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As one of the security issues, privacy protection (PP) has become a research hotspot. The paper studies the synchronization problem of stochastic networks based on PP. First, a synchronization standard for stochastic network with delay is given based on PP. Second, a finite‐time (FnT) synchronization criterion for stochastic network without delay is given based on PP. The PP function of continuous time‐varying function is designed to mask the real state of the controlled complex network before converging to the real value in FnT and infinite time. Finally, the effectiveness of the method discussed in this article was verified through simulation examples. [ABSTRACT FROM AUTHOR]

Background and Aims: Lenvatinib is a first‐line drug commonly used in the treatment of advanced hepatocellular carcinoma (HCC). However, its clinical efficacy is very limited due to drug resistance. Therefore, there is a great need to explore its combination with other agents to achieve better therapeutic effects. Metformin has been demonstrated to show an anti‐cancer effect. This study aimed to investigate the combined effect of lenvatinib with metformin in HCC cells both in vitro and in vivo and elucidate the possible molecular mechanisms. Methods: Flow cytometry, colony formation, CCK‐8 and transwell assays were used to study the effect of Lenvatinib–Metformin combination on the malignant behaviour of HCC cells in vitro. Constructing an animal model of tumour‐bearing to study the effect of combined drugs on HCC in vivo. Western blot experiments were performed to assess the relationship between AKT and FOXO3 and the cellular translocation of FOXO3. Results: Our results suggested that Lenvatinib and Metformin synergistically inhibited HCC growth and motility. Mechanistically, the combination of Lenvatinib and Metformin synergistically suppressed the activation of the AKT signalling pathway, which in turn reduced the phosphorylation level of downstream effector FOXO3 and induced its nuclear aggregation. In vivo studies further confirmed the synergistic suppression of lenvatinib with metformin in HCC growth. Conclusion: The Lenvatinib–Metformin combination may provide a potential therapeutic strategy to improve the prognosis of HCC patients. [ABSTRACT FROM AUTHOR]

Helicase-like transcription factor (HLTF) belongs to the family of SWI/SNF proteins, which has been reported to exert oncogenic function in several human cancers. However, to date, its functional role in hepatocellular carcinoma (HCC) has not been revealed. Here, we found that HLTF was highly expressed in HCC tissues compared to nontumor tissues. Additionally, upregulation of HLTF was significantly associated with poor prognosis of patients with HCC. Functional experiments demonstrated that knockdown of HLTF expression significantly inhibited the proliferation, migration, and invasion of HCC cells in vitro, and suppressed tumor growth in vivo. In conclusion, our results suggest that upregulation of HLTF is associated with the development of HCC, and HLTF may be a potential therapeutic target for HCC treatment. [ABSTRACT FROM AUTHOR]

As the COVID-19 outbreak has an impact on the global economy, there will be interest in how China's financial markets function during the outbreak. To investigate the path of risk contagion in China's financial sub-markets before and after the COVID-19 outbreak, we divided the 2016–2021 period into two phases. Based on the time of the COVID-19 outbreak, we divided the new stage of economic development into pre-epidemic and post-epidemic stages and employed the DCC-GARCH model to investigate the dynamic correlation coefficients among the financial sub-markets in China. Furthermore, we employed complex network theory and the minimum tree model to describe the risk contagion path between two-stage Chinese financial submarkets. Finally, we provided pertinent recommendations for investors and policymakers and conducted a brief discussion based on the findings of the research. [ABSTRACT FROM AUTHOR]

Since the speed that the $p$ th moment of an output signal norm tends to 0 can be used to measure the quality of the output signal, the stability of the $p$ th moment of complex networks has been widely concerned. This article studies fixed-time synchronization in the $p$ th moment for time-varying delay stochastic multilayer networks, where fixed-time synchronization of multilayer networks is realized by using nonlinear feedback or delay feedback, and the concrete expression of fixed settling time is evaluated. Compared with some existing fixed-time control methods, the optimal combination relationship between the exponential power of fixed-time controllers and the $p$ th moment is given, and the designed controllers are continuous function. Finally, the effectiveness of the method is verified by numerical simulations. [ABSTRACT FROM AUTHOR]

