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Background: Birth-related mortality is significantly increased by home births without skilled medical assistance during delivery, presenting a major risk to the public's health. The objective of this study is to predict home delivery and identify the determinants using machine learning algorithm in sub-Saharan African. Methods: This study used design science approaches. The data set obtained from demographic health survey in sub-Saharan African weighted sample of 299,759 women was included in the stud. Machine learning models such as Random Forest, Decision Tree, K-Nearest Neighbor, Logistic Regression, Extreme Gradient Boosting, AdaBoost, Artificial Neural Network, and Naive Bayes were used. The predictive model was evaluated by area under the curve, accuracy, precision, recall, and F-measure. Results: The final experimentation results indicated that random forest model performed the best to predict home delivery with accuracy (83%) and, ROC curve (89%). The Shapley additive explanation features an importance plot optimized for random forest model to identifying the most predictors of home delivery. Association rules findings showed that inadequate antenatal care visits, marital status married, no education, mobile phone, television, electricity, poor wealth index, infrequent television viewing, and rural residence were predictor of home delivery. Conclusion: The random forest machine learning model provides greater predictive power for estimating home delivery risk factors. To reduce the prevalence of home delivery, this finding recommends to emphasis on improving antenatal care services, education, and awareness about health facility delivery. [ABSTRACT FROM AUTHOR]

Background: Early and accurate diagnosis of drug resistance, including resistance to second-line anti-tuberculosis (TB) drugs, is crucial for the effective control and management of pre-extensively drug-resistant TB (pre-XDR-TB) and extensively drug-resistant TB (XDR-TB). The Xpert MTB/XDR assay is the WHO recommended method for detecting resistance to isoniazid and second-line anti-TB drugs when rifampicin resistance is detected. Currently, the Xpert MTB/XDR assay is not yet implemented in Ethiopia, thus the MTBDRsl assay continues to be used. However, the MTBDRsl assay requires additional patient visits and specimen collection, which can lead to delays in diagnosis and treatment initiation. Objective: This study aimed to evaluate the feasibility of using extracts from used Xpert MTB/RIF cartridges for detecting resistance to second-line anti-TB drugs by MTBDRsl assay in patients with rifampicin resistant-TB (RR-TB) in Eastern and Western Oromia, Ethiopia. Methods: A cross-sectional diagnostic evaluation study was conducted from June 2020 to May 2021 at two TB Referral Laboratories in Eastern and Western Oromia, Ethiopia. Sputum samples from RR-TB patients were split, with one aliquot being subjected for Xpert testing and the other being cultured on Lowenstein-Jensen media. DNA extracted from the used Xpert cartridges was amplified by PCR and tested by MTBDRsl assay, and the results were compared to those obtained from culture isolates. To establish the detection limits, the MTBDRsl assay was performed on cartridge extracts (CEs) from a series of dilutions of drug-susceptible and multidrug-resistant TB strains. Results: The MTBDRsl on CEs from dilutions at ≥ 102 CFU/mL (CT ≤ 22) accurately identified susceptibility and resistance patterns for fluoroquinolones (FQL) and second-line injectable drugs (SLIDs). The MTBDRsl on rifampicin-resistant CEs from sputum samples (n = 40) yielded 100% interpretable results for FQL and 90% (4 indeterminate) interpretable results for SLIDs. All interpretable CE results showed complete agreement with the MTBDRsl results from the culture isolates. Conclusion: This study demonstrated the feasibility of using extracts from used Xpert MTB/RIF cartridges for detecting resistance to second-line anti-TB drugs using the MTBDRsl assay. This approach could mitigate the need for additional specimen collection and allow for earlier treatment initiation, potentially improving patient outcomes and reducing the transmission of drug-resistant TB strains. [ABSTRACT FROM AUTHOR]

Background: Access to healthcare services for women in low- and middle-income countries (LMICs) is crucial for maternal and child health and achieving the Sustainable Development Goals (SDGs). However, women in LMICs face barriers to accessing healthcare, leading to poor health outcomes. This study used Demographic and Health Survey (DHS) data from 61 LMICs between 2010–2023 to identify women's healthcare access challenges. Methods: This study used data from the DHS conducted in 61 LMICs to identify women's healthcare access challenges from 2010 to 2023. A weighted sample of 1,722,473 women was included in the study using R-4.4.0 version software. A mixed-effects modeling approach was used to analyze access to healthcare, considering individual-level factors and contextual factors. The mixed-effects model takes into account clustering within countries and allows for the examination of fixed and random effects that influence women's healthcare access across LMICs. For the multivariable analysis, variables with a p-value ≤0.2 in the bivariate analysis were considered. The Adjusted Odds Ratio (AOR) with a 95% Confidence Interval (CI) and a P value < 0.05 was reported to indicate statistical significance and the degree of association in the final model. Results: The pooled prevalence of the healthcare access problem was found to be 66.06 (95% CI: 61.86, 70.00) with highly heterogeneity across countries and regions. Women aged 25–34 years, and 35–49 years, had primary education, and secondary or higher education, married women, poorer, middle, richer, and richest wealth indices, had mass media exposure, first birth at age ≥20 years, birth interval of 24–36, 37–59 and >59 months as compared to < 24 months birth interval, had health insurance, delivered at a health facility, had at least one ANC visit, being from lower-middle-income countries, upper-middle-income countries, regions like West Africa, South Asia, and East Asia/Pacific compared to women living in East Africa, low literacy rates, medium literacy rates, and high literacy rates as compared to very low literacy rate were associated with lower odds of having problems accessing healthcare respectively. On the other hand, divorced/widowed women, having 1–2, and more than two under five, living in households with 6–10 family members and >10 members, female household heads, living in rural areas, women living in South/Central Africa, Middle East/North Africa, Europe/Central Asia, and living in Latin America/Caribbean were associated with higher odds of having problems accessing healthcare respectively. Conclusions: Approximately two-thirds of women face healthcare access problems. Sociodemographic factors such as age, education, marital status, wealth, media exposure, and health insurance are associated with lower odds of experiencing healthcare access issues. On the other hand, factors such as divorce/widowhood, the number of young children, household size, female household heads, rural residence, and region have been linked to higher odds of facing healthcare access challenges. To address these disparities, policies, and interventions should focus on vulnerable populations by improving access to health insurance, increasing educational attainment, and providing support for single mothers and large households. Additionally, tailored regional approaches may be necessary to overcome barriers to healthcare access. [ABSTRACT FROM AUTHOR]

