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The article focuses on enhancing Cross-domain Named Entity Recognition (NER) by recognizing the discrepant transferability between entity detection and type prediction tasks. It introduces a novel paradigm called divide-and-transfer, employing separate functional modules for each task to improve domain transfer effectiveness.

Optical phased arrays (OPAs) are renowned for their exceptional ability to manipulate and direct light beams, positioning them as an ideal choice for solid-state light detection and ranging (LiDAR) technologies. This review provides a comprehensive examination of the current research landscape for photonic integrated circuit (PIC)-based OPAs. It begins by addressing the critical design elements at the component level necessary for optimal functionality. This review then delves into phase calibration techniques and the overarching architecture of OPAs. It concludes by emphasizing the innovative 3-D OPA design, which stands out for its enhanced optical efficiency. [ABSTRACT FROM AUTHOR]

There has been considerable interest in the search and design of two-dimensional (2D) van der Waals (vdW) compounds with exotic magnetic behavior. Here we establish the growth of phase pure crystals of Mn2In2Se5 and Mn2Ga2S5 and evaluate their structural, physical, and magnetic properties. These 2D vdW phases consist of double-octahedral thick Mn(S/Se)6 layers capped by InSe4 or GaS4 tetrahedra. Transmission electron microscopy confirms phase purity with the absence of impurity intergrowths of other closely related 2D vdW phases including Mn(In/Ga)2(Se/S)4 or In4Se3. Optical absorption measurements indicate these compounds have indirect band gaps of 1.33 and 1.58 eV, respectively. We also establish the Raman signatures for both compounds. Mn2In2Se5 and Mn2Ga2S5 are significantly frustrated magnetic materials due to the competing magnetic interactions in this double-thick triangular arrangement of metal atoms. They have magnetic transition temperatures of 7 and 13 K, respectively, compared to Weiss constants of −198 and −340 K, respectively. AC susceptibility experiments indicate that both Mn2In2Se5 and Mn2Ga2S5 exhibit significant spin glass character. The significant magnetic frustration makes these materials unique 2D magnetic vdW building blocks. [ABSTRACT FROM AUTHOR]

The problem of industrial bearing health monitoring and fault diagnosis has recently been a popular research topic. Extracting sufficient features from the input raw vibration signals and mapping them to the most likely fault labels is the essence of bearing fault diagnosis. This study proposes a novel framework for bearing defect diagnostics by merging dilated residual convolutional neural networks and attention mechanisms. In this framework, multiple parallel dilated convolutional networks can automatically learn rich fault features at each scale from vibration signals. Simultaneously, the attention approach boosts fault-related features and suppresses irrelevant ones, improving fault detection performance and generalization. According to the experimental results of two different bearing datasets, the framework achieves a higher accuracy and can accurately identify various types of faults. [ABSTRACT FROM AUTHOR]

In the first wave of the COVID-19 pandemic, China provided medical assistance on an unprecedented scale. While some observers have underscored the strategic purposes of China's COVID-19 aid, referred to as "mask diplomacy," they have yet to assess this argument against empirical evidence. We seek to examine whether China's medical aid was used as a strategic tool, or it remained reactionary and fragmented, by combining a new dataset on the global distribution of Chinese in-kind medical aid with a qualitative analysis of government and news reports during the first wave of the pandemic. Our findings show that although COVID-19 aid did have the potential to strengthen China's influence over recipients and promote Chinese knowledge of health governance, Chinese policymakers were underprepared to use aid strategically during the pandemic. The reactionary and fragmented nature of China's COVID-19 aid was reflected in its allocation, its policy-making processes, and its implementation. [ABSTRACT FROM AUTHOR]

This paper presents an experimental study on the emergence of the central recirculation zone (CRZ) in a basic V-shaped premixed swirling flame, using simultaneous measurement of particle image velocimetry and CH* chemiluminescence. Unlike most previous works that explored CRZ formation controlled by vortex breakdown (VB), the present experiment maintains a constant swirl intensity to rule out the influence of VB. We find that the CRZ characteristics and its emergence are strongly affected by the strength of the inner shear layer (ISL) surrounding the CRZ. However, the critical ISL intensity corresponding to CRZ emergence varies with the Reynolds number (R e) and the equivalence ratio (Φ). Upon employing dimensional analysis, the underlying mechanism can be interpreted with a non-dimensional parameter, R e s = γ max D / ν s , defined based on the maximum ISL intensity ( γ max) , the exit diameter (D) , and the kinematic viscosity (ν s ) of the burnt gas. The resultant γ max D − ν s regime diagram demonstrates the collapse of the critical R e s value for various cases with and without CRZ. The R e s mechanism explains the dependence of the critical ISL intensity on the equivalence ratio, further emphasizing the non-negligible roles of both the ISL intensity and the viscosity of the burned gas, in addition to VB, in determining the emergence of CRZ for V-shaped swirling flames. [ABSTRACT FROM AUTHOR]

This study aimed to investigate the levels of 12 sulfonamide antibiotics in freshwater fish species obtained from three cities in northeastern China (Harbin, Changchun, and Shenyang). The analysis was conducted using HPLC–MS/MS to accurately quantify the antibiotic concentrations in the fish samples. The results showed that the average levels of sulfonamide antibiotics in fish samples from Harbin, Changchun, and Shenyang were 1.83 ng/g ww, 0.98 ng/g ww, and 1.60 ng/g ww, respectively. Sulfamethoxazole displayed the highest levels and detection rates in all three cities, whereas sulphapyridine exhibited the lowest concentrations in all the fish samples. The levels of sulfonamide antibiotic residues in the different fish species varied widely among the cities, and the highest level of antibiotic residues was found in the muscle of carnivorous fish. The results from a health risk evaluation on the consumption of these fish indicated that the risk from long-term antibiotic exposure to local residents from the intake of the sampled fish was small and not sufficient to pose a significant health risk to consumers. [ABSTRACT FROM AUTHOR]

