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This case report describes a successful autotransplantation procedure for an impacted mandibular left second premolar with incomplete root formation. Despite caries and root resorption, the patient's mandibular left second primary molar was retained. Furthermore, the severe impaction of the mandibular left second premolar ruled out orthodontic realignment. Due to the young age of the patient, dental implantation was not feasible, leading to the selection of autotransplantation as the preferred method for replacing the retained primary molar. To address the insufficient buccolingual width of the recipient site, a combination of piezosurgery‐assisted alveolar ridge splitting and guided bone regeneration techniques was employed in this autotransplantation procedure. [ABSTRACT FROM AUTHOR]

Objective: To assess seizure outcomes, prognostic factors, and developmental changes in children undergoing total posterior quadrant disconnection (PQD) for drug‐resistant epilepsy (DRE). Methods: We conducted a retrospective analysis of the clinical data of children with DRE who underwent total PQD surgery. The study focused on Engel's classification for seizure outcomes, exploring correlation of preoperative data and surgical effectiveness, and predictors of seizure prognosis. It involved a comparative analysis of developmental levels pre‐ and 3 months postoperatively using Griffiths Mental Development Scales‐China (GMDS‐C), and the correlation between clinical characteristics and GMDS‐C results. Results: Out of 61 pediatric patients, 70.5% showed no seizure recurrence postoperatively. In the univariate analysis, interictal electroencephalogram (EEG), magnetic resonance imaging (MRI), fluorodeoxyglucose positron emission tomography (FDG‐PET), and acute postoperative seizure (APOS) were significantly related to surgical prognosis. In multivariate analysis, interictal EEG and APOS were identified as predictors of seizure prognosis. Survival analysis indicated significant associations between MRI, interictal EEG, FDG‐PET, APOS and postoperative seizure occurrence. Preoperative GMDS‐C levels were significantly correlated with epilepsy duration, seizure frequency, interictal EEG, and FDG‐PET. GMDS‐C scores improved postoperatively, while developmental quotients remained stable. Significance: For patients with structural abnormalities in the entire posterior quadrant, thorough preoperative assessment and timely total PQD surgery can effectively control seizures without causing neurological development deterioration. APOS and interictal EEG abnormalities beyond the posterior quadrant are predictors for seizure prognosis but should not be deemed contraindications for surgery. Plain Language Summary: Due to lack of analysis on pediatric total PQD cases, 61 pediatric patients who underwent total PQD surgery were retrospectively enrolled. Seizure and development results were collected and analyzed as dependent variables. The study found that 70.5% of patients were seizure‐free and showed development improvement, with no deaths or severe complications reported. Prognosis predictors included APOS and interictal EEG abnormalities beyond the posterior quadrant. [ABSTRACT FROM AUTHOR]

In recent years, the impact of methylation modifications on Dickkopf-1 (DKK1) in relation to ankylosing spondylitis (AS) has remained elusive. Our objective was to investigate the potential link between DKK1 methylation patterns and transcript levels and AS susceptibility. DNA methylation level of DKK1 was measured in 82 AS and 82 healthy controls (HCs) using targeted bisulfite sequencing. In addition, the transcript level of DKK1 in peripheral blood mononuclear cells from 35 AS patients and 35 HCs was detected using real-time quantitative transcription-polymerase chain reaction. Our study showed that the DKK1 was significantly hypomethylated in AS patients (P < 0.001). The Receiver operating characteristic curve (ROC) showed that DKK1 methylation may be a potential biomarker. The results showed that the difference in DKK1 transcript levels between AS and HCs was not statistically significant. Further analysis showed that DKK1 methylation levels were positively correlated with age and negatively correlated with C-reactive protein levels, neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR). The methylation level of DKK1 in PBMC of AS patients was significantly lower than that of HCs, and DKK1 methylation may be associated with susceptibility to AS. In addition, DNA methylation levels of DKK1 were negatively correlated with the level of inflammation in AS patients. [ABSTRACT FROM AUTHOR]

