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The outcome expectancy of social acceptance via internet gaming potentially contributes to internet gaming disorder (IGD) among adolescents. To better understand the relationship, this study developed and validated the 6-item Expected Social Acceptance via Internet Gaming Scale (ESAIGS) among 2339 adolescent internet gamers via a classroom survey in Guangzhou and Chengdu, China from October to December 2018. The prevalence of IGD was 18.0%. By using two half-split subsamples, exploratory and confirmatory factor analyses identified and confirmed a unidimensional structure of the ESAIGS, respectively. The ESAIGS showed satisfactory internal consistency, test–retest reliability, composite reliability, and absence of ceiling effect, although a slight-to-moderate floor effect was observed. It also demonstrated convergent and concurrent validity showing significant positive correlations with the three external variables (IGD, internet gaming time, and perceived rewards of internet gaming). Hence, the validated ESAIGS can be applied to assess expected social acceptance via internet gaming among adolescents in China. [ABSTRACT FROM AUTHOR]

Despite extensive research on the psychological impacts of digital technology, the nuanced dynamics between adolescent loneliness and problematic smartphone use, particularly across different educational levels and genders, remain underexplored. This study aims to fill this gap by employing a Random Intercept Cross-Lagged Panel Model to dissect the bidirectional relationship between loneliness and problematic smartphone use among adolescents, with a focus on the moderating roles of educational levels and gender. Engaging 3132 students from various educational institutions in China, the research conducted a three-wave longitudinal analysis across 2022–2023. The final number of participants included 1120 adolescents (53.5% female; age in 2022: M = 14.57 years, SD = 1.57). Results reveal that loneliness significantly predicts problematic smartphone use, but not vice versa, highlighting a unidirectional influence. The study uncovers crucial differences across educational levels and gender, emphasizing the stronger effect of loneliness on problematic smartphone use among junior high students and female adolescents. These findings underscore the complexity of adolescent loneliness and its relationship with digital behavior, suggesting a need for tailored interventions considering both gender and developmental stages. [ABSTRACT FROM AUTHOR]

Objective: The original 24-item School Refusal Assessment Scale-Revised (SRAS-R) assesses four functions/conditions regarding school refusal behavior (SRB), bridging assessments, and treatments of SRB. No validated Chinese versions are available. Methods: To validate the Chinese version of the SRAS-R, an anonymous cross-sectional survey was conducted from February to March 2022 among 1108 secondary school students in Taizhou, China. Results: Confirmatory factor analysis (CFA) did not support the original 4-factor model. Three items were thus removed in the exploratory factor analysis performed in the first half-spilt subsample, yielding a 5-factor model which was confirmed by CFA in the second subsample. The resulting 21-item scale/subscales of the Chinese SRAS-R generally demonstrated measurement invariance across sex and student types and satisfactory internal consistency, absence of ceiling effect and floor effect, and concurrent validity with the two external variables of preference of not going to school and depressive symptoms. Significant sex and student type differences in subscale scores were found. Conclusions: The 21-item and 5-factor Chinese version of the SRAS-R showed satisfactory psychometric properties and can be applied to research on SRB among Chinese adolescents. Future studies should validate it in other countries. [ABSTRACT FROM AUTHOR]

Background In patients with chronic kidney disease (CKD), vascular calcification (VC) is common and is associated with a higher risk of all-cause mortality. Shh, one ligand for Hedgehog (Hh) signaling, participates in osteogenesis and several cardiovascular diseases. However, it remains unclear whether Shh is implicated in the development of VC. Methods Inorganic phosphorus 2.6 mM was used to induce vascular smooth muscle cells (VSMCs) calcification. Mice were fed with adenine diet supplement with 1.2% phosphorus to induce VC. Results Shh was decreased in VSMCs exposed to inorganic phosphorus, calcified arteries in mice fed with an adenine diet, as well as radial arteries from patients with CKD presenting VC. Overexpression of Shh inhibited VSMCs ostosteoblastic differentiation and calcification, whereas its silencing accelerated these processes. Likewise, mice treated with smoothened agonist (SAG; Hh signaling agonist) showed alleviated VC, and mice treated with cyclopamine (CPN; Hh signaling antagonist) exhibited severe VC. Additionally, overexpression of Gli2 significantly reversed the pro-calcification effect of Shh silencing on VSMCs, suggesting that Shh inhibited VC via Gli2. Mechanistically, Gli2 interacted with Runx2 and promoted its ubiquitin proteasomal degradation, therefore protecting against VC. Of interest, the pro-degradation effect of Gli2 on Runx2 was independent of Smurf1 and Cullin4B. Conclusions Our study provided deeper insight to the pathogenesis of VC, and Shh might be a novel potential target for VC treatment. [ABSTRACT FROM AUTHOR]

This study investigated the sex-specific prevalence of smoking (past 30 days) and the associations with height among university/college students. 25,405 (11,579/14,826 males/females) college students in Xi'an China. A cross-sectional, self-administered survey. The male and female prevalence of smoking (past 30 days) was 32.9% and 7.4%, respectively. The prevalence of smoking of the male height groups ranged from 29.8% to 36.9%; only the ≥188 cm height group showed significantly higher prevalence than the reference group (i.e., 173–177cm; 33.0%). The female prevalence of smoking was 4.0–8.2% in the ≤170cm groups and increased to 12.3% in the 171–175 cm group and 36.1% in the ≥176 cm group, while it was 6.5% for the reference group (161–165 cm). This exploratory study firstly revealed the significantly higher prevalence of smoking among the "tallest" height groups, especially among females. Future studies are warranted to confirm such findings and explore related mechanisms. [ABSTRACT FROM AUTHOR]

Efficient and rapid synthesis of transition metal-based hydroxides with tailored microstructures has emerged as a promising approach to fabricate high-performance electrode materials for energy storage devices. However, many conventional synthesis methods are cumbersome, expensive and time-consuming, and the microstructures of electrode materials are usually uncontrollable. Herein, we propose a fast and cost-effective approach to electrochemically in situ grow NiFeCo-based ternary hydroxides (NiFeCo-THs) with layered nanosheet structures on pretreated nickel foam (NF). The in situ grown NiFeCo-THs were in direct contact with the NF to form a monolithic electrode as NiFeCo/NF. By engineering the ion exchange process for controlling the ionic ratio, the monolithic Ni1(Fe/Co = 1/1)0.5/NF electrode was fabricated and found to show the optimum electrochemical behavior with a specific capacitance of 2.32 C cm−2 at 2 mA cm−2 as a result of its characteristic microstructures. Furthermore, a hybrid supercapacitor was constructed utilizing the monolithic Ni1(Fe/Co = 1/1)0.5/NF electrode and activated carbon as the cathode and anode, respectively, and it was found to have an energy density of 81.1 μW h cm−2 at a power density of 808.8 μW cm−2. After 5000 cycles, 84.0% of the initial capacitance of the hybrid supercapacitor was maintained, and the monolithic Ni1(Fe/Co = 1/1)0.5/NF electrode still retained the arrayed nanosheet structure. [ABSTRACT FROM AUTHOR]