Basic magnesium sulfate cement (BMSC) is a kind of magnesium oxide (MgO)–magnesium sulfate (MgSO4)–water (H2O) modified ternary cementitious material prepared from light burned magnesia, magnesium sulfate heptahydrate, water and additives. The effects of α-magnesium oxide/magnesium sulfate ratio (MO/MS), water/magnesium sulfate ratio (W/MS), sand-to-binder ratio (s/b) and superplasticiser dosage (SPD) on the performance of BMSC mortar were studied for the first time in this work. The results showed that for, optimal 28-day flexural strength, α-MO/MS = 10:1, W/MS = 16:1, s/b = 0.8 and SPD = 0.3%. For optimal 28-day compressive strength, α-MO/MS = 8:1, W/MS = 14:1, s/b = 0.6 and SPD = 0.4%. For best water resistance, α-MO/MS = 12.5:1, W/MS = 14:1, s/b = 0.2 and SPD = 0.1%. Based on these results, the basic mix proportion ranges of BMSC mortar should be α-MO/MS = 8:1–12.5:1, W/MS = 14:1–16:1, s/b = 0.2–0.6 and SPD = 0.1–0.4%. [ABSTRACT FROM AUTHOR]

To achieve excellent electromagnetic wave (EMW) absorption properties, the microstructure design of the absorber is critical. In this work, six kinds of N-Ni/C nanostructures with different morphologies were prepared by one-step hydrothermal method and high temperature carbonization by adjusting the types of nickel salts and reaction solvents. The EMW absorption performance of six different morphologies of N-Ni/C nanostructures was compared and analyzed. Among them, it is found that the nanoflower-like N-Ni/C composite has excellent dielectric loss and magnetic loss synergistic effect due to its polycrystalline structure, and can obtain excellent EMW absorption performance. The minimum reflection loss value at a thickness of 1.9 mm is −59.56 dB at 16.88 GHz, and the effective absorption bandwidth value reaches 6.0 GHz at a thickness of 2.2 mm. Our research shows that different morphologies and multiple lattice structures of nanostructures with the same composition have a significant influence on EMW absorption performance, which provides new research ideas for developing high-performance EMW absorbing materials. [ABSTRACT FROM AUTHOR]

Background: The pentose phosphate pathway (PPP) is an important mechanism by which tumour cells resist stressful environments and maintain malignant proliferation. However, the mechanism by which the PPP regulates these processes in colorectal cancer (CRC) remains elusive. Methods: Closely related PPP genes were obtained from the TCGA and GEO databases. The effect of ATP13A2 on CRC cell proliferation was evaluated by performing in vitro assays. The connection between the PPP and ATP13A2 was explored by assessing proliferation and antioxidative stress. The molecular mechanism by which ATP13A2 regulates the PPP was investigated using chromatin immunoprecipitation and dual luciferase experiments. The clinical therapeutic potential of ATP13A2 was explored using patient‐derived xenograft (PDX), patient‐derived organoid (PDO) and AOM/DSS models. Findings: We identified ATP13A2 as a novel PPP‐related gene. ATP13A2 deficiency inhibited CRC growth and PPP activity, as manifested by a decrease in the levels of PPP products and an increase in reactive oxygen species levels, whereas ATP13A2 overexpression induced the opposite effect. Mechanistically, ATP13A2 regulated the PPP mainly by affecting phosphogluconate dehydrogenase (PGD) mRNA expression. Subsequent studies showed that ATP13A2 overexpression promoted TFEB nuclear localization by inhibiting the phosphorylation of TFEB, thereby enhancing the transcription of PGD and ultimately affecting the activity of the PPP. Finally, ATP13A2 knockdown inhibited CRC growth in PDO and PDX models. ATP13A2−/− mice had a lower CRC growth capacity than ATP13A2+/+ in the AOM/DSS model.Our findings revealed that ATP13A2 overexpression‐driven dephosphorylation of TFEB promotes PPP activation by increasing PGD transcription, suggesting that ATP13A2 may serve as a potential target for CRC therapy. [ABSTRACT FROM AUTHOR]

Seepage prevention and reinforcement of sandy soft soil layer are the important subjects in geotechnical engineering. A set of constant pressure permeable grouting device has been developed to study the diffusion rule of new permeable polymer in sandy soil layer. Based on the orthogonal experimental design, the effects of grouting pressure, grouting time, sand moisture content and sand porosity on the diffusion of new permeable polymer in sand are studied. Through the establishment of spatial coordinate system, the diffusion range of permeable polymer slurry is studied. The experimental results show that: the main and secondary order affecting the diffusion range of permeable polymer in the X-axis and Y-axis are sand porosity, grouting pressure, grouting time, and sand moisture content. The primary and secondary orders of influencing factors on the Z-axis diffusion range of permeable polymer are sand porosity, grouting time, grouting pressure, and sand moisture content. The effects of grouting pressure, grouting time, sand layer porosity on permeable polymer diffusion and the effect of permeable polymer on soil displacement during diffusion are studied by COMSOL numerical analysis software. The results of numerical analysis show that the grouting pressure, grouting time, and porosity of sand layer promote the diffusion of permeable polymer. The slight deformation of soil mass and small disturbance to soil layer can be caused by slurry during diffusion process. A function model between slurry diffusion range and grouting parameters are established, and verified by numerical simulation for comparison. The results show that the numerical simulation values of permeable polymer grouting results in the three comparison scenarios A1, A2 and A3 are greater than the theoretical calculation values, and the difference between them is not significant. The difference between the calculated value and the theoretical value of the three comparison schemes are 6.3%, 11.7% and 7.39%, respectively. [ABSTRACT FROM AUTHOR]

