ,ALUMINUM foil ,AIR pressure - Abstract
The effect of the sweat and grease deposits (SGD) from fingerprints on the detection efficiency of trace amounts of explosive substances—triacetone triperoxide (TATP), hexamethylene triperoxide diamine (HMTD), and ammonium nitrate (AN) by ion mobility spectrometry in air at atmospheric pressure was investigated. Among the main components of SGD, urea is identified as a positive mode influencer, while lactic acid (LA) affects in a negative mode. The presence of urea or SGD in the sample does not significantly affect the detection of TATP in the positive mode but decreases the efficiency of HMTD ion formation and leads to the appearance of adduct cations of HMTD and urea. The presence of lactic acid or SGD slightly decreases the efficiency of ammonium nitrate ion formation in the negative mode and significantly alters the qualitative composition of HMTD ions, leading to the appearance of HMTD and LA adduct anions. In the absence of any impurities in the sample, the best reduced limit of detection (signal-to-noise ratio = 3σ), estimated at 30–50 pg, was observed for HMTD. The lifetime of HMTD, TATP, and AN traces on aluminum foil under laboratory conditions was determined to be 1, 3, and 12 h for samples with masses of m
HMTD 1 × 10–9 , 2 × 10–9 , and 1 × 10–8 g and surface densities ds of 0.008, 0.016, and 0.08 μg/cm2 , respectively; 102 and 103 s for mTATP 1 × 10–5 and 1 × 10–4 g and ds of 80 and 800 μg/cm2 , respectively; 12 and 25 h for mAN 3 × 10–8 and 5 × 10–8 g and ds of 0.24 and 0.4 μg/cm2 , respectively. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
44. Effects of DC bias on evolutions of repetitively pulsed streamer discharge in humid air.
- Author
-
Zhao, Zheng, Gao, Qiuyu, Zhang, Haowei, Zheng, Haotian, Zheng, Xinlei, Sun, Zihan, Sun, Anbang, and Li, Jiangtao
- Subjects
ION mobility ,IONIC mobility ,ANIONS ,HEAT release rates ,SPACE charge - Abstract
Modulation efficiency and mechanisms of repetitively pulsed streamer discharge in humid air are ambiguous with dramatic variations in free electron availability, residual ion mobility, enhanced heat release, etc, caused by water molecules intentionally supplemented or existing in the surrounding environment. The inception and propagation patterns of repetitively pulsed streamer discharge modulated by superimposed DC bias are experimentally investigated in the needle-plane electrode configuration. The inception voltage decreases due to negative ion drift under positive DC bias. The secondary streamer with a bright glowing cloud prolongs towards the plane electrode and the diameter decreases under positive DC bias. The primary streamer tends to propagate along the off-axis direction under negative DC bias. The number of applied pulses before breakdown decreases with the increase in positive DC bias and illustrates an insignificant dependence on the negative DC bias. The effect of air humidity is more pronounced than the DC bias. The streamer inception, propagation, and morphological transition are explained by residual space charge distributions and drift velocity. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
45. Ion Mobility Mass Spectrometry‐Based Disaccharide Analysis of Glycosaminoglycans.
- Author
-
Polewski, Lukasz, Moon, Eunjin, Zappe, Andreas, Götze, Michael, Szekeres, Gergo Peter, Roth, Christian, and Pagel, Kevin
- Subjects
ION mobility spectroscopy ,ION mobility ,DISACCHARIDES ,IONIC mobility ,ION traps ,RADIOLABELING ,GLYCOSAMINOGLYCANS - Abstract
Glycosaminoglycans (GAGs) are linear and acidic polysaccharides. They are ubiquitous molecules, which are involved in a wide range of biological processes. Despite being structurally simple at first glance, with a repeating backbone of alternating hexuronic acid and hexosamine dimers, GAGs display a highly complex structure, which predominantly results from their heterogeneous sulfation patterns. The commonly applied method for compositional analysis of all GAGs is "disaccharide analysis." In this process, GAGs are enzymatically depolymerized into disaccharides, derivatized with a fluorescent label, and then analysed through liquid chromatography. The limiting factor in the high throughput analysis of GAG disaccharides is the time‐consuming liquid chromatography. To address this limitation, we here utilized trapped ion mobility‐mass spectrometry (TIM‐MS) for the separation of isomeric GAG disaccharides, which reduces the measurement time from hours to a few minutes. A full set of disaccharides comprises twelve structures, with eight possessing isomers. Most disaccharides cannot be differentiated by TIM‐MS in underivatized form. Therefore, we developed chemical modifications to reduce sample complexity and enhance differentiability. Quantification is performed using stable isotope labelled standards, which are easily available due to the nature of the performed modifications. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
46. Effects of Pulsed Electric Field and High-Pressure Processing Treatments on the Juice Yield and Quality of Sea Buckthorn.