Introduction: Despite the World Health Organization's advice against unhealthy feeding, many low- and middle-income countries, including sub-Saharan Africa (SSA) countries, are experiencing a nutritional transition to high in sugar, unhealthy fats, salts, and processed carbohydrates for younger children. However, there is a scarcity of recently updated multicounty information on unhealthy feeding practices and determinants in SSA countries. Therefore, this study aimed to assess the pooled prevalence of unhealthy feeding practices and determinants among children aged 6–23 months in five SSA countries. Method: A cross-sectional study design was employed with the most recent demographic and health survey secondary data (DHS) from five SSA countries. This secondary data was accessed from the DHS portal through an online request. The DHS is the global data collection initiative that provides detailed and high-quality data on population demographics, health, and nutrition in low- and middle-income countries. We used a weighted sample of 14,064 children aged 6–23 months. A multilevel mixed-effect binary logistic regression model was fitted to identify significant factors associated with unhealthy feeding practices. The level of statistical significance was declared with p-value < 0.05. Result: This study found that overall, 62.4% (95% CI: 61.62–63.17) of children aged 6–23 months in five SSA countries had unhealthy feeding practices. Rural residents, lower-middle-income SSA countries, and children aged above 12 months had lower odds of unhealthy feeding practices. On the other hand, richer households and women who had not had an optimal antenatal care visit had higher odds of unhealthy feeding practices. Conclusion: According to this study, nearly two out of three young children in five SSA countries had unhealthy feeding practices. Both individual and community-level factors are significantly associated with unhealthy feeding practices. As a result, responsible bodies shall make all efforts to reduce unhealthy feeding practices among young children in SSA countries. [ABSTRACT FROM AUTHOR]

Background: Depressive symptom is the most common type of psychiatric co-morbidity among persons with epilepsy. Epilepsy patients are identified as at higher risk of suffering depressive symptom explicitly in low- and middle-income countries due to poor mental health care systems and financial burdens. The co-occurrence of depressive symptom among epilepsy patients deteriorates the prognosis of the disease and diminishes the quality of life of both the patients and their families. However, there is limited evidence on the prevalence of depressive symptom and associated factors in Ethiopia. Therefore, this study is intended to assess the prevalence of depressive symptom and associated factors among epilepsy patients attending in Amhara region, Ethiopia. Method: A multi-center institution-based cross-sectional study was done among epilepsy patients attending at Amhara region, Ethiopia. The Hospital Anxiety Depression tool was used to assess depressive symptom. To determine the factors associated with depressive symptom, a binary logistic regression model was used. Adjusted Odds Ratio (AOR) with the 95% Confidence Interval (CI) was reported in the multivariable binary logistic regression analysis. Results: About 406 participants were registered in the study with a response rate of 97.6%. The prevalence of depressive symptom among epilepsy patients was 53.9% [95%CI: 49.1%, 58.8%]. In the multivariable binary logistic regression analysis, taking polytherapy treatment [AOR = 1.87, 95% CI: 1.04, 3.36], perceived stigma [AOR = 5.73, 95%CI: 3.11, 10.55], poor antiepileptic medication adherence [AOR = 3.33, 95%CI: 1.30, 8.54] and having poor [AOR = 5.83, 95%CI: 2.44, 13.90] and moderate social support [AOR = 3.08, 95%CI: 1.34, 7.09] were significantly associated with depressive symptom. Conclusions: This study revealed that the magnitude of depressive symptom among epilepsy patients in Ethiopia was relatively high and multiple factors determined the likelihood of depressive symptom. Thus, healthcare providers and concerned stakeholders should strengthen comprehensive health education to reduce the magnitude and consequences of depressive symptom among this segment of the population. Moreover, strong social support with special attention should be given to epilepsy patients. [ABSTRACT FROM AUTHOR]

Background: Metabolic syndrome has become a major public health problem worldwide and is attributable to the spread of different non-communicable diseases such as type 2 diabetes mellitus, coronary artery diseases, stroke, and permanent or temporary disabilities. It is not a single disease entity but encompasses different risk factors. However, there were inconsistencies among previously conducted primary studies, hence this systematic review and meta-analysis aimed to determine the pooled prevalence and determinants of metabolic syndrome among type2 diabetes patients in Ethiopia. Method: First-hand studies about the metabolic syndrome among adult type 2 diabetic patients in Ethiopia were searched through known and international databases (PubMed, Scopus, Web of Science, and Cochran Library) and search engines (Google and Google Scholar). Data was extracted using a standard data extraction checklist developed according to Joanna Briggs Institute (JBI). The I2 statistics are used to identify heterogeneity across studies. Funnel plot asymmetry and Egger's tests were used to check for publication bias. A random effect model was used to estimate the pooled prevalence of the metabolic syndrome among non-insulin-dependent patients in Ethiopia. The STATA version 11 software employed for statistical analysis was conducted using STATA version 11 software. Result: The overall pooled prevalence of metabolic syndrome among type2 diabetic patients in was 54.56% [95%CI (43.73, 65.38), I2 = 97.0%, P = 0.001] using NCEP-ATP III, 48.32% [95%CI (42.1, 54.44), I2 = 97.0%, P = 0.001] IDF diagnosis criteria, 47.0[95%CI(27.01–66.99)], I2 = 97.5%, p = 0.001 using WHO and 59.37%(95%CI(47.21–71.52), I2 = 91.2%, p = 0.001 using harmonized diagnosis criteria respectively. This meta-analysis identified several significant predictors of metabolic syndrome among type 2 diabetes patients in Ethiopia. The odds of having metabolic syndrome was reduced for females (Adjusted Odds Ratio [AOR] = 0.55, 95% CI: 0.35–0.87) compared to males. However, the odds of metabolic syndrome increased with alcohol intake (AOR = 1.44, 95% CI: 1.03–2.01), the odds of living in urban areas(AOR = 2.12, 95% CI: 1.55–2.88), and the odds of having a diabetes duration of six or more years since diagnosis (AOR = 2.94, 95% CI: 1.17–7.41) were significant predictors. Conclusion: The pooled prevalence was considerably high among type 2 diabetic patients in Ethiopia. The pooled prevalence of metabolic syndrome varies as per the diagnosis criteria used with the highest observed in harmonized diagnosis criteria. Being female, being rural residency, alcohol intake, and duration of diabetes since diagnosis were significant predictors of metabolic syndrome among type 2 diabetic patients in Ethiopia. [ABSTRACT FROM AUTHOR]

The Adigrat Sandstone Formation, representing the siliciclastic assemblage of the Lower Mesozoic succession, underlies the Gohatsion Formation in the Blue Nile Basin. Despite its stratigraphic and geological significance, the impact of diagenesis on the porosity value of the Adigrat sandstone remains poorly understood. By analyzing a detailed field description of two stratigraphic logs, along with the associated thin sections and additional correlated well data, the environment of deposition has been interpreted. The petrographic analysis was carried out to 30 sandstone samples collected from five selected outcrops, and complemented by the two stratigraphic columns. The main diagenetic processes affecting the Adigrat sandstone porosity were compaction, cementation, mineral dissolution, replacement, authigenesis, and recrystallization. The framework grain and cement relationship suggests an early quartz cement precipitation, followed by partial or intense calcite and hematite development in some samples as the second cementation phase. Feldspar alteration to lath-shaped kaolinite clusters causes kaolinite to act as a pore-lining and pore-filling cement, thereby reducing porosity. Conversely, the fracture and dissolution of some samples enhanced the fluid storage capacity. The estimated existing optical porosity (EOP) varies between 1 and 8%, with a mean value of 5%, of which 70% of the samples possess catenary and cul-de-sac porosities. Based on petrographic analysis, the sandstone is mineralogically categorized as sub-mature to mature. These findings significantly contribute to understanding the diagenetic evolution of the Adigrat Sandstone Formation, providing valuable insights for reservoir characterization and exploration strategies in the Blue Nile Basin (BNB). [ABSTRACT FROM AUTHOR]

