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Objective: This study aims to develop and validate SwinHS, a deep learning-based automatic segmentation model designed for precise hippocampus delineation in patients receiving hippocampus-protected whole-brain radiotherapy. By streamlining this process, we seek to significantly improve workflow efficiency for clinicians. Methods: A total of 100 three-dimensional T1-weighted MR images were collected, with 70 patients allocated for training and 30 for testing. Manual delineation of the hippocampus was performed according to RTOG0933 guidelines. The SwinHS model, which incorporates a 3D ELSA Transformer module and an sSE CNN decoder, was trained and tested on these datasets. To prove the effectiveness of SwinHS, this study compared the segmentation performance of SwinHS with that of V-Net, U-Net, ResNet and VIT. Evaluation metrics included the Dice similarity coefficient (DSC), Jaccard similarity coefficient (JSC), and Hausdorff distance (HD). Dosimetric evaluation compared radiotherapy plans generated using automatic segmentation (plan AD) versus manual hippocampus segmentation (plan MD). Results: SwinHS outperformed four advanced deep learning-based models, achieving an average DSC of 0.894, a JSC of 0.817, and an HD of 3.430 mm. Dosimetric evaluation revealed that both plan (AD) and plan (MD) met treatment plan constraints for the target volume (PTV). However, the hippocampal Dmax in plan (AD) was significantly greater than that in plan (MD), approaching the 17 Gy constraint limit. Nonetheless, there were no significant differences in D100% or maximum doses to other critical structures between the two plans. Conclusion: Compared with manual delineation, SwinHS demonstrated superior segmentation performance and a significantly shorter delineation time. While plan (AD) met clinical requirements, caution should be exercised regarding hippocampal Dmax. SwinHS offers a promising tool to enhance workflow efficiency and facilitate hippocampal protection in radiotherapy planning for patients with brain metastases. [ABSTRACT FROM AUTHOR]

Ti-V-based alloys are proved of huge potential in storing hydrogen, but the incomplete reversible hydrogen storage capacity caused by overstability of V hydride has limited the large-scale application. In this study, Ti32V40+xFe23-xMn5 (x=0, 4, 8, 12, at.%) alloys were designed, and the effects of V/Fe ratio on phase constitution and hydrogen storage properties were investigated. The main phase of the alloys is body-centered cubic (BCC) phase, and the lattice constants of the BCC phase decrease with the decrease of V/Fe ratio. Moreover, C14 Laves phase exists in alloys with a Fe content of 19at.% to 23at.%. For hydrogenation, the C14 Laves phase can accelerate the hydrogen absorption rate, but the hydrogen absorption capacity is reduced. With the decrease of V/Fe ratio, the hydride gradually destabilizes. Owing to its large lattice constant and high hydrogen absorption phase content, the Ti32V52Fe11Mn5 alloy shows the most enhanced hydrogen storage properties with hydrogenation and dehydrogenation capacities of 3.588wt.% at 298 K and 1.688wt.% at 343 K, respectively. The hydrogen absorption capacity of this alloy can be reserved to 3.574wt.% after 20 cycles of hydrogen absorption and desorption. [ABSTRACT FROM AUTHOR]

Objective: Rare coexistence of disease or pathology Background: Odontogenic keratocyst (OKC) is a common odontogenic cyst, and it occurs more frequently in the mandible, with the posterior region of the dental arch, the angle, or the ramus being the most commonly affected sites. Odontogenic keratocyst occurring within the maxillary sinus is extremely rare, accounting for only about 1% of cases. Case Report: A 20-year-old female patient without any clinical symptoms underwent an oral examination, during which a dense dental shadow was identified within the maxillary sinus, surrounded by a low-density shadow. Physical examination revealed absence of the left maxillary third molar, with intact mucosa. The patient reported no history of tooth extraction. X-ray and cone-beam computed tomography revealed a high-density image within the left maxillary sinus, resembling a tooth and surrounded by a soft-tissue shadow, which exhibited a greater density in comparison to conventional odontogenic cysts. The initial diagnosis was odontogenic keratocyst in the maxillary sinus with an ectopic maxillary third molar. Surgical enucleation of the cyst and extraction of the impacted tooth were carried out utilizing the Caldwell-Luc approach. Histopathological analysis confirmed the presence of OKC. No significant recurrence was noted during the 6 months of follow-up. Conclusions: Odontogenic keratocysts in the maxillary sinus with ectopic third molar are rare and may not have any symptoms in the early stage. Surgery can be performed using the Caroler-Luke approach to achieve ideal treatment results. In view of the high recurrence rate of OKC, close follow-up should be conducted after surgery. [ABSTRACT FROM AUTHOR]

Objective: To assess the effects of COVID-19 pandemic on the epidemiology of neonatal sepsis and the antibiotic resistance profiles of pathogens involved. Methods: This retrospective cohort study analyzed infants diagnosed with culture-proven sepsis at the neonatal department of a tertiary children's hospital in East China from January 2016 to December 2022. We compared the clinical and microbiological characteristics of neonatal sepsis cases between the pre-pandemic Phase I (2016-2019) and during the COVID-19 pandemic Phase II (2020-2022). Results: A total of 507 infants with 525 sepsis episodes were included, with 343 episodes in Phase I and 182 in Phase II. The incidence of early-onset sepsis (EOS) was significantly lower during Phase II (p < 0.05). Infants in Phase II had lower gestational ages and birth weights compared to Phase I. Clinical signs such as mottled skin, severe anemia, thrombocytopenia were more prevalent in Phase II, alongside a higher incidence of complications. Notably, necrotizing enterocolitis (NEC) (p < 0.05) and meningitis (p < 0.1) occurred more frequently during Phase II. Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) were the predominant pathogens isolated from infants of death and cases with complications. A significant decrease in the proportion of K. pneumoniae was observed in Phase II, alongside increased antibiotic resistance in both E. coli and K. pneumoniae. The period of the COVID-19 pandemic (Phase II) was identified as an independent risk factor for complications in infants with neonatal sepsis. Conclusion: COVID-19 pandemic response measures correlated with a decrease in EOS and an increase in neonatal sepsis complications and antibiotic resistance. [ABSTRACT FROM AUTHOR]