Purpose: This study aimed to evaluate the potential utility of [68Ga]Ga-FAPI-04 PET/CT for diagnosing primary and metastatic lesions in patients with liver cancer, as well as to compare it with contrast-enhanced CT (CE-CT), liver MRI, and [18F]-FDG PET/CT. Methods: We performed a single-center post hoc retrospective analysis of data obtained from a prospective parent study (NCT04416165). This study included 34 patients diagnosed with or suspected hepatic lesions who underwent concomitant [68Ga]Ga-FAPI-04 and [18F]-FDG/CT scans. Moreover, these patients underwent liver MRI (n = 34) and CE-CT (n = 25). Histopathologic (n = 62) or radiographic follow-up (n = 128) served as the reference standard for the final diagnosis. Results: Among the 34 patients, 20, 12, and 2 patients presented with hepatocellular carcinomas, intrahepatic cholangiocarcinomas, and benign hepatic nodules, respectively. The sensitivities of CE-CT, MRI, [68Ga]Ga-FAPI-04, and [18F]-FDG/CT for detecting primary liver tumors were 96%, 100%, 96%, and 65%, respectively. Regarding the diagnosis of all intrahepatic lesions, the per-lesion detection rate of [68Ga]Ga-FAPI-04 PET/CT was slightly lower than that of MRI (85% vs. 100%, P = 0.34) and significantly higher than that of [18F]-FDG PET/CT (85% vs. 52%, P < 0.001). Regarding the diagnosis of all malignant lesions (including extrahepatic disease), the tumor detection rate of [68Ga]Ga-FAPI-04 PET/CT was 87.4%, which was significantly higher than that of [18F]-FDG PET/CT (65.0%, P < 0.001). Conclusions: Our findings indicate that the sensitivity of [68Ga]Ga-FAPI-04 PET/CT to correctly identify primary liver tumors and metastatic lesions is equivalent to that of CE-CT and liver MRI. Moreover, [68Ga]Ga-FAPI-04 PET/CT is better at identifying liver lesions than [18F]-FDG PET/CT, and its use may improve tumor staging, recurrence detection, and implementation of necessary treatment modifications. [ABSTRACT FROM AUTHOR]

Purpose: We evaluated the potential usefulness of [68Ga]Ga-DOTA-FAPI-04 positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various types of cancer, compared with [18F] FDG PET/CT. Methods: A total of 75 patients with various types of cancer underwent contemporaneous [68Ga]Ga-DOTA-FAPI-04 and [18F] FDG PET/CT either for an initial assessment or for recurrence detection. Tumour uptake was quantified by the maximum standard uptake value (SUVmax). The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of [18F] FDG and [68Ga]Ga-DOTA-FAPI-04 PET/CT were calculated and compared to evaluate the diagnostic efficacy. Results: The study cohort consisted of 75 patients (47 males and 28 females; median age, 61.5 years; age range, 32–85 years). Fifty-four patients with 12 different tumour entities underwent paired [68Ga]Ga-DOTA-FAPI-04 and [18F] FDG PET/CT for initial assessment, while the other 21 patients underwent paired scans for recurrence detection. [68Ga]Ga-DOTA-FAPI-04 PET/CT was able to clearly identify 12 types of malignant tumours with favourable tumour-to-background contrast, which resulted in a higher detection rate of primary tumours than did [18F] FDG PET/CT (98.2% vs. 82.1%, P = 0.021). Meanwhile, [68Ga]Ga-DOTA-FAPI-04 PET/CT showed a better sensitivity than [18F] FDG PET/CT in the detection of lymph nodes (86.4% vs. 45.5%, P = 0.004) and bone and visceral metastases (83.8% vs. 59.5%, P = 0.004). Conclusion: [68Ga]Ga-DOTA-FAPI-04 PET/CT showed a superior diagnostic efficacy than [18F] FDG PET/CT for the diagnosis of primary and metastatic lesions in patients with various types of cancer, especially in identifying liver metastases, peritoneal carcinomatosis, and brain tumours. [ABSTRACT FROM AUTHOR]

