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Quaternary volcanoes from the southeastern Tibetan Plateau occur at the Tengchong volcanic field (TVF). The Daliuchong volcano is the largest volcano in the TVF, which has the most felsic compositions with explosive eruptions. The eruption history and origin of the Daliuchong volcano are a matter of debate. In the present paper, we report the groundmass K-Ar ages, whole-rock Sr-Nd-Pb-Hf isotopes, zircon U-Pb ages, and Hf-O isotopic compositions for the Daliuchong volcano to constrain its eruption history and petrogenesis. The groundmass K-Ar ages and zircon U-Pb ages indicate mid-Pleistocene (0.6 Ma to 0.3 Ma) eruptions. The presence of zircon phenocrysts with enriched mantle-like O-Hf isotopes (δ18O < 6‰, and εHf about −2) suggests the involvement of mantle-derived basaltic magmas. The whole-rock Pb isotope compositions and Sr-Nd isotope modeling reveal the involvement of magma from the lower crust. The zircon xenocrysts reveal previously unrecognized 20-Ma magmatic activity at the TVF and contamination of late Cretaceous (66–80 Ma) S-type granites during the formation of the Daliuchong dacites. The dacite magma at Daliuchong was formed by mixing of the mantle-derived magma and lower-crust-derived magma and subsequently contaminated by upper crustal materials, including late Cretaceous S-type granitic rocks. [ABSTRACT FROM AUTHOR]

This paper reports lithium concentrations and isotopic compositions of olivines in the oceanized subcontinental lithospheric mantle (SCLM) peridotites of the Tibetan Yunzhug ophiolite. The results show systematic Li isotope changes with distance from the rim of olivine grains. δ7Li values of olivine in dunites decrease from + 10.46 to + 1.33‰ with increasing distance to olivine rim from 26.15 to 124.71 μm. A negative correlation of δ7Li and Li content in olivine from dunite and harzburgite indicates recent diffusive ingress of Li into the peridotites. The extremely heavy Li isotopic composition requires the seawater or seawater alteration endmember in the mixing model, and reveals Li diffusion from seawater into olivine. As in dunites, olivines in a harzburgite sample show similar variations in δ7Li as a function of distance from the grain rim (e.g., 6.01 to 1.73 in sample 14YZ13). We suggest that the behavior of Li in the oceanized SCLM peridotites may be controlled by Li diffusion from seawater, as Li activity in the liquid state is higher than the solid state in transporting Li through the olivines in the peridotites. This study supports that seawater Li diffusion is one of the important factors for the heterogeneity of mantle Li isotopes in ophiolites. [ABSTRACT FROM AUTHOR]

This paper reports lithium concentrations and isotopic compositions of olivines in the oceanized subcontinental lithospheric mantle (SCLM) peridotites of the Tibetan Yunzhug ophiolite. The results show systematic Li isotope changes with distance from the rim of olivine grains. δ7Li values of olivine in dunites decrease from + 10.46 to + 1.33‰ with increasing distance to olivine rim from 26.15 to 124.71 μm. A negative correlation of δ7Li and Li content in olivine from dunite and harzburgite indicates recent diffusive ingress of Li into the peridotites. The extremely heavy Li isotopic composition requires the seawater or seawater alteration endmember in the mixing model, and reveals Li diffusion from seawater into olivine. As in dunites, olivines in a harzburgite sample show similar variations in δ7Li as a function of distance from the grain rim (e.g., 6.01 to 1.73 in sample 14YZ13). We suggest that the behavior of Li in the oceanized SCLM peridotites may be controlled by Li diffusion from seawater, as Li activity in the liquid state is higher than the solid state in transporting Li through the olivines in the peridotites. This study supports that seawater Li diffusion is one of the important factors for the heterogeneity of mantle Li isotopes in ophiolites. [ABSTRACT FROM AUTHOR]

Objective: This study aims to construct an artificial intelligence (AI) model capable of effectively discriminating between abdominal Henoch‐Schönlein purpura (AHSP) and acute appendicitis (AA) in pediatric patients. Methods: A total of 6965 participants, comprising 2201 individuals with AHSP and 4764 patients with AA, were enrolled in the study. Additionally, 53 laboratory indicators were taken into consideration. Five distinct artificial intelligence (AI) models were developed employing machine learning algorithms, namely XGBoost, AdaBoost, Gaussian Naïve Bayes (GNB), MLPClassifier (MLP), and support vector machine (SVM). The performance of these prediction models was assessed through receiver operating characteristic (ROC) curve analysis, calibration curve assessment, and decision curve analysis (DCA). Results: We identified 32 discriminative indicators (p <.05) between AHSP and AA. Five indicators, namely the lymphocyte ratio (LYMPH ratio), eosinophil ratio (EO ratio), eosinophil count (EO count), neutrophil ratio (NEUT ratio), and C‐reactive protein (CRP), exhibited strong performance in distinguishing AHSP from AA (AUC ≥ 0.80). Among the various prediction models, the XGBoost model displayed superior performance evidenced by the highest AUC (XGBoost = 0.895, other models < 0.89), accuracy (XGBoost = 0.824, other models < 0.81), and Kappa value (XGBoost = 0.621, other models < 0.60) in the validation set. After optimization, the XGBoost model demonstrated remarkable diagnostic performance for AHSP and AA (AUC > 0.95). Both the calibration curve and decision curve analysis suggested the promising clinical utility and net benefits of the XGBoost model. Conclusion: The AI‐based machine learning model exhibits high prediction accuracy and can differentiate AHSP and AA from a data‐driven perspective. [ABSTRACT FROM AUTHOR]