Pancreatic adenocarcinoma (PAAD) is one of the most aggressive digestive system tumors in the world, with a low early diagnosis rate and a high mortality. Integrin beta 5 (ITGB5) is demonstrated to be a potent tumor promoter in several carcinomas. However, it is unknown whether ITGB5 participates in the occurrence and development of PAAD. In this study, we confirmed a high expression of ITGB5 in PAAD and its role in promoting invasiveness and transitivity in PAAD. Besides, the knockdown of ITGB5 increased cell sensitivity to radiation by promoting DNA damage repair and the MEK/ERK signaling pathway. Collectively, these results show that ITGB5 plays an essential role in pancreatic cancer growth and survival. [ABSTRACT FROM AUTHOR]

Image super-resolution (SR) is a technique to recover lost high-frequency information in low-resolution (LR) images. Since spatial-domain information has beenwidely exploited, there is a newtrend to involve frequencydomain information in SR tasks. Besides, image SR is typically application-oriented and various computer vision tasks call for image arbitrary magnification. Therefore, in this article, we study image features in the frequency domain to design a novel image arbitrary-scale SR network. First, we statistically analyze LRHR image pairs of several datasets under different scale factors and find that the high-frequency spectra of different images under different scale factors suffer from different degrees of degradation, but the valid lowfrequency spectra tend to be retained within a certain distribution range. Then, based on this finding, we devise an adaptive scale-aware feature division mechanism using deep reinforcement learning, which can accurately and adaptively divide the frequency spectrum into the low-frequency part to be retained and the high-frequency one to be recovered. Finally, we design a scale-aware feature recovery module to capture and fuse multi-level features for reconstructing the high-frequency spectrum at arbitrary scale factors. Extensive experiments on public datasets show the superiority of our method compared with state-of-the-art methods. [ABSTRACT FROM AUTHOR]

Detecting points of interest is a fundamental problem in 3D shape analysis and can be beneficial to various tasks in multimedia processing. Traditional learning-based detection methods usually rely on each vertex's geometric features to discriminate points of interest from other vertices. Observing that points of interest are related to not only geometric features on themselves but also the geometric features of surrounding vertices, we propose a novel context-aware 3D points of interest detection algorithm by adopting the spatial attention mechanism in this article. By designing a context attention module, our approach presents a novel deep neural network to simultaneously pay attention to the geometric features of vertices and their local contexts during extracting points of interest. To obtain satisfactory extraction results, our method adaptively assigns different weights to those features in a data-driven way. Extensive experimental results on SHREC 2007, SHREC 2011, and SHREC 2014 datasets show that our algorithm achieves superior performance over existing methods. [ABSTRACT FROM AUTHOR]

Coumarin-3-carboxylic acid (3-CCA), previously screened from natural coumarins, was found to possess strong antibacterial activity against Acidovorax citrulli (Ac). In order to further evaluate the activity of this compound against plant bacterial pathogens and explore its potential value as a bactericidal lead compound, the activity of 3-CCA against 14 plant pathogenic bacteria in vitro and in vivo was tested. Results showed that 3-CCA exhibited strong in vitro activities against Ac, Ralstonia solanacearum, Xanthomonas axonopodis pv. manihotis, X. oryzae pv. oryzae, and Dickeya zeae with EC50 values ranging from 26.64µg/mL to 40.73µg/mL. Pot experiment results showed that 3-CCA had powerful protective and curative effects against Ac. In addition, the protective efficiency of 3-CCA was almost equivalent to that of thiodiazole copper at the same concentration. The results of SEM and TEM observation and conductivity tests showed that 3-CCA disrupted the integrity of the cell membrane and inhibited polar flagella growth. Furthermore, 3-CCA resulted in reductions in motility and extracellular exopolysaccharide (EPS) production of Ac while inhibiting the biofilm formation of Ac. These findings indicate that 3-CCA could be a promising natural lead compound against plant bacterial pathogens to explore novel antibacterial agents. [ABSTRACT FROM AUTHOR]

Carbon deposition on nickel-based anodes is a key problem for solid oxide fuel cells (SOFCs) using hydrocarbon fuels. One of the solutions is doping with other elements. In this work, DFT calculations were used to systematically study the processes of continuous CH4 dehydrogenation, carbon formation, and carbon elimination on Ni(111) surfaces doped with different amounts of Cu. The Cu doping concentrations on the Ni surface are set as 0, 1/9, 4/9, 5/9, 8/9, and 1 ml, namely Ni(111), NiCu1, NiCu4, NiCu5, NiCu8, and Cu9. The adsorption energies and adsorption sites of the important substances were obtained by calculation. In addition, the kinetics and thermodynamics of the main reactions and potential carbon removal pathways are discussed. Prior studies have shown that the introduction of Cu weakens the interaction between the Ni-based surface and the absorber, thereby enhancing the activity of various species on the surface of Ni-based catalysts. Second, the methane cracking path on the Ni-based surface is CH4 → CH3 → CH2 → CH, and the paths on the other five surfaces are the same. We found that the addition of Cu can weaken the adsorption of C, inhibit the activity of CH4 dehydrogenation, and promote the binding of C to the intermediate medium on the Ni-based surface, thus improving the ability of carbon deposition resistance. Finally, based on our DFT calculations, several potential carbon removal pathways are discussed in detail, and it is believed that the problem of carbon removal on SOFC anodes should focus on the oxidation of CH while preventing its direct cracking. [ABSTRACT FROM AUTHOR]

