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Summary: Numerous guidelines have called for personalized interventions to address childhood obesity. The role of fat mass and obesity‐associated gene (FTO) in the risk of childhood obesity has been summarized. However, it remains unclear whether FTO could influence individual responses to obesity interventions, especially in children. To address this, we systematically reviewed 12,255 records across 10 databases/registers and included 13 lifestyle‐based obesity interventions (3980 children with overweight/obesity) reporting changes in body mass index (BMI) Z‐score, BMI, waist circumference, waist‐to‐hip ratio, and body fat percentage after interventions. These obesity‐related outcomes were first compared between children carrying different FTO genotypes (rs9939609 or its proxy) and then synthesized by random‐effect meta‐analysis models. The results from single‐group interventions showed no evidence of associations between FTO risk allele and changes in obesity‐related outcomes after interventions (e.g., BMI Z‐score: −0.01; 95% CI: −0.04, 0.01). The results from controlled trials showed that associations between the FTO risk allele and changes in obesity‐related outcomes did not differ by intervention/control group. To conclude, the FTO risk allele might play a minor role in the response to obesity interventions among children. Future studies might pay more attention to the accumulation effect of multiple genes in the intervention process among children. [ABSTRACT FROM AUTHOR]

Background: Differentiated thyroid cancer (DTC) is increasingly common in women of reproductive age. However, whether pregnancy increases the risk of DTC progression/recurrence after treatment remains controversial. The study aimed to assess the association of pregnancy with risk of progression in patients previously treated for DTC. Methods: This was a retrospective cohort study following 123 pregnant women and 1376 nonpregnant women at Peking University Third Hospital after initial treatment for DTC between January 2012 and December 2022. To control the effect of confounding, we carefully matched pregnancy (n = 107) and nonpregnancy groups (n = 298) in terms of baseline characteristics by using propensity score matching (PSM). Results: At baseline, the pregnancy and nonpregnancy groups were balanced in all matched variables. At follow-up, the percentage of DTC progression in the two groups was 12 (11.8%) and 47 (15.8%), respectively. Regression models showed no evidence of association of pregnancy with the risk of progression (odds ratio: 0.74 and 95% confidence interval: 0.37–1.50; p = 0.404), and remained consistent across long/short follow-up and other subgroup variables. We found that the shorter the time interval between treatment and pregnancy, the higher the risk of DTC progression (ptrend = 0.019). Conclusions: The risk of DTC progression in pregnant women was not higher than that in the well-matched, nonpregnant women. For young women previously treated for DTC, disease progression might not be a concern for their future pregnancy plan, but it seems safer to wait at least 1 year before pregnancy compared with immediate pregnancy. [ABSTRACT FROM AUTHOR]

Aim: To 3‐dimensional radiographically assess the effect of titanium plate in guided bone regeneration (GBR) for the treatment of peri‐implant ridge defects in esthetic zone. Material and Methods: Nineteen patients with buccal peri‐implant defects in the maxillary esthetic zone were treated with GBR using xenograft, autogenous bone, and collagen membrane. Subjects were divided into two groups: control (conventional GBR, 10 patients with 16 implants) and test (GBR with an adjunctive titanium plate; nine patients with 15 implants). Cone‐beam computed tomography (CBCT) images obtained immediately after and 5–7 months following GBR were used to assess buccal crestal bone level (BBL) and buccal bone thickness (BBT) at different implant levels. Results: Thirty‐one implants in 19 patients were evaluated. Titanium plate exposure occurred in three cases (33.33%) of the test group. After 5–7 months, the mean BBL was located 1.48 ± 0.71 mm coronal to the platform in the test group and 0.90 ± 3.03 mm coronal to the platform in the control group (p = 0.03). The mean over all BBT (BBT‐M) was 4.16 ± 0.48 mm in the test group and 2.38 ± 0.97 mm in the control group (p < 0.01). More resorption occurred in the control group than in the test group regarding mean BBL (3.00 ± 3.11 mm vs. 0.78 ± 0.79 mm, respectively; p = 0.04), BBT‐M change (1.87 ± 1.59 mm vs. 0.56 ± 0.33 mm, respectively; p = 0.02), and percentage change in BBT‐M (40.69 ± 24.01% vs. 11.53 ± 5.86%, respectively; p < 0.01). Conclusion: In the short‐term, titanium plate‐enhanced GBR maintained ridge dimensions better than conventional GBR did. [ABSTRACT FROM AUTHOR]