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Microchannel cooling technology is an effective method to solve local thermal stacking. In this paper, four innovative microchannels with bionic fish-shaped rib arrangements (CM-O, CM-R, CM-H, and CM-G) are designed by imitating geese and fish clusters. The heat transfer and flow characteristics of the microchannels are simulated numerically at different Reynold's numbers (Re = 200 − 1600). The liquid water temperature and flow field in the four innovative microchannels with bionic ribs are analyzed. The results show that the ribs' arrangement has an influence on the thermal performance of microchannels. Compared to the smooth microchannel (CM), the of the N u microchannels with the bionic fish-shaped ribs increases by 33.00–53.26% while the f a v e increases by 28.63–34.93% at Re = 1200. The vortices around the ribs are clearly observed which improves the temperature gradient. The performance evaluation criterion (PEC) of CM-H is higher than that of the others. This indicates that the rib arrangement of CM-H is superior for heat dissipation application. [ABSTRACT FROM AUTHOR]

Reanalysis data play a vital role in weather and climate study as well as meteorological resource development and application. In this work, the East Asia Reanalysis System (EARS) was developed using the Weather Research and Forecasting (WRF) model and the Gridpoint Statistical Interpolations (GSI) data assimilation system. The regional reanalysis system is forced by the European Centre for Medium-Range Weather Forecasts (ECMWF) global reanalysis ERA-Interim data at 6 h intervals. Hourly surface observations are assimilated by the Four-Dimension Data Assimilation (FDDA) scheme during the WRF model integration; upper observations are assimilated in three-dimensional variational data assimilation (3D-VAR) mode at the analysis moment. It should be highlighted that many of the assimilated observations have not been used in other reanalysis systems. The reanalysis runs from 1980 to 2018, producing a regional reanalysis dataset covering East Asia and surrounding areas at 12 km horizontal resolution, 74 sigma levels, and 3 h intervals. Finally, an evaluation of EARS has been performed with respect to the root mean square error (RMSE), based on the 10-year (2008–2017) observational data. Compared to the global reanalysis data of ERA-Interim, the regional reanalysis data of EARS are closer to the observations in terms of RMSE in both surface and upper-level fields. The present study provides evidence for substantial improvements seen in EARS compared to the ERA-Interim reanalysis fields over East Asia. The study also demonstrates the potential use of the EARS data for applications over East Asia and proposes further plans to provide the latest reanalysis in real-time operation mode. Simple data and updated information are available on Zenodo at 10.5281/zenodo.7404918 (Yin et al., 2022), and the full datasets are publicly accessible on the Data-as-a-Service platform of the China Meteorological Administration (CMA) at http://data.cma.cn (last access: 19 May 2023). [ABSTRACT FROM AUTHOR]

Liver fibrosis is a chronic liver disease with the presence of progressive wound healing response caused by liver injury. Currently, there are no approved therapies for liver fibrosis. Exosomes derived from human adipose mesenchymal stem cells (hADMSCs-Exo) have displayed a prominent therapeutic effect on liver diseases. However, few studies have evaluated therapeutic effect of hADMSCs-Exo in liver fibrosis and cirrhosis, and its precise mechanisms of action remain unclear. Herein, we investigated anti-fibrotic efficacy of hADMSCs-Exo in vitro and in vivo, and identified important metabolic changes and the detailed mechanism through transcriptomic and metabolomic profiling. We found hADMSCs-Exo could inhibit the proliferation of activated hepatic stellate cells through aggravating apoptosis and arresting G1 phase, effectively inhibiting the expression of profibrogenic proteins and epithelial-to-mesenchymal transition (EMT) in vitro. Moreover, it could significantly block collagen deposition and EMT process, improve liver function and reduce liver inflammation in liver cirrhosis mice model. The omics analysis revealed that the key mechanism of hADMSCs-Exo anti-hepatic fibrosis was the inhibition of PI3K/AKT/mTOR signaling pathway and affecting the changes of metabolites in lipid metabolism, and mainly regulating choline metabolism. CHPT1 activated by hADMSCs-Exo facilitated formation and maintenance of vesicular membranes. Thus, our study indicates that hADMSCs-Exo can attenuate hepatic stellate cell activation and suppress the progression of liver fibrosis, which holds the significant potential of hADMSCs-Exo for use as extracellular nanovesicles-based therapeutics in the treatment of liver fibrosis and possibly other intractable chronic liver diseases. [ABSTRACT FROM AUTHOR]

Hepatocellular carcinoma (LIHC) accounts for 90% of all liver cancers and is a serious health concern worldwide. Long noncoding RNAs (lncRNAs) have been observed to sponge microRNAs (miRNAs) and participate in the biological processes of LIHC. This study aimed to evaluate the role of the ST8SIA6-AS1-miR-142-3p-HMGA1 axis in regulating LIHC progression. RT-qPCR and western blotting were performed to determine the levels of ST8SIA6-AS1, miR-142-3p, and HMGA1 in LIHC. The relationship between ST8SIA6-AS1, miR-142-3p, and HMGA1 was assessed using luciferase assay. The role of the ST8SIA6-AS1-miR-142-3p-HMGA1 axis was evaluated in vitro using LIHC cells. Expression of ST8SIA6-AS1 and HMGA1 was significantly upregulated, whereas that of miR-142-3p was markedly lowered in LIHC specimens and cells. ST8SIA6-AS1 accelerated cell growth, invasion, and migration and suppressed apoptosis in LIHC. Notably, ST8SIA6-AS1 inhibited HMGA1 expression by sponging miR-142-3p in LIHC cells. In conclusion, sponging of miR-142-3p by ST8SIA6-AS1 accelerated the growth of cells while preventing cell apoptosis in LIHC cells, and the inhibitory effect of miR-142-3p was abrogated by elevating HMGA1 expression. The ST8SIA6-AS1-miR-142-3p-HMGA1 axis represents a potential target for the treatment of patients with LIHC. [ABSTRACT FROM AUTHOR]