The preexisting structures that developed in the basement and subsalt strata play a key role in the salt structural deformation in the Kuqa Depression, Tarim Basin. The characteristics of preexisting structures and their controls on the salt structure are investigated via the latest three‐dimensional seismic data and numerical modelling. The results show that the preexisting structures that developed in the Kuqa Depression mainly consist of basement faults, palaeouplifts, subsalt slopes and early passive salt diapirs. Basement faults are mainly distributed in the Kelasu and Qiulitag structural belts and control the position of development and deformation style of the Miocene compressive salt structure. The differences in styles and reactivation degrees of basement faults lead to great diversity in the salt structure. The palaeouplifts mainly include the Wensu, western Qiulitag, Xinhe and Yaha‐Luntai palaeouplifts. The original sedimentary range and later deformation space of the salt layer are limited by the palaeouplift, resulting in strong salt thrusting in the Awate sag in the western part of the Kuqa Depression. The heterogeneous spatial distribution of the palaeouplift promoted the development of regional strike‐slip transform belts. Subsalt slopes are located mainly on the northern edge of the western Qiulitag low uplift and block the southward flow of the salt, causing the salt to form salt domes; the size of these domes is closely related to the subsalt slope. Early passive salt diapirs mainly developed in the Quele and Bozidun areas of the western Kuqa Depression, and they were preferentially active during the compression period, inducing the formation of a piercement salt nappe. Numerical modelling revealed that the preexisting structure strongly controlled the stress–strain distribution during the deformation of the salt structure. The spatial distribution heterogeneity of the basement structure is an important factor in the structural zonation along the north–south strike and segmentation along the west–east strike in the Kuqa Depression, as well as an important inducer of the piercement salt structure.Different salt structural deformation models controlled by preexisting structures in the Kuqa Depression. (a) In the Wensu segment, the sedimentary range and deformation space of the salt layer are restricted, resulting in the strong thrust of the subsalt faults and piercement of the salt. (b) In the Quele segment, progradational sedimentary load induces a passive salt diapir. Influenced by the blocking of the steep subsalt slope and the reactivation of the preexisting salt diapir, a piercement salt wall was formed on the right edge of subsalt slope. (c) In the Dabei segment, a salt dome was formed at the northern edge of the western Qiulitag palaeouplift due to the blocking of the steep subsalt slope. (d) In the Keshen segment, the subsalt slope and preexisting salt diapir are not developed, and finally, two salt domes are formed at the top of the basement faults in the Kelasu and Qiulitag structural belts. [ABSTRACT FROM AUTHOR]

The early attainment of high COVID-19 vaccination rates can minimize avoidable hospitalizations/deaths. The fifth wave COVID-19 outbreak in Hong Kong caused >9000 deaths, and most of them were unvaccinated older people. This study hence investigated determinants of taking the first dose vaccination at a later phase (Phase 3: during the fifth wave outbreak, i.e., February–July 2022) versus two earlier phases (Phase 1: first six months since vaccine rollout, i.e., February–July 2021; Phase 2: six months prior to the outbreak, i.e., August 2021–January 2022) via a random telephone survey among 386 ever-vaccinated Hong Kong older people aged ≥60 (June/July 2022). A total of 27.7%, 51.1%, and 21.3% took the first dose at Phase 1, Phase 2, and Phase 3, respectively. Unfavorable perceptions related to COVID-19/vaccination, exposure to conflicting/counter-information about the suitability of older people's vaccination from various sources, unsupportive family influences prior to the outbreak, and depressive symptoms were significantly associated with taking the first dose at Phase 3 instead of Phase 1 and Phase 2. To speed up COVID-19 vaccination and avoid unnecessary deaths, the government and health professionals should rectify misinformation, provide clear/consistent information for older people and their family members, and focus on those having depressive symptoms at an earlier stage of the pandemic. [ABSTRACT FROM AUTHOR]

As a critical component of many remote sensing satellites and model validation, pixel-scale surface quantitative parameters are often affected by scale effects in the acquisition process, resulting in deviations in the accuracy of image scale parameters. Consequently, various successive scale conversion methods have been proposed to correct the errors caused by scale effects. In this study, we propose ResTransformer, a deep learning model for scale conversion of surface reflectance using UAV images, which fully extracts and fuses the features of UAV images in the sample area and sample points and establishes a high-dimensional nonlinear spatial correlation between sample points and sample area in the target sample area, so that the scale conversion of surface reflectance at the pixel-scale can be completed quickly and accurately. We collected and created a dataset of 500k samples to verify the accuracy and robustness of the model with other traditional scale conversion methods. The results show that the ResTransformer deep learning model works best, providing average MRE, average MRSE, and correlation coefficient R values of 0.6440%, 0.7460, and 0.99911, respectively, and the baseline improvements compared with the Simple Average method are 92.48%, 92.45%, and 16.59%, respectively. The ResTransformer model also shows the highest robustness and universality and can adapt to surface pixel-scale conversion scenarios with different sizes, heterogeneous sample areas, and arbitrary sampling methods. This method provides a promising, highly accurate, and robust method for converting pixel-scale surface reflectance scale. [ABSTRACT FROM AUTHOR]

The widely distributed Eocene mafic microgranular enclaves in the Lhasa Terrane of southern Tibet carry important information regarding crust–mantle interactions in collisional zones. Here, we report geochronological and geochemical data of granitoids and mafic enclaves from Quxu in the southern Lhasa Terrane. Zircon LA‐ICP‐MS U–Pb dating indicates that the Quxu granitoids and enclaves were synchronously emplaced at ca. 50 Ma. The granitoids are medium‐ to high‐K calc‐alkaline, metaluminous (A/CNK = 0.82–0.90) and have high Al2O3 (14.48–16.57 wt%) and low MgO (2.81–2.99 wt%). The mafic enclaves (SiO2 = 50.55–54.57 wt%) have 5.12–5.37 wt% MgO and an Mg# of 49–51, with weakly negative Eu anomalies (Eu/Eu* = 0.85–0.91). The Quxu granitoids and enclaves have similar zircon Hf isotopic compositions, with εHf(t) values ranging from +7.62 to +13.32. A comprehensive study of the data available for coeval rocks from the Gangdese Batholith indicates that the Quxu granitoids were derived from partial melting of the lower crust, while the parental magmas of the mafic enclaves were most likely derived from lithospheric mantle beneath southern Tibet. The Quxu granitoids are interpreted as the result of mixing between the lower crust‐derived melts and lithospheric mantle‐derived mafic melts, which are likely the magmatic response to the breakoff of the Neo‐Tethyan Oceanic slab at about 50 Ma. [ABSTRACT FROM AUTHOR]