- Author
-
Zhang, Zhiwei, Chen, Yixuan, Cheng, Yuying, Gao, Zhenhong, Qu, Kunsheng, Chen, Zhixi, Yue, Lihua, and Guan, Wenqiang
- Subjects
SEA buckthorn ,ELECTRIC field effects ,FLAVOR ,ELECTRONIC noses ,ENZYMATIC browning ,VOLATILE organic compounds ,GAS chromatography/Mass spectrometry (GC-MS) ,ION mobility - Abstract
Sea buckthorn juice has high nutritional value and a rich flavor that consumers enjoy. Traditional sea buckthorn thermal processing (TP) technology has problems such as low juice yield, poor quality, and poor flavor. Sea buckthorn berries are processed using a technique combining pulsed electric field (PEF) and high-pressure processing (HPP) to increase juice yield and study its impact on the quality and volatile aroma of sea buckthorn juice. Results have show that, compared with TP, under the condition of PEF-HPP, the juice yield of sea buckthorn significantly increased by 11.37% (p > 0.05); TP and PEF-HPP treatments could effectively kill microorganisms in sea buckthorn juice, but the quality of sea buckthorn juice decreased significantly after TP treatment (p > 0.05), whereas PEF-HPP coupling technology could maximally retain the nutrients of sea buckthorn juice while inhibiting enzymatic browning to improve color, viscosity, and particle size. The flavor of sea buckthorn juice is analyzed using electronic nose (E-nose) and gas chromatography–ion mobility spectrometer (GC–IMS) techniques, and it has been shown that PEF-HPP retains more characteristic volatile organic compounds (VOCs) of sea buckthorn while avoiding the acrid and pungent flavors produced by TP, such as benzaldehyde, (E)-2-heptenal, and pentanoic acid, among others, which improves the sensory quality of sea buckthorn juice. PEF-HPP technology is environmentally friendly and efficient, with significant economic benefits. Research data provide information and a theoretical basis for the sea buckthorn juice processing industry. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
47. Elucidation of Dithiol-yne Comb Polymer Architectures by Tandem Mass Spectrometry and Ion Mobility Techniques.
- Author
-
Williams-Pavlantos, Kayla, Mokarizadeh, Abdol Hadi, Curole, Brennan J., Grayson, Scott M., Tsige, Mesfin, and Wesdemiotis, Chrys
- Subjects
TANDEM mass spectrometry ,MASS spectrometry ,ION mobility ,ION mobility spectroscopy ,POLYMER blends ,POLYMERS ,MOLECULAR dynamics - Abstract
Polymers have a wide range of applications depending on their composition, size, and architecture. Varying any of these three characteristics can greatly impact the resulting chemical, physical, and mechanical properties. While many techniques are available to determine polymer composition and size, determining the exact polymer architecture is more challenging. Herein, tandem mass spectrometry (MS/MS) and ion mobility mass spectrometry (IM-MS) methods are utilized to derive crucial architectural information about dithiol-yne comb polymers. Based on their unique fragmentation products and IM drift times, dithiol-yne oligomers with distinct architectures were successfully differentiated and characterized. Additionally, experimental collision cross-sections (Ω) derived via IM-MS were compared to theoretically extracted Ω values from molecular dynamics simulated structures to deduce the architectural motif of these comb oligomers. Overall, this work demonstrates the benefits of combining various mass spectrometry techniques in order to gain a complete understanding of a complex polymer mixture. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
