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Atherosclerosis is a cardiovascular disease, accounting for the most common mortality cause worldwide. Notoginsenoside R1 (NGR1) is a characteristic saponin of Radix notoginseng that exhibits anti-inflammatory and antioxidant effects while modulating lipid metabolism. Evidence suggests that NGR1 exerts cardioprotective, neuroprotective, and anti-atherosclerosis effects. However, underlying NGR1 mechanisms alleviating atherosclerosis (AS) have not been examined. This study used a network pharmacology approach to construct the drug-target-disease correlation and protein–protein interaction (PPI) network of NGR1 and AS. Moreover, functional annotation and pathway enrichment analyses deciphered the critical biological processes and signaling pathways potentially regulated by NGR1. The protective effect of NGR1 against AS and the underlying mechanism(s) was assessed in an atherogenic apolipoprotein E-deficient (ApoE−/−) mice in vivo and an oxidized low-density lipoprotein (ox-LDL)-induced macrophage model in vitro. The network pharmacology and molecular docking analyses revealed that NGR1 protects against AS by targeting the NLRP3/caspase-1/IL-1β pathway. NGR1 reduced foam cell formation in ox-LDL-induced macrophages and decreased atherosclerotic lesion formation, serum lipid metabolism, and inflammatory cytokines in AS mice in vivo. Therefore, NGR1 downregulates the NLRP3 inflammasome complex gene expression of NLRP3, caspase-1, ASC, IL-1β, and IL-18, in vivo and in vitro. [ABSTRACT FROM AUTHOR]

Plasmonic metasurfaces can significantly enhance the interaction between light and 2D materials. Hybrid structures of plasmonic lattices and 2D materials show great promise for both fundamental and practical studies because of their unprecedented ability for precise manipulation of light at the nanoscale. This review starts with an overview of the basic concepts of plasmonic lattices and optical properties of 2D materials, as well as fabrication strategies for hybrid metasurfaces. Then, the enhanced photoluminescence, quantum emission, optoelectronic detection, nonlinear process, and valleytronics in hybrid metasurfaces are summarized, and their development for nanophotonic functional devices are reviewed. Further, several compelling topics are also outlined that provide outlooks for future directions of hybrid metasurfaces such as novel structural design and high‐quality fabrication, all‐dielectric metasurfaces, dynamic metasurfaces, and plasmonic mediation of chemical reactions and physical processes. It is believed that hybrid metasurfaces of plasmonic lattices and 2D materials can open prospects for versatile platforms for light‐matter interactions and contribute to the revolutions on nanophotonic devices. [ABSTRACT FROM AUTHOR]

Based on the hierarchical model of psychopathology, the theory of compensatory internet use, and the sociocultural self model of behaviour, this study examined whether social anxiety mediated the relationship between neuroticism and problematic online gaming, and whether this mediating process was moderated by family socioeconomic status (FSES). The theoretical model was tested using data collected from 598 Chinese undergraduates (Mage = 19.45 years, SD = 1.63). These participants completed questionnaires anonymously. Testing for moderated mediation revealed that social anxiety partially mediated the association between neuroticism and problematic online gaming, with FSES moderating the second stage of it. Specifically, the indirect effect of neuroticism on problematic online gaming via social anxiety was significant only for undergraduates with low FSES. Results of this study extend research on the influencing factors of problematic online gaming and highlight the significance of uncovering the underlying mechanisms. [ABSTRACT FROM AUTHOR]

The interaction between green finance and other factors, such as ecological environment, has been a research hotspot nowadays. Especially, the reasonable guiding of capital into energy conservation and environmental protection industries would greatly affect those factors, so as to the relation between them. This paper aimed to analyze the relationships between green finance, technological progress, and ecological performance quantitatively. The entropy method was used to respectively construct the system of index for green finance and technological progress, and index for ecological performance was measured by the super-SBM model. The panel vector autoregressive (PVAR) model was selected to empirically analyze dynamic relationships based on datasets from 30 provinces in China during 2008–2019 period. The results told that (1) from 2008 to 2019, China's overall level of green finance, technological progress and ecological performance increased to varying degrees. Spatially, the areas with high-developed green finance greatly coincided with those such as large cities or the eastern coast that had good financial development. The distribution of technological progress index were similar, except some underdeveloped areas with relatively advanced scientific research institutes. The ecological performance, however, was high in the South and low in the north. (2) In the lag for 3 years, the influence of green finance on ecological performance in different regions was all positive for that all the coefficient symbols that passed the significance test were above 0, while that on technological progress was negative first and then positive. And the effects of technological progress on ecological performance were positive in ecological regions and negative in low ecological regions (0.0893 and -0.1211 in the case of three-stage lag respectively). (3) The contribution of green finance to ecological performance was high according to the results of variance decomposition, maintained at about 30%, and that of technological progress increased year by year (from 0.000 to 0.039). Therefore, we proposed to strengthen the development of green finance in underdeveloped regions. The emphasis should be laid on the researches and applications of green technology, the formulation of financing policies in innovation compensation and the establishment of a dynamic monitoring system for the ecological environment. [ABSTRACT FROM AUTHOR]

A growing body of research has pinpointed the consequences as well as mechanisms of phubbing. However, few studies have explored the relationship between peer phubbing and social networking site addiction. Based on the self-determination theory, the exclusion theory of anxiety, the social compensation model, and the reserve capacity model, the present study examined whether peer phubbing was positively related to social networking site addiction among undergraduates, whether social anxiety mediated the relationship, and whether this mediating process was moderated by family financial difficulty. Our theoretical model was tested using the data collected from 1,401 Chinese undergraduates (M age = 18.83 years, standard deviation = 0.93). The participants completed anonymous questionnaires that assessed their peer phubbing, social anxiety, social networking site addiction, and family financial difficulty. The correlation analysis indicated that peer phubbing was positively associated with social networking site addiction. The testing for moderated mediation further revealed that social anxiety partially mediated the association between peer phubbing and social networking site addiction, with family financial difficulty moderating the first stage. To be specific, the indirect association between peer phubbing and social networking site addiction via social anxiety was stronger for undergraduates in high family financial difficulty. The results from this study extend research on the potential consequences of phubbing as well as highlight the significance of uncovering the underlying mechanisms. [ABSTRACT FROM AUTHOR]