The rheological properties of warm-mix recycled asphalt binders are critical to enhancing design quality and interpreting the performance mechanisms of the corresponding mixtures. This study investigated the rheological behavior of warm-mix recycled asphalt binders with high percentages of RAP binder. The effects of two warm-mix additives [wax-based Sasobit (S) and surfactant-based Evotherm-M1 (E)], a rejuvenating aging [ZGSB (Z)], four RAP binder contents (0%, 30%, 50% and 70%), and three aging states (unaged, short-term aged and long-term aged) were evaluated in detail using the dynamic shear rheometer (DSR), bending beam rheometer (BBR) and Brookfield rotational viscometer tests as well as conventional performance tests over the whole range of temperatures. The results showed that the rejuvenating agent Z effectively alleviated the aging effect of the RAP binder; however, it could hardly eliminate entirely this negative impact, especially at higher RAP binder contents. The addition of S remarkably lowered the apparent viscosity of the warm-mix recycled binders by up to 35.0%, whereas E had little influence on the binder viscosity due to its surfactant nature. Besides, S performed much better in improving rutting resistance (with the increase of up to 411.3% in |G*|/sinδ) than E, while E exhibited superior fatigue performance (with the reduction of up to 42.3% in |G*|·sinδ) to that of S. In terms of the thermal cracking resistance, E had very slight influence and S even yielded an adverse impact (with the increase of up to 70.2% in Sa and the decrease of up to 34.1% in m-value). Further, S broadened the ranges of pavement service temperatures by about 12 °C, whereas E almost did not change the PG grades of the binders. Finally, regarding the characteristics of viscoelastic master curves, S considerably improved the dynamic modulus and lowered the phase angle of the binders over a wide range of frequencies and temperatures but led to the failure of the time-temperature superposition principle due to its thermorheologically complex nature. Nevertheless, in this regard, the effect of E was found very mild. [ABSTRACT FROM AUTHOR]

From 2015, China began to promote eco-sustainability in the Belt and Road Initiative (BRI) through not only vision statements but also specific guidelines and governance initiatives. What has driven these policy changes? Bringing together theories of norm localization, norm subsidiarity, and policy deliberation, we argue that China's move toward green BRI began as a norm localization process where environmental norms emerged in the open policy space created by China's top leaders carrying the ambition to make the BRI a new global governance model. After adopting a broad norm on environmental stewardship, state bureaucracies found opportunities to create procedural and operational rules. A novel procedural rule-making methodology emphasizing inclusive dialogue with host countries has emerged, driven by top leaders' pursuit of international leadership and preexisting local norms guiding South–South cooperation. With operational rules, different actors follow their preferences to localize existing international standards or develop new ones. [ABSTRACT FROM AUTHOR]

A chemical shape‐memory hydrogel containing crystalline structure is prepared via micellar copolymerization of hydrophilic monomer acrylamide (AM) and hydrophobic monomer octadecyl acrylate (C18) in a sodium dodecyl sulfate (SDS) solution. The influence of SDS on the shape‐memory behavior of hydrogel investigated by differential scanning calorimetry (DSC) and Temperature‐dependent X‐ray indicate that the melting and crystallization peaks derived from the thermal properties of C18 units is different from peaks corresponding to the pure SDS. In addition, the microstructure evolution information of hydrogels dose not change upon heating process, regardless of the presence or absence of SDS. Therefore, only the hydrophobic associations formed by C18 blocks play a decisive role in the shape memory function of hydrogel system. The difference between the transition process (from temporary shape to permanent shape) of hydrogel with and without SDS at different temperature is because that the hydrophobic region of side chain crystallization of SDS‐free hydrogel may escape the restriction of SDS and become more sensitive to temperature, they can preferentially return to their initial shape under the same time and temperature than SDS‐containing gels. Whether SDS exists only affect the speed of shape memory behavior, but not the microstructure evolution of hydrogel system. [ABSTRACT FROM AUTHOR]

Simple Summary: Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related death. In this study, we aimed to determine the biological function and regulatory mechanism of GMEB2 in CRC. We found that GMEB2 was highly expressed in CRC and significantly promoted the growth of CRC in vitro and in vivo. Mechanistically, GMEB2 acted as a transcription factor to activate ADRM1/NF-κB signalling and was upregulated by YTHDF1 through enhancing its mRNA stability. Our findings suggest that GMEB2 may serve as a new therapeutic target for CRC treatment in the future. Transcription factors are frequently aberrantly reactivated in various cancers, including colorectal cancer (CRC). However, as a transcription factor, the role of GMEB2 in cancer is still unclear, and further studies are needed. Here, we aimed to identify the function and mechanism of GMEB2 in regulating the malignant progression of CRC. GMEB2 was found to be highly expressed in online data analyses. We demonstrated that GMEB2 was markedly upregulated at both the mRNA and protein levels in CRC cells and tissues. GMEB2 knockdown inhibited CRC cell growth in vitro and in vivo. Mechanistically, as a transcription factor, GMEB2 transactivated the ADRM1 promoter to increase its transcription. Rescue experiments showed that ADRM1 downregulation partially reversed the promoting effects of GMEB2 on CRC growth in vitro. Moreover, the GMEB2/ADRM1 axis induced nuclear translocation of NF-κB, thus activating NF-κB signalling. Finally, we further revealed that YTHDF1 recognized and bound to the m6A site on GMEB2 mRNA, which enhanced its stability. Taken together, our findings reveal the crucial role and regulatory mechanism of GMEB2 in CRC for the first time and provide a novel potential therapeutic target for CRC therapy. [ABSTRACT FROM AUTHOR]

The purpose of target threat assessment is to quantitatively estimate the threat level of the target based on the target based on the target's attributes and status information and provide auxiliary support for operational decision-making. Existing threat assessment models mostly rely on numerical information, and it is difficult to effectively process target feature information containing qualitative and quantitative data. Based on this, this paper proposes an improved adaptive network based fuzzy inference system model. On the basis of the adaptive network based fuzzy inference system, the antecedent influence matrix and the consequent influence matrix are introduced to process the qualitative data, so that the influence of the quantitative and qualitative data acts on the antecedent parameters and the consequent parameters of the fuzzy rules at the same time. In order to further improve the output accuracy of the model, the output layer of the adaptive network based fuzzy inference system is replaced with a polynomial neural network. The structure of the improved model is identified by the affinity propagation clustering algorithm based on Gower distance, and the initial parameters of the fuzzy rules are determined. Simulation examples verify the effectiveness and feasibility of the proposed method. Compared with other mixed attribute data modeling methods, the proposed method has a higher prediction accuracy and can provide effective auxiliary support for battle command decision-making. [ABSTRACT FROM AUTHOR]

