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Treatment of glomerulonephritis presents several challenges, including limited therapeutic options, high costs, and potential adverse reactions. As a recognized Chinese patent medicine, Tripterygium wilfordii poly-glycosides (TWP) have shown promising benefits in managing autoimmune diseases. To evaluate clinical effectiveness and safety of TWP in treating glomerulonephritis, we systematically searched PubMed, Cochrane Library, Web of Science, and Embase databases for controlled studies published up to 12 July 2023. We employed weighted mean difference and relative risk to analyze continuous and dichotomous outcomes. This meta-analysis included 16 studies that included primary membranous nephropathy (PMN), type 2 diabetic kidney disease (DKD), and Henoch-Schönlein purpura nephritis (HSPN). Analysis revealed that additional TWP administration improved patients' outcomes and total remission rates, reduced 24-h urine protein (24hUP) and decreased relapse events. The pooled results demonstrated the non-inferiority of TWP to glucocorticoids in achieving total remission, reducing 24hUP, and converting the phospholipase A2 receptor (PLA2R) status to negative. For DKD patients, TWP effectively reduced 24hUP levels, although it did not significantly improve the estimated glomerular filtration rate (eGFR). Compared to valsartan, TWP showed comparable improvements in 24hUP and eGFR levels. In severe cases of HSPN in children, significant clinical remission and a reduction in 24hUP levels were observed with the addition of TWP treatment. TWP did not significantly increase the incidence of adverse reactions. Therefore, TWP could offer therapeutic benefits to patients with PMN, DKD, and severe HSPN, with a minimal increase in the risk of side effects. [ABSTRACT FROM AUTHOR]

Salix psammophila was converted to value-added chemicals in the presence of 1-butyl-3-methylimidazolium chloride ([Bmim]Cl) and water by the hydrothermal liquefaction method. [Bmim]Cl acted as both liquefier and catalyst, while water served as both co-solvent and reactant. The optimal reaction parameters for the highest liquefaction yield were determined by an orthogonal experiment. The possibility of application of the recycled [Bmim]Cl was investigated. FT-IR spectra results of the fresh used, the firstly reused, and the secondary reused IL [Bmim]Cl confirmed the high stability of [Bmim]Cl. Moreover, an explanation of the possible liquefaction mechanism for S. psammophila was also provided. This study may provide fundamental data for S. psammophila conversion and application. [ABSTRACT FROM AUTHOR]

The air supported membrane structure is a typical nonlinear flexible long-span space structure, the wind-induced drift and the resulting accumulation and distribution of snow particles on the structure may be the primary design concern among all loads in heavy-snowfall region. Thus, an accurate prediction of snow distribution on membrane surface is vital to structural design. A numerical simulation method is used to estimate snowdrift in this paper. Based on Euler-Euler method in multi-phase flow theory, this numerical model adopted Mixture model and combined with the snow deposition and erosion model, the snowdrift on an air-supported membrane coal shed is simulated, the distribution factor for roof snow load is given under different wind speed and different directions to estimate the worst load case, snow load on the air-supported membrane structure is significantly affected by snowdrift which causes significant non-uniform snow load. Furthermore, the response analysis of the air-supported membrane structure under snow load is studied, for comparison, uniform snow load case, non-uniform snow load case, and simulated snow load case under 0° wind direction are all considered. The results show that non-uniform snow load caused by snow drifting is more dangerous and should be considered. [ABSTRACT FROM AUTHOR]

For the state-of-the-art quantum dot light-emitting diodes, while the ZnO nanoparticle layers can provide effective electron injections into quantum dots layers, the hole transporting materials usually cannot guarantee sufficient hole injection owing to the deep valence band of quantum dots. Developing proper hole transporting materials to match energy levels with quantum dots remains a great challenge to further improve the device efficiency and operation lifetime. Here we demonstrate high-performance quantum dot light-emitting diodes with much extended operation lifetime using quantum dots with tailored energy band structures that are favorable for hole injections. These devices show a T95 operation lifetime of more than 2300 h with an initial brightness of 1000 cd m−2, and an equivalent T50 lifetime at 100 cd m−2 of more than 2,200,000 h, which meets the industrial requirement for display applications. [ABSTRACT FROM AUTHOR]