To improve the accuracy of electrocardiography (ECG) signal classification and identify abnormal heart rhythms, an arrhythmia classification algorithm based on adaptive refined composite multiscale fluctuation dispersion entropy (ARCMFDE) is proposed. First, an improved QRS complex detection algorithm named the improved Pan-Tompkins algorithm (IPTA) is used. The QRS wave is detected, and the waveform is further processed; then, the signal is decomposed into multiple modal components using variational mode decomposition with the optimized number of decomposition layers (K). Subsequently, the RCMFDE is extracted from the different modal components as a classification feature. Finally, differential evolution (DE) and grey wolf optimization (GWO) are combined to form the hybrid differential evolution-grey wolf pack optimization (DE-GWO) algorithm to optimize the penalty factor c and the kernel function parameter g of the support vector machine for performing pattern recognition. Experimental results show that compared with other methods such as variational mode decomposition (VMD), fluctuation dispersion entropy (FDE), genetic algorithms (GA), and support vector machine (SVM). The proposed classification model has superior performance, with an average accuracy of 96.1%, a sensitivity of 95.9%, and a specificity of 98.7% for four types of heart rhythm recognition. Thus, accurate classification of ECG signals can be achieved using the proposed ARCMFDE-based DE-GWO method. [ABSTRACT FROM AUTHOR]

Background: JAK inhibitors treat various autoimmune diseases, but an updated systematic review in treating alopecia areata is currently lacking. Objective: Evaluate the specific efficacy and safety of JAK inhibitors in alopecia areata by systematic review and meta-analysis. Methods: Eligible studies in PubMed, Embase, Web of Science, and Clinical Trials up to May 30, 2022, were searched. We enrolled in randomized controlled trials and observational studies of applying JAK inhibitors in alopecia areata. Results: 6 randomized controlled trials with 1455 patients exhibited SALT50 (odd ratio [OR], 5.08; 95% confidence interval [CI], 3.49-7.38), SALT90 (OR, 7.40; 95% CI, 4.34-12.67) and change in SALT score (weighted mean difference [WSD], 5.55; 95% CI, 2.60-8.50) compared to the placebo. The proportion of 26 observational studies with 563 patients of SALT5 was 0.71(95% CI, 0.65-0.78), SALT50 was 0.54 (95% CI 0.46-0.63), SALT90 was 0.33(95% CI, 0.24-0.42), and SALT score (WSD, -2.18; 95% CI, -3.12 to -1.23) compared with baseline. Any adverse effects occurred in 921 of 1508 patients; a total of 30 patients discontinued the trial owing to adverse reactions. Limitations: Few randomized controlled trials met the inclusion criteria and insufficiency of eligible data. Conclusion: JAK inhibitors are effective in alopecia areata, although associated with an increased risk. [ABSTRACT FROM AUTHOR]

Background: Proteus mirabilis is one of the pathogens commonly causing urinary tract infections (UTIs). The molybdate-binding protein ModA encoded by modA binds molybdate with high affinity and transports it. Increasing evidence shows that ModA promotes the survival of bacteria in anaerobic environments and participates in bacterial virulence by obtaining molybdenum. However, the role of ModA in the pathogenesis of P. mirabilis remains unknown. Results: In this study, a series of phenotypic assays and transcriptomic analyses were used to study the role of ModA in the UTIs induced by P. mirabilis. Our data showed that ModA absorbed molybdate with high affinity and incorporated it into molybdopterin, thus affecting the anaerobic growth of P. mirabilis. Loss of ModA enhanced bacterial swarming and swimming and up-regulated the expression of multiple genes in flagellar assembly pathway. The loss of ModA also resulted in decreased biofilm formation under anaerobic growth conditions. The modA mutant significantly inhibited bacterial adhesion and invasion to urinary tract epithelial cells and down-regulated the expression of multiple genes associated with pilus assembly. Those alterations were not due to anaerobic growth defects. In addition, the decreased bacteria in the bladder tissue, the weakened inflammatory damage, the low level of IL-6, and minor weight change was observed in the UTI mouse model infected with modA mutant. Conclusion: Here, we reported that in P. mirabilis, ModA mediated the transport of molybdate, thereby affecting the activity of nitrate reductase and thus affecting the growth of bacteria under anaerobic conditions. Overall, this study clarified the indirect role of ModA in the anaerobic growth, motility, biofilm formation, and pathogenicity of P. mirabilis and its possible pathway, and emphasized the importance of the molybdate-binding protein ModA to P. mirabilis in mediating molybdate uptake, allowing the bacterium to adapt to complex environmental conditions and cause UTIs. Our results provided valuable information on the pathogenesis of ModA-induced P. mirabilis UTIs and may facilitate the development of new treatment strategies. [ABSTRACT FROM AUTHOR]

