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When an organic molecule is placed inside a plasmonic cavity formed by two metallic nanoparticles (MNP) under illumination, the electronic excitations of the molecule couple to the plasmonic electromagnetic modes of the cavity, inducing new hybrid light–matter states called polaritons. Atomistic ab initio methods accurately describe the coupling between MNPs and molecules at the nanometer scale and allow us to analyze how atomistic features influence the interaction. In this work, we study the optical response of a porphine molecule coupled to a silver nanoparticle dimer from first principles, within the linear-response time-dependent density functional theory framework, using the recently developed Python Numeric Atomic Orbitals implementation to compute the optical excitations. The optical spectra show the splitting of the resonances of the plasmonic dimer and the molecule into two distinct polaritons, a characteristic feature of the strong light–matter coupling regime. Our results stress the importance of atomistic features, such as the gap configuration in determining the plasmon–exciton coupling strength and in the emergence of molecule-mediated charge-transfer plasmon (CTP) resonances at lower frequencies. Moreover, we show that the strength of the CTP resonance can be tuned by shifting the alignment of the molecular energy levels with respect to the Fermi level of the MNPs. [ABSTRACT FROM AUTHOR]

Purpose: The record power profile (RPP) has gained popularity as a method of monitoring endurance cycling performance. However, the expected variation of cyclists' performance between seasons remains unknown. We aimed to assess the between-seasons variability of peak performance (assessed through the RPP) in male professional cyclists. Methods: The study followed a longitudinal observational design. Sixty-one male professional cyclists (age 26 [5] y) with power output data from both training sessions and competitions were analyzed for a median of 4 consecutive seasons (range 2–12). The highest mean maximum power values attained for different durations (from 10 s to 30 min), as well as the resulting critical power, were determined for each season. Within-cyclist variability between seasons was assessed, and the upper threshold of expected changes (ie, twice the normal coefficient of variation) was determined. Results: All mean maximum power values showed an overall high agreement and low variability between seasons (intraclass correlation coefficient [ICC] =.76–.88 and coefficient of variation [CV] = 3.2%–5.9%), with the lowest variability observed for long efforts (>1 min). Critical power showed an ICC and CV of.79 (95% CI,.70–.85) and 3.3% (95% CI, 3.0%–3.7%), respectively. Upper thresholds of expected variation were <12% for short efforts (≤1 min) and <8% for long efforts. Conclusions: "Real-world" peak performance assessed through the RPP shows a low variability between seasons in male professional cyclists—especially for long efforts—with expected variation being around 6% and 3% for short (≤1 min) and long efforts, respectively, and with changes >12% and >8%, respectively, being infrequent for these effort durations. [ABSTRACT FROM AUTHOR]

In the realm of nanotechnology, the integration of quantum emitters with plasmonic nanostructures has emerged as an innovative pathway for applications in quantum technologies, sensing, and imaging. This research paper provides a comprehensive exploration of the photoluminescence enhancement induced by the interaction between quantum emitters and tailored nanostructure configurations. Four canonical nanoantennas (spheres, rods, disks, and crescents) are systematically investigated theoretically in three distinct configurations (single, gap, and nanoparticle-on-mirror nanoantennas), as a representative selection of the most fundamental and commonly studied structures and arrangements. A detailed analysis reveals that the rod gap nanoantenna configuration achieves the largest photoluminescence enhancement factor, of up to three orders of magnitude. The study presented here provides insights for the strategic design of plasmonic nanoantennas in the visible and near-IR spectral range, offering a roadmap for these structures to meet specific requirements in plasmon-enhanced fluorescence. Key properties such as the excitation rate, the quantum yield, the enhanced emitted power, or the directionality of the emission are thoroughly reviewed. The results of this overview contribute not only to the fundamental understanding of plasmon-enhanced emission of quantum emitters but also set the basis for the development of advanced nanophotonic devices with enhanced functionalities. [ABSTRACT FROM AUTHOR]

Traumatic brain injury (TBI) is one of the foremost causes of disability and mortality globally. While the scientific and medical emphasis is to save lives and avoid disability during acute period of injury, a severe health problem can manifest years after injury. For instance, TBI increases the risk of cognitive impairment in the elderly. Remote TBI history was reported to be a cause of the accelerated clinical trajectory of Alzheimer's disease-related dementia (ADRD) resulting in earlier onset of cognitive impairment and increased AD-associated pathological markers like greater amyloid deposition and cortical thinning. It is not well understood whether a single TBI event may increase the risk of dementia. Moreover, the cellular signaling pathways remain elusive for the chronic effects of TBI on cognition. We have hypothesized that a single TBI induces sustained neuroinflammation and disrupts cellular communication in a way that results later in ADRD pathology. To test this, we induced TBI in young adult CD1 mice and assessed the behavioral outcomes after 11 months followed by pathological, histological, transcriptomic, and MRI assessment. On MRI scans, these mice showed significant loss of tissue, reduced CBF, and higher white matter injury compared to sham mice. We found these brains showed progressive atrophy, markers of ADRD, sustained astrogliosis, loss of neuronal plasticity, and growth factors even after 1-year post-TBI. Because of progressive neurodegeneration, these mice had motor deficits, showed cognitive impairments, and wandered randomly in open field. We, therefore, conclude that progressive pathology after adulthood TBI leads to neurodegenerative conditions such as ADRD and impairs neuronal functions. [ABSTRACT FROM AUTHOR]

Purpose: Clinical practices vary between healthcare providers when it comes to asking for a Magnetic Resonance Imaging (MRI) during follow-up for chronic low-back pain (LBP). The association between progressive changes on the MRI and the clinical relevance of these findings is not clearly defined. The objective of our study is to investigate to what extent do MRI findings change during a period less than or equal to two years in patients with chronic LBP. We question the efficacy of its routinary use as a tool for follow-up and we also study the correlation between new changes on MRI and modifications in therapeutic attitude. Methods: Data was collected from 468 lumbar spine MRIs from 209 patients undergoing two or more MRIs between January 2015 and December 2019 with a mean of 2.24 MRIs per patient. The evaluated data included diagnosis, reason for request, MRI findings and treatment offered post-MRI. MRIs were assessed according to a standardized scoring system from 0 to 14 points according to the severity in findings (modified Babinska Score). Radiological changes were defined as increased severity of findings in the most affected segment. Results: 51.06% of MRI requests had no documented reason to be asked for. The average score of the findings on the first MRI was 5,733 (SD 2,462) and 6,131 (SD 2,376) on the second, not reaching a statistically significant difference (p = 0.062). There was no difference on the findings between the first and the second MRI in 40, 15% (n = 104) and up to 89, 96% with only mild changes (−1/ + 2 points over 14 possibles). After repeating the MRI, no modification to the treatment plan was made in 44, 79% of patients (n = 116) and only in 11.58% (n = 30) was surgical treatment indicated. Conclusion: The rate of lumbar MRI has risen to an alarming pace without evidence of consequent improvements in patient outcomes. A significant number of repeated MRIs did not show radiological changes, nor did they give rise to further surgical treatment after obtaining these images. This study should help to review the real applications of clinical guides on the appropriate use for image tests. [ABSTRACT FROM AUTHOR]

