1. Three new lanostane triterpenoids and two new amides from Alternaria sp. with NLRP3 inflammasome inhibitory activity.
- Author
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Bi, De-Wen, Feng, Jian-, Pang, Wen-Hui, Yang, Peng-Yun, Xu, Yao-Jun, Aurang Zeb, Muhammad, Wang, Meng-Ru, Zhang, Xing-Jie, Li, Xiao-Li, Zhang, Rui-Han, Wang, Wei-Guang, and Xiao, Wei-Lie
- Subjects
LACTATE dehydrogenase ,AMIDES ,NLRP3 protein ,ALTERNARIA ,ETHYL acetate ,PHENOL oxidase - Abstract
Three new lanostane triterpenoids (1-3) along with two new amides fatty compounds (4-5) were isolated from the ethyl acetate extract of a culture of the endophytic fungus Alternaria sp. gx-2. Their structures were identified by 1D and 2D NMR spectral data and HRESIMS. Compounds 1-12 were evaluated for their anti-inflammatory and tyrosinase inhibition activities. The isolated compounds did not show inhibitory activities at a concentration of 100 μM against tyrosinase, while under the concentration of 10 μM, the release of lactate dehydrogenase (LDH) inhibition rate of compound 1 was 54.45%, indicating that compound 1 had moderate anti-inflammatory activity on the activation of NLRP3 inflammasome. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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