Enterotoxigenic Escherichia coli (ETEC) strains, which produce the heat‐stable enterotoxin (ST) either alone or in combination with the heat‐labile enterotoxin, contribute to the bulk of the burden of child diarrheal disease in resource‐limited countries and are associated with mortality. Developing an effective vaccine targeting ST presents challenges due to its potent enterotoxicity, non‐immunogenicity, and the risk of autoimmune reaction stemming from its structural similarity to the human endogenous ligands, guanylin, and uroguanylin. This study aimed to assess a novel synthetic vaccine carrier platform employing a single chemical coupling step for making human ST (STh) immunogenic. Specifically, the method involved cross‐linking STh to an 8‐arm N‐hydroxysuccinimide (NHS) ester‐activated PEG cross‐linker. A conjugate of STh with 8‐arm structure was prepared, and its formation was confirmed through immunoblotting analysis. The impact of conjugation on STh epitopes was assessed using ELISAs with polyclonal and monoclonal antibodies targeting various epitopes of STh. Immunization of mice with the conjugate induced the production of anti‐STh antibodies, exhibiting neutralizing activity against STh. [ABSTRACT FROM AUTHOR]

Background: It is crucial to consider cultural, religious, and socio-behavioural factors that may influence the acceptability of Minimally Invasive Tissues Sampling (MITS). MITS is being used to understand the causes of child death and conducted in nine countries within Africa and South Asia with the highest child mortality. Progress has been made in the development of laboratory infrastructures and training for physicians to do MITS, but many communities are concerned about the religious acceptability of taking samples from deceased children. This paper explores the acceptability of MITS in a predominantly Muslim community. Methods: A qualitative study was conducted in Kersa and Harar, in Eastern Ethiopia between April 23, 2018 and April 21, 2019 where high child mortality rates have been recorded. The study involved interviews and focus groups with 76 participants, including mothers, elders, and religious leaders. In addition, observations were conducted at burial ceremonies and in grieving families’ homes. Grounded theory framework is used in this article to understand the acceptability of postmortem MITS. Results: We explore cultural, religious, and socio-behavioural barriers and facilitators that may influence the acceptability of minimally invasive tissue sampling. We identify three themes relating to the acceptability of MITS: (1) Perceptions and rituals related to child death (2), Religious acceptance of post-mortem investigation, and (3) Fears and suspicions of organ theft and body mutilation. Most participants hypothetically accepted MITS, but suggested that the procedure consider religious practices. Religious leaders and parents stated that they would accept the procedure if it would help reduce child deaths. Acceptance is inconsistent and differs across time and place. Some villages accepted the procedure swiftly, only to change their views when they became aware of suspicions from other villages about the procedure disfiguring the body. Parents of deceased children were concerned that taking samples from the children’s bodies would delay the burial. Conclusions: Mortality surveillance requires a thorough understanding of the cultural, religious, and sociocultural aspects that may affect the acceptability of MITS. MITS research should be conducted close to communities, involving community members, incorporating religious perspectives, and promoting health outreach campaigns to facilitate sociocultural perceptions of the research activities. [ABSTRACT FROM AUTHOR]

Introduction: Depression has become a major health problem that students in a University encounter during their study life. At least one-third and possibly up to one-half of medical students show some form of psychological distress during their medical school. Aggregated evidence is scarce in Africa though there are published articles with various outputs. Therefore, this systematic review and meta-analysis aimed to pool those outputs to draw concert information crucial for devising strategies to tackle depression among students at the University. Objective: To determine the pooled prevalence of depression among African medical students. Method: Original articles about the prevalence of depression among African medical students were searched through known and international databases (PubMed, Scopus, Web of Science, and Cochran Library) and search engines (Google and Google Scholar). Data were extracted using a standard data extraction checklist that was developed according to Joanna Briggs Institute (JBI). The I2 statistics were used to identify heterogeneity across studies. Funnel plot asymmetry and Egger's tests were used to check for publication bias. A Random effect model was used to estimate the pooled prevalence of depression among medical students in Africa. Statistical analysis was conducted using STATA version 11 software. Result: A total of 31 cross-sectional observational studies which provided information about the prevalence of depression among medical students were included in this systematic review and meta-analysis. The overall pooled prevalence of depression among medical students in Africa was 38.80% [95%CI (29.55, 48.05). Being a female medical student was [AOR = 0.25, 95%CI (0.15, 0.42)] and being a second-year medical student was [AOR = 0.26, 95%CI (0.10, 0.68)] times less likely to have depression. Conclusion: Depression affects well over one-third of medical students in Africa. Moreover, this systematic review and meta-analysis revealed that female medical students were less likely to develop depression. Therefore, this result suggested that medical schools or Universities and concerned authorities better offer possible early detection and prevention programs as per the magnitude. Furthermore, there has to be further research to figure out the potential factors perhaps using both qualitative and quantitative research approaches. [ABSTRACT FROM AUTHOR]

Introduction: Formula feeding is providing infants with prepared formula as an alternative to or alongside breastfeeding. While breast milk is widely regarded as the optimal source of nutrition for infants, formula feeding is a common practice. The recommended approach is exclusive breastfeeding for the first six months, followed by the introduction of complementary foods after that period, which is crucial for child growth and development. Formal feeding has a negative impact on an infant's health, causing malnutrition and other illnesses. Therefore, this study was investigated to assess formula feeding and determinant factors among mothers with infants in six sub-Saharan African countries. Methods: A total weighted sample of 26,119 mothers with infants and young children less than two years was included in this study. The data were taken from a recent demographic and health survey in six sub-Sahara African countries. A multilevel, multivariable logistic regression model was used to identify the determinant factors associated with formula feeding. In the multivariable analysis, the adjusted odds ratio with a 95% CI was used to declare a statistically significant association with formula feeding among mothers with infants. Results: In this study, the proportion of mothers with infants who use formula feeding was 17.1%. In multilevel logistic analysis (model III), the significant factors associated with formula feeding were the age of the mothers; 25–34 years (AOR = 1.3; 95% CI (1.2–1.41)), 35–49 years (AOR = 1.4; 95% CI (1.22–1.54)), multiple children (AOR = 1.4; 95% CI (1.23–1.77)), maternal educational status; secondary and higher (AOR = 2.4; 95% CI (2.11–2.66)), mother's employment status; (AOR = 1.24; 95% CI (1.14–1.5));, richer households (AOR = 1.2; 95% CI (1.10–1.36)), place of delivery (AOR = 2.1; 95% CI (1.83–2.44)), household media exposure (AOR = 1.5; 95% CI (1.3–1.68))place of residence (AOR = 1.97; 95% CI (1.79–2.17)), community illiteracy level (AOR = 1.17; 95% CI (1.02–1.34)), and community media exposure (AOR = 1.2; 95% CI (1.03–1.38)). Conclusion: Formula feeding among mothers with infants in Sub-Saharan Africa has emerged as a public health concern. The recommended approach is to promote exclusive breastfeeding for the first six months, followed by the introduction of complementary feeding after that period. Factors associated with formula feeding include older maternal age, secondary and higher education, delivery in health institutions, employment status, higher household income, twin births, urban residence, low community illiteracy rates, and increased community media exposure. Stakeholders and health policymakers should be focused on strategies to improve breast feeding and discourage infant formula feeding. [ABSTRACT FROM AUTHOR]