Magnoliids are the largest flowering plant clades outside of the eudicots and monocots, which are distributed worldwide and have high economic, ornamental and ecological values. Eudicots, monocots and magnoliids are the three major clades of Mesangiospermae, and their phylogenetic relationship is one of the most interesting issues. In recent years, with the continuous accumulation of genomic information, the evolutionary status of magnoliids has become a hot spot in plant phylogenetic research. Although great efforts have been made to study the evolution of magnoliids using molecular data from several representative species such as nuclear genome, plastid genome, mitochondrial genome, and transcriptome, the results of current studies on the phylogenetic status of magnoliids are inconsistent. Here, we systematically describe the current understanding of the molecular research on magnoliid phylogeny and review the differences in the evolutionary state of magnoliids. Understanding the research approaches and limitations of magnoliid phylogeny can guide research strategies to further improve the study of the phylogenetic evolution of magnoliids. [ABSTRACT FROM AUTHOR]

The article discusses the collaborative relative navigation problem for near-circular orbiting small satellites in close-range under GNSS denied environment. Topics include the orbital propagation model for the relative motion of multi-spacecraft is established based on Hill-Clohessy-Wiltshire dynamics; consensus constraint model for the relative orbit state is constructed by introducing the geometry constraint between the spacecraft, and digital simulations conducted to verify the algorithm.

Fungal infection is a serious global health issue, causing approximately 1.5 million mortalities annually. However, clinically available anti-fungal drugs are limited, especially for multidrug-resistant fungal infections. Therefore, new antifungal drugs are urgently needed to address this clinical challenge. In this study, we proposed two non-antifungal drugs, auranofin and pentamidine, in combination to fight against multidrug-resistant C. albicans. The insufficient antifungal activity of anti-rheumatic drug auranofin is partially due to fungal membrane barrier preventing the drug uptake, and anti-protozoal drug pentamidine was used here to improve the permeability of membrane. The auranofin/pentamidine combination displayed synergistic inhibitory effect against both drug-susceptible and drug-resistant C. albicans, as well as biofilm, and significantly reduced the minimum inhibitory concentration of each drug. At non-antifungal concentration, pentamidine can disrupt the membrane integrity and increase membrane permeability, leading to enhanced cellular uptake of auranofin in C. albicans. This repurposing strategy using the combination of non-antifungal drugs with complementary antifungal mechanism may provide a novel approach for discovery of antifungal drugs to fight against multidrug-resistant fungal infections. [ABSTRACT FROM AUTHOR]

Objective: To understand the occurrence of atopic dermatitis (AD) in children aged 2 years on exposure to maternal group B streptococcus (GBS) antibiotic prophylaxis (IAP).Design: Retrospective cohort study of 2909 mother-child pairs.Setting: Taixing People's Hospital in Eastern China.Participants: Term infants born 2018-2019, followed longitudinally from birth to 2 years.Exposures: The GBS-IAP was defined as therapy with intravenous penicillin G or ampicillin or cefazolin ≥ 4 h prior to delivery to the mother. Reference infants were defined as born without or with other intrapartum antibiotic exposure.Outcomes: The logistic regression models were employed to analyze the effect of intrapartum GBS prophylaxis on AD in 2-year-old children during delivery. Analysis was a priori stratified according to the mode of delivery and adjusted for relevant covariates.Results: The cohorts showed that preventive GBS-IAP was potentially associated with increased incidence of AD in children delivered vaginally according to logistic regression models before and after covariate-adjusted treatment (OR: 6.719,95% CI: 4.730-9.544,P < 0.001;aOR: 6.562,95% CI: 4.302-10.008, P < 0.001).Conclusion: Prophylactic treatment of intrapartum GBS may raise the risk of AD in vaginally delivered children. These findings highlight the need to better understand the risk between childhood AD and current GBS-IAP intervention strategies. [ABSTRACT FROM AUTHOR]

Booking decision is a typical decision-making behavior in hospitality, while the neural processing of it is still unclear. To address this issue, with the help of event-related potential (ERP), this work uncovered the neural mechanism of the influence of two extrinsic cues, namely, brand familiarity (familiar vs. unfamiliar) and online reviews (positive vs. negative) on online hotel booking decisions. Behavioral results indicated that the booking rate under the condition of positive reviews was higher than that of negative reviews. In addition, the response time in the case of familiar brands was longer than that of unfamiliar brands. ERP results showed that the P200 amplitude of familiar brands was smaller than that of unfamiliar brands, while for the late positive potential amplitude, the opposite was the case. It is suggested that in the early stage of cognitive processing, unfamiliar brands evoke more automatic and unconscious attention while in the later stage, familiar brands attract more conscious attention. This study also found that the N400 amplitude of negative online reviews was larger than that of positive online reviews, indicating that negative stimuli can result in a larger emotional conflicts than that of positive stimuli. This study provides new insights into the neural mechanism of online booking decisions in the hospitality. [ABSTRACT FROM AUTHOR]