Background: The levels of resource losses due to coronavirus disease 2019 (COVID-19) and mental distress may change during the pandemic period. Based on the Conservation of Resource (COR) Theory, this study investigated such changes and the mediation between survey time (Round 2 versus Round 1) and depression via resource losses. Methods: Two serial random population-based telephone surveys interviewed 209 and 458 Hong Kong Chinese adults in April 2020 and May 2021, respectively. Probable depression was defined as 9-item Patient Health Questionnaire (PHQ-9) score ≥ 10. The validated Conservation of Resources Scale for COVID-19 (CORS-COVID-19) scale was used to assess resource losses due to COVID-19. Multivariable logistic regression analysis, hierarchical logistic regression analysis, and structural equation modeling (SEM) was conducted to test the association, interaction, and mediation hypotheses, respectively. Results: The prevalence of probable depression declined from 8.6% to 1.0% over time, together with reductions in losses of financial resource (Cohen's d = 0.88), future control (Cohen's d = 0.39), social resource (Cohen's d = 0.60), and family resource (Cohen's d = 0.36) due to COVID-19. All the overall scale/subscales of the CORS-COVID-19 were positively and associated with probable depression [adjusted odds ratio (aOR) ranged from 2.72 to 42.30]. In SEM, the survey time was negatively associated with the latent variable of resource loss (β = − 0.46), which in turn was positively associated with probable depression (β = 0.73). In addition, the direct effect of survey time on probable depression was statistically non-significant (β = − 0.08), indicating a full mediation effect of resource losses. Conclusions: The lessening of the resource losses might have fully accounted for the significant decline in probable depression from Month 3 to 15 since the first COVID-19 outbreak in Hong Kong, China. The level of depression might have increased during the first phase of the pandemic, but might decline in the later phases if resources losses could be lessened. All stakeholders should hence work together to minimize individuals' COVID-19-related resource losses to prevent depression in the general population, as COVID-19 might be lasting. [ABSTRACT FROM AUTHOR]

Globally, the coronavirus disease 2019 (COVID-19) pandemic has caused severe and multi-dimensional resource losses among individuals. The Conservation of Resource (COR) theory postulates that resource loss generates related stress responses. It can suitably be applied to understand the pandemic's encompassing adverse consequences. Yet, no assessment tool exists. This study hence developed and validated the COR Scale for COVID-19 (CORS-COVID-19) to facilitate relevant research. The five hypothesized domains included losses in financial resource, family resource, future control, fun, and social resource. A population-based random telephone survey interviewed 300 Chinese adults in the general population in Hong Kong, China during April 3–10, 2020. The levels of different types of resource losses were high (especially for loss in fun). The 5-factor structure identified by factor analysis matches with the five hypothesized dimensions. Its psychometric properties are acceptable, including good internal consistency, content validity (the correlations between the items and their respective subscales were stronger than that between the items and the other four subscales), concurrent validity (significant correlations between the scale/subscale scores and both emotional distress due to COVID-19 and satisfaction with living in Hong Kong), and convergent validity (significant correlations between specific subscales and corresponding external variables). Relatively high floor effects were detected in some subscales. The scale, which is the first of the types to assess resource losses during a pandemic, can provide theory-based understandings/assessment about the negative impacts of COVID-19. It also facilitates warranted comparisons across countries and time periods in future studies. [ABSTRACT FROM AUTHOR]

Purpose: The prevalence of under-diagnosis among individuals with obstructive sleep apnea (OSA) is alarming, and may be associated with perceptions regarding OSA. To facilitate future studies on OSA, this study validated the revised version of the Illness Perception Questionnaire (IPQ-R) for OSA in a general population. Methods: A random anonymous population-based telephone survey interviewed 580 adults aged ≥ 50 years in Hong Kong, who self-reported not having been told by doctors as having OSA, from February 5 to March 19, 2021. Results: The confirmatory factor analysis identified a modified 7-factor model (i.e., timeline chronic, consequence, personal control, treatment control, illness coherence, timeline cyclical, and emotional representation) that showed satisfactory model fit index and internal consistency. Nine items were removed from the original version because of low factor loadings. No floor and ceiling effects were observed. Convergent validity was supported by the positive associations between the consequence subscale with perceived negative outcomes of OSA and between the illness coherence subscale and perceived understanding of OSA symptoms. The participants tended to endorse the items of timeline chronic, treatment control, and illness coherence but not with those of emotional representations. The mean scores of the IPQ-R subscales differed by age and education level. Conclusion: The modified IPQ-R of OSA showed acceptable psychometric properties. It is applicable to assessing illness perceptions of OSA in the Chinese general population aged ≥ 50 years not having received OSA diagnosis. The validated tool would support future studies and health practices related to OSA. [ABSTRACT FROM AUTHOR]

Promotion of COVID-19 vaccination requires understanding its determinants, an important one of which is outcome expectancy. However, reliable and valid measurement tools are absent. This study thus developed and validated an Outcome Expectancy Scale for COVID-19 Vaccination (OES-COVID-19). An inductive approach was used for scale development; content validity of the items was then assessed by an independent evaluation expert panel. Iteratively, 17 scale items were created and validated in a population-based telephone survey conducted among 500 adults of the general population in Hong Kong, China, from August to September 2021. Using half of the sample (n = 249), exploratory factor analyses identified four factors of the OES-COVID-19, including (a) positive contribution to society, (b) functional benefits, (c) protective effect, and (d) negative impacts. Confirmatory factor analysis of these factors conducted on the second subsample (n = 251) was satisfactory. The OES-COVID-19 showed good psychometric properties in terms of internal consistency, absence of floor/ceiling effects, and concurrent validity. The newly created and validated OES-COVID-19 is deemed suitable for application. It may advance future studies related to COVID-19 vaccination behavior and intention, and potentially allows for comparisons across studies. Further validation with modifications across countries, populations, and phase of the pandemic are warranted. [ABSTRACT FROM AUTHOR]

This study investigated an under-researched topic regarding the prevalence of COVID-19 vaccination behavior among Chinese men who have sex with men (MSM) and the associations of this with general and MSM-specific perceptions grounded in the health belief model (HBM) and the theory of planned behaviors (TPB). A total of 400 Chinese MSM were recruited from multiple sources (site recruitment, online recruitment, and peer referral) in Hong Kong from July to October 2021, who then participated in a structured telephone interview. Of all the participants, the prevalence of COVID-19 vaccination (i.e., taking at least one dose of COVID-19 vaccination) was 78.3%. Multivariable logistic regression analyses showed that, after adjusting for background factors, (1) the general and MSM-specific HBM variables of perceived benefits and self-efficacy were positively associated with COVID-19 vaccination behavior; (2) the items or scale of general/MSM-specific perceived barriers and social norms were negatively associated with COVID-19 vaccination behavior; (3) the general perceived severity and MSM-specific perceived susceptibility, perceived severity, and cue to action were not significantly associated with COVID-19 vaccination behavior. The findings suggest that the HBM and social norm construct of the TPB only partially explained the participant's COVID-19 vaccination behavior. Health promotion may need to focus more on modifying perceptions related to COVID-19 vaccination rather than COVID-19. [ABSTRACT FROM AUTHOR]