One approach to structural health monitoring (SHM) involves embedding sensors within a composite material. However, the integration of these sensors can potentially introduce flaws that might affect the composite's mechanical properties. This research aims to explore the impact of embedding exfoliated graphite (EG)/epoxy sensors on the mechanical characteristics of composite systems through laboratory experiments and numerical simulations. Sensor strips composed of varying volume fractions of EG/epoxy were fabricated. Tensile test specimens were prepared by embedding these sensors in the epoxy matrix oriented both lengthwise and widthwise. Baseline specimens of EG/epoxy without sensors were also created for comparison. Tensile tests were performed on the samples to evaluate the effects of the embedded sensors on the composite's elastic modulus and tensile strength. The results indicated a slight improvement in both elastic modulus and tensile strength with the introduction of EG. Crucially, the orientation of the sensors within the samples had a significant impact on the composite's mechanical properties. Samples with widthwise-aligned sensors showed reduced tensile strength due to delamination along the sensor edges. Finite element simulations using a viscoelastic model based on the experimental data were conducted to analyze the effect of sensor alignment on mechanical properties. The findings revealed that a grid pattern alignment of sensors significantly enhanced mechanical performance compared to lengthwise or widthwise alignment, particularly at 0.1% and 0.3% EG volume fractions, highlighting the effectiveness of a grid pattern for embedding sensors in SHM applications. [ABSTRACT FROM AUTHOR]

Background: E-health literacy is defined as an individual's ability to look for and appraise health information from online electronic sources. In this digital age, e-health literacy is one of the most important determinants of health and health behaviors, particularly among adolescents who often influenced by information from various social network sites (SNSs) in developed countries. However, there is limited evidence regarding eHealth literacy level and its associated factors among jimma university undergraduate students using SNSs in less developed settings. Objective: The aim of this study is to examine eHealth literacy level and its associated factors among Jimma university students using Social Network Sites, Ethiopia. Methods: A cross-sectional study was conducted at Jimma University from June 2022 to July 2022. A multistage stratified sampling method was applied to select 794 study participants. Multivariate linear regression modeling was performed to examine the associations between the dependent and independent variables. A P value < 5% was considered statistically significant. Result: A total of 794 respondents (response rate 93.8%) participated in the study. The majority of the respondents (485, 61.1%) were male, with a mean age of 22.6 years. The mean e-health literacy score was (M = 26.68 (SD ± 4.90) range = 31).Year [β = 0.086; 95% CI (0.082–0.676)], urban residents [β = 0.202; 95% CI (1.341– 2.634)], SNSs for health information [β = 0.165; 95% CI (-0.998–3.190)], Membership in SNSs [β = 0.569; 95% CI (0.324-0.814)], you tube usage [β = 1.545; 95% CI (1.177–1.913)], Google usage (β = 0.898; 95% CI (0.512-1.284)], and medical application users [β = 0.194; 95% CI (-1.227- -2.595)] were significantly related to eHealth literacy. Conclusion: This study indicated that the participants had a low level of eHealth literacy. In addition, year of study, previous residency, SNSs for health information, medical application user, Membership in SNSs, youtube usage and Google usages were among the factors significantly associated with e-health literacy. Expanding internet access and infrastructure across higher educational institutions are key ways to improve e-health literacy. [ABSTRACT FROM AUTHOR]

Renewable energy sources are crucial for addressing the energy crisis and global warming, but their intermittent nature necessitates storage. Metal–air batteries, such as Li–air batteries, offer high specific capacity and environmental friendliness but face issues like poor reaction kinetics and high overpotential during charging and discharging. To address these issues, noble metal-based catalysts have been utilized, which require the replacement of such precious and scarce resources with affordable and commercially accessible materials. Biomass, a renewable resource, plays a critical role in preparing carbon-based electrocatalysts and porous cathodes with excellent performance due to its rich heteroatom and pore structure, and potential doping and co-doping with transition metals and their oxides. Metal-free biomass carbon nanostructured bifunctional electrocatalysts have been identified as potential alternatives for the next generation of oxygen reduction and evolution reactions. These catalysts have comparable catalytic activity and improved stability compared to the current state-of-the-art Pt-based catalysts, making them essential for the commercialization of lithium–air batteries. Thus, this paper reviews the most recent advances in biomass-derived metal-free heteroatom-doped nanostructured carbon electrocatalysts for rechargeable lithium–air batteries and discusses how different biomass sources affect the cathode's composition, morphology, and structure–activity relationship. It gives a reasonable approach to doping methodologies, which may guide non-noble electrocatalyst and electrode designs. [ABSTRACT FROM AUTHOR]

Introduction: Intimate partner sexual violence (IPSV) is sexual violence against women by a current or former sexual partner. Sexual violence among pregnant women is higher in low-income countries, particularly in sub-Saharan Africa (SSA), which has numerous negative impacts for both the mother and the growing fetus. There is no recent and distinct information on the magnitude and factors associated with IPSV among pregnant women in SSA. Objective: This study aimed to assess the prevalence of IPSV and its determinants among pregnant women in SSA. Design: A cross-sectional study design using demographic health survey data from 2015 to 2022 in 20 sub-Saharan African countries was used. Methods: The analysis was conducted using a weighted sample of 10,775 women who were pregnant during the survey period (2015–2022). A multilevel logistic regression model was used to identify the determinants of IPSV among pregnant women. The adjusted odds ratio at 95% confidence interval (95% CI) was computed to assess the strength and significance of the association between explanatory and outcome variables. Factors with a p -value of <0.05 are declared statistically significant. Result: In this study, the pooled prevalence of IPSV among pregnant women in SSA was 11.06% (95% CI: 10.48–11.67). Respondents currently working, male-headed households, presence of justified beating, respondent mother's history of abuse, respondent having no media access, respondent having self-reported sexually transmitted diseases (STIs), partner alcohol use, and residing in East Africa had increased odds of IPSV during pregnancy. On the other hand, nulliparous respondents, respondents involved in healthcare decision-making, households with a high wealth index, and residents of West Africa had decreased odds of IPSV among pregnant women. Conclusion: This study revealed that a significant proportion (11%) of pregnant women experienced intimate partner sexual violence during pregnancy in SSA. Hence, the government, policymakers, and other relevant authorities should give special attention to women's at-risk of sexual violence, including women who live in households with justified beatings, women with STIs, working women's, women with drunken partners, and non-autonomous women's. Prioritization of the east African region, increasing media access, and promoting a healthy lifestyle in the community shall be done to reduce the burden of the problem. [ABSTRACT FROM AUTHOR]