Metasurfaces consisting of an array of planar sub-wavelength structures have shown great potentials in controlling thermal infrared radiation, including intensity, coherence, and polarization. These capabilities together with the two-dimensional nature make thermal metasurfaces an ultracompact multifunctional platform for infrared light manipulation. Integrating the functionalities, such as amplitude, phase (spectrum and directionality), and polarization, on a single metasurface offers fascinating device responses. However, it remains a significant challenge to concurrently optimize the optical, electrical, and thermal responses of a thermal metasurface in a small footprint. In this work, we develop a center-contacted electrode line design for a thermal infrared metasurface based on a gold nanorod array, which allows local Joule heating to electrically excite the emission without undermining the localized surface plasmonic resonance. The narrowband emission of thermal metasurfaces and their robustness against temperature nonuniformity demonstrated in this work have important implications for the applications in infrared imaging, sensing, and energy harvesting. [ABSTRACT FROM AUTHOR]

This article proposes an analytical framework on China's engagement with international ideas that stresses the crucial role of Chinese bureaucracies' deliberation. It argues that bureaucratic deliberation is influenced by three factors: orthodox bureaucratic norms, candidate ideas' performance in policy experimentation, and bureaucratic interests. When orthodox norms decline, bureaucracies become more open to novel ideas. But only when policy experiments with a novel idea generate positive performance and when the new policy fits bureaucratic interests, can the idea be adopted. China's adoption of Carbon Emissions Trading (ET) was influenced by the National Development and Reform Commission (NDRC), the deliberation within which was influenced by the change of China's defensive position in climate governance, the unsatisfactory performance of command-and-control measures, and the NDRC's political interests. [ABSTRACT FROM AUTHOR]

Zero-valent metal (ZVMs)-based persulfate activation systems are extensively applied for the elimination of organic pollutants in aqueous environments. In this study, for the first time, zero-valent copper (ZVC) was employed as the peroxymonosulfate (PMS) activator for the efficient degradation of Orange G (OG). The physicochemical properties of ZVC were systematically characterized by FESEM, EDX, TEM, XRD and XPS measurements. Furthermore, the effects of catalyst loading, PMS dosage, OG concentration and inorganic anions on the ZVC/PMS system were, respectively, investigated and explicated. The formation of •OH and SO4•− in the system was verified by quenching experiments and then the possible reaction mechanism was proposed. This work can provide insight into water treatment technology based on ZVMs. [ABSTRACT FROM AUTHOR]

Simple Summary: The expression of a variety of microRNAs (miRNAs) and their target genes in gastric cancer is dysregulated and affects the progression of gastric cancer but has not been fully clarified, while bioinformatics is expected to become a method to reveal the relationship and function between them. Thus, through a variety of bioinformatics analyses and experiments, we confirmed that miR-137-3p played a tumor-suppressive role in gastric cancer, and its target gene COL5A1 could reversely sponge miR-137-3p to relieve its targeted inhibition of FSTL1, which may promote the progression of gastric cancer by affecting immune infiltration. These results may provide new ideas for the treatment and future research of gastric cancer. MicroRNAs (miRNAs) and their target genes have been shown to play an important role in gastric cancer but have not been fully clarified. Therefore, our goal was to identify the key miRNA–mRNA regulatory network in gastric cancer by utilizing a variety of bioinformatics analyses and experiments. A total of 242 miRNAs and 1080 genes were screened from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), respectively. Then, survival-related differentially expressed miRNAs and their differentially expressed target genes were screened. Twenty hub genes were identified from their protein–protein interaction network. After weighted gene co-expression network analysis was conducted, we selected miR-137-3p and its target gene, COL5A1, for further research. We found that miR-137-3p was significantly downregulated and that overexpression of miR-137-3p suppressed the proliferation, invasion, and migration of gastric cancer cells. Furthermore, we found that its target gene, COL5A1, could regulate the expression of another hub gene, FSTL1, by sponging miR-137-3p, which was confirmed by dual-luciferase reporter assays. Knockdown of COL5A1 inhibited the proliferation, invasion, and migration of gastric cancer cells, which could be rescued by the miR-137-3p inhibitor or overexpression of FSTL1. Ultimately, bioinformatics analyses showed that the expression of FSTL1 was highly correlated with immune infiltration. [ABSTRACT FROM AUTHOR]

China's approach to International Development Cooperation (IDC) has been one of continuous evolution. The 2000s version of Chinese IDC applied a request-/project-centrism methodology, focused on the infrastructure sector, and mixed aid with business. Since the launch of the Belt and Road Initiative (BRI), the methodological dimension of the existing IDC model has changed by virtue of a growing emphasis on top-level design, sectoral programmes, and high standards for project implementation. How to explain these changes? Different from the conventional material-functionalist approaches, this article attributes the development of China's IDC to cognitive evolution—an intra-community collective learning mechanism that drives changes in norms and practices. Cognitive evolution consists of the following three interconnected processes: uncertainty build-up; experimentation; and selection. Three factors that may shape the trajectories of cognitive evolution are as follows: the legacy of orthodox norms; the availability of transferable local ideas; and the communal interpretation of candidate ideas' performance. The IDC model of the 2000s was constructed based on critical reflections on the internationalist foreign aid model of the Mao era and on the IDC policy community's interpretation and transplantation of China's development experience. The methodology of this IDC model—request-/project-centrism—has come under new pressure for change due to the BRI's ambition to engender more substantial and sustainable developmental impact. [ABSTRACT FROM AUTHOR]