Defects in the mitochondrial tRNA genes cause a group of highly clinically and genetically heterogeneous disorders, which poses a challenge for clinical identification and genetic diagnosis. Here, we present a pre‐school boy with a novel MT‐TD variant m.7560T>C at the heteroplasmy level of 76.53% in blood, 93.34% in urine sediments, and absent in the healthy mother's blood and urine. Besides convulsions, brain magnetic resonance imaging abnormalities and high plasma lactate, the boy presented with the prominent extra‐neurologic phenotype including steroid‐resistant nephrotic syndrome associated with focal segmental glomerulosclerosis characterized by abnormal mitochondria in podocytes, cortical blindness, and pancreatitis. To our knowledge, this is the unique case with MT‐TD m.7560T>C‐related multi‐organ impairments, which expands the phenotypic and mutational spectrum of primary mitochondrial diseases. [ABSTRACT FROM AUTHOR]

The Huaniushan lead–zinc–silver deposit is a hydrothermal sedimentary exhalative deposit (SEDEX), and the mining area has complex geological conditions, with the main tectonic structure being the Huaheitan–Shuangfengshan Fault (F3), which controls the distribution of strata and magmatic rocks. Since the discovery of the Huaniushan lead–zinc–silver deposit, diverse interpretations of its genesis and metallogeny have been proposed, making it challenging to establish a definitive geological explanation. Moreover, using a single geophysical exploration method relies on limited rock physical parameters, making it difficult to effectively characterize underground structures. The combined use of multiple geophysical methods can effectively integrate the geophysical characteristics of different rock physical parameters, reducing the multiplicity and uncertainty of the inverse interpretation of geophysical data. The comprehensive interpretation of three-dimensional inversion based on various geophysical data, the construction of geological–geophysical models on geological grounds, the establishment of hidden ore exploration and positioning, and the rapid evaluation of geophysical technological systems are the current research trends in mineral exploration. In light of this, in this study, we conducted research on the three-dimensional inversion interpretation of gravity and magnetoelectric exploration data of the Huaniushan sedimentary exhalative lead–zinc–silver polymetallic deposit and constructed a three-dimensional geological–geophysical model of the study area based on the obtained three-dimensional physical structure of the underground density, magnetization intensity, resistivity, and polarizability of the study area, in combination with related geological and drilling hole data. Finally, we comprehensively interpreted the favorable mineralization sites in the study area. [ABSTRACT FROM AUTHOR]

The therapeutic efficacy of vaccines for treating cancers in clinics remains limited. Here, a rationally designed cancer vaccine by placing immunogenically differential and clinically approved aluminum (Al) or manganese (Mn) in a 2D nanosheet (NS) architecture together with antigens is reported. Structurally optimal NS with a high molar ratio of Mn to Al (MANS‐H) features distinctive immune modulation, markedly promoting the influx of heterogeneous innate immune cells at the injection site. Stimulation of multiple subsets of dendritic cells (DCs) significantly increases the levels, subtypes, and functionalities of antigen‐specific T cells. MANS‐H demonstrates even greater effectiveness in the production of antigen‐specific antibodies than the commercial adjuvant (Alhydrogel) by priming T helper (Th)2 cells rather than T follicular helper (Tfh) cells. Beyond humoral immunity, MANS‐H evokes high frequencies of antigen‐specific Th1 and CD8+ cell immunity, which are comparable with Quil‐A that is widely used in veterinary vaccines. Immunized mice with MANS‐H adjuvanted vaccines exert strong potency in tumor regression by promoting effector T cells infiltrating at tumor and overcoming tumor resistance in multiple highly aggressive tumor models. The engineered immunogen with an intriguing NS architecture and safe immunopotentiators offers the next clinical advance in cancer immunotherapy. [ABSTRACT FROM AUTHOR]

Q&A platforms are vital sources of information but often face challenges related to their high ratios of passive to active contributors, which can impede knowledge construction and information exchange on the platforms. This study introduced a novel method for identifying trend discoverers, key users who can detect and initiate discussions on emerging question trends, through response order analysis of data from Zhihu and Stack Overflow. This study underscores the significant role of trend discoverers in influencing question popularity. Trend discoverers not only exhibit higher engagement in knowledge‐sharing activities but also participate in discussions across a broader range of topics compared to regular users. The insights derived from this research have crucial implications for improving the development and functionality of Q&A platforms. [ABSTRACT FROM AUTHOR]