The text critiques a scientific paper titled "COVID-19 Prediction Using Black-Box Based Pearson Correlation Approach" by Uzun Ozsahin et al., published in Diagnostics. It highlights issues with the methodology, data pre-processing, validation, experimental design, AI writing, result reporting, and open science practices. The authors point out discrepancies in the research questions, dataset origins, data pre-processing methods, and lack of statistical significance tests. They also discuss the use of AI writing tools without disclosure and the need for greater rigor in the review process to ensure scientific accuracy and transparency. [Extracted from the article]

Reactive oxygen species (ROS) are intermediates in oxidation–reduction reactions with the capacity to modify biomolecules and temporarily or permanently alter cell behaviour through signalling pathways under physiological and pathophysiological conditions where there is an imbalance between oxidative factors and the antioxidant response of the organism, a phenomenon known as oxidative stress. Evidence suggests that the differential modulation of ROS-mediated oxidative stress occurs in the pathogenesis and progression of melanoma, and that this imbalance in redox homeostasis appears to be functionally linked to microRNA (miRNA o miRs)-mediated non-mutational epigenetic reprogramming involving genes and transcription factors. The relationship between ROS-mediated stress control, tumour microenvironment, and miRNA expression in melanoma is not fully understood. The aim of this review is to analyse the involvement of miRNAs in the modulation of the signalling pathways involved in ROS-mediated oxidative stress in melanoma. It is hoped that these considerations will contribute to the understanding of the mechanisms associated with a potential epigenetic network regulation, where the modulation of oxidative stress is consolidated as a common factor in melanoma, and therefore, a potential footprint poorly documented. [ABSTRACT FROM AUTHOR]

A new thermal helium beam diagnostic has been implemented in the outer lower divertor of the ASDEX Upgrade tokamak. The purpose of this diagnostic is to measure two-dimensional profiles of electron density (ne) and temperature (Te) with high temporal and spatial resolution. The geometry of the lines of sight is chosen to avoid the influence of prompt recycling and to optimize the resolution without significantly impacting the divertor structure. Moreover, the effect of long-term helium recycling has been analyzed, and its amplitude compared to the active signal is negligible. Finally, the reconstruction of ne and Te is done via a collisional radiative model, while a static and a dynamic model were implemented and compared with SOLPS simulations as well as divertor Thomson scattering data. Furthermore, a new 2D parameterization of the outer divertor volume, which is required for the dynamic model, was developed. Due to its fast and local ne and Te profile measurements, the diagnostic is suitable for investigating fast processes such as divertor transitions and filaments. [ABSTRACT FROM AUTHOR]

High-harmonic generation from solid films is an attractive method for converting infrared laser pulses to ultraviolet and vacuum ultraviolet wavelengths and for examining the films using the generation process. In this work, AlN thin films grown on a sapphire substrate are studied. Below-band-gap third harmonics and above-band-gap fifth harmonics were generated using a Ti:sapphire oscillator running at 800 nm. A strong enhancement of the fifth-harmonic signal in the forward direction was observed from thicker 39 nm and 100 nm films compared to thinner 8 nm and 17 nm films. For the fifth harmonic generated in the backward direction, and also for the third harmonic in both the forward and backward directions, only a weak dependence of the harmonic signal on the film thickness was measured. Using both X-ray diffraction and dependence of the fifth harmonic on the laser polarization measurements, these behaviors are attributed to the crystallization and the grain size of the films, promising fifth-harmonic generation as a suitable tool to study AlN film properties. [ABSTRACT FROM AUTHOR]

The polypropylene (PP) synthesis process is crucial in the plastics industry, requiring precise control as it directly impacts the catalytic activity and the final product's performance. This study investigates the effects of trace amounts of four different mercaptans on the polymerization of propylene using a fourth-generation Ziegler–Natta (ZN) catalyst. Various concentrations of these mercaptans were tested, and results showed that their presence significantly reduced the melt flow index (MFI) of the final PP. The most notable MFI decrease occurred at 37.17 ppm of propyl mercaptan and 52.60 ppm of butyl mercaptan. Methyl and ethyl mercaptan also reduced the MFI at lower concentrations, indicating that mercaptans act as inhibitors by slowing down the polymerization process and reducing the fluidity of molten PP. The highest MFI increase was observed at lower concentrations of each mercaptan, suggesting that smaller molecular inhibitors require less concentration. This trend was also seen in the catalyst's productivity, where lower concentrations of methyl mercaptan reduced PP production more effectively than higher concentrations of butyl mercaptan. Fourier transform infrared spectroscopy (FTIR) identified interactions between the mercaptans and the ZN catalyst. Computational analysis further supported these findings, providing insights into the molecular interactions and suggesting possible inhibition mechanisms that could impact the final properties of polypropylene. [ABSTRACT FROM AUTHOR]

The increase in agricultural data has created a need for developing tools that can manage, share, and visualise this information, while also being accessible to farmers. The use of different technical languages, varying needs, and differing objectives for the tools being developed and used creates a gap between technology developers and farmers, leading to inefficient information transfer. Consequently, interfaces are often poorly adapted to the real needs of end-users and lack essential functionality. This white paper aims to propose a User-Centred Design methodology in order to address the challenges encountered in creating interfaces for shared agricultural Data Space Ecosystems. The proposed methodology, an adaptation of ISO 9241:210-2019, highlights the importance of user participation at various stages of the interface design cycle for the creation of user-adaptive technologies. [ABSTRACT FROM AUTHOR]

Purpose: To investigate the effects of prehabilitation on the perioperative functional capacity of patients awaiting oncological resections. Methods: A systematic review and meta-analysis were performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist and within the databases Cochrane Library, EBSCOhost, Google Scholar, MEDLINE PubMed, and Web of Science. The eligibility criteria were set to include peer-reviewed randomised control trials including only adult (≥ 18 years old) patients undergoing any type of prehabilitation (PREHAB) prior to any type of oncological resection. The studies had to feature at least one control group undergoing standard care (SC) and had to assess functional capacity by means of a 6-min walk distance (6MWD) or peak oxygen uptake (VO2Peak) at different stages pre- and post- operatively. Results: Twenty-seven randomised controlled trials involving 1994 patients were included. After processing the data, the number of patients was 1889. Studies featured different cancer specialties: lung (11), colorectal (5), urological (4), abdominal (3), esophagogastric (2), liver (1), and gastrointestinal (1). Overall, PREHAB enhanced both 6MWD (g = 0.273, 95% CI 0.174 to 0.371, Z = 5.406, p < 0.001) and VO2Peak (g = 0.615, 95% CI 0.243 to 0.987, Z = 3.240, p = 0.001) compared with SC. The 6MWD subgroup analysis revealed a small mean effect size favouring both unimodal and multimodal PREHAB interventions. Conclusion: These findings support that prehabilitation, whether implemented as unimodal or multimodal format, elicits small preoperative improvements in functional capacity in patients awaiting oncological resections. PROSPERO registration number CRD42023428676. [ABSTRACT FROM AUTHOR]