HCV cell-culture system uses hepatoma-derived cell lines for efficient virus propagation. Tumor cells cultured in glucose undergo active aerobic glycolysis, but switch to oxidative phosphorylation for energy production when cultured in galactose. Here, we investigated whether modulation of glycolysis in hepatocytes affects HCV infection. We showed HCV release, but not entry, genome replication or virion assembly, is significantly blocked when cells are cultured in galactose, leading to accumulation of intracellular infectious virions within multivesicular body (MVB). Blockade of the MVB-lysosome fusion or treatment with pro-inflammatory cytokines promotes HCV release in galactose. Furthermore, we found this glycometabolic regulation of HCV release is mediated by MAPK-p38 phosphorylation. Finally, we showed HCV cell-to-cell transmission is not affected by glycometabolism, suggesting that HCV cell-to-supernatant release and cell-to-cell transmission are two mechanistically distinct pathways. In summary, we demonstrated glycometabolism regulates the efficiency and route of HCV release. We proposed HCV may exploit the metabolic state in hepatocytes to favor its spread through the cell-to-cell transmission in vivo to evade immune response. Author summary: Hepatitis C virus (HCV) is a positive-stranded RNA virus that causes acute and chronic hepatitis and hepatocellular carcinoma. HCV infectious cycle comprises viral entry, uncoating, translation and replication of viral RNA, assembly into new virions and release. Establishment of HCV cell culture system (HCVcc) has yielded many insights into complete HCV infectious cycle in Huh7 cell and Huh7-derived human hepatoma cell lines. However, because hepatoma-derived cell lines and hepatocytes vary in metabolism, HCV infectious cycle in tumor cell lines and the patient's liver may also be different. Therefore, we explored the alterations of HCV infectious cycle by forcing the tumor cell lines to switch their glycometabolic pathways. We found that HCV release can be blocked by culturing cells in galactose-containing medium, leading to accumulation of intracellular infectious virions within MVB. Moreover, we provided new evidence to suggest that HCV cell-to-cell transmission may be mechanistically distinct from cell-to-supernatant release. Finally, we proposed a new concept that HCV release from hepatocytes into circulation may be naturally inefficient due to the metabolic state in liver that may favor more HCV cell-to-cell transmission. This strategy would allow HCV to effectively evade neutralizing antibodies to establish persistent infection. [ABSTRACT FROM AUTHOR]

We consider the 1 s 2 s 1 , 3 S states of the two-electron three-dimensional quantum dot with a Gaussian one-body potential, - V 0 exp (- λ r 2) . For a single electron, a simple scaling relation allows the reduction into a one-parameter problem in terms of V 0 λ . However, for the two-electron system, the interelectronic repulsion term, 1 r 12 , frustrates this simple scaling transformation, so we face a genuine two-parameter system. We pay particular attention to the location and nature of the critical well-depths, at which the binding energy of the second electron vanishes. Several observations are noteworthy: For all λ , the triplet critical well-depth is lower than that in the singly excited singlet state. Hence, there exists a finite range of well-depths for which the triplet is bound and the singlet is not, a feature that can possibly be applied in some device. Above its critical well-depth, the triplet state energy is always lower than that of the singly excited singlet. Both well-depths are considerably higher than the critical well-depth in the ground state. The expectation value of the interelectronic repulsion is always lower in the triplet, like the harmonic quantum dot but unlike He-like atoms, the two-particle Debye (Yukawa) atom, or the confined He atom. In the infinite well-depth ( V 0 ) limit, keeping the well-width 1 λ constant, the energies and other expectation values of the bound states of the two-electron Gaussian quantum dot approach those of a non-interacting harmonic two-electron system. [ABSTRACT FROM AUTHOR]

Salt wastes containing halides from the molten salt reactor system are unstable during storage. These waste should be immobilized. In this paper, a glass–ceramic wasteform containing SrF2 is prepared from iron phosphate glass and fluorapatite (FAP) ceramic powder by a two-step sintering process. The results of XRD and SEM showed that main crystalline phase in samples is fluorapatite with Sr, and a large number of amorphous phase wrapped around the FAP. The result of product consistency test showed that the glass–ceramic sample has a good leaching resistance for wasteform long-term storage. [ABSTRACT FROM AUTHOR]

Two-dimensional nanolayers have found increasingly widespread applications in modern flexible electronic devices. Their adhesion with neighbouring layers can significantly affect the mechanical stability and the reliability of those devices. However, the measurement of such adhesion has been a great challenge. In this work, we develop a new and simple methodology to measure the interfacial adhesion between a mica nanolayer (MNL) and a single-layer graphene (SLG) supported by a SiO2 substrate. The method is based on the well-known Obreimoff method but integrated with innovative nanomanipulation and profile measuring approaches. Our study shows that the adhesion energy of MNLs on the SLG/SiO2 substrate system is considerably lower than that on the SiO2 substrate alone. Quantitative analyses reveal that the wrinkles formed on the SLG can considerably lower the adhesion. This outcome is of technological value as the adhesion maybe tailored by controlling the wrinkle formation in the graphene layer in a flexible electronic device. [ABSTRACT FROM AUTHOR]

Accumulation of evidence has indicated a close relationship between alternative splicing (AS) and gastric cancer (GC), whereas systematic analyses of the differentially expressed AS events (DEAS) between GC and normal tissues are lacking. RNA-Seq data and the corresponding clinical information were downloaded from TCGA GC cohort. The percent spliced-in (PSI) value calculated in the GC tissues and normal tissues was employed to quantify the DEAS. Further, survival-associated DEAS and DEAS signatures were identified by univariate and multivariate cox regression analyses. To evaluate the association between DEAS and patients' clinical features, Kaplan-Meier analysis, receiver operator characteristic (ROC) curve, Cox proportional regression and nomograms incorporating the DEAS signatures were performed. DEAS and their splicing networks were finally analyzed by bioinformatics methods. In addition, we use the method of random grouping to divide the samples into the training group and the test group. The final results of the two groups are consistent. After strict filtering, a total of 44,935 AS events were identified, among which 11,141 DEAS were preliminarily screened from 5032 genes. A total of 454 DEAS was associated with OS, and 872 DEAS were associated with DFS. The final prognostic signatures were constructed from the survival-associated DEAS with an area under the receiver operating characteristic (ROC) curve (AUC) greater than 0.6. Only ES in ABI1 was simultaneously associated with OS and DFS. Finally, we identified the splicing correlation network between the prognostic splicing factors (SF) and DEAS in GC. Our study provided a systematic portrait of survival-associated DEAS in GC and uncovered splicing networks that are valuable in deciphering the underlying mechanisms of AS in GC. [ABSTRACT FROM AUTHOR]

