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Background: Chitinase 3-like 1 (CHI3L1) is an important factor involved in the development of asthma. This meta-analysis assessed the association of the CHI3L1 polymorphisms rs4950928, rs10399931, rs883125, rs880633, and rs10399805 with asthma risk. Methods: The literature searches were conducted in PubMed, Web of Science, Wanfang, and China National Knowledge Infrastructure up until September 4, 2021, for relevant studies. Sixteen publications with 18 studies involving 5,005 asthma patients and 9,725 controls were included in this meta-analysis. Results: The meta-analyses showed that among East-Asian subjects, increased asthma risk was associated with CHI3L1 rs4950928 (GG + CG vs. CC: odds ratio [OR] = 1.43, 95% confidence interval [CI]: 1.09–1.88, p = 0.011; GG vs. CG + CC: OR = 1.64, 95% CI: 1.20–2.26, p = 0.002; GG vs. CC: OR = 1.97, 95% CI: 1.41–2.75, p = 0.000; and G vs. C: OR = 1.36, 95% CI: 1.12–1.66, p = 0.002) and rs883125 (G vs. C: OR = 1.42, 95% CI: 1.01–1.99, p = 0.043), whereas CHI3L1 rs10399931 was associated with reduced asthma risk (TT vs. CT + CC: OR = 0.79, 95% CI: 0.64–0.99, p = 0.038; TT vs. CC: OR = 0.77, 95% CI: 0.61–0.98, p = 0.030). In addition, we found an association between CHI3L1 rs4950928 and asthma risk in adult subjects but not children, while CHI3L1 rs883125 was associated with asthma risk in children. Conclusion: The CHI3L1 polymorphisms rs4950928, rs10399931, and rs883125 are important genetic factors for asthma among East-Asian subjects. [ABSTRACT FROM AUTHOR]

Lung adenocarcinoma (LUAD) needs to be stratified for its heterogeneity. Oncogenic driver alterations such as EGFR mutation, ALK translocation, ROS1 translocation, and BRAF mutation predict response to treatment for LUAD. Since oncogenic driver alterations may modulate immune response in tumor microenvironment that may influence prognosis in LUAD, the effects of EGFR , ALK , ROS1 , and BRAF alterations on tumor microenvironment remain unclear. Immune-related prognostic model associated with oncogenic driver alterations is needed. In this study, we performed the Cox-proportional Hazards Analysis based on the L1-penalized (LASSO) Analysis to establish an immune-related prognostic model (IPM) in stage I-II LUAD patients, which was based on 3 immune-related genes (PDE4B , RIPK2 , and IFITM1) significantly enriched in patients without EGFR , ALK , ROS1 , and BRAF alterations in The Cancer Genome Atlas (TCGA) database. Then, patients were categorized into high-risk and low-risk groups individually according to the IPM defined risk score. The predicting ability of the IPM was validated in GSE31210 and GSE26939 downloaded from the Gene Expression Omnibus (GEO) database. High-risk was significantly associated with lower overall survival (OS) rates in 3 independent stage I-II LUAD cohorts (all P < 0.05). Moreover, the IPM defined risk independently predicted OS for patients in TCGA stage I-II LUAD cohort (P = 0.011). High-risk group had significantly higher proportions of macrophages M1 and activated mast cells but lower proportions of memory B cells, resting CD4 memory T cells and resting mast cells than low-risk group (all P < 0.05). In addition, the high-risk group had a significantly lower expression of CTLA-4 , PDCD1 , HAVCR2 , and TIGIT than the low-risk group (all P < 0.05). In summary, we established a novel IPM that could provide new biomarkers for risk stratification of stage I-II LUAD patients. [ABSTRACT FROM AUTHOR]