Aims: The present study investigated the association between resilience, stigma, life satisfaction and the intention to receive a COVID‐19 vaccination among Chinese HCWs. It also explored the mediating role of stigma and life satisfaction on the association between resilience and intention to receive a COVID‐19 vaccination. Design: An anonymous cross‐sectional survey. Methods: 1733 HCWs from five hospitals in four provinces of mainland China completed a cross‐sectional online survey in October and November 2020. Results: Among the HCWs, the rate of intention to receive a COVID‐19 vaccination was 73.1%. Results from structural equation modelling showed that resilience was associated both directly, and indirectly with greater intent to receive a COVID‐19 vaccination through two pathways: first by increasing life satisfaction, and second by reducing stigma and increasing life satisfaction. Conclusion: Promoting the resilience of HCWs has the potential to increase the COVID‐19 vaccination uptake rate among HCWs in China. Impact: This study tested the relationship between several psychological factors and the COVID‐19 vaccination intention of HCWs in China, finding that resilience played a significant role in improving COVID‐19 vaccination intention rates by reducing stigma and increasing life satisfaction. [ABSTRACT FROM AUTHOR]

Purpose: This study investigated the associations between some factors related to working from home status (WFHS) and positive/negative experiences due to social distancing and their interactions effects on depressive symptoms during the COVID-19 pandemic. Methods: A random population-based telephone survey interviewed income-earning adults in the Hong Kong general population during April 21–28, 2020 (n = 200). Results: Mild to severe depression (according to PHQ-9) was reported by 12% of the participants. The prevalence of WFHS categories was 14% for 3–7 days and 13% for ≥ 8 days (past 2 weeks). The multivariable regression analysis showed that, social isolation (β = 0.36; p < 0.001), relaxation feeling in daily life (β = − 0.22; p = 0.002), and WFHS ≥ 8 days (β = 0.15; p = 0.027), but not perceived huge inconvenience and improved family relationship, were associated with depressive symptoms. Statistically significant interaction effects were found. Some positive experiences buffered the potential harms of some negative experiences of social distancing on depressive symptoms; WFHS ≥ 8 days significantly moderated the risk/protective effects of social isolation, improved family relationship, and relaxation feeling on depressive symptoms. Conclusions: Social distancing is double-edged. Positive experiences should be maximized while negative experiences be minimized, as both were directly and interactively associated with depression. Intensive but not mild to moderate (< 80%) WFHS may impact depressive symptoms negatively via its direct association with depression; it also moderated the associations between positive/negative experiences due to social distancing and depression. Further research is required to discern the inter-relationships among WFHS, positive/negative experiences of social distancing, and depression to better cope with the stressful pandemic. [ABSTRACT FROM AUTHOR]

Background: Restriction of gathering size in all public areas is a newly and commonly exercised governmental social distancing policy during the COVID-19 pandemic. Its effectiveness depends on the general public's compliance. This study applied the Protection Motivation Theory (PMT) to investigate determinants (i.e., perceived severity, perceived susceptibility, perceived response efficacy, and perceived self-efficacy) of compliance with the social distancing policy of banning gathering of >4 people in all public areas (BG4PA) in the Hong Kong general adult population. Methods: 300 participants were interviewed through a population-based telephone survey during April 21–28, 2020. Results: The compliance rate of BG4PA was high (78%). Adjusted for the background factors, multiple linear regression analysis found that perceived response efficacy and perceived self-efficacy were significantly and positively associated with compliance with BG4PA (p<0.05), while the associations between perceived severity/perceived susceptibility and compliance were of marginal significance (0.05

Objective: This study aimed to compare the efficacy and safety (infection events) between rituximab (RTX), tacrolimus (TAC), mycophenolate mofetil (MMF), and cyclophosphamide (CYC) as induction therapies in lupus nephritis (LN). Methods: Electronic databases, including PubMed, EMBASE, and the Cochrane Library, were searched from inception up to December 9, 2021. Bayesian network meta-analysis was used to combine the direct and indirect evidence of different drugs for LN patients. The pooled relative effects were shown using odds ratios (ORs) and 95% credible intervals (CrIs). Results: Nineteen studies (1,566 patients) met the inclusion criteria and were selected in the present study. The network meta-analysis reported that no statistically significant differences were found in partial remission (PR) and infection among the four drugs. RTX showed a significantly higher complete remission (CR) than MMF (OR = 2.60, 95% CrI = 1.00–7.10) and seemed to be more effective than CYC (OR = 4.20, 95% CrI = 1.70–14.00). MMF had a better CR than CYC (OR = 1.60, 95% CrI = 1.00–3.20). TAC presented a better overall response than CYC (OR = 3.70, 95% CrI = 1.20–12.00). Regarding CR and overall response, the maximum surface under the cumulative ranking curve (SUCRA) values were 96.94% for RTX and 80.15% for TAC. The maximum SUCRA value of infection reaction was 74.98% for RTX and the minimum value was 30.17% for TAC, respectively. Conclusions: RTX and TAC were the most effective drugs for induction remission in LN. Among the four drugs, TAC had the lowest probability of infection, and RTX showed the highest probability of experiencing an infection. This meta-analysis could not conclude about other adverse events. [ABSTRACT FROM AUTHOR]

In this work, pure SnO2 and Ni-doped SnO2 nanorods were synthesized through a one-step template-free hydrothermal method and then used to detect isopropanol. Sensors fabricated with the Ni-doped SnO2 nanocomposites showed the best gas sensing performance when the Ni doping amount was 1.5 mol.%. The response reached 250 at 225 °C, which was approximately 8.3 times higher than that of the pure SnO2 nanorods. The limit of detection for isopropanol was as low as 10 ppb at the optimum working temperature. In addition, it also displayed good selectivity and excellent reproducibility. It is believed that the enhanced isopropanol sensing behavior benefit from the increased oxygen defects and larger specific surface area by Ni doping. [ABSTRACT FROM AUTHOR]

The present study investigated the associations between the three psychological needs (autonomy, competence and relatedness) derived from the Self‐determination Theory and well‐being [health‐related quality of life (HRQOL) and subjective well‐being (SWB)] among older people in Hong Kong SAR, China. A cross‐sectional study was conducted from May to August 2018 in Hong Kong. A total of 230 participants aged 60‐year‐old or above were recruited from eight community service centres. Results from adjusted regression analysis showed that, among the three psychological needs, competence and relatedness were positively associated with SWB, while relatedness was positively associated with physical health domain of HRQOL. The three psychological needs had no significant associations with mental health domain of HRQOL. Interventions to improve HRQOL and SWB should promote older people's sense of competence and relatedness. Longitudinal studies are warranted to clarify the causal relationships and look at other physical, mental and social health outcomes. [ABSTRACT FROM AUTHOR]