The present study explored the extraction of cellulose from forest residues of four timber species, namely Cedrela montana Moritz ex Turcz, Buddleja incana Ruiz & Pav, Vallea stipularis L. f. and Myrsine andina (Mez) Pipoly, in the high montane forest of Chimborazo province, Ecuador, for the sustainable utilization of leaves, branches, and flowers. An alkaline extraction method was used on the residues without the need for prior degreasing. An ANOVA analysis was applied to evaluate significant differences in cellulose extraction yields among the species' residues. The characterization techniques used were Fourier transform infrared spectroscopy (FTIR) and polarized light optical microscopy, which confirmed the successful extraction of cellulose with characteristics comparable to standard cotton cellulose and other traditional species. The results showed significant variations in cellulose yield among the species, with Vallea stipularis L. f achieving the highest yield of 80.83%. The crystallinity of the samples was clearly evidenced by the polarity of the light in the samples during microscopy, demonstrating that the residues can be a viable and sustainable source of cellulose, contributing to a circular economy and reducing the environmental impact of forest waste. [ABSTRACT FROM AUTHOR]

The paper defines 'cluster identity' as an intangible attribute of clusters comprised of place branding and trademarking by cluster organizations, respectively anchored in a 'logic of belonging' and a 'logic of similarity'. We expand the taxonomy of proximities and their dynamics according to their belonging/similarity logic and their tangible/intangible nature. As illustrated in the context of the Bordeaux wine region of France, we find that a prevailing logic of belonging leads to reputational inertia. We propose that trademarking by cluster organizations can facilitate the adaptation of cluster identity, thereby emphasizing its potential as an instrument for cluster managers to engage in community-building. [ABSTRACT FROM AUTHOR]

Background: Research suggests that positivity and self-efficacy beliefs may impact adaptive behavior and developmental outcomes, such as social adjustment and subjective wellbeing. The present study explored the effect of positive dimensions (positivity and self-efficacy beliefs) and individual characteristics (gender, type of country, age, and sexual orientation) on family cohesion and flexibility in a group of Colombian and Italian young adults. An online survey was administered to 949 Colombian and 2,073 Italian people aged between 18 and 40 years (Mage = 24.3; SDage = 4.5; 67% women). A mediational model was performed to test the influence of positivity on family functioning via the mediational role of self-efficacy beliefs, analyzing the moderated effects of gender, type of country, sexual orientation, and age. Results: Filial self-efficacy mediated the effect of positivity on family functioning, showing stronger paths in men and Colombian participants than in women and Italian counterparts. Regulatory self-efficacy mediated the associations between positivity and family functioning for both genders and types of countries. Conclusion: The results suggest that positivity and self-efficacy beliefs may allow families to engage in more adaptive family functioning across countries and genders. Further research should focus on implications from a crossnational perspective to examine other culture-specific factors that may impact family adjustment. [ABSTRACT FROM AUTHOR]

We used numerical methods to define the normative structure of the different stages of sleep and wake (W) in a pilot study of 19 participants without pathology (18–64 years old) using a double-banana bipolar montage. Artefact-free 120–240 s epoch lengths were visually identified and divided into 1 s windows with a 10% overlap. Differential channels were grouped into frontal, parieto-occipital, and temporal lobes. For every channel, the power spectrum (PS) was calculated via fast Fourier transform and used to compute the areas for the delta (0–4 Hz), theta (4–8 Hz), alpha (8–13 Hz), and beta (13–30 Hz) bands, which were log-transformed. Furthermore, Pearson's correlation coefficient and coherence by bands were computed. Differences in logPS and synchronization from the whole scalp were observed between the sexes for specific stages. However, these differences vanished when specific lobes were considered. Considering the location and stages, the logPS and synchronization vary highly and specifically in a complex manner. Furthermore, the average spectra for every channel and stage were very well defined, with phase-specific features (e.g., the sigma band during N2 and N3, or the occipital alpha component during wakefulness), although the slow alpha component (8.0–8.5 Hz) persisted during NREM and REM sleep. The average spectra were symmetric between hemispheres. The properties of K-complexes and the sigma band (mainly due to sleep spindles—SSs) were deeply analyzed during the NREM N2 stage. The properties of the sigma band are directly related to the density of SSs. The average frequency of SSs in the frontal lobe was lower than that in the occipital lobe. In approximately 30% of the participants, SSs showed bimodal components in the anterior regions. qEEG can be easily and reliably used to study sleep in healthy participants and patients. [ABSTRACT FROM AUTHOR]

Previous research on aphasia has recognised the need for cross-linguistic studies and studies on bi/multilingual aphasia. However, a study by Beveridge and Bak revealed that papers published between 2000 and 2009 were restricted to a few languages, with a clear predominance of English. The aim of this study is to present a follow-up to that study with more recent literature from the next decade (2010–2019) and to compare it with the previous one. We analysed 307 articles published between 2010 and 2019 following a similar procedure to the one used by Beveridge and Bak. The results revealed that there still is a pronounced bias towards studies on English speakers (60.29%), that the distribution of language families is similar across the two decades, with the exception of the increment in non-Indo-European languages, and that there has been an increase in studies reporting bi/multilinguals' performance in more than one language. Still, the literature on aphasia between 2010 and 2019 seems not to reflect the reality of the world's languages. We discuss some possible explanations for these findings related to challenges for clinical practice as well as insights for future research. [ABSTRACT FROM AUTHOR]

We describe a case of autochthonous human Babesia divergens infection in an immunocompetent woman in England. The patient had fever, hemolysis, multiorgan failure, and 18% parasitemia. We confirmed B. divergens by 18S rDNA PCR and sequencing. Clinicians should consider babesiosis as a differential diagnosis in patients with unexplained hemolysis. [ABSTRACT FROM AUTHOR]