Objective: To investigate whether extending adjuvant temozolomide (TMZ) improved the prognosis of newly diagnosed glioblastoma (GBM) patients with different mutation statuses of O6-methylguanine DNA methyltransferase (MGMT), isocitrate dehydrogenase 1 (IDH1), p53 and different expression level of Ki67. Methods: This study was a retrospective cohort study that postoperative patients with newly diagnosed GBM who did not progress after receiving radiotherapy with concomitant and 6 cycles of adjuvant TMZ were enrolled in control group, and those received more than 6 cycles of adjuvant TMZ were incorporated in extended group. Patients were stratified by MGMT expression, IDH1 mutation, p53 mutation and expression level of Ki67. The primary endpoints were overall survival (OS) and progression-free survival (PFS). Result: A total of 93 postoperative patients with newly diagnosed GBM were included in this study, 40 and 53 cases were included in control group and extended group, respectively. On the whole, extended adjuvant TMZ chemotherapy significantly prolonged OS and PFS of patients with newly diagnosed GBM [median OS (mOS): 29.00 months vs. 16.70 months, P < 0.001; median PFS (mPFS): 13.80 months vs. 9.60 months, P = 0.002]. The results of subgroup analysis showed that patients with methylated MGMT in extended group had significantly longer OS and PFS than those in control group; patients with IDH1 mutation benefited more from extended adjuvant TMZ chemotherapy than those with wild-type IDH1; there was no significant difference in the effect of extended TMZ chemotherapy on OS between GBM patients with wild-type p53 and those with mutant p53; compared with GBM patients with lower expression of Ki67, extended adjuvant TMZ treatment dramatically improved the OS and PFS of those with higher expression of Ki67. Conclusion: The therapeutic schedule of extended adjuvant TMZ significantly prolonged OS and PFS of patients with newly diagnosed GBM regardless of p53 mutation status, and patients with different MGMT methylation, IDH1 mutation and Ki67 expression level benefited differently from extended adjuvant TMZ chemotherapy. [ABSTRACT FROM AUTHOR]

As a noninvasive imaging technique for the interior of objects, Electrical Impedance Tomography (EIT) is widely used in many fields of biomedicine. Sparse reconstruction algorithms have made major breakthroughs in the field of image reconstruction in recent years. The K-SVD algorithm is an adaptive dictionary signal sparse representation algorithm, which could improve the reconstruction accuracy. However, the parameters in the K-SVD algorithm are fixed, which cannot match all the measurement data of EIT very well. Moreover, the K-SVD algorithm adopts a greedy algorithm in the sparse coding stage, which has high computational complexity. In this study, an electrical impedance sparse imaging method based on DK-SVD (deep k-singular value decomposition) was designed. It provides the corresponding optimal model parameters for each set of measurement data through the method of multi-layer perceptron (MLP) network training, thereby improving the imaging quality. At the same time, the iterative soft threshold algorithm (ISTA) is used in the sparse coding stage to improve the convergence speed. The reconstruction results show that compared with the KSVD algorithm and Total Variation (TV) algorithm, the reconstruction error of the DK-SVD method is smaller, and the irregular and sharp inclusions can be accurately reconstructed. Image artifacts are also greatly reduced. [ABSTRACT FROM AUTHOR]

Photodynamic therapy (PDT)-mediated oxidation treatment is extremely attractive for skin melanoma ablation, but the strong hydrophobicity and poor tumor selectivity of photosensitizers, as well as the oxygen-consuming properties of PDT, leading to unsatisfactory therapeutic outcomes. Herein, a tumor acidic microenvironment activatable dissolving microneedle (DHA@HPFe-MN) was developed to realize controlled drug release and excellent chemo-photodynamic therapy of melanoma via oxidative stress amplification. The versatile DHA@HPFe-MN was fabricated by crosslinking a selfsynthesized protoporphyrin (PpIX)-ADH-hyaluronic acid (HA) conjugate HA-ADH-PpIX with "iron reservoir" PA-Fe3+ complex in the needle tip via acylhydrazone bond formation, and dihydroartemisinin (DHA) was concurrently loaded in the hydrogel network. HA-ADH-PpIX with improved water solubility averted undesired aggregation of PpIX to ensure enhanced PDT effect. DHA@HPFe-MN with sharp needle tip, efficient drug loading and excellent mechanical strength could efficiently inserted into skin and reach the melanoma sites, where the acidic pH triggered the degradation of microneedles, enabling Fe-activated and DHA-mediated oxidation treatment, as evidenced by abundant reactive oxygen species (ROS) generation. Moreover, under light irradiation, a combined chemo-photodynamic therapeutic effect was achieved with amplified ROS generation. Importantly, the Fecatalyzed ROS production of DHA was oxygen-independent, which work in synergy with the oxygen-dependent PDT to effectively destroy tumor cells. This versatile microneedles with excellent biosafety and biodegradability can be customized as a promising localized drug delivery system for combined chemo-photodynamic therapy of melanoma. [ABSTRACT FROM AUTHOR]

Depression is a common comorbid symptom in patients with chronic insomnia disorder (CID). Previous neuroimaging studies found that the orbital frontal cortex (OFC) might be the core brain region linking insomnia and depression. Here, we used a machine learning approach to differentiate CID patients with depressive symptoms from CID patients without depressive symptoms based on OFC functional connectivity. Seventy patients with CID were recruited and subdivided into CID with high depressive symptom (CIDHD) and low depressive symptom (CID-LD) groups. The OFC functional connectivity (FC) network was constructed using the altered structure of the OFC region as a seed. A linear kernel SVM-based machine learning approach was carried out to classify the CID-HD and CID-LD groups based on OFC FC features. The predict model was further verified in a new cohort of CID group (n = 68). The classification model based on the OFC FC pattern showed a total accuracy of 76.92% (p = 0.0009). The area under the receiver operating characteristic curve of the classification model was 0.84. The OFC functional connectivity with reward network, salience network and default mode network contributed the highest weights to the prediction model. These results were further validated in an independent CID group with high and low depressive symptom (accuracy = 67.9%). These findings provide a potential biomarker for early diagnosis and intervention in CID patients comorbid with depression based on an OFC FC-based machine learning approach. [ABSTRACT FROM AUTHOR]