Chloride solid electrolytes (SEs) have attracted widespread attention due to their high room-temperature ionic conductivity and excellent cathode compatibility. However, the conventionally selected central metal elements (e.g., In, Y and Ta) are usually rare and heavy, inevitably causing the high cost and high density of the obtained chloride SEs. Here, by choosing abundant and light Mg and Al as central metal elements, we develop a cheap and low density Li1.2Mg0.95Al0.3Cl4 SE for high active material ratio in all solid state cathode. Partial replacement of Mg2+ by Al3+ in the framework yields vacancies and lowers the non-lithium metal ions occupancy at Mg/Li co-occupied 16d site, effectively relieving the blocking effects by Mg2+ in the pristine spinel Li2−2xMg1+xCl4. Thus, a significantly improved room-temperature conductivity of 3.08 × 10−4 S·cm−1 is achieved, two orders of magnitude higher than that of Li1.2Mg1.4Cl4. More attractively, its low density of only 1.98 g·cm−3 enables low SE mass ratio in cathodes (only 16 wt.%) with still effective electrolyte/cathode contact and lithium-ion conduction inside. When charged to potential of 4.30 V, the asfabricated Li1.2Mg0.95Al0.3Cl4-based solid lithium battery with uncoated NCM523 cathode can be cycled for over 100 cycles with a capacity retention of 86.68% at room temperature. [ABSTRACT FROM AUTHOR]

The advancement of analytical techniques, such as comprehensive two-dimensional gas chromatography coupled with mass spectrometry (GC × GC–MS), enables the efficient separation of complex organics. Developing innovative methods for data processing and analysis is crucial to unlock the full potential of GC × GC–MS in understanding intricate chemical mixtures. In this study, we proposed an innovative method for the semi-automated identification and quantification of complex organic mixtures using GC × GC–MS. The method was formulated based on self-constructed mass spectrum patterns and the traversal algorithms and was applied to organic vapor and aerosol samples collected from the tailpipe emissions of heavy-duty diesel vehicles and the ambient atmosphere. Thousands of compounds were filtered, speciated, and clustered into 26 categories, including aliphatic and cyclic hydrocarbons, aromatic hydrocarbons, aliphatic oxygenated species, phenols and alkylphenols, and heteroatom-containing species. The identified species accounted for over 80 % of all the eluted chromatographic peaks at the molecular level. A comprehensive analysis of quantification uncertainty was undertaken. Using representative compounds, quantification uncertainties were found to be less than 37.67 %, 22.54 %, and 12.74 % for alkanes, polycyclic aromatic hydrocarbons (PAHs), and alkyl-substituted benzenes, respectively, across the GC × GC space, excluding the first and the last time intervals. From a source apportionment perspective, adamantane was clearly isolated as a potential tracer for heavy-duty diesel vehicle (HDDV) emissions. The systematic distribution of nitrogen-containing compounds in oxidized and reduced valences was discussed, and many of them served as critical tracers for secondary nitrate formation processes. The results highlighted the benefits of developing self-constructed models for the enhanced peak identification, automated cluster analysis, robust uncertainty estimation, and source apportionment and achieving the full potential of GC × GC–MS in atmospheric chemistry. [ABSTRACT FROM AUTHOR]

Objective: Midfoot osteotomy combined with Ilizarov methods of correction is a rarely reported treatment that is particularly well‐suited for severe rigid pes cavus. The study aimed to assess the radiological and clinical results of patients who had been treated for rigid pes cavus using this method. Methods: The study retrospectively analyzed the clinical and radiological data of 15 pes cavus in 12 patients who were corrected by midfoot osteotomy with Ilizarov external frame in our department from March 2020 to September 2022. Radiologic outcomes were measured using the Meary angle (MA), talus‐first metatarsal angle (TM1A), calcaneal varus angle (CVA) and foot length with weight‐bearing radiographs. Functional assessments were evaluated in terms of pain, function, and quality of life by using the visual analogue scale (VAS), the American Orthopedic Foot and Ankle Society hindfoot scale score (AOFAS), and 36‐item Short Form Health Survey (SF‐36). Additionally, the postoperative satisfaction of patients was investigated by a questionnaire. The clinical and radiological results were evaluated by a paired t‐test. Results: All patients received plantigrade feet and pain relief. The mean follow‐up was 33.1 ± 5.0 months (range from 25 to 41 months). The etiology included poliomyelitis (4), idiopathic (3), trauma (2), spina bifida (2) and tethered cord syndrome (1). The duration of gradual correction was 30.4 ± 10.6 days, and the external fixation time was 116.3 ± 33.3 days. The bony union rate was 100%. The VAS, AOFAS, and SF‐36 scores significantly improved (p < 0.05). The MA, TM1A, and CVA were close to or reached the normal range postoperative (p < 0.01). The length of each foot was well preserved, which was increased more than 0.8 cm than preoperative. No major complications were reported except two cases of mildly hindfoot varus deformity. The results of the questionnaire showed that patients' satisfaction was 92% (11/12). Conclusion: Midfoot osteotomy combined with Ilizarov external frame proved to be a reasonable procedure with satisfying mid‐term results for the gradual correction of rigid pes cavus. [ABSTRACT FROM AUTHOR]