Purpose: The aim of this study is to explore how pedicle screws (PSs) and cortical bone trajectory (CBT) screws differ in fixation strength when implanted in L1–L5 with osteoporosis, providing support for choosing implants and trajectories in spine internal fixation surgeries. Methods: We filtered 30 lumbar segments out from CT images of eight osteoporotic participants and simulated PS or CBT screw implantation in each segment, generating 60 vertebra-screw assembly FE models. To evaluate the fixation effect, we performed a pull-out force test simulation in each model and analyzed the maximal pull-out force, pull-out stiffness, and equivalent stress of vertebrae and screws. Results: The maximal pull-out force of PS and CBT screws in L1–L5 was in the range of 905–1552 (N) and 587–1012 (N), while the pull-out stiffness was in the range of 1990–2617 (N/mm) and 1007–1681 (N/mm). The fixation strength of PS in L4 and L5 was higher (p < 0. 0 5), while in L1–L3 PS and CBT screws are similar (p > 0. 0 5). The maximal stress of vertebrae and screws when PS was pulled at 0.25 mm was larger than that of CBT screws. Conclusions: For patients with moderate osteoporosis, it is recommended to insert PS into L4 and L5 to attain better fixation strength, but vertebrae are more prone to fracture. Consequently, under severe osteoporosis, the implantation of CBT screws should be considered first. Bone cement injection may be necessary to consolidate the screw-vertebrae interface with osteoporosis. [ABSTRACT FROM AUTHOR]

Olivine grains from Songshugou mylonitized peridotite massif record δ18O both lower and higher than in pristine mantle samples in North Qinling Orogen, Central China. Olivines from dunites exhibit large variations in δ18O (4.03–7.07‰), and some porphyroclasts display negative correlations between δ18O and forsterite content {Fo; [100×Mg/(Mg+Fe2+)]}. The porphyroclast cores have low-δ18O values, indicating that they formed in the oceanic lithospheric mantle prior to subduction. We attribute low-δ18O values to seawater-peridotite interaction under high-temperature conditions. The porphyroclast rims and small olivines exhibit high-δ18O values. These features suggest that high-δ18O olivines formed during mylonitization in the exhumation process. Olivines reacted with 18O-rich melt/fluids released from subducted altered oceanic basalts and continental sediments at low temperature (<610–680 °C). The 18O-rich melt/fluids selectively affected porphyroclast rims and small olivine grains. Unlike the olivines in the dunites, the olivines and orthopyroxenes in the harzburgites show limited variations in δ18O (4.21–5.45‰ and 5.5–5.8‰, respectively), due to orthopyroxene exchange with melt/fluid at a slower rate than the coexisting olivine. The preservation of the low-δ18O signature in olivines indicates a short residence time (<20 Ma) for subducting peridotites to mantle depths. [ABSTRACT FROM AUTHOR]

In this study, high-resolution weather research and forecasting (WRF) simulations are used to explore the sensitivity of lake-effect convection over Poyang Lake (PL) to the change of lake surface temperature (LST). A control experiment (CTR) with climate mean LST (303 K) is compared with six sensitivity experiments (CTR−1/2/3K and CTR+1/2/3K) in which the LSTs are set based on the mean LST difference of 6 K between the maximum and minimum. The results show that the CTR experiment reasonably reproduces the lake-effect convection, and the lake-effect convection in sensitivity experiments is significantly influenced by the LST. With the increase of LST, the initiation time of the lake-effect convection is advanced gradually, while the initiation location moves PL from its shore. The lake-effect convection strengthens (weakens) in the increase-temperature CTR+1/2/3K (decrease-temperature CTR−1/2/3K) experiments, but the lake-effect convection does not monotonically strengthen with the LST, for the strongest one occurring in the CTR+1K experiment. The corresponding diagnostic analysis shows that the upward sensible heat flux and latent heat flux over PL increase with the LST, resulting in the enhancement of the lake-land breeze and the enlargement of the convective available potential energy (CAPE). This is the main reason for the changes in the initiation time and location, as well as the intensity of lake-effect convection in different experiments. In addition, the non-monotonous variation of the level of free convection, which is mainly induced by the non-monotonous variation of the lifting condensation level, is responsible for the non-monotonous variation of the lake-effect convection intensity with the LST. [ABSTRACT FROM AUTHOR]