The multipurpose tree Neltuma alba is widely distributed in forests of north-central Argentina but overexploitation and deforestation have led to forest transformation and endangered genetic diversity of this species. Thus, developing germplasm management strategies for the conservation and use of the species is crucial. In this context, the availability of georeferenced ecogeographic information along with multivariate analysis techniques facilitates the characterisation, classification and prediction of adaptive patterns, providing a framework for decision-making. In the present study, an Ecogeographic Land Characterisation (ELC) map was generated to assess the ecogeographic representativeness of N. alba germplasm collections and design seed transfer zones (STZs). Adaptive trait data recorded for different plant materials from several provenances across the species’ range in Argentina were used to validate the methodology. The germplasm collections were ecogeographically representative of the occurrence observed; however, some ecogeographic gaps were identified. Of the 45 ecogeographical categories generated in the ELC map, 12 provisional STZs were established. The STZs showed consensus with the morphological groups generated using adaptive traits. This study demonstrates the usefulness of ecogeographic analyses as a preliminary tool to develop strategies for the collection and use of native plant genetic resources. Furthermore, the validation of models with genetic data ensures their effectiveness for restoration and/or afforestation activities. [ABSTRACT FROM AUTHOR]

Residual stresses and surface roughness have been recognized to play a critical role in the fatigue strength of metal components. Machining processes can induce different roughness and residual stress conditions depending on the parameters used in the process. Therefore, it is essential to develop knowledge that helps to predict the residual stresses and roughness that would be obtained from different machining conditions. Due to the growing interest from the industry in the use of 42CrMo4 steel because of its excellent mechanical properties, the main objective of this work is to establish two phenomenological models to accurately predict the residual stress and roughness values in turned specimens of this material. The models are derived from data of four process variables: (a) insert tip radius; (b) feed rate; (c) cutting speed; and (d) depth of cut. For this purpose, a wide experimental campaign has been developed, which includes the machining of 68 specimens under various cutting scenarios, and their subsequent measurement of residual stresses and roughness. Once the experimental data were obtained, the response surface method based on the central composite design was used to fit the models, obtaining a correlation index R 2 higher than 0.9 in both cases. In this article, it is concluded that feed rate and insert radius have a greater effect on the residual stress and roughness obtained, while cutting speed and depth of cut have a lesser impact on the results. It is hoped that the findings will establish a groundwork for the machining of this material type, ensuring controlled conditions of residual stress and roughness. [ABSTRACT FROM AUTHOR]

Cardiac catheterization for congenital heart disease (CHD) performed under fluoroscopic guidance still lacks definition and requires exposure to ionizing radiation and contrast agents, with most patients needing multiple procedures through their lifetime, leading to cumulative radiation risks. While fusion overlay techniques have been employed in the past to aid, these have been limited to a single plane, while interventions are traditionally performed under biplane fluoroscopy. We describe our initial experience performing cardiac catheterizations guided by an enhanced biplane GuideCCI system© (Siemens Healthcare, Germany) augmented by 3D magnetic resonance imaging and computed tomography modeling. Twenty-one children and young adults with CHD undergoing catheterization procedures between October 2019 and May 2021 were chosen based on their degree of complexity of cardiac anatomy. 3D stereolithography models were generated, overlayed, and displayed in real time, alongside angiographs in both planes on the screen during these procedures. We report successful implementation of this novel technology for performance of 26 interventions including stent placements, balloon dilations, vessel occlusion and percutaneous valve and transvenous pacemaker implantation all in patients with various complex cardiac anatomies. A statistically significant reduction in radiation and contrast use was noted for coarctation of the aorta stent angioplasty and transcatheter pulmonary valve replacement when compared with national benchmarks and local institutional metrics (with and without single plane overlay). No complications were encountered with the use of this technology. Use of a tracheal registration technique provided very good correlation in most cases. Operators preferred using biplane augmented catheterization over traditional fluoroscopy in patients with complex cardiac anatomy undergoing interventions. [ABSTRACT FROM AUTHOR]

Background: Economic hardships have far-reaching implications for families with children, impacting their well-being and development during the COVID-19 pandemic. The pandemic has led to household financial problems following job loss and reduced income. As parents or caregivers face financial difficulties, children may experience emotional distress through heightened anxiety and a sense of helplessness. This study examined the effects of household job insecurity and food insufficiency due to the pandemic's aftermath on the mental well-being of children in the United States. Method: This study utilized data from the Household Pulse Survey (HPS) during June 7–19, 2023 (Phase 3.9). The prevalence and effect of job insecurity, delineated by recent household job loss and employment status, and food insufficiency, measured through levels of food insufficiency, were analyzed across households with different age groups of children: under 5 years, 5–11 years, and 12–17 years, with an overall perspective on children under 18. We calculated unweighted observations, survey-weighted proportions, and survey-weighted 95% confidence intervals to analyze the impact of job insecurity and food insufficiency on children's mental health treatment needs. Results: This study highlighted differences in economic hardships due to household job insecurity and food insufficiency across households with children in multiple age groups. There were almost twice as many respondents with no work in the last 7 days (33.68%) compared to those who experienced job loss within the last 4 weeks (14.82%). Additionally, 51.68% of respondents reported food insufficiency over the last 7 days, with more than half of the households experiencing food insufficiency due to the inability to afford more food. Mental health treatment needs among children were significantly higher in households experiencing job loss and food insufficiency. The need for mental health support for children increased with age in households facing job loss or no employment. Conclusions: This study enhances our understanding of post-pandemic economic hardships and their influence on children's mental health needs across different age groups. By identifying disparities and patterns, policymakers and practitioners can design targeted interventions to address employment opportunities and food access in the aftermath of the COVID-19 pandemic. Providing mental health treatments is crucial, especially for children aged 5–11 and 12–17, who are at higher risk of experiencing emotional distress due to household economic hardships. [ABSTRACT FROM AUTHOR]

Background: Spain healthcare system is decentralized, with seventeen autonomous regions overseeing healthcare. However, penitentiary healthcare is managed nationally, except in Catalonia, the Basque Country, and Navarra. These variations impact mental health care provision for inmates with serious mental illness (SMI). Objective: To delineate differences between regions in terms of mental health care provision for individuals with SMI, available resources, and the perspectives of healthcare professionals operating in the Spanish prison environment. Methods: Employing an explanatory sequential mixed-method approach, the study conducted an extensive literature review, quantitative data collection through structured questionnaires, and qualitative data collection via focus groups and four in-depth interviews. Analysis involved calculating percentages and ratios for quantitative data and thematic analysis for qualitative data interpretation to comprehensively understand mental healthcare provision. Results: In December 2021, about 4% of inmates in Spain had SMI. There are three distinct models of mental healthcare within the Spanish prison system. The traditional penitentiary model, representing 83% of the incarcerated population, operates independently under the General Secretariat of Penitentiary Institutions at a national level. This model relies on an average of 5.2 penitentiary General Practitioners (pGP) per 1,000 inmates for psychiatric and general healthcare. External psychiatrists are engaged for part-time psychiatric assessment. Acute psychiatric hospitalization occurs in general nursing modules within penitentiary centers or in Restricted Access Units (RAUs) in reference hospitals. Two penitentiary psychiatric hospitals provide care to unimputable SMI inmates from all over Spain. Innovative penitentiary models, constituting 17% of the prison population, integrate penitentiary healthcare within regional public health systems. The Basque Country features a Mental Health Unit with fulltime care teams within the penitentiary center. Catalonia emphasizes community care, providing full-time dedicated psychiatric services within and outside prisons, ensuring continued care in the community. Both models prioritize personnel with specialized mental health training and compensation akin to non-prison healthcare settings. Conclusions: Regional disparities in penitentiary mental healthcare models in Spain result in resource inequalities, impacting specialized care for inmates with SMI and opportunities for healthcare professionals. The models in the Basque Country and Catalonia offer valuable experiences for penitentiary healthcare. [ABSTRACT FROM AUTHOR]

