Aim: The aim of this study is to analyze the response and survival rate of pediatric Hodgkin's disease and investigate the parameters influencing the survival. Material and Method: Forty-three Hodgkin's disease (HD) patients who were treated in our Pediatric Hematology-Oncology Department between 1996-2011 were retrospectively analyzed. Twenty-three male and 20 female patients who were younger than 18 year newly diagnosed and untreated were included in the study. Results: The median age was nine years five months; one patient had stage I, 21 patients had stage II, 12 patients had stage III and nine patients had stage IV disease. Nineteen patients were in early stage disease and 24 patients were in advanced stage disease. The most common histological subtype was nodular sclerosis (22 patients). Eighteen of the patients had B symptoms. Hemoglobin levels, leukocyte count, erythrocyte sedimentation rates, serum copper, fibrinogen, lactic dehydrogenase, ferritin and haptoglobin levels were analyzed for response to treatment. Thirty-eight patients are alive, seven patients relapsed and five patients died. The median follow-up period was seven years four months. Mean overall survival was 12.66±0.70 years. Five-year overall survival was 85.99%. Mean overall survival for early stages was 13.10±0.81 years, and 12.56±0.96 years for late stages. Conclusions: Bulky disease was bad prognostic factor for OS. Female sex, bulky disease and nodular sclerosis histological subtype were adverse prognostic factors for disease free survival. [ABSTRACT FROM AUTHOR]