For a blood pump, high shear stress and bearing wear produced by its high rotational speed are the major factors causing mechanical damage to blood cells inside the pump. To eliminate frictional damage to blood cells, a novel magnetic levitation (maglev) nutation blood pump with low speed and small volume flow is developed in this study. The flow-field characteristics and hemolysis performance of the newly designed blood pump are analyzed and the feasibility of its design is demonstrated. We use computational fluid dynamics and the dynamic grid method to solve the unsteady 3D Navier-Stokes equation in conjunction with the standard k-e model to simulate and analyze the internal flow field of the blood pump. In an in vitro experiment, an in vitro circulation loop system including four monitoring sensors is established and fresh sheep blood is used as the circulating medium. The flow pressure is tested by adjusting the speed and load of the pump. To calculate the normalized index of hemolysis (NIH) of sheep blood, its plasma-free hemoglobin and hematocrit levels are detected simultaneously. The prediction results of velocity, pressure, and shear stress distributions in the 3D flow field of the pump demonstrate that our newly designed pump has an antithrombotic property and will not cause serious blood damage. The in vitro experiment suggests that a continuous output of more than 5 L/min can be obtained at a 100 mmHg pressure load and that the output flow of the pump is stable at different pressures. The NIH of the nutation pump is 0.0039 ± 0.0006 g/100 L. The research results reveal that our newly designed maglev nutation blood pump has good hemolytic performance and a stable hydraulic property that can meet the requirements for animal experiments. [ABSTRACT FROM AUTHOR]

Quantum transducers that can convert quantum signals from the microwave to the optical domain are a crucial optical interface for quantum information technology. Coherent microwave-to-optics conversions have been realized with various physical platforms, but all of them are limited to low efficiencies of less than 50%—the threshold of the no-cloning quantum regime. Here we report coherent microwave-to-optics transduction using Rydberg atoms and off-resonant scattering technique with an efficiency of 82 ± 2% and a bandwidth of about 1 MHz. The high conversion efficiency is maintained for microwave photons ranging from thousands to about 50, suggesting that our transduction is readily applicable to the single-photon level. Without requiring cavities or aggressive cooling for the quantum ground states, our results would push atomic transducers closer to practical applications in quantum technologies. The demonstration of high-efficiency coherent microwave-to-optics conversion could push atomic transducers closer to practical applications in quantum technologies. [ABSTRACT FROM AUTHOR]

Necroptosis, a distinctive type of programmed cell death different from apoptosis or necrosis, triggered by a series of death receptors such as tumor necrosis factor receptor 1 (TNFR1), TNFR2, and Fas. In case that apoptosis process is blocked, necroptosis pathway is initiated with the activation of three key downstream mediatorswhich are receptor-interacting serine/threonine protein kinase 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like protein (MLKL). The whole process eventually leads to destruction of the cell membrane integrity, swelling of organelles, and severe inflammation. Over the past decade, necroptosis has been found widely involved in life process of human beings and animals. In this review, we attempt to explore the therapeutic prospects of necroptosis regulators by describing its molecular mechanism and the role it played in pathological condition and tissue homeostasis, and to summarize the research and clinical applications of corresponding regulators including small molecule inhibitors, chemicals, Chinese herbal extracts, and biological agents in the treatment of various diseases. [ABSTRACT FROM AUTHOR]

Rotor stability is an important index of the performance of a magnetically levitated blood pump. In this study, we developed a novel nutation blood pump using a passive magnetic spherical bearing to achieve dynamic stability of a levitated rotor. The structure and working principle of the proposed blood pump are first introduced. A mathematical model based on the theory of equivalent magnetic charges is derived to calculate the axial and rotational stiffnesses of the passive magnetic spherical bearing. Furthermore, considering the gyro effect on the dynamic stability, an analytical expression for the gyroscopic moment of the nutating rotor is deduced. Finally, a prototype of a self-designed blood pump is fabricated, and a hydraulic experiment on the real-time levitation state is carried out. Experimental results obtained via different sensing components show that a continuous output flow rate of 5 L/min can be obtained against a pressure head of 100 mmHg at a rotational speed of 1600 rpm, and the output flow conditions are found to be stable at various pressures. In addition, it is found that the rotor becomes more stable with increasing rotational speed. The maximum fluctuation of the levitated gap is only 0.2 mm when the rotational speed of the rotor is 2300 rpm. [ABSTRACT FROM AUTHOR]

In the task of Person re-identification (reID), the range of motion of pedestrians often spans multiple camera areas, and their motion direction and behavior cannot be constrained, and irrelevant people or objects in different scenes will also obtain target pedestrian information for us Cause interference. At the same time, the surveillance system also has many characteristics such as a fixed shooting angle of a single camera, different angles between different cameras, and low image resolution. These characteristics make the task of Person re-identification difficult. This paper proposes a Multi-level Feature Extraction Network (MFEN) based on SEResNet-50. Extracting richer and more diverse pedestrian features from poor-quality images will effectively improve the re-identification ability of the network, and MFEN can obtain Multistage key features in the image through the Feature Re-extraction Method (FRM) proposed in this paper. Experiments show that compared with AANet-50, MFEN has 3.85% /0.71% improvements of mAP/ Rank-1 on the Market1501 dataset, and 2.74% /1.28% improvements of mAP/ Rank-1 on the DukeMTMC-reID dataset. [ABSTRACT FROM AUTHOR]

Obesity is an escalating global pandemic posing a serious threat to human health. The intervention therapy using weight-reducing drugs, accompanied by lifestyle modification, is a strategy for the treatment of obesity. In the present study, we explored the role of fucoidan, a seaweed compound, on high-fat diet (HFD)-induced obesity in mice. We found that fucoidan treatment significantly reduced the body fat and caused redistribution of visceral and subcutaneous fat in HFD-fed mice. Meanwhile, fucoidan treatment inhibited adipocyte hypertrophy and inflammation in adipose tissue. Collectively, these results suggest that fucoidan may be a promising treatment for obesity and obesity-induced complications. [ABSTRACT FROM AUTHOR]