Objective: The clinical evidence on the management for congenital pseudoarthrosis of the tibia (CPT) in adults is limited. The aim of this study is to assess the functional and radiological outcomes of Ilizarov distraction for treating CPT in adults. Methods: A retrospective analysis was conducted. Between 2013 and 2022, an Ilizarov distraction technique was performed on 14 adults (14 limbs) with CPT in our limb deformity center. There were seven females and seven males with a mean age of 33.7 (range, 18 ~ 53) years. The diagnosis of NF‐1 was confirmed in seven (50.0%) patients. Eight patients had a history of previous surgical failure. The pseudoarthrosis occurred in the middle and lower tibia in all limbs (six left and eight right). The CPT was classified by Crawford classification and Paley classification. The surgical procedures, external fixation time (EFT), and all outcomes and complications were recorded. The Kolmogorov–Smirnov test was performed to test the normality of the data. The American Orthopedic Foot and Ankle Society (AOFAS) ankle‐hindfoot score at the preoperative and final follow‐up was compared by using the Wilcoxon's signed‐rank test. The limb‐length discrepancy (LLD) and a self‐made exercise capacity score at the preoperative and final follow‐up were compared by using the student's t‐test. The clinical and radiological outcomes were assessed by the Inan scale. Results: The mean EFT of Ilizarov fixator was 19.5 months (range, 7.3 ~ 39.1). At a median follow‐up of 26.8 months (IQR, 20.2 ~ 34.3), bone union of the pseudarthrosis and consolidation of the distraction zone were achieved in all patients. The mean LLD was decreased from 11.3 cm (range, 3.4 ~ 17.3) preoperatively to 1.1 cm (range, 0.3 ~ 3.7) (p < 0.05). The mean or median AOFAS ankle‐hindfoot score was improved from 53.5 (IQR, 26.5 ~ 60.5) preoperatively to 63.9 (range, 53 to 73) at final follow‐up (p < 0.05). The mean score for exercise capacity were improved from 4.9 (range, 1 to 8) preoperatively to 9.6 (range, 7 ~ 12) at final follow‐up (p < 0.05). According to the criteria described by Inan et al., the clinical results were classified as good in 10 and fair in 4, while the radiological results were classified as excellent in three, good in 8, and fair in 2. The success rate was 92.9%, as refracture was defined as treatment failure and occurred in one patient. Conclusion: Ilizarov distraction provided a suitable treatment option for the CPT in adults, as it could achieve a high rate of bone union, a good correction of secondary deformity, a low risk of refracture, and consequently restore a relatively functional limb. [ABSTRACT FROM AUTHOR]

Purpose: The aim of this study was to investigate the effect of individualized ocular refraction customized (IORC) spectacle lenses with different actual amounts of peripheral myopic defocus (MD) on myopia control over 1 year. These lenses compensate for the original peripheral refraction via the free‐form surface on the back of the lens. Methods: This 1‐year, double‐masked randomised clinical trial included 184 myopic schoolchildren aged 8–12 years. Participants were randomised to receive IORC lenses with high (IORC‐H group, +4.50 D), medium (IORC‐M group, +3.50 D) or low (IORC‐L group, +2.50 D) MD or single‐vision (SV) lenses. The spherical equivalent refractive error (SER) and axial length (AL) were measured at baseline and 6‐monthly intervals. Results: After 1 year, the mean (SD) changes in SER were −0.18 (0.37), −0.36 (0.37), −0.52 (0.39) and −0.60 (0.42) D for the IORC‐H, IORC‐M, IORC‐L and SV groups, respectively. Compared with the SV group, the effects of slowing myopia progression were 70%, 40% and 13% for the IORC‐H (difference of 0.47 D, p < 0.001), IORC‐M (difference of 0.32 D, p = 0.001) and IORC‐L (difference of 0.15 D, p > 0.05) groups, respectively. The mean (SD) changes in AL were 0.12 (0.16), 0.23 (0.17), 0.29 (0.17) and 0.36 (0.17) mm for the IORC‐H, IORC‐M, IORC‐L and SV groups, respectively. The axial elongation was 67%, 36% and 19% lower in the IORC‐H (difference of 0.25 mm, p < 0.001), IORC‐M (difference of 0.15 mm, p < 0.001) and IORC‐L (difference of 0.10 mm, p = 0.04) groups, respectively, compared with the SV group. The IORC‐H group exhibited significantly less axial elongation than the IORC‐M and IORC‐L groups (p = 0.01 and p < 0.001, respectively). Conclusion: Compared with the IORC‐M and IORC‐L lenses, the IORC‐H lens was found to have superior efficacy in inhibiting myopic progression and slowing eye growth in schoolchildren, with better myopia control efficacy in younger children. [ABSTRACT FROM AUTHOR]