Background: Gynura segetum (GS) is widely used in medical care and in community settings in China as the herbal remedy. It is widely thought to have antiphlogistic properties and pain relief in traditional Chinese medicine. It has been reported that GS can cause chronic drug-induced liver injury (DILI), manifested as hepatic sinusoid obstruction syndrome (HOSO). But case reports of acute DILI developing acute liver failure (ALF) due to GS are extremely rare. Case presentation: We report a case of a 63-year-old female patient with hepatolithiasis for more than 6 years. There were no deterioration of liver function and no history of viral liver disease, autoimmune liver disease, blood transfusion or surgical allergy before operation. ALF and grade II liver encephalopathy occurred after partial hepatectomy. To follow up the medical history, the patient has been taking GS (Tusanqi) for a year and a half. The causality assessment was done by the updated Roussel Uclaf Causality Assessment Method, and the possibility of DILI caused by GS as highly probable for the score was 6 points. Excluding other causes, a diagnosis of DILI-associated ALF was established. After symptomatic support and artificial liver support system (ALSS) treatment, the clinical symptoms and signs of the patients were significantly improved. After discharge, the liver function of the patients returned to normal. Conclusions: Based on this rare case of severe liver injury, we recommend that timely prevention, identification, and appropriate management of DILI is essential for patients with a history of taking GS and other hepatotoxic drugs, and careful monitoring of liver function for patients with DILI could avoid ALF as far as possible. [ABSTRACT FROM AUTHOR]

Nonalcoholic fatty liver disease (NAFLD) is the common disease in the liver, which is associated with metabolic syndrome and hepatocellular carcinoma. Accumulated evidence establishes that small non-coding microRNAs (miRNAs) contribute to the initiation and progression of NAFLD. However, the molecular repertoire of miRNA in NAFLD is still largely unknown. Here, using an integrative approach spanning bioinformatic analysis and functional approaches, we demonstrate that miR-124-3p participates in the development of NAFLD by directly targeting preadipocyte factor-1 (Pref-1). In response to high-fat diet (HFD), expression of miR-124-3p was increased in the liver. Inhibition of miR-124-3p expression led to a dramatic reduction of triglyceride contents in hepatocytes, in parallel with decreased inflammatory factors. Mechanistically, miR-124-3p directly controls the transcription of Pref-1, a secretory factor that has been proved to resist metabolic syndrome. Our work identifies a novel molecular axis in hepatosteatosis, and highlights miR-124-3p /Pref-1 as potential targets for clinical interventions of NAFLD. [ABSTRACT FROM AUTHOR]

Purpose anterior cervical decompression and fusion is a common surgical procedure. Traditionally, experienced doctors observe X-ray films regularly examined by patients to determine postoperative conditions by observing the tiny movements between the limited vertebral bodies. But it is not accurate. This may lead to error diagnostics and serious deterioration of the condition and secondary injury to the patient and will also put a greater financial burden on them. Doctors need a quantitative standard to determine small motion with limited vertebral landmarks after surgery. Computer vision technology is needed to match the over-extension and over-flexion cervical vertebral body to provide objective measurement data for further quantification of intervertebral activity. Based on conventional scheme, the point mean square error is used as the evaluation criterion of the matching effect, and the iterative matching scheme is proposed to improve the stability of the original scheme. The cervical X-ray films of patients from the China–Japan Friendship Hospital were collected as samples to verify the reliability of the scheme. Compared with the existing image matching schemes based on feature points, our scheme is superior in matching effect, matching speed and stability. This scheme can provide a solid foundation for further assisting doctors in the study of rehabilitation after anterior cervical fusion. [ABSTRACT FROM AUTHOR]

With the 1 h-averaged data of atmospheric precipitable water vapor (PWV) for 2015–2018 retrieved from 18 ground-based Global Positioning System (GPS) observation stations near Poyang Lake (PL), China, the diurnal variations of the PWV during midsummer (July-August) are studied by the harmonic method. Results show that significant diurnal variations of PWV are found at the 18 GPS stations. The harmonics with 24 h cycle (diurnal cycle) over PL (i.e., Duchang and Poyang) and Nanchang city only have about 50% (or even smaller than 50%) of variance contribution with the amplitude of about 0.2 mm, while above 70% (or even 80%) of variance contribution occurs elsewhere around PL, with the amplitude of about 0.9 mm. The harmonics with diurnal cycles in most stations peak from afternoon to evening (i.e., 1200-2000 LST), but one exception is Duchang site, where the diurnal cycle peaks in the morning (i.e., 1000 LST). Moreover, the harmonics with 12 h cycle (semidiurnal cycle) have the relatively uniform amplitude of about 0.2 mm, but their variance contributions show uneven distribution, with the contributions of about or above 50% in PL and Nanchang city (the semidiurnal cycles peak about 0000 LST or 1200 LST) and below 30% (or even 10%) in other areas. The preliminary diagnosis analysis shows that the diurnal variation of the low-level (below 850 hPa) air temperature (increasing after the sunrise, decreasing after the sunset, and peaking around 1400-1800 LST) may be responsible for the diurnal cycle. Moreover, in PL (Duchang and Poyang) and Nanchang city, the effects (heating or cooling) of lake and urban, the diurnal variation of the 10 m wind over PL, and the acceleration of PL on overlying air also contributed to the diurnal variation of PWV. [ABSTRACT FROM AUTHOR]