Purpose: The aim of this study was to conduct a meta-analysis for single nucleotide polymorphisms (SNPs) in interleukin-13 (IL-13) and cluster of differentiation 14 (CD14) genes and the risk for allergic rhinitis (AR).Methods: We screened studies identified through seven databases including Pubmed, Medline, Web of Science, Embase, China Biology Medicine disc, Wanfang, and China Academic Journal Network Publishing Database. The odds ratios (ORs) and 95% confidence intervals (CIs) were determined to assess the association under allelic, dominant and recessive models.Results: Twelve studies with a total of 8547 participants (3223 cases and 5324 controls) investigated IL-13 SNP rs20541, five studies combining 4580 participants (1411 cases and 3169 controls) examined IL-13 SNP rs1800925, and nine studies with 2301 participants (1174 cases and 1127 controls) assessed CD14 SNP rs2569190. We found that the A allele of IL-13 SNP rs20541 was associated with an increased risk of AR (OR 1.19, 95% CI 1.11-1.28, P < 0.001). Stratifying studies by ethnic group produced significant results in Asians (OR 1.21, 95% CI 1.11-1.32, P < 0.001), but not in Caucasians (OR 1.14, 95% CI 1.00-1.30, P = 0.051). No association of IL-13 SNP rs1800925 and CD14 SNP rs2569190 with AR risk was found in either Asians or Caucasians (P > 0.05).Conclusion: Our findings suggest that IL-13 SNP rs20541 is significantly associated with AR risk in Asians but not in Caucasians. However, the accumulating evidence does not support an association of IL-13 SNP rs1800925 and CD14 SNP rs2569190 with AR risk. [ABSTRACT FROM AUTHOR]

Background: Several recent studies have provided evidence that polymorphisms in the interleukin-1 ( IL1) gene are implicated in tuberculosis (TB). However, results of different studies are inconsistent. The aim of this study was to perform a meta-analysis investigating the association of the IL1B (−511 and +3954) and IL1RN VNTR polymorphisms with TB risk. Methods: A systematic review of the English literature was conducted by searching Pubmed, Scopus, and ISI Web of Knowledge databases for relevant studies. Pooled odds ratios (OR) with 95 % confidence intervals (CI) were calculated using fixed effects models. Between-study heterogeneity and publication bias were also evaluated. Results: Nine case-control studies including 3327 participants were reviewed and analyzed. Our results did not indicate any association of the IL1B (−511 and +3954) and IL1RN VNTR polymorphisms with TB risk in the overall populations. The pooled OR of the IL1B −511 polymorphism was 1.09 (95 % CI 0.87-1.36) for the dominant model, 1.11 (0.89-1.38) for the recessive model, 1.15 (0.87-1.50) for the homozygote model, and 1.07 (0.94-1.23) for the allelic comparison model. ORs for the IL1B +3954 and IL1RN VNTR polymorphisms were similar. In subgroup analysis stratified by ethnicity, the results revealed no association between these polymorphisms and TB risk in black people, Asians, and Caucasians, respectively. We did not identify significant between-study heterogeneity across all studies, and there was no evidence of publication bias. Conclusions: Our results indicate there is a lack of association between the IL1B (−511 and +3954), IL1RN VNTR polymorphisms and TB risk. [ABSTRACT FROM AUTHOR]

Background and Objectives: Genetic studies have revealed that the regulated upon activation normal T-cell expressed and secreted (RANTES) −28C/G and −403G/A polymorphisms are associated with asthma risk, but contradictory findings have also been reported. Therefore, we undertook a meta-analysis on this topic. Methods: The PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang databases were used to identify relevant studies published in the medical literature from 1990 to March 26, 2014. Nine studies (containing 2,103 cases and 2,876 controls) investigated the −28C/G polymorphism, and 11 studies (including 2,015 cases and 1,909 controls) assessed the −403G/A polymorphism. Results: The pooled results demonstrated that the −28C/G polymorphism was not associated with asthma risk in the overall populations (Caucasians, Asians, and a mixed population). However, in subgroup analysis according to age, the −28G allele was associated with an increased risk of asthma in children (odds ratio [OR] 1.27, 95 % confidence interval [CI] 1.03-1.57, P value for heterogeneity [ P] = 0.163, P value for the overall effect [ P] = 0.028). When we further stratified the studies performed in children on the basis of ethnicity, we found that the −28G allele was associated with an increased risk of asthma in Asian children (OR 1.28, 95 % CI 1.02-1.62, P = 0.127, P = 0.035), but not in Caucasian children (OR 1.20, 95 % CI 0.68-2.12, P = 0.137, P = 0.530). In subgroup analysis by asthma phenotype, no association between either atopic or non-atopic asthma and the −28C/G polymorphism was identified. For the −403G/A polymorphism, meta-analysis showed no association with asthma risk in the overall populations (Caucasians, Asians, and black people). In subgroup analyses by age, ethnicity, and asthma phenotype, we still did not find any association between the −403G/A polymorphism and asthma. Conclusion: Current findings suggest an association between the −28G allele and asthma risk in Asian children but not in Caucasian children. [ABSTRACT FROM AUTHOR]