48. Mobility of Zn and Cu in Bentonites: Implications for Environmental Remediation.
- Author
-
Nartowska, Edyta, Podlasek, Anna, Vaverková, Magdalena Daria, Koda, Eugeniusz, Jakimiuk, Aleksandra, Kowalik, Robert, and Kozłowski, Tomasz
- Subjects
BENTONITE ,ENVIRONMENTAL remediation ,INDUCTIVELY coupled plasma atomic emission spectrometry ,COPPER ,NUCLEAR magnetic resonance ,ION mobility ,DIFFERENTIAL scanning calorimetry - Abstract
The aim of this study was to evaluate the mobility of copper (Cu) and zinc (Zn) and their impact on the properties of bentonites and unfrozen water content. Limited research in this area necessitates further analysis to prevent the negative effects of metal interactions on bentonite effectiveness. Tests involved American (SWy-3, Stx-1b) and Slovak (BSvk) bentonite samples with Zn or Cu ion exchange. Sequential extraction was performed using the Community Bureau of Reference (BCR) method. Elemental content was analyzed via inductively coupled plasma optical emission spectrometry (ICP-OES). Unfrozen water content was measured using nuclear magnetic resonance (
1 H-NMR) and differential scanning calorimetry (DSC). Results showed a significant influence of the main cation (Zn or Cu) on ion mobility, with toxic metal concentrations increasing mobility and decreasing residual fractions. Mobile Zn fractions increased with larger particle diameters, lower clay content, and shorter interplanar spacing, while the opposite was observed for Cu. Zn likely accumulated in larger clay pores, while Cu was immobilized in the bentonite complex. The stability of Zn or Cu ions increased with higher clay content or specific surface area. Residual Zn or Cu fractions were highest in uncontaminated bentonites with higher unfrozen water content, suggesting the potential formation of concentrated solutions in sub-zero temperatures, posing a threat to the clay–water environment, especially in cold regions. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
49. Investigations of nuclear isomeric states utilizing heavy-ion storage rings.
- Author
-
Litvinov, Yury A. and Korten, Wolfram
- Subjects
STORAGE rings ,PHYSICS experiments ,ION mobility - Abstract
Heavy-ion storage rings allow for storing secondary ion beams for extended periods of time. Sophisticated beam manipulation techniques, detection capabilities and thin targets provide unique conditions for a broad range of physics experiments. In this work, the investigations related to nuclear isomeric states are reviewed. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
50. Atmospheric pressure field desorption-trapped ion mobility-mass spectrometry coupling.
- Author
-
Gross, Jürgen H.
- Subjects
ATMOSPHERIC pressure ,IONS ,PROPYLENE glycols ,POLYCYCLIC aromatic compounds ,ION mobility ,ION traps ,MOLECULES ,BENZOPYRENE - Abstract
While field ionization (FI) and field desorption (FD) are established soft vacuum ionization methods in mass spectrometry (MS), the technique of atmospheric pressure field desorption (APFD) has only recently been added to the repertoire. Similar to FI and FD, APFD can yield both positive even-electron ions of highly polar or ionic compounds and positive molecular ions, M
+• , e.g., of polycyclic aromatic compounds. Thus, a dedicated APFD source assembly has been constructed and demonstrated to allow for robust APFD operation. This device also enabled observation of the emitter during operation and allowed for resistive emitter heating, thereby speeding up the desorption of the analytes and expanding the range of analytes accessible to APFD. While initial work was done using a Fourier transform-ion cyclotron resonance (FT-ICR) mass spectrometer, the new APFD source offered the flexibility to also be used on a trapped ion mobility-quadrupole-time-of-flight (TIMS-Q-TOF) instrument, and thus, it would be possible to be mounted to any Bruker mass spectrometer featuring an atmospheric pressure (AP) interface. Operating an APFD source at a TIMS-Q-TOF instrument called for the exploration of the combined use of APFD and TIMS. Here, operation, basic properties, and capabilities of this new atmospheric pressure field desorption-trapped ion mobility-mass spectrometry (APFD-TIMS-MS) coupling are described. APFD-TIMS-MS is employed for the separation of individual components of oligomers and for the accurate determination of their collision cross section (CCS). This work describes the application of APFD-TIMS-MS on poly(ethylene glycol) forming [M + Na]+ ions by cationization and on an amine-terminated poly(propylene glycol) yielding [M + H]+ ions. Some compounds forming molecular ions, M+• , by field ionization such as [60]fullerene and a mixture of four polycyclic aromatic hydrocarbons (PAHs) are examined. In APFD-TIMS-MS, the limits of detection (LODs) of fluoranthene and benzo[a]pyrene M+• ions are determined as ≈100 pg and <1 pg, respectively. Finally, [60]fullerene is analyzed by negative-ion APFD-TIMS-MS where it yields a molecular anion, M−• . [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.