Drug discovery focused on target proteins has been a successful strategy, but many diseases and biological processes lack obvious targets to enable such approaches. Here, to overcome this challenge, we describe a deep learning–based efficacy prediction system (DLEPS) that identifies drug candidates using a change in the gene expression profile in the diseased state as input. DLEPS was trained using chemically induced changes in transcriptional profiles from the L1000 project. We found that the changes in transcriptional profiles for previously unexamined molecules were predicted with a Pearson correlation coefficient of 0.74. We examined three disorders and experimentally tested the top drug candidates in mouse disease models. Validation showed that perillen, chikusetsusaponin IV and trametinib confer disease-relevant impacts against obesity, hyperuricemia and nonalcoholic steatohepatitis, respectively. DLEPS can generate insights into pathogenic mechanisms, and we demonstrate that the MEK–ERK signaling pathway is a target for developing agents against nonalcoholic steatohepatitis. Our findings suggest that DLEPS is an effective tool for drug repurposing and discovery. Drug discovery based on transcriptional profiling does not require knowledge of protein targets. [ABSTRACT FROM AUTHOR]

Social and physical distancing is important in controlling the COVID-19 pandemic and it impacts people's financial/social well-being tremendously. This study tested the application of the Theory of Planned Behaviors (TPB) to three types of social/physical distancing indicators (i.e. the number of close physical contacts on a single day in public venues, the frequencies of avoiding social gathering, and the levels of physical distancing in public venues). A population-based random telephone survey interviewed 300 Hong Kong Chinese adults in April 2020 when gatherings involving >4 people were banned. The participants on average made 15.3 close physical contacts (<1.5 m and for >3 min) in a day (5.0 in public transportation). About 80% practiced social distancing (avoided/reduced social gatherings) and physical distancing in public spaces (e.g. avoidance of going out, visiting crowded places, and gatherings of >4 people) but only 35.4% avoided using public transportations. Positive but not negative attitudes (inconvenience and lack of necessity), perceived behavioral control, and subjective norm were significantly associated with the three social/physical distancing outcomes. The data suggest that the levels of social/physical distancing were relatively high in the Hong Kong general population, and it, in general, supports the application of TPB to understand factors of social distancing for preventing COVID-19. Health promotion should take the findings into account. Furthermore, cross-cultural and time-series studies are warranted to compare the levels of social/physical distancing across countries and further explore their effectiveness in controlling the COVID-19 pandemic. [ABSTRACT FROM AUTHOR]

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies and is known for its high resistance and low response to treatment. Tumor immune evasion is a major stumbling block in designing effective anticancer therapeutic strategies. Karyopherin alpha 2 (KPNA2), a member of the nuclear transporter family, is elevated in multiple human cancers and accelerates carcinogenesis. However, the specific role of KPNA2 in PDAC remains unclear. In this study, we found that expression of KPNA2 was significantly upregulated in PDAC compared to adjacent nontumor tissue and its high expression was correlated with poor survival outcome by analyzing the GEO datasets. Similar KPNA2 expression pattern was also found in both human patient samples and KPC mouse models through IHC staining. Although KPNA2 knockdown failed to impair the vitality and migration ability of PDAC cells in vitro, the in vivo tumor growth was significantly impeded and the expression of immune checkpoint ligand PD-L1 was reduced by silencing KPNA2. Furthermore, we uncovered that KPNA2 modulated the expression of PD-L1 by mediating nuclear translocation of STAT3. Collectively, our data suggested that KPNA2 has the potential to serve as a promising biomarker for diagnosis in PDAC. [ABSTRACT FROM AUTHOR]

Background: As a large capillary network, the human placenta plays an important role throughout pregnancy. Placental vascular development is complex and delicate and involves many types of placental cells, such as trophoblasts, and mesenchymal stem cells. There has been no systematic, comparative study on the roles of these two groups of placental cells and the whole placental tissue in the placental angiogenesis. In this study, primary cytotrophoblasts (CTBs) from early pregnancy and primary human placenta-derived mesenchymal stem cells (hPDMSCs) from different stages of pregnancy were selected as the cell research objects, and full-term placental tissue was selected as the tissue research object to detect the effects of their conditioned medium (CM) on human umbilical vein endothelial cell (HUVEC) angiogenesis. Methods: We successfully isolated primary hPDMSCs and CTBs, collected CM from these placental cells and sub-cultured placental tissue, and then evaluated the effects of the CM on a series of angiogenic processes in HUVECs in vitro. Furthermore, we measured the levels of angiogenic factors in the CM of placental cells or tissue by an angiogenesis antibody array. Results: The results showed that not only placental cells but also sub-cultured placental tissue, to some extent, promoted HUVEC angiogenesis in vitro by promoting proliferation, adhesion, migration, invasion, and tube formation. We also found that primary placental cells in early pregnancy, whether CTBs or hPDMSCs, played more significant roles than those in full-term pregnancy. Placental cell-derived CM collected at 24 h or 48 h had the best effect, and sub-cultured placental tissue-derived CM collected at 7 days had the best effect among all the different time points. The semiquantitative angiogenesis antibody array showed that 18 of the 43 angiogenic factors had obvious spots in placental cell-derived CM or sub-cultured placental tissue-derived CM, and the levels of 5 factors (including CXCL-5, GRO, IL-6, IL-8, and MCP-1) were the highest in sub-cultured placental tissue-derived CM. Conclusions: CM obtained from placental cells (primary CTBs or hPDMSCs) or sub-cultured placental tissue contained proangiogenic factors and promoted HUVEC angiogenesis in vitro. Therefore, our research is helpful to better understand placental angiogenesis regulation and provides theoretical support for the clinical application of placental components, especially sub-cultured placental tissue-derived CM, in vascular tissue engineering and clinical treatments. [ABSTRACT FROM AUTHOR]

The Daqingshan area in China located in the center part of the Khondalite belt, north of the Ordos Block and south of the Yinshan Block. The Daqingshan basin is the best-preserved Mesozoic basin that is oriented nearly east-west. Previous studies suggest that the provenance of Jurassic sediment is mainly the Khondalite belt and no material from Yinshan Block. We present detailed data on the detrital-zircon geochronology of the Jurassic sandstones from the Daqingshan area. The detrital-zircon U–Pb age data of the Wudanggou and Changhangou Formations show two peaks at ~2450 Ma and 1970–1930 Ma, with a few of Archean ages. The detrital-zircon age data of the Daqingshan Formation show three distinctive age populations of 2560–2460 Ma, 1950–1750 Ma, and 320–265 Ma. Comparison with the age of the surrounding magmatic rocks suggests that the main source area is the Wulashan–Daqingshan Complex, with the Yinshan Block being a lesser source. However, more Archean and Paleozoic detrital zircon occurs in the Daqingshan Formation, probably as a result of the rise of the western part of the basin and eastward movement of the center of the basin, thereby increasing provenance from the Yinshan Block. The Yanshan movement caused massive amounts of Yinshan material to move southward during the Middle-Late Jurassic. However, the barrier of the Yinshan Mountains caused Yinshan material to be deposited mainly in the eastern part of the basin. [ABSTRACT FROM AUTHOR]