Introduction: Worldwide, breast cancer accounts for about 2.3 million new cases and 685,000 deaths, making it the second most common cancer in women. It can be detected through breast examination like mammograms, self-breast examination and clinical breast examinations in the early stage potentially before it spreads to other organs. The current study aimed to determine the awareness of breast examination to detect breast cancer and its determinant factors. Methods: A total of 16,474 women of reproductive age were included. The 2022 Kenyan demographic and health survey dataset were used. The data were analyzed using STATA version14.0. Multilevel mixed-effects logistic regression was employed to identify potential factors of the outcome variable. Variables with p-values <0.05 were considered statistically significant. Result: Nearly 44.4% of women were aware of breast examinations to detect breast cancer. Older age [AOR = 2.517, 95%CI: 2.11–3.00], higher educational level [AOR = 5.755, 95%CI: 4.631–7.153], being an active worker [AOR = 1.343, 95%CI:1.232–1.465], being the wealthiest [AOR = 1.526, 95%:1.336–1.744], use of the internet [AOR = 1.451, 95%CI:1.323–1.592], exposure to different media [AOR = 1.350, 95%CI:1.187–1.536] and health facility contact within 12 months [AOR = 1.496, 95%CI:1.385–1.615] were positively associated at the individual level, while low community poverty [AOR = 0.777, 95%:0.676–0.892] and high literacy level [AOR = 1.412, 95%CI:1.190–1.677] were significant factors at the community level. Conclusion and recommendation: Less than half of the women were aware of breast examination to detect breast cancer. Older age, high level education, being active worker, exposure for media, using internet, being rich were favorable covariates at the individual level while high literacy and low poverty were found to be enabling factors at the community level. This study recommends that educating women, engaging them in different occupational activities, decreasing poverty, improving media and internet accessibility can bring positive change of women's awareness towards breast examination. [ABSTRACT FROM AUTHOR]

Introduction: HIV/AIDS is a global public health concern that is closely related to other sociocultural problems. The prevention of mother to child transmission cascade often begins with and is integrated into antenatal care in order to ensure a high rate of case detection and optimal treatment coverage. Although guidelines suggest that all pregnant women should have HIV testing as part of their regular screening checks during antenatal care, a significant proportion of pregnant women were not tested for HIV during antenatal care follow-up in sub-Saharan Africa. Hence, this study was aimed at assessing the determinants of women not tested for HIV during antenatal care follow-up in sub-Saharan Africa. Method: A cross-sectional study was conducted to assess the determinants of non-testing for HIV among women as part of antenatal care in sub-Saharan Africa, utilizing secondary data from the 2015–2022 Demographic and Health Surveys. The study included a weighted sample of 788,421 women who had antenatal care follow-up during their most recent pregnancy within five years preceding the survey. A multilevel mixed effect logistic regression analysis was employed to identify the determinants of non-testing for HIV among these women. The adjusted odds ratios with 95% confidence intervals were calculated to determine the associations between the outcome and explanatory variables. Statistical significance was determined using a p-value of less than 0.05. Result: The hierarchical analysis of this study identified several significant factors associated with women not being tested for HIV during antenatal care in sub-Saharan Africa. These factors include young age, low or no education, not being in a union, unemployment, and low household wealth index. Additionally, limited media exposure, stigmatizing attitudes towards people living with HIV, male-headed households, and rural residence were significant at the individual and household levels. At the community level, low media exposure and high illiteracy rates were significant, while at the country level, high fertility rates and low literacy rates were also associated with lower rates of HIV testing during antenatal care. Conclusion: This study identified significant individual, community, and country-level factors associated with women not testing for HIV during antenatal care in sub-Saharan Africa. Key factors include young age, low education, unemployment, not being in a union, low household wealth, limited media exposure, stigmatizing attitudes towards people living with HIV, male household head, rural residence, low community media exposure, high community illiteracy, high fertility rates, and low literacy rates. These findings highlight the need for targeted, context-specific interventions to improve HIV testing rates and enhance maternal and child health outcomes in the region. [ABSTRACT FROM AUTHOR]

Introduction: Physical exercise non-adherence is one of the leading risk behavioral factors for type two diabetic patients and one of the leading causes of mortality of patients worldwide. Therefore, the current study was conducted to determine the pooled prevalence and its determinants of non-adherence to physical exercise among type two diabetes adult patients in Ethiopia. Methods: Studies were searched systematically using International databases from PubMed, Google Scholar, Cochrane Library, Embase, and CINAHL. The quality of articles that were searched was assessed using the New Castle Ottawa scale for a cross-sectional study design. Statistical analysis was performed using STATA version 14 and a meta-analysis was carried out using a random effect model method. Assessment of the certainty evidence's was done by applying the GRADE method. The Preferred Reporting Item for Systematic Review and Meta-analyses (PRISMA) guideline was followed for reporting results. The title and the protocol of this meta-analysis were registered at the online database PROSPERO registration number CRD42023430579. Result: From the total 1711 records screened, 7 studies with 3437 participants who fulfilled the inclusion criteria were included in this systematic review. The estimated pooled prevalence of exercise non-adherence in Ethiopia was 50.59%. Being female (OR = 1.27, 95% CI (1.82, 1.97)), primary level education (OR = 1.19, 95% CI (1.01, 1.39)) and rural residency (OR = 4.87, 95% CI (2.80, 8.48)) were significantly associated with exercise non-adherence. Conclusion: According to papers evaluated by the GRADE assessment the certainty of evidence's was poor. More than half of the diabetes patients had physical exercise non-adherence. Strategies such as emotional support, health education, and emphasis on rural diabetic patients can improve the problem of non-adherence. [ABSTRACT FROM AUTHOR]

This study presents algorithms for addressing split equality variational inequality and fixed point problems in real Hilbert spaces that are inertial-like subgradient extragradient and inertial-like Tseng extragradient, respectively. We prove that the resulting sequences of the proposed algorithms converge strongly to solutions of the problem provided that the underlying mappings are quasi-monotone, uniformly continuous and quasi-nonexpansive mappings under some mild conditions. Furthermore, numerical experiments are shown to demonstrate the effectiveness of our techniques. [ABSTRACT FROM AUTHOR]

This study delves into the correlation between street width and land use patterns in Dire Dawa, Ethiopia, analyzing their relationship across various developmental stages, including organic and planned areas. Employing a mixed-methods case study approach, the research identifies four land use categories and examines their association with street width. Results highlight the nuanced connection between street hierarchy and land use intensity, influenced by the city's morphological period and urban planning interventions. The findings underscore the importance of tailored land use policies that accommodate both formal and informal developments, emphasizing the necessity for further research. [ABSTRACT FROM AUTHOR]

In this paper, we introduce and study an inertial algorithm for solving bilevel variational inequality problems with a fixed point constraint involving a uniformly continuous pseudomonotone mapping in the lower level variational inequality problem and a demimetric mapping for the fixed point constraint. We prove a strong convergence theorem under some suitable conditions on the control sequences. We also provide a numerical example to demonstrate the effectiveness of the method. [ABSTRACT FROM AUTHOR]