Levels of heavy metals and polybrominated diphenyl ethers (PBDEs) were determined in fishes sampled in Jilin Songhua Lake, China. Concentrations and congener profiles of these contaminants varied by fish type. The highest concentrations of Zn, Cu, Mn, and Cd were found in three omnivorous fish (Carassius carassius, Hypomesus olidus, and Hemiculter leucisculus). The highest concentrations of Ni, Cr, and Hg were found in Silurus asotus and Hemibarbus maculatus which are two kinds of carnivorous fish. The minimum total concentration of the seven PBDEs of fish was 0.093 ng/g wet weight (ww) in Ctenopharyngodon idellus, while the maximum, 0.342 ng/g ww, was detected in Aristichthys nobilis. Of all the congeners, BDE 28 and 47 were dominant. The estimated daily intake (EDI) of these metals and PBDEs via consuming the fishes was estimated to be 1.159–10.121 μg/kg bw/day and 0.046–0.597 ng/kg bw/day, respectively. The total hazard quotients (THQs) of both types of pollutants were far below 1, indicating that the health risks of these pollutants were low for the people who consumed the fish species from the Songhua Lake. [ABSTRACT FROM AUTHOR]

Unmixing is a key but difficult issue in hyperspectral image (HSI) processing, and many unmixing methods have been proposed. However, an effective introduction of the spatial context in unmixing remains a challenge but is a necessary condition for many real scene applications. In this letter, a new nonnegative matrix factorization (NMF) method that combines nonlocal spatial information with spatial group sparsity (NLNMF) is proposed. Each superpixel generated by the simple linear iterative clustering (SLIC) segmentation method was used as a group. The search region of the nonlocal means method was adaptively set using a superpixel label from each spectrum to find the similar spectra to reestimate the reference spectrum. Additionally, the sparsity of spectra in the same superpixel was considered to be the same. Experiment results for synthetic and real HSI showed that the proposed method not only can more accurately estimate the endmember and abundance compared with other unmixing methods but also has good performance regarding antinoise. [ABSTRACT FROM AUTHOR]

Mica nanolayers (MNL) are a new dielectric material that can improve the electron transport properties of Si based microelectronic devices. However, the mechanical reliability of such devices is not well understood because measurement of the adhesion between an MNL and a Si substrate is insufficiently accurate. The recent work reports a bridging method that is developed based on the linear beam theory and can characterize the adhesion of MNL on a mica substrate in a reasonably accuracy. In this work, the accuracy of the bridging method is improved by using a nonlinear mechanical model. 15 MNL specimens are measured on a Si substrate in air and the new model gives an average adhesion energy of 119.69 ± 20.47 mJ m–2. The effect of environment on the adhesion is also investigated. The increase in temperature from 25 to 300 °C enhances adhesion, attributed to the increased bonding effect of interfacial contaminants. When humidity is below a threshold value, 80% in this case, the adhesion energy remains unchanged, but above the threshold, the nanobridges collapse during testing. Molecular dynamics simulation reveal that the collapse is because the increase of interfacial water molecules reduces the frictional force between the MNL and Si substrate. [ABSTRACT FROM AUTHOR]

Chopped basalt fibre (BF)-reinforced silicone rubber/fluorine rubber composites were investigated to improve their mechanical and thermal properties, in which the blend of silicone rubber (MVQ) and fluorine rubber (FKM) was used as a matrix of the composites, the BF was used as a reinforcement, and the coupling agents of KH550 (3-amino propyltriethoxysilane), KH590 (3-mercaptopropyl trimethoxysilane) and Si69 (bis(3-triethoxysilylpropyl) tetrasulfane) were used as the compatibiliser. The effect of length and content of the BF, and the type of coupling agent on the mechanical properties of composites were discussed. The results confirm that the mechanical and thermal properties of the KH590-BF/MVQ/FKM composites were optimal when the BF was 7 phr (parts per hundred rubber) with a length of 12 mm, and treated with coupling agent KH590 of 2.0 phr. Further compatibility between the BF and MVQ/FKM was optimum. The glass transition temperature (Tg) reduced from − 19.2 °C to − 28.0 °C, while the application range of KH590-BF/MVQ/FKM composites was widened. [ABSTRACT FROM AUTHOR]

The evolution of retained species during the whole methanol-to-olefins process was revealed with the aid of GC-MS, thermogravimetric analysis (TG) and density functional theory (DFT) calculations. Precise routes for the transformation of retained methylbenzenes to methylnaphthalenes were proposed, based on the direct capture of three possible organic intermediates, to explain the catalyst deactivation procedure. [ABSTRACT FROM AUTHOR]

Novel therapeutic strategies for breast cancer are urgently needed due to the sustained development of drug resistance and tumor recurrence. Trivalent arsenic derivative (arsenite, AsIII) has been reported to induce cytotoxicity in breast cancer cells. We recently demonstrated that AsIII plus tetrandrine (Tetra), a Chinese plant-derived alkaloid, exerted potent antitumor activity against human breast cancer cells, however, the underlying mechanisms for their action have not been well defined. In order to provide fundamental insights for understanding the action of AsIII plus Tetra, the effects of the combined regimen on two breast cancer cell lines T47D and MDA-MB-231 were evaluated. Compared to T47D cells, MDA-MB-231 cells were much more susceptible to the synergistic cytotoxic effects of AsIII and Tetra. Besides the induction of apoptotic/necrotic cell death, S-phase arrest and autophagic cell death were also observed in MDA-MB-231 cells. Exposure of MDA-MB-231 cells to AsIII and Tetra caused the activation of MAPKs. Cytotoxicity of the combined regimen in MDA-MB-231 cell was significantly abrogated by SP600125, a potent c-Jun N-terminal kinase (JNK) inhibitor. However, similar abrogation was not caused by p38 and ERK inhibitors. The addition of either autophagy inhibitors (3-methyladenine or wortmannin) or SP600125 corrected the combined regimen-triggered S-phase arrest, whereas had little effect on the apoptosis/necrosis induction in the cells. Surprisingly, SP600125NC, a negative control for SP600125, significantly strengthened S-phase arrest and the cytotoxicity induced by the combined regimen. The addition of SP600125 did not alter autophagy induction. In conclusion, the cytotoxicity of AsIII combined with Tetra was attributed to the induction of S-phase arrest, apoptotic/necrotic and autophagic cell death. The enhanced cytotoxicity of the two drugs by SP600125NC might be explained by its capability to strengthen S-phase arrest. Our results suggested that JNK and autophagy independently contributed to the cytotoxicity via modulating cell cycle progression. The study further provides fundamental insights for the development of AsIII in combination with Tetra for patients with different types of breast cancer. [ABSTRACT FROM AUTHOR]