The global population is aging and the demand for critical care wards increasing. Aging is associated not only with physiological and cognitive vulnerability, but also with a decline in organ function. A new topic in geriatric care is how to appropriately use critical care resources and provide the best treatment plan for very old patients (VOPs). Our special geriatric intensive care unit has admitted nearly 500 VOPs. In this review, we share our VOP treatment strategy and summarize the key points as "ABCCDEFGHI bundles." The aim is to help intensivists to provide more comprehensive therapy for VOPs in intensive care units. [ABSTRACT FROM AUTHOR]

In order to improve the high-temperature deformation resistance and creep resistance of TiAl-based alloys, cold crucible directional solidification (CCDS) technology was employed. A β-type TiAl-based alloy with the nominal composition of Ti44Al6Nb1Cr2V was prepared using the optimized CCDS parameters of 45 kW input power and 0.5 mm·min-1 solidification rate. Thermo-compression testing was utilized to evaluate the hightemperature deformation resistance and creep resistance of the CCDS Ti44Al6Nb1Cr2V alloy. Results show that the CCDS Ti44Al6Nb1Cr2V alloy billets contain aligned columnar grains and a high percentage of small-angle lamellae. Thermo-compression testing results in the radial direction of the CCDS alloy show a much higher peak stress than other reported results in similar conditions. The much higher hardening exponent and deformation activation energy are obtained, corresponding to the excellent high-temperature deformation resistance and creep resistance, which are because of the hard-oriented grains, weaker stress-strain coordination capability of lamella structure and relatively more hysteretic dynamic recrystallization. Thermo-compression testing results in the longitudinal direction of the CCDS Ti44Al6Nb1Cr2V alloy show the much higher peak stress than that in the radial direction, indicating the better high-temperature deformation resistance and creep resistance attributed to the hard-oriented lamellae in this condition. [ABSTRACT FROM AUTHOR]

Background: Listeriosis is a rare but severe foodborne infectious disease. Perinatal listeriosis is often associated with septicemia, central nervous system (CNS) infection, and serious adverse pregnancy outcomes (miscarriage and neonate death). Here we report the characteristics and outcomes of perinatal listeriosis cases treated over 6 years at Beijing Obstetrics and Gynecology Hospital (BOGH), the largest maternity hospital in China.Methods: We retrospectively reviewed the records of laboratory-confirmed, pregnancy-associated listeriosis cases treated from January 1, 2013 to December 31, 2018. The clinical manifestations, laboratory results, perinatal complications and outcomes (post-natal follow-up of 6 months) were investigated.Results: In BOGH, 12 perinatal listeriosis cases were diagnosed based on Listeria monocytogenes positive culture, including 10 single pregnancies and 2 twin pregnancies. The corresponding incidence of pregnancy-associated listeriosis was 13.7/100,000 deliveries. Among those cases, four pregnant women and four newborns had septicemia, and two of the neonates with septicemia also suffered CNS infection. All the maternal patients recovered. Two inevitable miscarriages and four fetal stillbirths occurred. Of the eight delivered newborns, six survived, and two died within 2 days from birth. None of the survivors had neurological sequelae during a 6-month follow-up. The overall feto-neonatal fatality rate was 57.1%; notably, this rate was 100% for infections occurring during the second trimester of pregnancy and only 14.3% for those occurring in the third trimester.Conclusions: Perinatal listeriosis is associated with high feto-neonatal mortality, and thus, a public health concern. Additional large-scale studies are needed to strengthen the epidemiological understanding of listeriosis in China. [ABSTRACT FROM AUTHOR]

In view of the disadvantages of various types of industrial close-boiling liquid mixtures and azeotropic as well as high energy consumption and easy pollution caused by traditional separation methods, the integrated distillation-membrane separation process has obvious economic advantages of energy saving and consumption reduction. The systematic and economic research is helpful to realize the win-win of environment and economy. In this paper, a comprehensive solution strategy for the integrated distillation-membrane separation process based on intelligent genetic programming (GP) is proposed. According to the characteristics of the material system and separation requirements, the most suitable membrane type and material can be matched, and then the most economical and environmentally friendly new distillation-membrane separation process can be calculated quickly. On this basis, the hot issues related to chemical industry are further discussed, including energy saving and consumption reduction, carbon or other pollutant discharge control, etc. At the same time, the improvement of the separation model and the cost model are predicted for different membrane types. The significant influence of the above key factors on the system and economy of the integration process is discussed. The modification measures of membrane materials are proposed to predict whether they have industrialization potential and finally promote the common development of membrane and integration technology effectively. [ABSTRACT FROM AUTHOR]

The geological conditions of coal roadway excavation are complicated. Seismic advanced detection is strongly influenced by the loose circle of fractured rock surrounding the competent coal seam. However, the three-dimensional wave field characteristics of small fault advanced detection in the condition of the loose circle of coal roadway have not examined. In this paper, numerical modeling and field tests were conducted to address this knowledge gap. The results indicate that when a seismic source near the tunnel face is excited, the body waves and a Love channel wave propagate in the tunneling direction toward the small fault, then produces reflected body waves whose amplitude is relatively weak, and a reflected Love channel wave whose amplitude is relatively strong. When reflected body waves and the reflected Love channel wave enter the loose circle of surrounding rock, the former's signal is unrecognizable in seismic record; but the latter converts to a Love wave whose amplitude is strong in the loose circle of coal seam. The Love wave which has a large interval from other wave trains in the time domain is easily recognizable in seismic record, which makes it suitable for advanced detection of small fault. The signal-to-noise ratio of seismic record of X component is higher than those of Y component and Z component. [ABSTRACT FROM AUTHOR]