Purpose: We aimed to explore the risk factors of preoperative sleep quality in patients with lumbar spinal stenosis (LSS) and the association of sleep-related beliefs with sleep quality in these patients. Methods: Sleep quality and related risk factors of sleep quality disturbances in patients with LSS preoperatively were assessed by questionnaires. Pittsburgh Sleep Quality Index (PSQI) for sleep quality, Oswestry Disability Index (ODI) for clinical outcomes, Visual Analog Scale for Pain (VAS Pain), Self-Rating Anxiety Scale (SAS) for anxiety level, and Dysfunctional Beliefs and Attitudes about Sleep (DBAS-16) for sleep-related beliefs were assessed. Bivariate logistic regression analysis was used to assess the risk factors of sleep quality disturbances. Results: A total of 227 patients were enrolled, mean age 64 years (SD 13.1), 119 women (52%). The incidence of sleep quality disturbances in patients was 37% (83/227). Increased DBAS-16 scores (OR = 0.781; 95% CI, 0.725–0.841; p < 0.001) significantly decreased the probability of developing sleep quality disturbances, while increased anxiety levels (OR = 1.241; 95% CI, 1.152–1.337; p < 0.001) significantly increased the probability of developing sleep quality disturbances in patients. Factors including educational level, increased age, sex, preoperative length of stay, VAS Pain scores, and ODI scores showed no significant association and were therefore excluded from the model. Conclusions: High levels of anxiety and mistaken sleep-related beliefs were risk factors of sleep quality disturbances in patients with LSS before surgery. The more mistaken sleep-related beliefs were, the greater the probability of sleep disturbances. [ABSTRACT FROM AUTHOR]

A convective storm crossing Poyang Lake (PL) in China during 1200-1600 UTC on 13 May 2015 is examined. The results show that this storm occurs ahead of a 500-hPa trough with weak low-level temperature advection and a convectively stable layer between 925 and 850 hPa, and the tail of the storm is enhanced when its spearhead sweeps over PL after the sunset. Due to the heating and moistening of PL, the convectively stable layer over PL is destabilized; and instead, a deep (below 700 hPa) convectively unstable layer is organized. Moreover, both the radiative cooling and the storm-induced cooling result in a rapid air (near-surface) and land temperature decrease in the surrounding areas. Thus, a large lake-land temperature difference (about 6°C) occurs, which is conducive to generating land-lake breeze and enhancing the convergence of the low-level wind. Finally, the PL-induced deep convectively unstable layer and the enhanced low-level convergence jointly strengthen the crossing storm. To further confirm this, two simulations (with or without PL) are conducted with the Weather Research and Forecast (WRF) model. The simulation with PL successfully reproduces the evolution of the storm crossing PL, while the simulation without PL fails. In the simulation with PL, a high θse tongue at 850 hPa associated with the storm moves eastward and downward, and merges with the PL-induced lake boundary layer, forming a deep convectively unstable layer under 700 hPa. However, in the simulation without PL, the stable layer constantly maintains under 900 hPa. In addition, the 900-hPa wind difference between the simulations with and without PL shows a land-lake breeze circulation that strengths the convergence of the low-level wind. [ABSTRACT FROM AUTHOR]

BACKGROUND: Curcumin pre-conditioning can alleviate liver injury induced by limb ischemia/reperfusion (l/R), but whether curcumin post-conditioning has protective effect against liver cold l/R injury and its mechanism are still poorly studied. OBJECTIVE: To investigate the effects of curcumin post-conditioning on hepatocyte apoptosis in rats with liver cold l/R injury in rats. METHODS: Eighty adult male Sprague-Dawley rats were randomly divided into four groups (n=20 per group) by using a random number table: sham group, l/R group, curcumin post-conditioning group (l/R+Cur group), and dexamethasone group {l/R+Dex group). The liver blood flow was completely blocked. Then the splenic vein and the adrenal vein were used as the inflow and outflow tracts to inject 0 °C compound Ringer lactate solution followed by cold perfusion for 30 minutes. After stopping cold perfusion, the proximal splenic vein and the right adrenal vein were ligated to remove the spleen, and then the blood flow in the liver restored. The cold l/R model was successfully established. After 30 minutes of cold ischemia, 60 mg/kg curcumin was injected into the rat tail vein in the l/R+Cur group, 0.5 mg/kg dexamethasone was injected into the rat tail vein in the l/R+Dex group, and the same amount of saline was injected in the other groups. Blood sample was taken from the carotid artery at 6 hours after reperfusion. Serum levels of aspartate aminotransferase and alanine transferase were detected. Then the rats were sacrificed to detect malondialdehyde level in liver tissue, observe liver pathological changes by hematoxylin-eosin staining, measure hepatocyte apoptosis index by Hoechst 33258 staining, detect expression of Bcl-2 and Bax protein by western blot, expression of caspase-9 mRNA by RT-PCR, and levels of tumor necrosis factor-α and interleukin-1β by ELISA. RESULTS AND CONCLUSION: Compared with the sham group, aspartate aminotransferase, alanine transferase, malondialdehyde levels and apoptosis index in the l/R group increased significantly (P < 0.05). Hematoxylin-eosin staining showed a large number of inflammatory cells infiltrated in the hepatic sinusoids, eosinophilic changes of hepatocytes, cytoplasmic loosening, balloon-like changes of hepatocytes, occasional patchy necrosis, and scattered punctate necrosis foci in the l/R group. The l/R group had significantly decreased expression of Bcl-2, and increased expression of Bax (P < 0.05), Caspase-9 mRNA, tumor necrosis factor-α and interleukin-1β (P < 0.05). Compared with the l/R group, aspartate aminotransferase, alanine transferase, malondialdehyde levels and apoptosis index in the l/R+Cur group decreased significantly (P < 0.05). Hematoxylin-eosin staining showed that inflammatory infiltration in the hepatic sinusoids decreased significantly, eosinophilic and balloon-like hepatocytes decreased significantly, but occasionally a small amount of scattered punctate necrosis was observed in the l/R+Cur group. There was significantly increased Bcl-2 expression, and significantly decreased Bax (P < 0.05), Caspase-9 mRNA, tumor necrosis factor-α and interleukin-1β (P < 0.05). No significant differences were observed between l/R+Cur group and l/R+Dex group (P > 0.05). In a word, curcumin-post conditioning can alleviate liver injury induced by cold l/R in rats. Its mechanism may be related to down-regulation of Bci-2/Bax ratio, inhibition of caspase-9 m RNA expression, and reduction of the release of tumor necrosis factor-α and interleukin-1β. therefore playing an anti-apoptotic role in liver protection. [ABSTRACT FROM AUTHOR]