Noise-induced hearing loss (NIHL) is responsible for significant adverse effects on cognition, quality of life and work, social relationships, motor skills, and other psychological aspects. The severity of NIHL depends on individual patient characteristics, sound intensity, and mainly the duration of sound exposure. NIHL leads to the production of a reactive oxygen (ROS) inflammatory response and the activation of apoptotic pathways, DNA fragmentation, and cell death. In this situation, antioxidants can interact with free radicals as well as anti-apoptotics or anti-inflammatory substances and stop the reaction before vital molecules are damaged. Therefore, the aim of this study was to analyze the effects of different pharmacological treatments, focusing on exogenous antioxidants, anti-inflammatories, and anti-apoptotics to reduce the cellular damage caused by acoustic trauma in the inner ear. Experimental animal studies using these molecules have shown that they protect hair cells and reduce hearing loss due to acoustic trauma. However, there is a need for more conclusive evidence demonstrating the protective effects of antioxidant/anti-inflammatory or anti-apoptotic drugs' administration, the timeline in which they exert their pharmacological action, and the dose in which they should be used in order to consider them as therapeutic drugs. Further studies are needed to fully understand the potential of these drugs as they may be a promising option to prevent and treat noise-induced hearing loss. [ABSTRACT FROM AUTHOR]

Physical diseases have become an alarming social problem worldwide. Several conditions related to limb mobility are more frequent due to a high level of demand in the repetitive execution of activities. Assistive technologies have been proposed to improve the experience of physical rehabilitation. This paper presents a framework with the mechanical design criteria for an upper limb assistive robotic system. We define the design specifications and construction characteristics of an assistive system. As a result, a 7-degree-of-freedom system for upper limb physical rehabilitation is designed with a novel characteristic of arm-switching configuration for the treatment of both arms. [ABSTRACT FROM AUTHOR]

Currently, young people with disabilities practice less sport than people without disabilities, which is a risk to their health and affects their well-being. The aim of this research was to identify the specific dimensions and tools used to measure psychological well-being (PWB) in young athletes with physical disabilities and to analyze the influence of sport. A systematic review was conducted using PUBMED/MEDLINE, Web of Science, Scopus, and Sportdiscus databases, and the search was completed without limitation to any specific year, including results up to and including 29 May, 2023. A total of 2112 articles were obtained in the initial search. Eligibility criteria were: (i) athletes with a physical disability, (ii) performing adapted and non-adapted physical activity and/or sport, (iii) the study aimed to analyse well-being, and (iv) outcomes of psychological well-being variables were identified. Exclusion criteria were (i) people with injury or transient difficulty, (ii) rehabilitative physical activity, and (iii) the results did not show any psychological well-being variables or mentions. This review identified that the most used dimension was mastery of the environment, together with the autonomy. All studies showed a positive correlation between sport practice and psychological well-being. Five measurement tools were identified knowing the state of psychological well-being of young athletes with disabilities is essential to promote successful participation in sports activities. [ABSTRACT FROM AUTHOR]

Currently, 4.0 technologies have generated important changes in government entities, promoting digital government transformation (DGT). This article addresses the challenge of improving the security, reliability and traceability of communications and certified notifications of state entities, particularly in the case of the Colombian government entity called the Comisión de Regulación de Comunicaciones (CRC). Four important points are presented in this report: (a) Research interest in blockchain and smart contracts has been greatly increasing, evidenced in a literature review conducted in the SCOPUS index; (b) a global reference framework on the use of emerging technologies, as is the case of blockchain, has been developed, as well as the legal and juridical framework in Colombia as a baseline; (c) a multi-criteria decision making framework has been used, resulting in the choice of the Zilliqa platform; and (d) The Tecnotifica™ V1.0 software tool is developed to automate notifications with stakeholders using blockchain. Its effectiveness and acceptance is validated with a technology acceptance level test (TAM). It is concluded that the incorporation of emerging technologies such as blockchain is of a very high interest and relevance in the digital transformation of the state sector in the world. [ABSTRACT FROM AUTHOR]

A multi-energy soft x-ray diagnostic is planned to operate in the small aspect ratio tokamak (SMART), consisting of five cameras: one for core measurements, two for edge, and two for divertors. Each camera is equipped with four absolute extreme ultra-violet diodes, with three of them filtered by Ti and Al foils for C and O line emissions, respectively, and Be foils for temperature measurements. In addition, two spectrometers will be installed with a vertical line of sight for impurity control. This study introduces a synthetic model designed to characterize radiated power and soft x-ray emissions. The developed code extracts the radiated power and Zeff values by leveraging distributions of electron density, temperatures, and impurity concentrations. The investigation is centered on the predicted scenarios of SMART's first phase of operation (Ip = 100 kA; Bt = 0.1 T), employing a double-null configuration with positive and negative triangularity. The anticipated impurities encompass C (1%) and Fe (0.01%) from the vessel, as well as O and N (0.1%) from air and water. For simplicity, the distribution is assumed to be homogeneous within the plasma, considering different mixtures with Zeff values ranging between 1 and 2. Finally, the model estimates signal strength for the diagnostic design, proving its feasibility. [ABSTRACT FROM AUTHOR]

We describe the design of a Thomson scattering (TS) diagnostic to be used on the SMall Aspect Ratio Tokamak (SMART). SMART is a spherical tokamak being commissioned in Spain that aims to explore positive triangularity and negative triangularity plasma scenarios at a low aspect ratio. The SMART TS diagnostic is designed to operate at high spatial resolution, 6 mm scattering length in the low-field side and 9 mm in the high-field side regions, and a wide dynamic range, electron temperature from 1 eV to 1 keV and density from 5 × 1 0 18 m − 3 to 1 × 1 0 20 m − 3 , to resolve large gradients formed at the plasma edge and in the scrape-off layer (SOL) under different triangularities and low aspect ratios. A 2 J @ 1064 nm laser will be used that is capable of operating in the burst mode at 1, 2, and 4 kHz to investigate fast phenomena and at 30 Hz to study 1 s (or more) long discharges. The scattered light will be collected over an angular range of 60 ° – 120 ° from 28 spatial points in the midplane covering the entire plasma width and the outer midplane SOL. Each scattering signal will be spectrally resolved on five wavelength channels of a polychromator to obtain the electron temperature measurement. We will also present a method to monitor in situ laser alignment in the core during calibrations and plasma operations. [ABSTRACT FROM AUTHOR]