This brief investigates the fixed-time synchronization of complex networks with a simpler nonchattering controller. First, a new finite-time stability theorem is proposed. Second, a novel sufficient criterion is derived for fixed-time synchronized of complex networks. Compared with some existing results, the new controller without sign function is designed to realize fixed-time synchronization. Moreover, the designed controller without include the linear parts, which means the controller is simpler than the existing controllers by using finite-/fixed-time methods, and the chattering phenomenon can also be avoided. Finally, the application of fixed-time non-chattering controller is discussed by designing synchronization circuit of complex systems. [ABSTRACT FROM AUTHOR]

Background: Due to the high recurrence and metastasis rate, the clinical outcomes of patients with hepatocellular carcinoma (HCC) are still unsatisfactory. Hepatitis B virus X-interacting protein (HBXIP) has been reported to play crucial roles in carcinogenesis. Purpose: We aimed to reveal the functional significance and underlying mechanism of HBXIP in HCC metastasis.Methods: Cell transwell assay, in vivo metastasis model, real-time PCR, western blot analysis, luciferase reporter and chromatin immunoprecipitation assays were applied. Results: Here, we detected the HBXIP expression level and determined its clinical significance in HCC. We found that HBXIP was significantly upregulated in HCC tissues, and correlated with vascular invasion, tumor metastasis and worse prognosis of HCC patients. HBXIP enhanced cell migration and invasion in vitro, and promoted the metastasis of HCC in vivo. Furthermore, we confirmed that HBXIP increased MMP15 expression through association with proto-oncogene c-myc. Depletion of c-myc abolished HBXIP-mediated MMP-15 upregulation. We also observed a positive correlation between HBXIP and MMP15 expression in HCC tissues. Conclusion: Our results establish a novel function for HBXIP-MMP15 regulation in HCC metastasis and suggest its candidacy as a new prognostic biomarker and therapeutic target for HCC metastasis. [ABSTRACT FROM AUTHOR]

This paper discusses the problem of adaptive finite-time synchronization for neutral type dynamical network model with double derivative coupling. Based on the Lyapunov functional theory, inequality theorem, and adaptive control technique, some synchronization criteria of neutral type dynamical network are established by using adaptive finite-time control, which is different from the existence of finite-time synchronization of neutral type network using LMI and matrix equality constraint methods. Moreover, when the dynamics nodes of the neutral type network contain delay or no delay, the control gain of the response network are also provided. Finally, the effectiveness of the synchronization criteria proposed in this paper is verified by numerical simulations. [ABSTRACT FROM AUTHOR]

This paper investigates the bounded scaling function projective synchronization of uncertain chaotic systems using adaptive finite-time control. Based on finite-time control and inequality principle, the new adaptive finite-time controller is designed to achieve two chaotic systems scaling function projective synchronized, and uncertain parameters of chaotic systems are also identified. Moreover, in comparison with those of the existing scaling function synchronization, the given scaling function can be more complex bounded functions. Some numerical are also given to show the effectiveness of the proposed method. [ABSTRACT FROM AUTHOR]

This paper studies a simple dynamical system of stock price fluctuation time series based on the rule of stock market. When the stock price fluctuation system is disturbed by external excitations, the system exhibits obviously chaotic phenomena, and its basic dynamic properties are analyzed. At the same time, a new fixed-time convergence theorem is proposed for achieving fixed-time control of stock price fluctuation system. Finally, the effectiveness of the method is verified by numerical simulation. [ABSTRACT FROM AUTHOR]