Background: Echinocandins belong to the fourth generation of antifungals, and there are no systematic studies on their risk in coagulation dysfunction; this study will predict the risk of coagulation dysfunction of echinocandins using the US Food and Drug Administration Adverse Event Reporting System (FAERS) database. Method: Data from January 2004 to March 2024 were obtained from FAERS. We examined the clinical characteristics of the coagulation dysfunction events and conducted disproportionality analysis by using reporting odds ratios (ROR) to compare echinocandins with the full database. Results: There were 313 reports of coagulation dysfunction related to echinocandins as the primary suspect (PS) drug. The median time to incident for coagulation dysfunction was 3 (interquartile range [IQR] 1–9) days. Compared to triazoles and polyenes, echinocandins have a stronger signal (ROR 3.18, 95%CI 2.81–3.51, p < 0.01) of coagulation dysfunction. Compared to caspofungin and micafungin, anidulafungin has a stronger signal (ROR 6.84, 95%CI 4.83–9.70, p < 0.01). The strongest signal corresponding to disseminated intravascular coagulation (DIC), platelet count decreased, thrombocytopenia, gastrointestinal haemorrhage, cerebral haemorrhage, pulmonary haemorrhage and thrombotic thrombocytopenic purpura (TTP) is micafungin (ROR 27.19, 95%CI 18.49–39.98), micafungin (ROR 3.50, 95%CI 2.36–5.19), anidulafungin (ROR 9.75, 95%CI 5.22–18.19), micafungin (ROR 3.17, 95%CI 2.02–4.97), micafungin (ROR 4.95, 95%CI 2.81–8.72), caspofungin (ROR 20.76, 95%CI 11.77–36.59), micafungin (ROR 20.43, 95%CI 8.49–49.14), respectively. Conclusions: For coagulation dysfunction, we found stronger signals for echinocandins than triazoles and polyenes, and stronger signals for anidulafungin than micafungin and caspofungin. Coagulation parameters should be closely monitored while using the respective drugs. Highlights: Real world data were used to predict the risk of coagulopathy for three classes of drugs: echinocandins, triazoles, and polyenes. Real-world data were used to compare the risk of coagulopathy between caspofungin, micafungin, and anidulafungin. Different causes of coagulation dysfunction were analyzed by subgroups. [ABSTRACT FROM AUTHOR]

The burgeoning demand for perovskite-based photodetectors (PDs) in leading sectors can be attributed to their extraordinary stability and superior optoelectronic properties. All-inorganic halide perovskites, in particular, have emerged as the preferred choice for photoactive layers. However, significant obstacles hinder their widespread adoption, such as inadequate crystal quality, inconsistent manufacturing reproducibility, and environmental concerns. This review offers a comprehensive summary of the latest advancements in PD devices utilizing both lead-based and lead-free all-inorganic perovskite films. Special attention is given to material composition, structural and electronic dimensions, and lead-free perovskites (e.g., tin-based, bismuth-based, and copper-based perovskites). Subsequently, we explore various preparation strategies for thin films of inorganic halide perovskites, shedding light on their respective strengths and limitations. Different preparation techniques cater specifically to diverse application requirements, reflecting their unique functional attributes in optoelectronic applications. In conclusion, the review describes the current state and highlights key challenges faced by PD devices based on all-inorganic perovskite films. The comprehensive overview aims to provide researchers with deep insights into the intricacies of these complex devices and the advantages and disadvantages of various preparation methods, thereby guiding future research towards the development of sustainable, low-carbon PD devices. [ABSTRACT FROM AUTHOR]