Multivariate analysis applied in biosensing greatly improves analytical performance by extracting relevant information or bypassing confounding factors such as nonlinear responses or experimental errors and noise. Plasmonic sensors based on various light coupling mechanisms have shown impressive performance in biosensing by detecting dielectric changes with high sensitivity. In this study, gold nanodiscs are used as metasurface in a Kretschmann setup, and a variety of features from the reflectance curve are used by machine learning to improve sensing performance. The nanostructures of the metasurface generate new plasmonic features, apart from the typical resonance that occurs in the classical Kretschmann mode of a gold thin film, related to the evanescent field beyond total internal reflection. When the engineered metasurface is integrated into a microfluidic chamber, the device provides additional spectral features generated by Fresnel reflections at all dielectric interfaces. The increased number of features results in greatly improved detection. Here, multivariate analysis enhances analytical sensitivity and sensor resolution by 200% and more than 20%, respectively, and reduces prediction errors by almost 40% compared to a standard plasmonic sensor. The combination of plasmonic metasurfaces and Fresnel reflections thus offers the possibility of improving sensing capabilities even in commonly available setups. [ABSTRACT FROM AUTHOR]

The coefficient of friction (CoF) between the deflection pulley and rope in a lift strongly affects the life span of the rope. Although surface roughness is a key factor affecting the metallic pulley–rope CoF, its effect on polymeric pulleys is unknown. The present study analyses the effect of roughness and working conditions on cast polyamide 6 (PA6G) deflection pulley–thermoplastic polyurethane (TPU)-coated rope contacts. The statistical analysis revealed that the effect of surface roughness on the CoF for low-load tests was significant. The present study contributes significantly to parameter selection in deflection pulley machining to minimise friction between the pulley and rope. [ABSTRACT FROM AUTHOR]

A common challenge for exoskeleton control is discerning operator intent to provide seamless actuation of the device with the operator. One way to accomplish this is with joint angle estimation algorithms and multiple sensors on the human–machine system. However, the question remains of what can be accomplished with just one sensor. The objective of this study was to deploy a modular testing approach to test the performance of two joint angle estimation models—a kinematic extrapolation algorithm and a Random Forest machine learning algorithm—when each was informed solely with kinematic gait data from a single potentiometer on an ankle exoskeleton mock-up. This study demonstrates (i) the feasibility of implementing a modular approach to exoskeleton mock-up evaluation to promote continuity between testing configurations and (ii) that a Random Forest algorithm yielded lower realized errors of estimated joint angles and a decreased actuation time than the kinematic model when deployed on the physical device. [ABSTRACT FROM AUTHOR]

In the fast-changing technological landscape, novel applications are emerging with the potential to reshape the world. These applications, while promising, impose stringent requirements in terms of quality of service (QoS). The advent of wireless networks like 5G, 6G and Wi-Fi 6 brings about resource management solutions to ensure these requirements while meeting the user expectations within the interconnected environment. Nevertheless, user behaviors are also evolving, highlighting the importance of satisfaction and quality of experience (QoE). Furthermore, changes in user behavior trigger shifts in business models, where the quality of business (QoBiz) takes on a pivotal role. This evolving ecosystem, encompassing QoS, QoE, and QoBiz, demands a comprehensive and adaptable approach that conventional QoS management frameworks fail to perform. This paper introduces an implementation methodology for a global QoS management model named QoXphere. The implementation methodology is grounded in machine learning techniques and addresses the multifaceted aspects of quality of service (QoX) and their interconnections within wireless networks. The objective is to facilitate dynamic resource management that not only elevates user satisfaction but also optimizes provider benefits. Real-world examples illustrate the methodology's applicability in widely deployed networks, complemented by simulated scenarios of modern network environments that further validate the approach. [ABSTRACT FROM AUTHOR]

Although there are several healthcare and Information Technology (IT) practices in Implementing and Managing integrated care for Multimorbid patients (IMM), a synchronized perspective of the existing and emerging practices is still lacking. Our earlier research initiated the adoption of Soft Systems Methodology (SSM) to derive a model, that specifies strategic drivers for guiding alignment of healthcare and IT practices in IMM. However, the model does not directly reveal details of how a programme can implement and continuously assess specific healthcare and IT practices in a coherent/integrated way, so as to realize goals and outcomes of IMM. This implies the need to extend the model by providing a mechanism that synchronizes specific elements of healthcare and IT practices, with the strategic goals of delivering integrated care for multimorbid patients. Such a synthesis of best practices in IMM, can serve as Scorecard for Continuous Assessment and improvement of programmes on Integrated Care for multimorbid patients (SAICO). To design SAICO, SSM's multi-level thinking technique was mutually adopted with Co-Creation, Enterprise Architecture, and Balanced Scorecard approaches. SAICO's design was enhanced using a Co-Creation by validation approach, that involved 18 co-creators or subject matter experts from Spain and Uganda. Findings from SAICO evaluation affirmed its usefulness and provided insights that improved its design, understandability, and usability. SAICO can be perceived as an evolving reference map of elements/capabilities that shape a programme's capacity for IMM, because it can be used to conduct continuous self assessment and identify actions for improvement. [ABSTRACT FROM AUTHOR]

In this paper, I explore how the racial structure of an immigrant-receiving Latin American society informs the strategies that are available to its members when they are confronted with the arrival of perceived racial outsiders. Using survey data, I explore how Dominicans responded to the rapid influx of displaced Haitians in the aftermath of the 2010 earthquake in Haiti, and find that when surveyed after the earthquake, Dominicans were more likely to self-identify with the popular and nationalist identity category of indio. I argue that this signaled a heightening of anti-Haitian sentiment in a moment of perceived increased racial threat to the Dominican racial order, and that this shift was facilitated by Latin American racial dynamics that allow for movement between enumerated racial categories in societies structured around the logic of mestizaje. [ABSTRACT FROM AUTHOR]

A set of magnetic diagnostics has been designed, manufactured, and calibrated for the first operational phase of the small aspect ratio tokamak. The sensor suite comprises of Rogowski coils; 2D magnetic probes; and poloidal, saddle, and diamagnetic flux loops. A set of continuous Rogowski coils has been manufactured for the measurement of plasma current and induced eddy currents in conductive elements. A set of flux loops and magnetic probes will be used as input for the reconstruction of the magnetohydrodynamic equilibrium. The quantity and position of these sensors have been verified to be sufficient with synthetic equilibrium reconstructions using the equilibrium fitting code and baseline scenarios computed with the Fiesta code. These sensors will also be used as input for the real-time control system, and magnetic probes will be used for the detection of plasma instabilities. The calibration procedure for the magnetic probes is described, and the results are shown. The signal conditioning and data acquisition systems are described. [ABSTRACT FROM AUTHOR]