Accumulating evidence has demonstrated that the aberrant expression of microRNAs (miRs or miRNAs) may contribute to the initiation and progression of various types of human cancer and may also constitute biomarkers for cancer diagnosis and therapy. However, the specific function of miR‐9 in hepatocellular carcinoma (HCC) remains unclear, and the mechanisms that underlie HCC are incompletely understood. Here, we report that miR‐9 expression was significantly decreased in clinical tumor tissue samples, as well as in a cohort of HCC cell lines. In addition, it was demonstrated that overexpression of miR‐9 suppressed the proliferative and migratory capacity of HCC cells and impaired cell cycle progression. Furthermore, high mobility group AT‐hook 2 (HMGA2) was verified as a downstream target gene of miR‐9 using a luciferase reporter assay. Quantitative RT‐PCR and western blotting implicated HMGA2 in the miR‐9‐mediated reduction of HCC cell growth. In vivo, transfection with miR‐9 mimics down‐regulated the expression of HMGA2, thus leading to a dramatic reduction in tumor growth in a mouse xenograft model. These results suggest that miR‐9 may exert critical antitumor effects on HCC by directly targeting HMGA2, and the miR9/HMGA2 signaling pathway may be of use for the diagnosis and prognosis of patients with HCC. [ABSTRACT FROM AUTHOR]

The present research was major in investigating the regulation association among hsa_circ_0101432 (has_circ_RPPH1), miR-1258, miR-622 and MAPK1 in hepatocellular carcinoma (HCC), and we explored the mechanism underlying pathogenesis of HCC. Microarray analysis was employed to detect hsa_circ_0101432 expression in HCC. Hsa_circ_0101432 was verified as a circRNA by testing divergent primers and RNase R. And qRT-PCR was performed to determine the expression of hsa_circ_0101432, miR-1258, miR-622 and MAPK1 mRNA. Furthermore, miRanda predicted that mRNAs targeted miR-1258 and miR-622. CCK-8 assay, colony formation assay, flow cytometry as well as transwell assay were performed to detect cell viability, proliferation, apoptosis and invasive ability, respectively. Xenograft in nude mice was applied to observe tumor growth in vivo. Up-regulated hsa_circ_0101432 and down-regulated miR-1258 and miR-622 were detected in HCC while Hsa_circ_0101432 enhanced expression of MAPK1 mRNA by targeting miR-1258 and miR-622. Knocking down hsa_circ_0101432 or overexpressing miR-1258 and miR-622 inhibited proliferation and invasive ability of HCC cell and promoted cell apoptosis. Hsa_circ_0101432 was confirmed to promote tumor growth via inhibiting miR-1258 and miR-622 expression and promoting MAPK1 mRNA expression by in vivo experiment. Hsa_circ_0101432 inhibited HCC cell apoptosis, promoted cell proliferation, invasive ability and HCC tumor growth by targeting miR-1258 and miR-622 and upregulating MAPK1 mRNA expression. [ABSTRACT FROM AUTHOR]

A method named BTREC, which is in fact an extension of tracking a radar echo by cross-correlation (TREC) method, is proposed based on the Barnes filter in this paper. BTREC is an efficient objective analysis method for smoothing the motion vectors of radar echo patterns. A comparative analysis of the BTREC vectors and the COTREC (another extension of TREC, which is restricted by the 2D continuity equation) vectors is conducted. The results show that the BTREC method corrects the noise and inconsistencies in TREC vectors (often induced by shielding, ground clutter, and rapid morphological changes of the radar patterns) more thoroughly than COTREC. Then the BTREC, COTREC, and TREC methods are applied to extrapolate the real radar echo pattern over Jiangxi Province in China for two cases (1900–2100 UTC 4 June and 0900–1100 UTC 30 June 2018). Results show that the BTREC method performs the best out of the three methods to forecast the radar echo patterns in the following 1 and 2 h, and has the least distortion. To further confirm that, 892 radar composite reflectivity mosaic images with precipitation in summer (June–August) over Jiangxi are collected to test the three methods. The results show that in the 1- and 2-h extrapolations, the mean differences of the threat score (TS), correlation (CORR), and probability of detection (POD) between BTREC and TREC are obviously more than 0, while that of the false alarm ratio (FAR) is remarkably less than 0 (the threshold to identify whether a grid is correctly predicted is set to 10 dBZ). Although the mean difference of TS, CORR, POD, and FAR between COTREC and TREC have similar variation, their magnitudes are obviously decreased (especially for the 2-h extrapolation). This further indicates that the BTREC method obviously improves the forecast of the radar echo pattern within the next 2 h compared to the COTREC and TREC methods. [ABSTRACT FROM AUTHOR]