Recently, many studies show that long non-coding RNAs (lncRNAs) play important roles in cancer biology. Although its expression was reported dysregulated during tumorigenesis, the contributions of lncRNAs to hepatocellular carcinoma (HCC) are still largely unknown. In particular, the lncRNA CARLo-5 has a functional role in cell-cycle regulation in colon cancer, while the clinical significance and biological function of CARLo-5 in HCC remain unelucidated. In order to fill those study blanks, the expression level of CARLo-5 in human HCC specimens was tested, and its correlation with clinicopathologic features as well as the prognosis for patients with HCC was analyzed. Additionally, MTT, wound healing and transwell assays were employed to investigate the biological function of CARLo-5. The results showed that CARLo-5 levels were significantly overexpressed in HCC tissues compared to ANLT. Besides, high expression of CARLo-5 was associated with liver cirrhosis ( P = 0.001), tumor number ( P < 0.001), vascular invasion ( P = 0.001), capsular formation ( P = 0.014) and Edmondson-Steiner grade ( P < 0.001), which proved that CARLo-5 was an independent risk factor for overall survival and disease-free survival. In addition, in highly metastatic HCC cell lines (HCCLM3 and MHCC97-L), CARLo-5 was up-regulated, but in lowly metastatic HCC cell lines (HepG2, SNU387), it showed down-regulated. Besides, by using gain and loss of function experiments in HCC cell lines (HCCLM3 and HepG2), the results showed that CARLo-5 overexpression significantly enhanced cell proliferation, migration and invasion in vitro. Our study also revealed that CARLo-5 was prominently up-regulated in HCC specimens and its high expression was associated with poor prognosis of HCC patients. Totally, those findings together indicate that CARLo-5 promotes proliferation and metastasis of HCC and potentially emerged as a novel therapeutic target. [ABSTRACT FROM AUTHOR]

This paper discusses some basic dynamical properties of the chaotic finance system with parameter switching perturbation, and investigates chaos projective synchronization of the chaotic finance system with the time-varying delayed feedback controller, which are not fully considered in the existing research. Different from the previous methods, in this paper, the delayed feedback controller is not only time-varying, but also the time-varying delay is adaptive. Finally, an illustrate example is provided to show the effectiveness of this method. [ABSTRACT FROM AUTHOR]

This paper investigates the problem of two kinds of function projective synchronization of financial chaotic system with definite integration scaling function, which are not fully considered in the existing research. Different from the previous methods, in this paper, the following two questions are investigated: (1) two kinds of the definite integration scaling function projective synchronization are given; (2) the upper and lower limit of the definite integral scaling function are the bound dynamical systems. Finally, illustrative example is provided to show the effectiveness of this method. [ABSTRACT FROM AUTHOR]

This paper investigates a kind of binary function projective lag synchronization of uncertain chaotic systems with stochastic perturbation. In comparison with those of the existing scaling function synchronization, we assume that the given scaling function can be the binary boundary function, even an n-ary boundary function. Based on the LaSalle-type invariance principle for stochastic differential equation, the adaptive control law is derived to make the state of two chaotic systems function projective lag synchronized. Some numerical is also given to show the effectiveness of the proposed method. [ABSTRACT FROM AUTHOR]

Background: CDK5, an atypical member of the CDK family, play a significant role in the tumorigenesis of multiple organ, but CDK5 and its substrates in genesis and development of HCC is still unclear. Methods: Expression of CDK5 in HCC tumor and paired adjacent noncancerous tissues from 90 patients were measured by Western blotting, immunohistochemistry, and real-time PCR. The role of CDK5 in cell function and tumorigenesis was explored in HCC cell lines, ex vivo xenografts and diethylnitrosamine induced HCC model. Furthermore, comparative phosphoproteomic screening identified the oncoprotein TPX2 as a new substrate of CDK5. We also identified the effect of CDK5/P25 interaction blocker tamoxifen on HCC cell growth and migration. Results: CDK5 was increased in HCC tisues and the level of CDK5 was correlated with the severity of HCC based on patient recurrence and 5-year fatality rate. Exogenously expressed CDK5 but not kinase-dead CDK5 promoted proliferation, migration, and invasion of HCC cells. Functional ablation of CDK5 significantly inhibited the exacerbation of HCC cells. Xenograft implantation of HCC cells overexpressing CDK5 promoted tumorigenesis, and genetic knockdown of CDK5 reduced HCC growth and metastasis in vivo. More importantly, heterozygous knockout CDK5 (Cdk5+/−) attenuated HCC tumorigenesis induced by diethylnitrosamine. CDK5-mediated phosphorylation of TPX2 at serine 486 promoted its protein stability. TPX2 silence could restore HCC cell migration capability with overexpression CDK5. Treatment with tamoxifen inhibited cell growth and migration of HCC, demonstrating the role of active CDK5 in HCC. Conclusions: Our results suggest activation of CDK5 is associated with HCC tumorigenesis. CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular proliferation and tumorigenicity. [ABSTRACT FROM AUTHOR]