The extracellular matrix component collagen is widely expressed in human tissues and participates in various cellular biological processes. The collagen amount generally remains stable due to intricate regulatory networks, but abnormalities can lead to several diseases. During the development of renal fibrosis and vascular calcification, the expression of collagen is significantly increased, which promotes phenotypic changes in intrinsic renal cells and vascular smooth muscle cells, thereby exacerbating disease progression. Reversing the overexpression of collagen substantially prevents or slows renal fibrosis and vascular calcification in a wide range of animal models, suggesting a novel target for treating patients with these diseases. Stem cell therapy seems to be an effective strategy to alleviate these two conditions. However, recent findings indicate that the natural pore structure of collagen fibers is sufficient to induce the inappropriate differentiation of stem cells and thereby exacerbate renal fibrosis and vascular calcification. A comprehensive understanding of the role of collagen in these diseases and its effect on stem cell biology will assist in improving the unmet requirements for treating patients with kidney disease. [ABSTRACT FROM AUTHOR]

Environmental context: Antimony pollution has become a global issue given its wide distribution in the environment and its potential threat to human health. This large population-based study demonstrated that exposure to high levels of antimony may impair liver function in adults. The study highlights the potential hazard to liver function of antimony exposure, and provides convincing evidence of the need to monitor and control antimony exposure in the prevention of liver dysfunction. The association of antimony exposure with serum liver enzymes and bilirubin levels remains unknown. We aimed to prospectively evaluate the associations of the plasma antimony concentration with serum liver enzymes [alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST)] and bilirubin [total (TBil), direct (DBil) and indirect bilirubin (IBil)] levels among the Chinese middle-aged and elderly population. A total of 4733 participants who were free of cardiovascular disease (CVD), cancer and chronic hepatitis at the baseline survey (2008–2010) of the Dongfeng-Tongji cohort were included in the current study. We measured the baseline plasma antimony concentration by inductively coupled plasma mass spectrometry (ICP-MS), and the serum liver enzymes and bilirubin levels at the resurvey visit (2013) by using an automatic analyser. In the fully adjusted generalised linear models, we observed that an increased plasma antimony concentration was significantly associated with higher bilirubin levels. Moreover, we found that plasma antimony was positively associated with the elevation of DBil (≥7.0 μmol L−1), where the adjusted odds ratios (ORs) comparing the extreme tertiles was 1.35 (95 % CI: 1.06, 1.70, P trend = 0.01). Spline regression analyses indicated that the plasma antimony concentration was linearly associated with the elevation of TBil and DBil (overall P = 0.004 and P = 0.002 respectively). Our study suggested that exposure to high levels of antimony may impair liver function in adults. Further investigations are warranted to confirm these findings in other populations. Environmental context. Antimony pollution has become a global issue given its wide distribution in the environment and its potential threat to human health. This large population-based study demonstrated that exposure to high levels of antimony may impair liver function in adults. The study highlights the potential hazard to liver function of antimony exposure, and provides convincing evidence of the need to monitor and control antimony exposure in the prevention of liver dysfunction. [ABSTRACT FROM AUTHOR]

Background: Understanding the latest human immunodeficiency virus (HIV) epidemic in voluntary blood donors could be of great value to further increase blood safety in China, as transfusion-transmitted infection places a heavy burden on both infected individuals and the whole society. Therefore, we evaluated the national HIV prevalence of voluntary blood donors in China and characteristics of HIV-infected blood donors.Study Design and Methods: We searched literature in Chinese and English concerning the prevalence of HIV infections in Chinese voluntary blood donors from 2010 to 2017, yielding 97 eligible papers. We performed a meta-analysis to calculate pooled HIV prevalence, and characteristics of HIV-infected blood donors were also extracted.Results: The pooled sample consisted of 21,100,755 voluntary blood donors and 4,755 HIV-infected blood donors. Pooled HIV prevalence of China voluntary blood donors during 2010 to 2017 was 21.02 in 100,000. Pooled HIV prevalence varied in different provinces, showing greater severity in Southwest, Northwest, and South China. Subgroup analysis also showed a significantly increasing trend from 2010 to 2017. The majority of HIV-infected blood donors in China were male, young, unmarried, nonlocal residents, receiving 12 years or less of schooling, and first-time donors. Nearly 90% of HIV-infected blood donors acquired their infections through sexual contact.Conclusion: The prevalence of HIV increased in China among voluntary blood donors during 2010 to 2017, highlighting the risk of HIV transmission by transfusion. Blood centers and public health services should improve screening and intervention programs targeting voluntary blood donors and expand education on blood safety in areas experiencing severe epidemics and among high-risk populations. [ABSTRACT FROM AUTHOR]

The Ordos Basin is the largest and most important intracontinental sedimentary depression in China, and a significant amount of crude oil resources has developed within this Mesozoic formation. High-grade organic-rich shale is prevalent in the large-scale areas of the Chang 7 sedimentary stage and provides essential hydrocarbon resources for abundant oil enrichment in the Mesozoic. This research investigated the geochemical characteristics of Chang 7 shale using core samples and well logs and via laboratory tests. In addition, the microscopic components of the shale organic matter (OM), biological marker compounds, carbon isotopes, enrichment grade of trace elements, and elemental ratio were analysed systematically. Moreover, the aspects related to the shale OM source, sedimentary environment and resource potential were evaluated. Our results revealed that spherical alginate and calcium spherical alginate were predominant in the micropetrological components of the shale. Many biomarkers, including n -alkanes, steranes and terpanes, were detected in the gas chromatography – mass spectrometry spectra. An analysis of n -alkanes, regular sterane shapes (C21−/C22− and C26+C27/C28+C29), odd–even predominance index (OEP) and carbon preference index (CPI) values and carbon isotope distributions showed that OM was produced from aquatic organisms. The indicators of trace elements, such as Sr/Ba and V/V+Ni, combined with the biomarker compound in Pr/Ph and the gammacerane index showed the presence of a semi-deep – deep lake environment containing fresh–brackish water. In addition, the hydrocarbon conversion rate index and shale rock pyrolysis parameters revealed that Chang 7 has a high hydrocarbon generation ability and hydrocarbon expulsion efficiency. [ABSTRACT FROM AUTHOR]