Two novel Ce(III) metal organic frameworks (MOFs) with formulas [Ce(5Meip)(H-5Meip)]nGR-MOF-17 and [CeCl(5Meip)(DMF)]nGR-MOF-18 (5Meip = 5-methylisophthalate, DMF = N,N-dimethylformamide) have been synthesized, forming 3-dimensional frameworks. Magnetic measurements show that both compounds present field-induced slow magnetic relaxation under a small applied dc field. For GR-MOF-17, the temperature dependence of relaxation times is best described by a Raman mechanism, whereas for GR-MOF-18, relaxation occurs through a combination of Raman and local-mode pathways. Moreover, when avoiding short Ce⋯Ce interactions by magnetic dilution in GR-MOF-17@La and GR-MOF-18@La, only the local-mode mechanism is responsible for magnetic relaxation. Photophysical studies show the occurrence of ligand-centred luminescence in both compounds and phosphorescence emission at low temperature for GR-MOF-17. [ABSTRACT FROM AUTHOR]

Background: Metabolic syndrome (MetS) is a cluster of medical conditions and risk factors correlating with insulin resistance that increase the risk of developing cardiometabolic health problems. The specific criteria for diagnosing MetS vary among different medical organizations but are typically based on the evaluation of abdominal obesity, high blood pressure, hyperglycemia, and dyslipidemia. A unique, quantitative and independent estimation of the risk of MetS based only on quantitative biomarkers is highly desirable for the comparison between patients and to study the individual progression of the disease in a quantitative manner. Methods: We used NMR-based metabolomics on a large cohort of donors (n = 21,323; 37.5% female) to investigate the diagnostic value of serum or serum combined with urine to estimate the MetS risk. Specifically, we have determined 41 circulating metabolites and 112 lipoprotein classes and subclasses in serum samples and this information has been integrated with metabolic profiles extracted from urine samples. Results: We have developed MetSCORE, a metabolic model of MetS that combines serum lipoprotein and metabolite information. MetSCORE discriminate patients with MetS (independently identified using the WHO criterium) from general population, with an AUROC of 0.94 (95% CI 0.920–0.952, p < 0.001). MetSCORE is also able to discriminate the intermediate phenotypes, identifying the early risk of MetS in a quantitative way and ranking individuals according to their risk of undergoing MetS (for general population) or according to the severity of the syndrome (for MetS patients). Conclusions: We believe that MetSCORE may be an insightful tool for early intervention and lifestyle modifications, potentially preventing the aggravation of metabolic syndrome. [ABSTRACT FROM AUTHOR]

Inflammation of the bile ducts and surrounding tissues can impede bile flow from the liver into the intestines. If this occurs, a plastic or self-expanding metal (SEM) stent is placed to restore bile drainage. United States (US) Food and Drug Administration (FDA)-approved plastic biliary stents are less expensive than SEMs but have limited patency and can occlude bile flow if placed spanning a duct juncture. Recently, we investigated the effects of variations to post-processing and autoclaving on a commercially available stereolithography (SLA) resin in an effort to produce a suitable material for use in a biliary stent, an FDA Class II medical device. We tested six variations from the manufacturer's recommended post-processing and found that tripling the isopropanol (IPA) wash time to 60 min and reducing the time and temperature of the UV cure to 10 min at 40 °C, followed by a 30 min gravity autoclave cycle, yielded a polymer that was flexible and non-cytotoxic. In turn, we designed and fabricated customizable, SLA 3D-printed polymeric biliary stents that permit bile flow at a duct juncture and can be deployed via catheter. Next, we generated an in silico stent 3-point bend test to predict displacements and peak stresses in the stent designs. We confirmed our simulation accuracy with experimental data from 3-point bend tests on SLA 3D-printed stents. Unfortunately, our 3-point bend test simulation indicates that, when bent to the degree needed for placement via catheter (~30°), the peak stress the stents are predicted to experience would exceed the yield stress of the polymer. Thus, the risk of permanent deformation or damage during placement via catheter to a stent printed and post-processed as we have described would be significant. Moving forward, we will test alternative resins and post-processing parameters that have increased elasticity but would still be compatible with use in a Class II medical device. [ABSTRACT FROM AUTHOR]

Epilepsy affects millions worldwide, making timely seizure detection crucial for effective treatment and enhanced well-being. Electroencephalogram (EEG) analysis offers a non-intrusive solution, but its visual interpretation is prone to errors and requires a lot of time. Many existing works focus solely on achieving competitive levels of accuracy without considering processing speed or the computational complexity of their models. This study aimed to develop an automated technique for identifying epileptic seizures in EEG data through analysis methods. The efforts have been primarily focused on achieving high accuracy results by operating exclusively within a narrow frequency band of the signal, while also aiming to minimize computational complexity. In this article, a new automated approach is presented for seizure detection by combining signal processing and machine learning techniques. The proposed method comprises four stages: (1) Preprocessing: Savitzky–Golay filter to remove the background noise. (2) Decomposition: discrete wavelet transform (DWT) to extract spontaneous alpha and beta frequency bands. (3) Feature extraction: six features (mean, standard deviation, skewness, kurtosis, energy, and entropy) are computed for each frequency band. (4) Classification: a support vector machine (SVM) method classifies signals as normal or containing a seizure. The method was assessed using two publicly available EEG datasets. For the alpha band, the highest achieved accuracy was 92.82%, and for the beta band it was 90.55%, which demonstrates adequate capability in both bands for accurate seizure detection. Furthermore, the obtained low computational cost suggests a potentially valuable application in real-time assessment scenarios. The obtained results indicate its capacity as a valuable instrument for diagnosing epilepsy and monitoring patients. Further research is necessary for clinical validation and potential real-time deployment. [ABSTRACT FROM AUTHOR]

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Ion temperature, rotation, and density are key parameters to evaluate the performance of present and future fusion reactors. These parameters are critical for understanding ion heat, momentum, and particle transport, making it mandatory to properly diagnose them. A common technique to measure these properties is charge exchange recombination spectroscopy (CXRS). For characterizing positive and negative triangularity plasmas at the small aspect ratio tokamak, a poloidal array of gas puff based CXRS diagnostics will be measuring the ion properties in different poloidal positions. In this work, the modeling of the expected signal and spatial coverage using the FIDASIM code is presented. Furthermore, the design and characterization of the low field side midplane CXRS diagnostic are described. Each diagnostic is composed of a gas injection system, an optical system that collects the light emitted by the plasma, and a spectrometer. These systems will provide ion temperature, rotation, and density with a radial resolution of 3.75 mm and a temporal resolution of 2.2 ms. [ABSTRACT FROM AUTHOR]