Modulated synthesis and isoreticular expansion of Th-MOFs enable the stepwise construction of hierarchical complexes in which porosity and functionality can be fine-tuned, affording new Th-MOFs with a record high void space (74.0%), the largest surface area (3396.5 m2 g−1) among thorium materials, and excellent adsorption capacities toward radioactive iodine. [ABSTRACT FROM AUTHOR]

Dataflow visualization systems enable flexible visual data exploration by allowing the user to construct a dataflow diagram that composes query and visualization modules to specify system functionality. However learning dataflow diagram usage presents overhead that often discourages the user. In this work we design FlowSense, a natural language interface for dataflow visualization systems that utilizes state-of-the-art natural language processing techniques to assist dataflow diagram construction. FlowSense employs a semantic parser with special utterance tagging and special utterance placeholders to generalize to different datasets and dataflow diagrams. It explicitly presents recognized dataset and diagram special utterances to the user for dataflow context awareness. With FlowSense the user can expand and adjust dataflow diagrams more conveniently via plain English. We apply FlowSense to the VisFlow subset-flow visualization system to enhance its usability. We evaluate FlowSense by one case study with domain experts on a real-world data analysis problem and a formal user study. [ABSTRACT FROM AUTHOR]

Hepatitis C virus (HCV) is a member of Hepacivirus and belongs to the family of Flaviviridae. HCV infects millions of people worldwide and may lead to cirrhosis and hepatocellular carcinoma. HCV envelope proteins, E1 and E2, play critical roles in viral cell entry and act as major epitopes for neutralizing antibodies. However, unlike other known flaviviruses, it has been challenging to study HCV envelope proteins E1E2 in the past decades as the in vitro expressed E1E2 heterodimers are usually of poor quality, making the structural and functional characterization difficult. Here we express the ectodomains of HCV E1E2 heterodimer with either an Fc-tag or a de novo designed heterodimeric tag and are able to isolate soluble E1E2 heterodimer suitable for functional and structural studies. Then we characterize the E1E2 heterodimer by electron microscopy and model the structure by the coevolution based modeling strategy with Rosetta, revealing the potential interactions between E1 and E2. Moreover, the E1E2 heterodimer is applied to examine the interactions with the known HCV receptors, neutralizing antibodies as well as the inhibition of HCV infection, confirming the functionality of the E1E2 heterodimer and the binding profiles of E1E2 with the cellular receptors. Therefore, the expressed E1E2 heterodimer would be a valuable target for both viral studies and vaccination against HCV. [ABSTRACT FROM AUTHOR]

Short-term traffic volume forecasting is one of the most essential elements in Intelligent Transportation System (ITS) by providing prediction of traffic condition for traffic management and control applications. Among previous substantial forecasting approaches, K nearest neighbor (KNN) is a nonparametric and data-driven method popular for conciseness, interpretability, and real-time performance. However, in previous related researches, the limitations of Euclidean distance and forecasting with asymmetric loss have rarely been focused on. This research aims to fill up these gaps. This paper reconstructs Euclidean distance to overcome its limitation and proposes a KNN forecasting algorithm with asymmetric loss. Correspondingly, an asymmetric loss index, Imbalanced Mean Squared Error (IMSE), has also been proposed to test the effectiveness of newly designed algorithm. Moreover, the effect of Loess technique and suitable parameter value of dynamic KNN method have also been tested. In contrast to the traditional KNN algorithm, the proposed algorithm reduces the IMSE index by more than 10%, which shows its effectiveness when the cost of forecasting residual direction is notably different. This research expands the applicability of KNN method in short-term traffic volume forecasting and provides an available approach to forecast with asymmetric loss. [ABSTRACT FROM AUTHOR]

Abstract: PIWI‐interacting RNAs (piRNAs) silence transposons in germ cells to maintain genome stability and animal fertility. Rhino, a rapidly evolving heterochromatin protein 1 (HP1) family protein, binds Deadlock in a species‐specific manner and so defines the piRNA‐producing loci in the Drosophila genome. Here, we determine the crystal structures of Rhino‐Deadlock complex in Drosophila melanogaster and simulans. In both species, one Rhino binds the N‐terminal helix–hairpin–helix motif of one Deadlock protein through a novel interface formed by the beta‐sheet in the Rhino chromoshadow domain. Disrupting the interface leads to infertility and transposon hyperactivation in flies. Our structural and functional experiments indicate that electrostatic repulsion at the interaction interface causes cross‐species incompatibility between the sibling species. By determining the molecular architecture of this piRNA‐producing machinery, we discover a novel HP1‐partner interacting mode that is crucial to piRNA biogenesis and transposon silencing. We thus explain the cross‐species incompatibility of two sibling species at the molecular level. [ABSTRACT FROM AUTHOR]

Fault tolerance is increasingly important in high-performance computing due to the substantial growth of system scale and decreasing system reliability. In-memory/diskless checkpoint has gained extensive attention as a solution to avoid the IO bottleneck of traditional disk-based checkpoint methods. However, applications using previous in-memory checkpoint suffer from little available memory space. To provide high reliability, previous in-memory checkpoint methods either need to keep two copies of checkpoints to tolerate failures while updating old checkpoints or trade performance for space by flushing in-memory checkpoints into disk. In this paper, we propose a novel in-memory checkpoint method, called self-checkpoint, which can not only achieve the same reliability of previous in-memory checkpoint methods, but also increase the available memory space for applications by almost 50 percent. To validate our method, we apply self-checkpoint method to an important problem: High-Performance Linpack (HPL) with fault tolerance. We implement a scalable and fault tolerant HPL based on this new method, called SKT-HPL, and validate it on two large-scale systems. Experimental results with 24,576 processes show that SKT-HPL achieves over 95 percent of the performance of the original HPL. Compared to the state-of-the-art in-memory checkpoint method, it improves the available memory size by 47 percent and the performance by 5 percent. [ABSTRACT FROM AUTHOR]