Background: Gastric carcinoma (GC) is the third most frequent malignancy and the second most common cancer-related cause of death cause worldwide. Gastric intraepithelial neoplasia (GIN) is a well-documented precancerous lesion of GC. In this case–control study, we comprehensively explored the clinical and pathological characteristics of GIN, with the aim to identify its potential risk factors. Patients and methods: A total of 630 consecutive patients who underwent endoscopic submucosal dissection or mucosal resection for GIN were initially included. The detailed characteristics of all eligible patients and well-matched healthy controls were recorded and analyzed. Both univariate and multivariate logistic regression analyses were performed and presented with odds ratio (OR) and 95% confidential interval (CI), with additional subgroup analyses based on lesion location. Results: A total of 485 GIN-eligible patients were selected, among which 156 had proximal GIN. After follow-up, 434 patients with GIN and 310 age- and gender-matched healthy controls were included in the comparative analyses. Family cancer history (FCH); alcohol abuse; tobacco abuse; intake of high sodium, preserved food, spicy food, and less fruit; Helicobacter pylori (Hp) infection; and atrophic gastritis with intestinal metaplasia were more frequent in GIN patients. Thus, FCH (OR =3.485, 95% CI: 2.031–5.981), high sodium intake (OR =2.830, 95% CI: 1.645–4.868), less fruit intake (OR =4.082, 95% CI: 2.515–6.625), Hp infection (OR =2.307, 95% CI: 1.417–3.755), and atrophic gastritis with intestinal metaplasia (OR =15.070, 95% CI: 8.999–25.237) were independent risk factors for GIN. Further subgroup analyses demonstrated that the specific independent risk factor for proximal GIN was age (OR =2.001, 95% CI: 1.003–3.994), whereas that for distal GIN was intake of high sodium (OR =3.467, 95% CI: 1.896–6.338). Conclusion: This study reported a comprehensive overview of the clinical and pathological characteristics of GIN. FCH, high sodium intake, less fruit intake, Hp infection, and atrophic gastritis were identified as the independent risk factors for GIN. [ABSTRACT FROM AUTHOR]

Background: Epidemiologic studies have found that moderate alcohol consumption was associated with a decreased risk of coronary heart disease (CHD) incidence. Nevertheless, whether the drinking pattern is associated with CHD incidence still remains inconclusive. Methods: We included 8,469 Chinese men aged 45–81 years, who were free of CHD, stroke, or cancer at baseline from Dongfeng-Tongji cohort. A semi-structured questionnaire was used to collect information on alcohol consumption and other covariates. Cox proportional hazard regression model was applied to estimate the multivariable-adjusted hazard rations (HRs) and 95% confidence intervals (95% CIs). Results: During an average of 4.36 years of follow-up, we identified 959 incident CHD events. Compared with non-drinkers, the multivariable-adjusted HR (95% CI) of CHD incidence was 0.84 (0.71–0.98) in current drinkers. With respect to drinking pattern, men who consumed 20.01–40 grams ethanol once a time had a 24% lower risk of incident CHD (HR = 0.76, 95% CI = 0.62, 0.94) compared with non-drinkers. The adjusted HRs (95% CI) of CHD incidence were 0.80 (0.65, 0.99), 1.02 (0.84, 1.22), and 0.75 (0.59–0.96) in subjects who consumed 0.01–10, 10.01–30, and > 30 grams ethanol per day, respectively. Participants who consumed 20.01–40 grams ethanol per time with less than 5 times per week had the lowest risk of CHD incidence (HR = 0.73, 95% CI = 0.52, 0.96). No significant associations were observed between type or frequency of alcohol consumption and CHD incidence. Conclusions: Drinking was associated with a lower risk of CHD incidence in middle-aged and older Chinese men and moderate quantity of ethanol amounts once a time with lower frequency could been considered as a healthy drinking pattern, which might modify the relationship between alcohol consumption and incident CHD. [ABSTRACT FROM AUTHOR]

Lumican (LUM) is a candidate gene for myopia in the MYP3 locus. In this study, a mutant lumican (L199P) transgenic mouse model was established to investigate the axial length changes and ultrastructural features of the sclera. The mouse model was established by pronuclear microinjection. Transgenic mice and wild-type B6 mice were killed at eight weeks of age. Gene expression levels of LUM and collagen type I (COL1) in the sclera were analyzed by quantitative real-time polymerase chain reaction (qPCR), and the protein levels were assessed by Western blot analysis. Ocular axial lengths were measured on the enucleated whole eye under a dissecting microscope. Ultrastructural features of collagen fibrils in the sclera were examined with transmission electron microscopy (TEM). Lumican and collagen type I were both elevated at the transcriptional and protein levels. The mean axial length of eyes in the transgenic mice was significantly longer than that in the wild-type mice (3,231.0 ± 11.2 μm (transgenic group) vs 3,199.7 ± 11.1 μm (controls), p<0.05 =). Some ultrastructural changes were observed in the sclera of the transgenic mice under TEM, such as evident lamellar disorganizations and abnormal inter-fibril spacing. The average collagen fibril diameter was smaller than that in their wild-type counterparts. These results indicate that the ectopic mutant lumican (L199P) may induce enlargement of axial lengths and abnormal structures and distributions of collagen fibrils in mouse sclera. This transgenic mouse model can be used for the mechanistic study of myopia. [ABSTRACT FROM AUTHOR]

Introduction: Literature on the age at first anal intercourse (AFAI) among men who have sex with men (MSM) is limited. We aimed to elucidate the evolution of AFAI and the factors associated with early AFAI, based on a large sample of MSM in China. Methods: We collected information on the demographics and sexual behaviours of MSM from seven large cities in China from 2012 to 2013. Blood samples were collected for HIV serology. AFAI was calculated for MSM born in different time periods. Linear regression models were used to explore factors associated with younger AFAI. Results: A total of 4491 MSM (median age: 27 years, median AFAI: 21 years) were recruited. Median AFAI decreased steadily from 33 years of age among MSM born from 1940 to 1959 to 18 years of age among MSM born from 1990 to 1996. Factors significantly associated with younger AFAI included more recent birth cohort, being unmarried or living with a male partner, being a student or industry worker, the gender of the first partner being male, and using Rush or Ecstasy in the past six months (p for all B0.05). Conclusions: AFAI among MSM in China has considerably decreased over the past few decades. The decreasing AFAI and factors associated with younger AFAI point to the necessity of early sex education and control of recreational drug use among MSM in China. [ABSTRACT FROM AUTHOR]

Limonium sinense is a halobiotic herb endemic to China that has been traditionally used for hundreds of years for its good restorative function. Genetic variation and population structure of this species were investigated by using amplified fragment length polymorphisms (AFLPs) and inter simple sequence repeats (ISSRs). A high level of genetic diversity was detected [AFLP: H = 0.284, percentage of polymorphic loci (PPL) = 92.68 %; ISSR: H = 0.257, PPL = 85.71 %] at the species level with POPGENE. Based on analysis of molecular variation (AMOVA), the among-population component accounted for 29.03 % (AFLP) and 28.81 % (ISSR) of the genetic variation, indicating that most of the genetic variation was between individuals within populations. The Shannon diversity index ( I) was higher for AFLP (0.432) than for ISSR (0.395). Five main clusters were shown in the unweighted pair-group method with arithmetic mean (UPGMA) dendrogram created using TFPGA, consistent with the result of principal coordinate analysis using NTSYS. In situ conservation is advocated first. Keeping a stable environment for this halobiotic herb is necessary. For ex situ conservation, it is important to establish a germplasm bank. AFLP and ISSR markers were proved to be efficient tools in assessing the genetic variation among populations of L. sinense. The patterns of variation appeared to be consistent for these two marker systems, and they can be used for management of genetic structure, protection of the halobiotic plant, and conservation of germplasm. [ABSTRACT FROM AUTHOR]