Purpose: Unhealthy dietary patterns contribute to an increased risk of colorectal cancer (CRC). Limited prior research has used reduced rank regression (RRR) to assess dietary patterns relative to CRC risk. This study aimed to identify dietary patterns derived by RRR and assess their associations with CRC risk and mortality. Methods: We used data from the multicentre Prostate, Lung, Colorectal, and Ovarian Cancer Screening (PLCO) trial. Dietary intake was assessed using a Dietary History Questionnaire. In the RRR intake of fibre, folate, and the percentage of energy from carbohydrates, saturated and unsaturated fatty acids were used as response variables. Cox models and competing risk survival regression, with age as the time scale, were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for CRC risk and mortality, respectively. Results: The median follow-up time for CRC risk (n = 1044) and mortality (n = 499) was 9.4 years (Interquartile Range: 8. 0, 10.1) and 16.9 years (11.9, 18.6), respectively. Two dietary patterns were identified: the first was characterised by high carbohydrate, folate and low fatty acid intake, and the second by high fibre and unsaturated fatty acid. Compared to participants in the first tertile of the high fibre and unsaturated fatty acid pattern, those in the third tertile had a lower risk of CRC (HR = 0.88; 95% CI: 0.76, 1.03), and colon cancer (HR = 0.85; 95% CI: 0.72, 1.01). Conversely, the high carbohydrate, high folate and low fatty acid pattern had no association with CRC outcomes. None of the dietary patterns showed associations with rectal cancer or CRC mortality. Conclusion: A diet enriched with high fibre and unsaturated fatty acids may reduce the risk of CRC. These results highlight the potential protective effect of adequate fibre intake in conjunction with high consumption of unsaturated fatty acids against CRC. [ABSTRACT FROM AUTHOR]

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Background: Patients with type 2 diabetes mellitus (T2D) have an increased risk of vascular complications. Despite the rise in the prevalence of T2D and its complications throughout the globe, there is a paucity of data regarding the prevalence and determinants of vascular complications of T2D in Ethiopia. Hence, this study aimed to assess the prevalence, patterns, and determinants of the microvascular and macrovascular complications of T2D among adult patients attending a teaching hospital in Addis Ababa, Ethiopia. Methods: A retrospective study was done by reviewing the electronic health records of adult patients with T2D attending the general medical and endocrine referral clinics of Yekatit 12 Hospital Medical College, Addis Ababa, Ethiopia, from June 1, 2023, to November 30, 2023. Statistical Package for Social Sciences (SPSS), version 25, was used to analyze the data. Descriptive analysis was used to summarize the sociodemographic, clinical, and laboratory profiles as well as the patterns of vascular complications of T2D. Bivariate and multivariate logistic regression models were fitted, and the crude odds ratio (COR) and adjusted odds ratio (AOR), together with the 95% confidence interval (CI), were computed to identify the determinants of microvascular and macrovascular complications of T2D. Results: A total of 272 patients with T2D were included in this study; 50.5% were females, and the mean (± standard deviation) age was 56.3 ± 12.8 years. The majority of patients (62.5%) had diabetes for ≥ 5 years. More than half (51.5%) had poor glycemic control with glycated haemoglobin (HbA1c) value of ≥ 7%. The overall prevalence of vascular complications was 39%. The prevalence of microvascular complications was 23.5%, the most common being neuropathy (11.8%), and the prevalence of macrovascular complications was 21%, the most common being coronary artery disease (12.1%). The determinants of microvascular complications were age ≥ 60 years (AOR = 2.25, 95% CI: 1.17, 4.33), diabetes duration of ≥ 5 years (5–10 years [AOR = 3.13, 95% CI: 1.37, 7.18], and > 10 years [AOR = 3.88, 95% CI: 1.66, 9.06], and HbA1c value of ≥ 7% (AOR = 2.21, 95% CI: 1.14, 4.28). The odds of developing macrovascular complications were higher with diabetes duration of ≥ 5 to 10 years (AOR = 2.89, 95% CI: 1.37, 6.12) as compared with diabetes duration of < 5 years. Conclusions: This study demonstrated a high prevalence of microvascular and macrovascular complications in adult patients with T2D. Older age, prolonged duration of diabetes, and poor glycemic control were identified as the determinants for the development of microvascular complications of T2D, while prolonged duration of diabetes was the determining factor for the development of macrovascular complications. Hence, targeted initiatives are required to enhance the prevention and early detection of vascular complications of T2D in resource-limited countries like Ethiopia. [ABSTRACT FROM AUTHOR]

Introduction: Pneumococcal disease is a serious global public health concern. The primary causative agent of severe illnesses such as pneumonia, meningitis, acute otitis media, and bacteremia is the pneumococcus bacterium. The pneumococcal conjugate vaccine is a key strategy to reduce the burden of pneumococcal disease. Understanding the spatial distribution of complete childhood pneumococcal conjugate vaccine utilization and its associated factors is crucial for designing strategies to improve vaccination implementation. Therefore, this study aimed to determine the spatial distribution of complete childhood pneumococcal conjugate vaccination coverage and identify its determinants in Ethiopia. Method: A spatial and multilevel analysis was conducted using data from the 2019 Ethiopian Mini Demographic and Health Survey. The analysis included a total of 2,055 weighted children. The association between the outcome variable and the explanatory variables was determined by calculating adjusted odds ratios at a 95% confidence interval. Explanatory variables were considered significantly associated with the outcome if the p-value was less than 0.05. Result: The prevalence of complete childhood pneumococcal conjugate vaccination in Ethiopia was 53.94% (95% CI: 51.77, 56.08). Higher complete childhood pneumococcal vaccination coverage was observed in the Addis Ababa, Tigray, Amhara, Benishangul-Gumuz, and Oromia regions, while lower coverage was seen in the Afar, Somali, and SNNPR regions of Ethiopia. Factors significantly associated with complete childhood pneumococcal conjugate vaccination included maternal age, antenatal care visits, place of delivery, region, community women's literacy level, community poverty level, and community antenatal care utilization. Conclusion: The distribution of complete childhood pneumococcal conjugate vaccination exhibited spatial variability across Ethiopia. Approximately half of children aged twelve to thirty-five months received the full dose of the childhood pneumococcal conjugate vaccine in the country. Several factors were identified as statistically significant determinants of complete childhood pneumococcal conjugate vaccination, including maternal age, antenatal care visits, place of delivery, region, community women's literacy level, community poverty level, and community ANC utilization. Therefore, policies and strategies aimed at combating pneumococcal disease should consider these determinants and address areas with low vaccination coverage. [ABSTRACT FROM AUTHOR]

Population pressure is the most important underlying cause of land degradation in Ethiopia. While large-scale investments have been made for landscape restoration over years and commendable results are achieved, implementation of the national population policy has been unsatisfactory and the population has continued to grow fast. This challenge needs to be addressed if Ethiopia is to achieve environmental sustainability and socioeconomic development. This opinion note argues that the ongoing landscape restoration initiatives can be used as an effective platform to integrate and promote voluntary use of family planning and reproductive health services, because it is community-based, well-funded, participatory, and inclusive. Women are already key actors in the landscape restoration activities including representation in community leadership positions. This will facilitate buy-in and ownership of family planning and reproductive health services by enhancing community awareness and women’s empowerment to exercise their reproductive health rights if delivered as a component of the already established participatory landscape restoration activities implemented by co-leadership of community institutions. [ABSTRACT FROM AUTHOR]