The molecular mechanisms governing the secretion of the non-coding genome are poorly understood. We show herein that cyclin D1, the regulatory subunit of the cyclin-dependent kinase that drives cell-cycle progression, governs the secretion and relative proportion of secreted non-coding RNA subtypes (miRNA, rRNA, tRNA, CDBox, scRNA, HAcaBox. scaRNA, piRNA) in human breast cancer. Cyclin D1 induced the secretion of miRNA governing the tumor immune response and oncogenic miRNAs. miR-21 and miR-93, which bind Toll-Like Receptor 8 to trigger a pro-metastatic inflammatory response, represented >85% of the cyclin D1-induced secreted miRNA transcripts. Furthermore, cyclin D1 regulated secretion of the P-element Induced WImpy testis (PIWI)-interacting RNAs (piRNAs) including piR-016658 and piR-016975 that governed stem cell expansion, and increased the abundance of the PIWI member of the Argonaute family, piwil2 in ERα positive breast cancer. The cyclin D1-mediated secretion of pro-tumorigenic immuno-miRs and piRNAs may contribute to tumor initiation and progression. [ABSTRACT FROM AUTHOR]

Background: YKL-40, a chitinase-like glycoprotein has been identified as a candidate tumor marker. The current study evaluated the clinical significance of plasma YKL-40 in esophageal cancer patients. Methods: We enrolled 127 esophageal cancer patients, 29 healthy controls. Plasma YKL-40 levels were measured through enzyme linked immunosorbent assay. Receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic efficiency of plasma YKL-40 in esophageal cancer patients. The correlations between plasma YKL-40 and clinicopathological characteristics of esophageal were analyzed. Results: Plasma YKL-40 levels were significantly higher in patients with lymph node metastasis than those that were non-metastatic (p = 0.005). Patients with tumor thrombus formation presented with significantly higher YKL-40 levels than those without thrombus formation (160.3 vs. 74.7 ng/mL, p = 0.012). YKL-40 levels in patients with advanced stage (III and IV) were significantly higher than those in the early stages (I and II, p = 0.016). ROC curve analysis showed that the area under curve was 0.909, and the best diagnostic threshold of YKL-40 for esophageal cancer was 80.6 ng/mL with 68.9% sensitivity and 96.6% specificity. Conclusions: This study indicated that YKL-40 may be a biomarker for esophageal cancer and potential biomarker for identification of invasive esophageal cancer. [ABSTRACT FROM AUTHOR]

Cookeite usually occurs as a late alteration product in lithium--cesium--tantalum-type granitic pegmatite. Consequently, cookeite-bearing crystal-rich inclusions (CIs) in pegmatite are considered to be of secondary origin, which constrains our understanding of pegmatite formation. Thus far, no reported cookeite has produced a distinct Raman spectrum. However, the CIs hosted in spodumene in the Jiajika pegmatite deposit, China, contain a cookeite-like hydrous lithium--aluminum--silicate phase, yielding a distinct Raman spectrum. In electron microprobe analysis, focused ion beam scanning electron microscopy, and time-of-flight secondary ion mass spectrometry (ToF-SIMS), the average composition of this hydrous phase was determined as Li1.005(Al3.997Fe0.018)(Si3.086Al0.914)O10.076OH7.902F0.098, close to the International Mineralogical Association (IMA) formula of cookeite, (Al, Li)3Al2(Si, Al)4O10(OH)8. The distinct Raman peaks at 98, 167, 219, 266, 342, 382, 457, 592, 710, and 3640 cm-1 were consistent with those of natural cookeite recrystallized in a hydrothermal diamond-anvil cell. The peaks were ascribed to the crystallization of cookeite from the liquid trapped in the closed space during the spodumene crystallization, which occurred at relatively high temperature and pressure without incorporating the minor elements commonly present during alteration processes. These minor elements often obscure the Raman signals, primarily by fluorescence effects. This type of cookeite in CIs with distinct Raman signals is unusual and can indicate whether the cookeite crystallized from fluid trapped within the closed space of a primary inclusion. In such a case, the fluid can be considered a flux-rich hydrous melt in pegmatite formation models. [ABSTRACT FROM AUTHOR]

In this paper, a single-fed high-gain circularly polarized microstrip antenna is proposed. The circular polarization is obtained by two unequal-length arc-shaped radiation patches, which excite two orthogonal linearly polarized modes with a 90◦ phase difference. The antenna is excited by coaxial feed. The proposed circularly polarized antenna consists of two arc-shaped radiation patches and a ground plane, which has a simple structure and a higher gain than 10.0 dB. The antenna is fabricated and measured to verify the design. The measured results are in good agreements with the simulated ones. The measured results show that the impendence bandwidth (IBW) for S11 < −10 dB is 16.7% (3.78-4.47 GHz), and the axial-ratio bandwidth (ARBW) for AR < 3 dB is 3.6% (4.09-4.24 GHz). Further, the gain is higher than 10.0 dB from 4.09 to 4.24GHz. The antenna radiation pattern performs well over the whole band, and the peak gain can reach 10.67 dB at 4.11 GHz. It is a good candidate for advanced wireless communication systems. [ABSTRACT FROM AUTHOR]