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Light therapies have been applied to millions of patients for treating many kinds of diseases, especially superficial ones. Currently, mainstream light therapies utilize the combined effects of photosensitizers and light to either remove disordered tissue or promote the growth of healthy tissue. Adverse effects of light therapy, including metabolic burden caused by circulatory photosensitizer and skin damage induced by high irradiance light, are yet to be addressed. This study provides a Miniaturized all-in-one Light therapy Device (MiLD). All components required for light therapy, including dual-function microneedles, LED array, control circuit, and battery are integrated together to form a miniaturized portable device with 2 cm in length, 1.7 cm in width, 1.2 cm in height, and 3.6 g in weight. The all-in-one design and patch-to-cure operation of MiLD enables the successful demonstration of point-of-care light therapy. Satisfactory therapeutic effects have been verified in mice on both types of light therapy. Meanwhile, transdermally co-delivering both photosensitizer and light in situ fully avoids photosensitizer accumulation in blood and remarkably reduces the irradiance of light, therefore significantly alleviating metabolic burden and light-induced skin damage. Overall, the MiLD lays the technical foundation of point-of-care light therapy with its miniaturized all-in-one design, simple patch-to-cure operation, satisfactory therapeutic effects, and minimum adverse effects. [ABSTRACT FROM AUTHOR]

In this study, the Chinese yam peel polysaccharide (CYPP) was obtained under the extraction conditions optimized by the Response Surface Methodology (RSM). Further biological properties of CYPP‐1 purified from CYPP were also determined. The results indicated that the optimum extraction conditions were an extraction temperature of 90.5°C, a liquid–solid ratio of 28.0 ml/g, and an extraction time of 2.94 h, along with a yield of 8.81 ± 1.48%. CYPP‐1 was identified as a kind of heteropolysaccharide mostly composed of glucose and galactose (59.4:1.0). The molecular weights were two main parts of 50.5 kDa (54.77%) and 4.4 kDa (21.02%), and the triple‐helix conformation was not formed in CYPP‐1. Besides, CYPP‐1 showed good biological properties including in vitro antioxidant activity and immunomodulatory function on RAW264.7 cells, as well as favorable hypoglycemic effect. Overall, the high‐value utilization of CYPP‐1 reveals a broad application prospect in the industrial production of functional foods and pharmaceuticals. Practical applications: Yam peel, which is discarded in large quantities during postharvest processing, results in the production of tremendous by‐products and is a great waste of resources. In this study, the yield of water‐soluble polysaccharide from yam peel reached 8.81 ± 1.48%. Besides, the purified CYPP‐1 exhibited excellent antioxidant activity, favorable immunomodulatory function, and hypoglycemic effect. The high productivity and bioactive effects are both great merits for Chinese yam peel polysaccharide as a promising candidate for foods and medicines industrial production. [ABSTRACT FROM AUTHOR]

Photodynamic therapy (PDT) is a minimally invasive method for treating oral leukoplakia. In this paper, we propose a portable PDT device consisting of a flexible circuit board with a liquid flow cooling module on the back. The light source size was 17 mm × 1 1 mm × 4 mm, and the irradiation area of the light source was up to 100 mm2. The irradiance range of this device was from 10 mW/cm2 to 100 mW/cm2. Simulation and experimental results showed that the irradiance coefficient variation for a treatment area of 81 mm2 was less than 7%. At an irradiance of 100 mW/cm2, a device surface temperature of lower than 42∘C can be achieved to satisfy the safety requirements under the conditions that the temperature of cooling liquid is 10∘C and the liquid flow speed is above 12 mL/min. [ABSTRACT FROM AUTHOR]

Irradiance uniformity is an important parameter for a Photodynamic Therapy (PDT) device. The calibration and verification of a LED array light source based on computer vision technology were implemented and carried out. First, the correlation coefficients between the pulse width modulate value and the irradiance were calibrated. Then, the correction of the actual light center and divergence angle were solved by image processing to reduce errors from each LED lens. Finally, uniformity was optimized according to the irradiance formula of the Lambertian source. The lowest coefficients of variation of irradiance were 4.87% in a 5 cm × 1 2 cm area and 3.55% in a 3 cm × 1 0 cm area within the depth range of 8–12 cm when the expected irradiance was 100 mW/cm2. This finding indicated that the light source can achieve a more uniform illumination and provide a better therapeutic effect for the PDT of port-wine stains. [ABSTRACT FROM AUTHOR]