Inhalation exposure to iron oxide occurs in many workplaces and respirable aerosols occur during thermal processes (e.g. welding, casting) or during abrasion of iron and steel products (e.g. cutting, grinding, machining, polishing, sanding) or during handling of iron oxide pigments. There is limited evidence of adverse effects in humans specifically linked to inhalation of iron oxides. This contrasts to oxides of other metals used to alloy or for coating of steel and iron of which several have been classified as being hazardous by international and national agencies. Such metal oxides are often present in the air at workplaces. In general, iron oxides might therefore be regarded as low-toxicity, low-solubility (LTLS) particles, and are often considered to be nontoxic even if very high and prolonged inhalation exposures might result in diseases. In animal studies, such exposures lead to cancer, fibrosis and other diseases. Our hypothesis was that pulmonary-workplace exposure during manufacture and handling of SPION preparations might be harmful. We therefore conducted a systematic review of the relevant literature to understand how iron oxides deposited in the lung are related to acute and subchronic pulmonary inflammation. We included one human and several in vivo animal studies published up to February 2023. We found 25 relevant studies that were useful for deriving occupational exposure limits (OEL) for iron oxides based on an inflammatory reaction. Our review of the scientific literature indicates that lowering of health-based occupational exposure limits might be considered. [ABSTRACT FROM AUTHOR]

Species within the Bacillus cereus sensu lato group, known for their spore‐forming ability, are recognized for their significant role in food spoilage and food poisoning. The spores of B. cereus are adorned with numerous pilus‐like appendages, referred to as S‐ENAs and L‐ENAs. These appendages are thought to play vital roles in self‐aggregation, adhesion, and biofilm formation. Our study investigates the role of S‐ENAs and L‐ENAs, as well as the impact of various environmental factors on spore‐to‐spore contacts and the interaction between spores and vegetative cells, using both bulk and single‐cell approaches. Our findings indicate that ENAs, especially their tip fibrillae, play a crucial role in spore self‐aggregation, but not in the adhesion of spores to vegetative cells. The absence of L‐BclA, which forms the L‐ENA tip fibrillum, reduced spore aggregation mediated by both S‐ENAs and L‐ENAs, highlighting the interconnected roles of S‐ENAs and L‐ENAs. We also found that increased salt concentrations in the liquid environment significantly reduced spore aggregation, suggesting a charge dependency of spore‐spore interactions. By shedding light on these complex interactions, our study offers valuable insights into spore dynamics. This knowledge can inform future studies on spore behaviour in environmental settings and assist in developing strategies to manage bacterial aggregation for beneficial purposes, such as controlling biofilms in food production equipment. [ABSTRACT FROM AUTHOR]

Introduction: Despite remarkable achievements in improving maternal and child health, early neonatal deaths still persist, with a sluggish decline in Ethiopia. As a pressing public health issue, it requires frequent and current studies to make appropriate interventions. Therefore, by using the most recent Ethiopian Mini Demographic Health Survey Data of 2019, we aimed to assess the magnitude and factors associated with early neonatal mortality in Ethiopia. Methods: Secondary data analysis was conducted based on the demographic and health survey data conducted in Ethiopia in 2019. A total weighted sample of 5,753 live births was included for this study. A multilevel logistic regression model was used to identify the determinants of early neonatal mortality. The adjusted odds ratio at 95% Cl was computed to assess the strength and significance of the association between explanatory and outcome variables. Factors with a p-value of < 0.05 are declared statistically significant. Results: The prevalence of early neonatal mortality in Ethiopia was 26.5 (95% Cl; 22.5–31.08) per 1000 live births. Maternal age 20–35 (AOR, 0.38; 95% Cl, 0.38–0.69), richer wealth index (AOR, 0.47; 95% Cl, 0.23–0.96), having no antenatal care visit (AOR, 1.86; 95% Cl, 1.05–3.30), first birth order (AOR, 3.41; 95% Cl, 1.54–7.56), multiple pregnancy (AOR, 18.5; 95% Cl 8.8–38.9), presence of less than two number of under-five children (AOR, 5.83; 95% Cl, 1.71–19.79) and Somali region (AOR, 3.49; 95% Cl, 1.70-12.52) were significantly associated with early neonatal mortality. Conclusion: This study showed that, in comparison to other developing nations, the nation had a higher rate of early newborn mortality. Thus, programmers and policymakers should adjust their designs and policies in accordance with the needs of newborns and children's health. The Somali region, extreme maternal age, and ANC utilization among expectant moms should all be given special consideration. [ABSTRACT FROM AUTHOR]

Laminins are essential components of the basement membranes, expressed in a tissue- and cell-specific manner under physiological conditions. During inflammatory circumstances, such as atherosclerosis, alterations in laminin composition within vessels have been observed. Our study aimed to assess the influence of tumor necrosis factor-alpha (TNF), a proinflammatory cytokine abundantly found in atherosclerotic lesions, on endothelial laminin gene expression and the effects of laminin-332 (LN332) on endothelial cells' behavior. We also evaluated the expression of LN332-encoding genes in human carotid atherosclerotic plaques. Our findings demonstrate that TNF induces upregulation of LAMB3 and LAMC2, which, along with LAMA3, encode the LN332 isoform. Endothelial cells cultured on recombinant LN332 exhibit decreased claudin-5 expression and display a loosely connected phenotype, with an elevated expression of chemokines and leukocyte adhesion molecules, enhancing their attractiveness and adhesion to leukocytes in vitro. Furthermore, LAMB3 and LAMC2 are upregulated in human carotid plaques and show a positive correlation with TNF expression. In summary, TNF stimulates the expression of LN332-encoding genes in human endothelial cells and LN332 promotes an endothelial phenotype characterized by compromised junctional integrity and increased leukocyte interaction. These findings highlight the importance of basement membrane proteins for endothelial integrity and the potential role of LN332 in atherosclerosis. [ABSTRACT FROM AUTHOR]

In this paper, we introduce the split equality Minty variational inequality problem in reflexive real Banach spaces. Then we construct a single projection inertial algorithm for solving the introduced problem. We establish a strong convergence result with the assumption that the mappings under consideration are Lipschitz continuous and quasimonotone. We give some specific applications of the main result and finally provide a numerical example to demonstrate the workability of our method. [ABSTRACT FROM AUTHOR]

The Research was conducted at KARC during June to November, 2023 to phenotypic screening of bread wheat genotypes for yellow and leaf rust resistance. Both rusts were recorded based on the modified Cobb scale. Severity of yellow rust showed from immune to 70%. 826 genotypes showed slow rusting resistance ranging from 0-30%), 575 genotypes observed as slow rusting plant resistance ranging from 31-50%) and 96 genotypes observed as low adult plant resistance (>50% of yellow rust severity). Tested genotypes showed diverse reactions for yellow rust ranging from immune to susceptible responses. 57 genotypes were observed immune, 161 genotypes were showed moderately resistant reaction type. 317 genotypes were observed moderately susceptible reaction and 962 genotypes were observed susceptible reactions for yellow rust response. The leaf rust severity of the studied genotypes showed from immune to 90. 607 genotypes (showed slow rusting resistance ranging from 0-20% of severity), 563 genotypes observed as slow rusting plant resistance ranging from 21-50% of severity) and 326 genotypes observed as low adult plant resistance (>50% of leaf rust severity. Tested genotypes showed diverse reactions for leaf rust ranging from immune to susceptible responses. 58 genotypes were observed immune, 30 genotypes were observed moderately resistant, 80 genotypes were observed moderately resistant to moderately susceptible, 464 genotypes were showed moderately susceptible reaction, 864 genotypes were showed susceptible reactions for leaf rust disease response. Based on yellow rust, leaf rust and agronomic performance 76 genotypes were selected for the next breeding step. [ABSTRACT FROM AUTHOR]