Using echo-top height and hourly rainfall datasets, a new reflectivity-rainfall (Z-R) relationship is established in the present study for the radar-based quantitative precipitation estimation (RQPE), taking into account both the temporal evolution (dynamical) and the types of echoes (i.e., based on echo-top height classification). The new Z-R relationship is then applied to derive the RQPE over the middle and lower reaches of Yangtze River for two short-time intense rainfall cases in summer (2200 UTC 1 June 2016 and 2200 UTC 18 June 2016) and one stratiform rainfall case in winter (0000 UTC 15 December 2017), and then the comparative analyses between the RQPE and the RQPEs derived by the other two methods (the fixed Z-R relationship and the dynamical Z-R relationship based on radar reflectivity classification) are accomplished. The results show that the RQPE from the new Z-R relationship is much closer to the observation than those from the other two methods because the new method simultaneously considers the echo intensity (reflecting the size and concentration of hydrometers to a certain extent) and the echo-top height (reflecting the updraft to a certain extent). Two statistics of 720 rainfall events in summer (April to June 2017) and 50 rainfall events in winter (December 2017) over the same region show that the correlation coefficient (root-mean-squared error and relative error) between RQPE derived by the new Z-R relationship and observation is significantly increased (decreased) compared to the other two Z-R relationships. Besides, the new Z-R relationship is also good at estimating rainfall with different intensities as compared to the other two methods, especially for the intense rainfall. [ABSTRACT FROM AUTHOR]

Using China New Generation Weather Radar (CINRAD) level-II data, the original algorithms for removing isolated non-meteorological echoes and ground clutters in radar data, which have been applied to Weather Surveillance Radar-1988 Doppler (WSR-88D) in the USA and Severe Weather Automatic Nowcast (SWAN) system in China, are modified and improved. To remove isolated non-meteorological echoes, the new algorithm introduces a constraint parameter (Po) to distinguish whether a window of 5 × 5 points is isolated as external echoes. A statistical analysis of 150 radar scans (5 cases, with each case comprising 30 scans) under three different echo types (small-scale convection, typhoon, and large-scale synoptic system) shows that the constraint parameter Po ⩽ 0.167 is suitable for removing isolated non-meteorological echoes while preserving the edge of meteorological echoes. A new parameter, NDZ, which promotes the ability of the algorithm to identify the ground clutters appearing at two adjacent elevation angles, is constructed based on the vertical continuity of reflectivity. These improved algorithms are tested for four cases (three cases of isolated non-meteorological echoes and one case of ground clutters). Based on the statistics of 232 volume scans of radar data (on a temporal resolution of 1 h) measured at Nanchang station from 0000 UTC 5 to 1600 UTC 14 March 2015, it is found that the improved algorithms not only eliminate most (over 95% under clear-sky conditions) of the isolated non-meteorological echoes and ground clutters (including those appearing at two adjacent elevation angles), but also well preserve the structure of meteorological echoes (storms). Key words: radar, isolated non-meteorological echoes, ground clutter, quality control [ABSTRACT FROM AUTHOR]

After a tropical cyclone (TC) making landfall, the numerical model output sea level pressure (SLP) presents many small-scale perturbations which significantly influence the positioning of the TC center. To fix the problem, Barnes filter with weighting parameters C=2500 and G=0.35 is used to remove these perturbations. A case study of TC Fung-Wong which landed China in 2008 shows that Barnes filter not only cleanly removes these perturbations, but also well preserves the TC signals. Meanwhile, the centers (track) obtained from SLP processed with Barnes filter are much closer to the observations than that from SLP without Barnes filter. Based on the distance difference (DD) between the TC center determined by SLP with/without Barnes filter and observation, statistics analysis of 12 TCs which landed China during 2005–2015 shows that in most cases (about 85%) the DDs are small (between −30 km and 30 km), while in a few cases (about 15%) the DDs are large (greater than 30 km even 70 km). This further verifies that the TC centers identified from SLP with Barnes filter are more accurate compared to that directly obtained from model output SLP. Moreover, the TC track identified with Barnes filter is much smoother than that without Barnes filter. [ABSTRACT FROM AUTHOR]

Background: At present, Da Vinci robotic assisted hepatectomy has been routinely carried out in conditional units. But there is no report concerning the use of Da Vinci robots for hepatic hydatid cystectomy and experience on this aspect is seldom mentioned before. This study was to summarize the preliminary experience in laparoscopic resection of hepatic hydatidectocyst with the Da Vinci Surgical System (DVSS).Case Presentation: A 29-year-old female diagnosed as hepatic hydatid in the right anterior lobe of liver was treated with laparoscopic resection by the DVSS under general anesthesia. Appropriate disposal of tumor cell in vascular system and disinfection of surgical field with hypertonic saline were conducted. The hepatic hydatidectocyst was resected completely with an operation time of 130 min, an intraoperative blood loss of 200 ml and a length of hospital stay for five days. The vital signs of patient were stable and no cyst fluid allergy occurred after operation.Conclusions: Our result showed that laparoscopic resection of hepatic hydatidectocyst by using the DVSS is safe and feasible on the basis of hospitals have rich experience in treatment of cystic echinococcosisliver, resection with DVSS and laparoscopic excision. [ABSTRACT FROM AUTHOR]