Introduction: The aim of the present study is to analyze the clinical–radiological outcomes of patients undergoing knee prosthesis revision surgery using constrained condylar prosthesis (LCCK; Zimmer-Biomet). Material and methods: Retrospective study of 89 patients operated on between the years 2008 and 2020 with a minimum of 2 years of follow-up. Clinical outcomes were evaluated using the WOMAC Index score and KOOS scales. Radiological results (radiolucent lines, osteolysis, and cortical hypertrophy) were evaluated by two independent observers. Implant survival was analyzed using the Kaplan–Meier method. Results: At the end of follow-up, a mean WOMAC Index score of 78.67 and KOOS score of 68.8 were obtained. Radiolucent lines (both non-progressive and progressive) were detected in 83.3% of the patients in the sample. Areas of osteolysis > 5 mm around the components were present in 6.75%. Cortical hypertrophy was seen around the femoral stem in 20.3% of cases, around the tibial stem in 20.3% and around both components in 6.76%. No statistically significant relationship was found between the presence of radiolucent lines, osteolysis or cortical hypertrophy with functional results. Implant survival was 88.1% at 13 years. Conclusion: The present study shows high survival of LCCK prosthesis in revision surgery. The progressive radiolucencies, were associated with worst clinical outcome. [ABSTRACT FROM AUTHOR]

Identity fusion is a visceral feeling of oneness with a group, known to strongly motivate extreme pro‐group behaviour. However, the evidence on its causes is currently limited, primarily due to the prevalence of cross‐sectional research. To address this gap, this study analysed the evolution of fusion in response to a massive collective ritual, Korrika—a race in support of the Basque language—, over three time periods: before (n = 748) and immediately following participation (n = 402), and 7 weeks thereafter (n = 273). Furthermore, we explored the potential mediating roles of two key factors: perceived emotional synchrony, a sense of emotional unity among participants that emerges during collective rituals, and kama muta (moved by love), an unexplored emotion in relation to fusion, which arises from feelings of shared essence. The proportion of fused participants increased significantly after participation and remained stable for at least 7 weeks. Perceived emotional synchrony and kama muta apparently explained the effect of participants' behavioural involvement in the ritual on subsequent fusion, but only among those who were not previously fused with Korrika participants. We conclude that emotional processes during collective rituals play a fundamental role in the construction of identity fusion. [ABSTRACT FROM AUTHOR]

The dental implant surface plays a crucial role in osseointegration. The topography and physicochemical properties will affect the cellular functions. In this research, four distinct titanium surfaces have been studied: machined acting (MACH), acid etched (AE), grit blasting (GBLAST), and a combination of grit blasting and subsequent acid etching (GBLAST + AE). Human amniotic mesenchymal (hAMSCs) and epithelial stem cells (hAECs) isolated from the amniotic membrane have attractive stem-cell properties. They were cultured on titanium surfaces to analyze their impact on biological behavior. The surface roughness, microhardness, wettability, and surface energy were analyzed using interferometric microscopy, Vickers indentation, and drop-sessile techniques. The GBLAST and GBLAST + AE surfaces showed higher roughness, reduced hydrophilicity, and lower surface energy with significant differences. Increased microhardness values for GBLAST and GBLAST + AE implants were attributed to surface compression. Cell viability was higher for hAMSCs, particularly on GBLAST and GBLAST + AE surfaces. Alkaline phosphatase activity enhanced in hAMSCs cultured on GBLAST and GBLAST + AE surfaces, while hAECs showed no mineralization signals. Osteogenic gene expression was upregulated in hAMSCs on GBLAST surfaces. Moreover, α2 and β1 integrin expression enhanced in hAMSCs, suggesting a surface−integrin interaction. Consequently, hAMSCs would tend toward osteoblastic differentiation on grit-blasted surfaces conducive to osseointegration, a phenomenon not observed in hAECs. [ABSTRACT FROM AUTHOR]

Purpose: No information is available on the torque/cadence relationship in road cyclists. We aimed to establish whether this relationship differs between cyclists of different performance levels or team roles. Methods: Mean maximal power (MMP) output data from 177 riders were obtained from 2012 to 2021 from training and competitions. Cyclists were categorized according to their performance level (world-tour [WT, n = 68], procontinental [PC, n = 63], or under 23 [U23, n = 46]) and team role (time trialists [n = 12], all-rounders [n = 94], climbers [n = 64], or team leaders [n = 7]). Results: A significant interaction effect was found for absolute and relative MMP (P <.001), with higher values in PC than WT for short (5–60 s) efforts and the opposite trend for longer durations. MMP was also greater in PC than in U23 for short efforts (30–60 s), with WT and PC attaining higher MMP than U23 for longer bouts (5–60 min). A significant interaction effect was found for cadence (P =.007, but with no post hoc differences) and absolute (P =.010) and relative torque (P =.002), with PC and WT showing significantly higher torque (all P <.05) than U23 for 5- to 60-minute efforts, yet with no differences between the former 2 performance levels. No interaction effect between team roles was found for cadence (P =.185) or relative torque (P =.559), but a significant interaction effect was found for absolute torque (P <.001), with all-rounders attaining significantly higher values than climbers for 5-second to 5-minute efforts. Conclusions: Differences in MMP between cycling performance levels and rider types are dependent on torque rather than cadence, which might support the role of torque development in performance. [ABSTRACT FROM AUTHOR]

It has been suggested that core stability and plyometric training (CPT) can enhance athletes' postural control. Nevertheless, the effects of an integrated core and plyometric training program on rhythmic gymnastics (RG) performance are unclear. This study aimed to evaluate the effects of an integrated functional CPT program on young rhythmics gymnasts' postural performance. A sample of 44 young female rhythmic gymnasts from a competitive team (age = 10.5 ± 1.8 years) participated in the study. The subjects were randomly divided into a control group and an experimental group. Pre- and posttest design was used. Postural control was assessed using single-leg stance tests and RG-specific balances over a force platform and evaluated by expert RG judges. The experimental group (n = 23) completed an 8-week functional CPT program based on RG technical requirements. Meanwhile, the control group (n = 21) received their usual training sessions. A mixed model of analysis of variance was applied to evaluate the effects of an intrasubject factor and an intersubject factor on each of the dependent variables. After 8 weeks, the experimental group obtained significant better results in some variables of the right support leg with eyes open and left support leg with eyes open single-leg support (p < .01), improvements were also found in some specific RG balances: Arabesque measured on the force platform (p < .01) and the side leg with help balance scored by the judges (p < .01). In conclusion, an integrated functional CPT program improved postural control in young rhythmic gymnasts. Coaches should consider using this CPT to improve RG performance. [ABSTRACT FROM AUTHOR]