Background: Previous studies have provided conflicting evidence implicating the IL-13 C-1112T and G2044A polymorphisms in Graves' disease (GD) risk. We undertook a meta-analysis to address this issue. Methods: The Medline, Pubmed and Web of Science databases were searched for published case-control studies investigating the relation of the IL-13 C-1112T and G2044A polymorphisms with GD risk. Data were extracted using standardized forms and odds ratios (OR) with 95% confidence intervals (CI) were calculated. Results: Available data did not suggest an association between any of the two IL-13 polymorphisms and GD risk. For the C-1112T polymorphism, the combined OR was 0.96 (95% CI: 0.77-1.19) for dominant model (TT + CT vs CC), 0.97 (95% CI: 0.69-1.38) for recessive model (TT vs CT + CC), and 0.97 (95% CI: 0.68-1.39) for homozygote model (TT vs CC). ORs for the G2044A polymorphism were similar. In subgroup analyses stratified by ethnicity, we also did not find associations between these two variants and GD risk in Asians or Caucasians. Sensitivity analyses by excluding each of the involved study in turn did not change the pooled results. Conclusion: The IL-13 C-1112T and G2044A polymorphisms are not associated with GD risk. [ABSTRACT FROM AUTHOR]

Background: Data on the association between the interleukin-1 (IL-1) gene polymorphisms and Graves' disease (GD) risk were conflicting. A meta-analysis was undertaken to assess this association. Methods: We searched for case-control studies investigating the association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk. We extracted data using standardized forms and calculated odds ratios (OR) with 95% confidence intervals (CI). Results: A total of 11 case-control studies were included in this meta-analysis. Available data indicated that the IL1B (-511) polymorphism was associated with GD risk in the overall populations (Caucasians and Asians) in homozygote model (TT vs. CC, OR = 0.86, 95% CI: 0.76–0.97, Pz = 0.015), but not in dominant and recessive models (TT+TC vs. CC: OR = 0.95, 95% CI: 0.81–1.12, Pz = 0.553 and TT vs. TC+CC: OR = 0.82, 95% CI: 0.60–1.12, Pz = 0.205, respectively). No association between the IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk was found in the overall populations in any of the genetic models. In subgroup analyses according to ethnicity, the IL1B (-511) polymorphism was associated with GD risk in Asians in recessive and homozygote models (TT vs. TC+CC: OR = 0.68, 95% CI: 0.55–0.84, Pz<0.001 and TT vs. CC: OR = 0.81, 95% CI: 0.70–0.93, Pz = 0.003, respectively), but not in dominant model (TT+TC vs. CC: OR = 0.92, 95% CI: 0.77–1.11, Pz = 0.389). No association between the IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk was indicated in Asians, and we found no association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk in Caucasians in any of the genetic models. Conclusion: The IL1B (-511) polymorphism, but not the IL1B (+3954) and IL1RN (VNTR) polymorphisms was associated with GD risk in Asians. There was no association between these polymorphisms and GD risk in Caucasians. [ABSTRACT FROM AUTHOR]

Background: Dysregulated levels of interleukin-1 (IL-1) were observed in patients with multiple sclerosis (MS). Previous studies have provided conflicting evidence implicating the IL-1 gene polymorphisms in MS risk. Methods: A meta-analysis of 16 case-control studies involving 3,482 cases and 3,528 controls was conducted to evaluate this association. Results: No association was found between the IL-1α −889 (rs1800587), IL-1α +4,845 (rs17561), IL-1β −511 (rs16944), IL-1β +3,953 (rs1143634), IL-1ra variable number tandem repeat (VNTR) polymorphisms and MS risk. However, in subgroup analyses for the IL-1ra VNTR polymorphism, we found that individuals carrying the 2 allele had a 32 % increased risk for bout-onset MS (relapsing remitting and secondary progressive MS) when compared to the LL homozygotes (OR = 1.32, 95 % CI = 1.06-1.66, P = 0.014). Conclusion: Common variants in the IL-1 region are not associated with MS risk but our data suggest that the IL-1ra VNTR polymorphism might be associated with bout-onset MS subtype. [ABSTRACT FROM AUTHOR]

A letter to the editor is presented in response to the article "Associations between the major histocompatibility complex class I chain-related gene A transmembrane polymorphism and susceptibility to psoriasis and psoriatic arthritis: a meta-analysis" by Song GG in the September 17, 2013 issue.