So far, Puguang gas field is the largest and most abundant oversize marine carbonate reservoir that has been exploited in China. The range of H2S and CO2 content in natural gas is 13% -- 18% (v) and 8% -- 10% (v) respectively, organic sulfur content is 340.6 mg/m³. The conventional acid gas removal process is not applicable. By research and analysis on high sulfur natural gas purification technology, the gas purification process of Puguang gas field is set up. MDEA is selected as main absorption solvent, and organic sulfur is removed by catalytic reaction. To control the CO2 absorption, an interstage cooler is et between the first main absorber and the second absorber. The rich MDEA from acid gas removal unit and tail gas treating unit is regenerated in the same stripper to reduce the cost and energy consumption. This technology has been applied in Puguang gas field for more than one year, and the technical specifications meet requirements, the content of H2S in product is tower than 6 mg/m³, CO2 is lower than 3%(v), and the total sulfur is lower than 200 mg/m³. [ABSTRACT FROM AUTHOR]

Two integrins, α3β1 and α6β4, are high-affinity receptors for laminin 332, the major laminin isoform of the dermal–epidermal junction, although they are thought to have different functions. Biological and genetic studies have firmly established that the α6β4 integrin is indispensable for the stable anchorage of the epidermis to the underlying dermis. In contrast, the α3β1 integrin is thought to be important for cell migration, although the issue is controversial, and both positive and negative effects have been reported. To address the function of α3β1 integrin, we used small interfering RNA to down-regulate the α3 subunit in human keratinocytes. The resulting phenotype indicates that lack of α3β1 integrin compromises intercellular adhesion and collective migration, while it enhances single cell migration with a concomitant increase of both focal adhesion kinase and extracellular signal-regulated kinase. In addition, down-regulation of integrin α3 subunit results in an increased expression of fibronectin and precursor laminin 332, two extracellular matrix proteins known to be up-regulated during wound healing. Thus, down-regulation of α3β1 integrin recapitulates crucial events governing keratinocyte migration associated with wound healing and tissue repair. [ABSTRACT FROM AUTHOR]

Background: Perceptions related to COVID-19 vaccination are evolving over time, leading to potential changes in vaccination intention among unvaccinated people, which helps in the predictions of vaccination rates. This study investigated the changes in COVID-19 vaccination intention at the population level during a post-rollout period and two potential mechanisms underlying the change via the mediation/suppression effects that involve the perceived benefits/severe side effects of vaccination. Methods: Two serial random population-based telephone surveys interviewed 358 and 145 Chinese adults (aged 18–70) who were unvaccinated and who were unscheduled for COVID-19 vaccination, respectively, in May and August 2021 in Hong Kong, China. Results: The prevalence of vaccination intention increased from 14.5% to 22.8%, while the levels of perceived benefits (protection and travel-related advantages due to vaccination) and the perceived risk of severe side effects resulting from COVID-19 vaccination both significantly declined over time. Structural equation modeling found a simultaneous partial suppression effect via perceived benefits and a partial mediation effect via perceived severe side effects between the time when the surveys were conducted and COVID-19 vaccination intention, with adjustment for background factors. Conclusion: Perceptions related to COVID-19 vaccination are likely to change over time and partially account for changes in vaccination intention, sometimes in opposite directions. Ongoing health promotion may take such changes into account. Serial surveillance is warranted to monitor these changes. [ABSTRACT FROM AUTHOR]

Vaccination is one of the most effective ways of controlling the COVID-19 pandemic. However, vaccine hesitancy is prevalent, and relatively few studies have explored how variables related to personal and external motives have affected the intention to vaccinate. The present study investigated the association between perceived personal benefits, variables reflecting external motives (i.e., perceived social benefits, collectivism, and national pride) and intention to receive COVID-19 vaccination among university students in China. The interaction between perceived personal benefits and the three factors reflecting external motives on intention to receive COVID-19 vaccination was also examined. A total of 6922 university students from five provinces of China completed a cross-sectional survey. Results showed that adjusting for significant background variables, perceived personal benefits, perceived social benefits, collectivism, and national pride were all significant factors of intention to receive COVID-19 vaccination. Results from interaction analyses also showed that the association between perceived personal benefits and COVID-19 vaccination intention was stronger among those with lower levels of national pride. Findings highlighted the important role of self-directed interest and external motives in promoting uptake of COVID-19 vaccination. [ABSTRACT FROM AUTHOR]

Background: Vaccination resistance is the key hurdle against herd immunity as it limits the final vaccination coverage. This study investigated the prevalence and factors of COVID-19 vaccination resistance (i.e., those indicating definitely not taking up COVID-19 vaccination), including individualism, perceived personal benefits (PPB) and perceived societal benefits (PSB) of COVID-19 vaccination, and related mechanisms of the association. Methods: A random telephone survey interviewed 395 unvaccinated adults aged 18–75 not having scheduled for COVID-19 vaccination in May 2021 in Hong Kong, China (response rate = 56.8%). Results: The prevalence of vaccination resistance was 56.5%. Adjusted for background factors, individualism, PPB, and PSB were significantly associated with vaccination resistance. Path analysis showed that individualism exhibited a direct effect on vaccination resistance and a 3-step indirect effect (individualism → PSB → PPB→ vaccination resistance) that explained 46.8% of the total effect. The two 2-step indirect paths via PPB only and via PSB only were non-significant. Conclusion: High prevalence of vaccination resistance was observed. Individualism increased vaccination resistance via its direct and indirect effects. Health promotion may emphasize collective good to reduce the impact of individualism and promote PPB/PSB, which may reduce vaccination resistance directly and alleviate the impact of individualism on vaccination resistance indirectly. [ABSTRACT FROM AUTHOR]

Background: Globally, COVID-19 vaccination programs have been rolled out. To inform health promotion, this study investigated the prevalence and associated factors of performance or being scheduled to perform at least one dose of COVID-19 vaccination (PSCV) in a Chinese adult general population. Methods: An anonymous, random telephone survey interviewed 500 adults aged 18–75 in Hong Kong, China from 14–27 May 2021. Results: The prevalence of PSCV was 21.0%, which was significantly lower among females and those aged ≤30. Positively associated factors of PSCV included perceived protection effect of vaccination, self-perceived physical fitness for vaccination, compulsory COVID-19 testing experience, perceived need to travel, general trust toward the government, and trust toward the governmental vaccination program, while negatively associated factors included perceived low efficacy of vaccination, concerns about side effects, and chronic disease status. Furthermore, the association between sex and PSCV was fully mediated by stronger concern about side effects and lower levels of self-perceived physical fitness for COVID-19 vaccination among females than males. Conclusion: Moderately low prevalence of COVID-19 vaccination was observed in Hong Kong, where there was no shortage of vaccine supply. To achieve herd immunity, health promotion is greatly warranted and may incorporate messages based on the findings of this study. [ABSTRACT FROM AUTHOR]