Uranium-series dating of carbonatitic ejecta clasts constrains the crystallization and differentiation timescales of the Laacher See volcano, which erupted 6·3 km3 of magma (dense rock equivalent) during one of the largest Late Quaternary eruptions in Central Europe. Carbonatites form a distinct population among plutonic ejecta that are present in the middle and late erupted Laacher See tephra. Characteristic trace element patterns of the carbonatites, including negative Eu anomalies, and mantle-like oxygen isotopic compositions preserved in zircon indicate that the Laacher See carbonatites are cogenetic with their phonolite host. Carbonatite U–Th zircon isochron ages range from 32·6 ± 4·1 ka (2σ; MSWD = 1·7; n = 24) to near-eruption age (12·9 ka). Uranium-series carbonatite ages qualitatively agree with alkali feldspar compositions that lack prominent magmatic zonation, but show evidence for perthitic unmixing during subsolidus residence at elevated temperatures (<700°C) in an intrusive carapace surrounding the liquid-dominated interior of the magma system (>720°C). Model differentiation ages and crystallization ages for the carbonatites overlap within a few thousand years as resolved by U–Th dating and indicate rapid crystallization following carbonatite segregation from its parental phonolite. Model differentiation and zircon isochron ages peak at ∼17 ka, suggesting a major phase of differentiation of the Laacher See magma system at this time, although the onset of phonolite differentiation dates back to at least ∼10–20 kyr prior to eruption. Phenocrysts in the middle and late erupted phonolite magma crystallized shortly before eruption, and the lack of older crystals implies crystal removal through settling or resorption. Crystal ages from both crystal-rich and liquid-dominated parts of a magma system are thus complementary, and reveal different aspects of magma differentiation and residence timescales. [ABSTRACT FROM PUBLISHER]

The Yandangshan syenite is a representative Late Cretaceous igneous pluton cropping out in SE China. U-Pb zircon dating using LA-ICP-MS yielded a crystallization age of 98±1 Ma for the syenite. Petrographically and geochemically of shoshonitic affinity, it is enriched in LREE and LILE, and has a pronounced Nb-Ta trough in the primitive mantle-normalized trace element spider diagram. Zircon εHf(t) values vary from -3.04 to -7.71, displaying a unimodal distribution. The syenite also has high Sr [(87Sr/86Sr) i = 0.7086-0.7089], low Nd [εNd(t) = -6.57 to -7.64] isotopic ratios, plotting in the enriched mantle field on an εNd(t) versus (87Sr/86Sr) i diagram. We propose that the Yandangshan syenite was generated by pyroxene-dominated high-pressure fractional crystallization from basaltic magma that was derived from an enriched mantle source. Although coexisting Yandangshan rhyolites have Sr-Nd isotopic compositions similar to the Yandangshan syenite, they were not derived from the same source. Instead, the rhyolitic magma was produced by partial melting of crustal materials as a result of the underplating of basaltic magma. The crust-like Sr-Nd-Hf isotopic signature of the Yandangshan syenite is ascribed to mantle sources that were enriched by subducted sediments. Formation of Yandangshan syenite may represent roll-back of the subducting palaeo-Pacific plate and migration of the arc front to the Yandangshan area at ∼98 Ma. [ABSTRACT FROM AUTHOR]

Magmatism in SE China was dormant during 204–180 Ma, but was reactivated in 180–170 Ma (early J2), and then became more and more intensive towards the end of early Cretaceous. The small-scale early J2 magmatism is the incipience to long-term and large-scale magmatism in this region. A near east-west (EW) trend volcanic belt was distributed across south Hunan, south Jiangxi and southwest Fujian was formed during early J2 time. Along this belt from the inland toward the coast, the lithology of basalts changes from alkali into tholeiite, and the amount of erupted volcanic rocks and the proportions of rhyolites coexisting with the basalts increase. On the basis of geochemical characteristics of these basalts, we infer that the melting degree of source rocks and the extent of fractional crystallization and crustal contamination all increased whereas the depth of mantle source decreased from the inland to the coast, which led to the variations of geological characteristics of the volcanic belt. In early J2, the western spreading Pacific plate began to subduct underneath SE China continental block, reactivating near EW trend deep fault that was originally formed during the Indosinian event. The stress of the western spreading Pacific plate and the extent of asthenosphere upwelling increased from the inland to the coast, which is consistent with the generation and evolution of early J2 basalts. [ABSTRACT FROM AUTHOR]

Background: Spine surgery is widely accepted as an effective management for patients with lumbar disc herniation; however, the factors influencing intraoperative procedure and prognosis are not fully understood. The present study was aimed to identify the factors influencing intraoperative blood loss, postoperative drainage volume, and recovery in patients undergoing spinal surgery.Methods: We retrospectively analyzed the clinical data of 183 consecutive patients with lumbar disc herniation who underwent spine surgery. The clinical characteristics, operation procedure, and outcome were documented and the correlations were analyzed.Results: There were significant differences between one-level and two-level operations in the bleeding volumes of male (P = 0.005) and female (P = 0.002) patients, and in final drainage of male (P = 0.043) and female (P = 0.003) patients. The blood loss was correlated with the operation duration. There were differences in intraoperative bleeding and final drainage between groups with one-level and two-level operations. Additionally, there were differences in intraoperative autologous blood transfusion among various groups. There were significant differences in intraoperative bleeding between autologous blood transfusion and non-transfusion groups.Conclusions: The key factors affecting the intraoperative blood loss and postoperative drainage volume include operation methods, operation duration, blood-transfusion modes, and usage of anticoagulants. These results should be taken into consideration in the attempt to optimize operation procedure and improve post-operative recovery. [ABSTRACT FROM AUTHOR]