The diversity in genome resources is fundamental to designing genomic strategies for local breed improvement and utilisation. These resources also support gene discovery and enhance our understanding of the mechanisms of resilience with applications beyond local breeds. Here, we report the genome sequences of 555 cattle (208 of which comprise new data) and high-density (HD) array genotyping of 1,082 samples (537 new samples) from indigenous African cattle populations. The new sequences have an average genome coverage of ~30X, three times higher than the average (~10X) of the over 300 sequences already in the public domain. Following variant quality checks, we identified approximately 32.3 million sequence variants and 661,943 HD autosomal variants mapped to the Bos taurus reference genome (ARS-UCD1.2). The new datasets were generated as part of the Centre for Tropical Livestock Genetics and Health (CTLGH) Genomic Reference Resource for African Cattle (GRRFAC) initiative, which aspires to facilitate the generation of this livestock resource and hopes for its utilisation for complete indigenous breed characterisation and sustainable global livestock improvement. [ABSTRACT FROM AUTHOR]

Introduction: Currently, the problem of cancer has been increasing around the world, predominantly in middle- and low-income countries. Anemia, a major and often overwhelming health burden for cancer patients, significantly distorts their quality of life. It is well-established that the length of treatment increases the frequency of anemia, with hematological malignancies experiencing nearly double the rate compared to solid tumors. Despite this established knowledge, data on the prevalence of anemia among cancer patients in Ethiopia remains scarce, according to the investigators. Objective: This study aimed to assess the prevalence of baseline anemia and associated factors among adult cancer patients at Northwest Amhara Comprehensive Specialized Hospitals, oncology treatment units, Northwest Ethiopia, in 2021. Methods: This study employed an institutional-based cross-sectional design and was conducted in Northwest Amhara Comprehensive Specialized Hospitals. A systematic random sampling technique was used to select 315 participants. The data were collected using interviewer-administered questionnaires and chart reviews of existing medical records using a structured and pretested questionnaire format. The data were entered into Epi. Data version 4.6 and analyzed using Stata version 14.0. Bivariable and multivariable logistic regression were carried out to identify factors associated with anemia. Adjusted odds ratios with a 95% confidence interval and variables with a p-value of < 0.05 were considered significantly associated with anemia. Results: The prevalence of baseline anemia among adult patients with cancer was found to be 34.84%. Being a woman (AOR = 1.97; 95% CI: 1.00-3.87), being underweight (AOR = 1.96; 95% CI: 1.09-3.52), and having stage III cancer (AOR = 2.35; 95% CI: 1.12-3.01) were significantly associated with anemia. Conclusion: The prevalence of baseline anemia among adult cancer patients was significant. Women, cancer patients with an underweight body mass index, and those diagnosed with clinical-stage III cancer were more likely to have baseline anemia. For health policymakers and healthcare providers, it is better to give special attention to female patients, patients who are underweight, and patients with advanced-stage cancer to reduce the risk of developing the outcome. This would allow for timely intervention to manage anemia and potentially improve treatment tolerance and quality of life for cancer patients. [ABSTRACT FROM AUTHOR]

Background: The recommended essential micronutrient such as food rich in vitamin-A or iron, multiple micronutrient powder or iron supplement, routine daily consumption of iodine, and vitamin-A supplement are deficient among children in Ethiopia. This has been a significant public health problem despite the government efforts. Although few studies have examined the micronutrient intake among children, they are limited in scope and methodological measurements. Analyzing the micronutrient intake among children across all regions and leveraging all essential micronutrient elements are crucial for generating improved evidence to better inform policy. Thus, we examined the micronutrient intake among children aged 6 to 23 months in Ethiopia. Methods: We used data from the Ethiopian Demographic and Health Survey. A two-stage stratified sampling technique was employed, and 1392 children aged 6 to 23 months were included in our analysis. We conducted a multilevel mixed-effect binary logistic regression analysis to identify determinants of micronutrient intake. In the final model, we used a p-value of less than 0.05 and Adjusted Odds Ratio (AOR) with their 95% confidence interval (CI). Results: We found that only 27.6% (95% CI: 26.8–31.6) of children aged 6 to 23 months were received the recommended micronutrients in Ethiopia. We identified that maternal educational status (Educated mothers (AOR = 2.09, 95%CI:1.23–3.58)), health facility delivery (AOR = 2.14, 95%CI:1.42–2.98), household wealth status (middle quantile (AOR = 1.80, 95%CI:1.01–3.21)), children's age (12 to 23 months age (AOR = 2.36, 95% CI: 1.33–4.21)), and mother's exposure to media (AOR = 1.70, 95%CI: 1.42–2.04) were increased micronutrient intake, whereas residing in the rural communities (AOR = 0.27, 95%CI: 0.21–0.34) decreased micronutrient intake. Conclusions: Nearly three-fourths of children aged 6 to 23 months did not receive the recommended essential micronutrients in Ethiopia. Therefore, there is a need to broaden strategies aimed at enhancing the intake by improving information and knowledge dissemination among mothers during facility visits and through media channels. [ABSTRACT FROM AUTHOR]

Background: Antepartum hemorrhage continues to be a major cause of maternal and perinatal morbidity and mortality in developing countries including Ethiopia and it complicates 2–5% of all pregnancies with an increased rate of maternal and perinatal morbidity and even mortality. Despite many activities, still, poor fetomaternal outcomes of antepartum hemorrhage are still there. Moreover, studies around the current study area emphasize the magnitude and associated factors for antepartum hemorrhage rather than its feto-maternal outcomes. Thus, there is a need to identify the determinants associated with the fetomaternal outcomes of antepartum hemorrhage to guide midwives and obstetricians in the early diagnosis and treatment. Method: An institution-based case-control study was conducted in four-year delivery charts diagnosed with antepartum hemorrhage from April 2, 2022, to May 12, 2022, at Awi Zone public hospitals. To see the association between dependent and independent variables logistic regression model along with a 95% confidence interval (CI) and a p-value of <0.05 were used. Result: No antenatal care follow-up (AOR: 2.5, 95% CI 1.49–4.2), rural residence (AOR: 1.706, 95%CI 1.09–2.66), delay to seek care >12 hours (AOR: 2.57, 95% CI: 1.57–4.23) and advanced maternal age (AOR: 3.43, 95% CI 1.784–6.59) were significant factors associated with feto-maternal outcomes of antepartum Hemorrhage. Conclusion: This study revealed that rural residence, delay in seeking the care of more than 12 hours, not having antenatal care follow up and advanced maternal age were significant factors associated with feto-maternal outcomes of Antepartum hemorrhage. Recommendation: The findings of our study suggest the need for health education about the importance of antenatal care follow-up which is the ideal entry point for health promotion and early detection of complications, especially for rural residents. [ABSTRACT FROM AUTHOR]