In the past two decades, the reaction mechanism of C−C bond formation from either methanol or dimethyl ether (DME) in the methanol-to-hydrocarbons (MTH) process has been a highly controversial issue. Described here is the first observation of a surface methyleneoxy analogue, originating from the surface-activated DME, by in situ solid-state NMR spectroscopy, a species crucial to the first C−C bond formation in the MTH process. New insights into the first C−C bond formation were provided, thus suggesting DME/methanol activation and direct C−C bond formation by an interesting synergetic mechanism, involving C−H bond breakage and C−C bond coupling during the initial methanol reaction within the chemical environment of the zeolite catalyst. [ABSTRACT FROM AUTHOR]

In the past two decades, the reaction mechanism of C−C bond formation from either methanol or dimethyl ether (DME) in the methanol-to-hydrocarbons (MTH) process has been a highly controversial issue. Described here is the first observation of a surface methyleneoxy analogue, originating from the surface-activated DME, by in situ solid-state NMR spectroscopy, a species crucial to the first C−C bond formation in the MTH process. New insights into the first C−C bond formation were provided, thus suggesting DME/methanol activation and direct C−C bond formation by an interesting synergetic mechanism, involving C−H bond breakage and C−C bond coupling during the initial methanol reaction within the chemical environment of the zeolite catalyst. [ABSTRACT FROM AUTHOR]

Data flow systems allow the user to design a flow diagram that specifies the relations between system components which process, filter or visually present the data. Visualization systems may benefit from user-defined data flows as an analysis typically consists of rendering multiple plots on demand and performing different types of interactive queries across coordinated views. In this paper, we propose VisFlow, a web-based visualization framework for tabular data that employs a specific type of data flow model called the subset flow model. VisFlow focuses on interactive queries within the data flow, overcoming the limitation of interactivity from past computational data flow systems. In particular, VisFlow applies embedded visualizations and supports interactive selections, brushing and linking within a visualization-oriented data flow. The model requires all data transmitted by the flow to be a data item subset (i.e. groups of table rows) of some original input table, so that rendering properties can be assigned to the subset unambiguously for tracking and comparison. VisFlow features the analysis flexibility of a flow diagram, and at the same time reduces the diagram complexity and improves usability. We demonstrate the capability of VisFlow on two case studies with domain experts on real-world datasets showing that VisFlow is capable of accomplishing a considerable set of visualization and analysis tasks. The VisFlow system is available as open source on GitHub. [ABSTRACT FROM AUTHOR]

This study investigates the efficiency of carbon nanotubes (CNTs) as reinforcement for polypropylene (PP) for biocompatible application as a function of different surface functionalization of CNTs. PP composites were reinforced using various CNTs: single- and multi-walled carbon nanotubes (SWCNTs, MWCNTs), SWCNTs were covalently functionalized by plasma, for comparison, the MWCNTs were functionalized noncovalently. Different CNTs were incorporated into PP by solution blending. The type of CNTs and surface functionalization affects the mechanical and biocompatibility results significantly. Differences in nanostructure and the chemical compositions, number of functional groups, and structural defects for the CNTs may be the key factors affecting the mechanical properties and biocompatibility of PP nanocomposites compared to the neat PP. Finally, suitable CNTs and surface functionalization of CNTs were selected for making the PP/CNTs composites. [ABSTRACT FROM PUBLISHER]

With recent advances on mobile computing, power consumption has become a significant limiting constraint for many graphics applications. As a result, rendering on a power budget arises as an emerging demand. In this paper, we present a real-time, power-optimal rendering framework to address this problem, by finding the optimal rendering settings that minimize power consumption while maximizing visual quality. We first introduce a novel power-error, multi-objective cost space, and formally formulate power saving as an optimization problem. Then, we develop a two-step algorithm to efficiently explore the vast power-error space and leverage optimal Pareto frontiers at runtime. Finally, we show that our rendering framework can be generalized across different platforms, desktop PC or mobile device, by demonstrating its performance on our own OpenGL rendering framework, as well as the commercially available Unreal Engine. [ABSTRACT FROM AUTHOR]

Enhanced visible light photocatalytic activity of BiWO photocatalyst modified with different ratio of polyvinyl pyrrolidone (PVP) was synthesized by a facile solvothermal process. The as-prepared photocatalysts were characterized by X-ray diffraction, field emission scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, UV-Vis diffuse reflectance spectra and photoluminescence spectra. The results indicated that the addition of PVP could control the particle morphology of bismuth tungstate catalyst to form high phase purity of BiWO. The solvent-thermal reaction time was critical in deciding the structure and shapes of the catalysts, and the optimal solvent-thermal reaction time was 24 h. The photocatalytic activities of the PVP-BiWO catalysts were determined by photocatalytic degradation of tetracycline hydrochloride (TCH) in aqueous solution under visible light irradiation. Optical properties and the TCH degradation results showed that PVP-BiWO catalysts exhibited enhanced photodegradation for TCH under visible-light irradiation. Among them, P5 (PVP % = 1.0 wt%) exhibited the best photocatalytic activity for degradation ratio of TCH reaching 86.88 % in 90 min. [ABSTRACT FROM AUTHOR]

A novel fluoride ion adsorbent, which uses natural clay modified by lanthanum and aluminum, was successfully prepared. The adsorbent was characterized by scanning electron microscope, BET surface area measurement, and X-ray photoelectron spectroscopy. Batch experiments were carried out to investigate the adsorbent performance for fluoride ion. Fluoride ion adsorbent onto modified clay followed the pseudo-second order kinetic model with the correlation coefficient value of 0.9846. The isotherm data was well fitted to the Langmuir model. The adsorption capacity of the modified clay was 1.3033 mg/g. The optimum pH value for fluoride ion removal was 6. The modified clay adsorbent can be regenerated by KAl(SO4)2·12H2O. Six times’ regeneration experiments showed that the regeneration rate of the modified clay still higher than 80 %, and the mass loss rate lower than 10 %. The modified clay performed strong adsorption capacity for fluoride ion and high regeneration rate. It could be a cost-effective adsorbent to remove fluoride from groundwater in undeveloped regions. [ABSTRACT FROM AUTHOR]