The detection of excess toxic anions or cations in an aqueous solution through various fluorescent materials such as organic or inorganic fluorescent materials has aroused significant interest recently. Herein, a new tetraimidazole ligand 1,3-bis(1-imidazolyl)-5-[3,5-bis(1-imidazolyl)-phenoxymethyl]-benzene (timpb) and its two Cd(II) metal–organic frameworks {[Cd2(1,4-bdc)2(timpb)]·5.5(H2O)}n (1) (1,4-benzenedicarboxylic acid = 1,4-H2bdc) and {[Cd2(4,4′-bpdb)2(timpb)]·(MeCN)·2.5(H2O)}n (2) (4,4′-biphenyldicarboxylic acid = 4,4′-H2bpdb) were synthesized. Through X-ray single crystal diffraction analysis, 1 can be considered as a 2-fold interpenetrating pillared-bilayer framework formed by linking [Cd2(1,4-bdc)4]n layers with pairs of timpb ligands, whereas 2 exhibits a 2-fold interpenetrating 3D honeycombed framework formed by linking [Cd(4,4′-bpdb)]n chains with timpb ligands. The solid-state luminescent properties of timpb, 1 and 2 at ambient temperature were also investigated. Moreover, timpb acted as a potential luminescent sensor for the detection of cations Fe3+ or Cu2+ and the anion Cr2O72−, whereas 1 displayed high sensitivity toward the cation Fe3+ and anion Cr2O72−. [ABSTRACT FROM AUTHOR]

Presbycusis, or age-related hearing loss, affects both elderly humans and dogs, significantly impairing their social interactions and cognition. In humans, presbycusis involves changes in peripheral and central auditory systems, with central changes potentially occurring independently. While peripheral presbycusis in dogs is well-documented, research on central changes remains limited. Diffusion tensor imaging (DTI) is a useful tool for detecting and quantifying cerebral white matter abnormalities. This study used DTI to explore the central auditory pathway of senior dogs, aiming to enhance our understanding of canine presbycusis. Dogs beyond 75% of their expected lifespan were recruited and screened with brainstem auditory evoked response testing to select dogs without severe peripheral hearing loss. Sixteen dogs meeting the criteria were scanned using a 3 T magnetic resonance scanner. Tract-based spatial statistics was used to analyze the central auditory pathways. A significant negative correlation between fractional lifespan and fractional anisotropy was found in the acoustic radiation, suggesting age-related white matter changes in the central auditory system. These changes, observed in dogs without severe peripheral hearing loss, may contribute to central presbycusis development. [ABSTRACT FROM AUTHOR]

We use panel data from 780 Chinese listed companies from 2006–2019 to investigate the threshold impact of supply chain relationship structure on supply chain governance performance. The results indicate that supplier concentration has a single threshold effect on supplier and internal governance performance but no threshold effect on customer governance performance. Customer concentration has single and dual threshold effects on internal and customer governance performance, respectively. Although customer concentration has a single threshold effect on supplier governance performance, it is not significant before or after it reaches the threshold. These findings enrich the literature on supply chain relationship management and supply chain governance and can guide managers in managing supply chain relationships to improve governance performance. [ABSTRACT FROM AUTHOR]

Objective: To provide evidence for choosing surgical or nonsurgical treatment for epilepsy in patients with unilateral multilobar and hemispheric polymicrogyria (PMG). Methods: We searched published studies until September 2022 related to unilateral multilobar and hemispheric PMG and included patients who were followed up at the Pediatric Epilepsy Centre of Peking University First Hospital in the past 10 years. We summarized the clinical characteristics and compared the long‐term outcomes after surgical or nonsurgical (anti‐seizure medications, ASMs) treatment. Results: A total of 70 patients (49 surgical, 21 non‐surgical) with unilateral multilobar and hemispheric PMG were included. The median age at epilepsy onset was 2.5 years (1.0–4.1). The most common seizure types were focal and atypical absence seizures. In the whole cohort, 87.3% had hemiparesis and 67.1% had electrical status epilepticus during slow sleep (ESES). There were significant differences in age at epilepsy onset, extent of lesion, and EEG interictal discharges between the two groups. At the last follow‐up (median 14.1 years), the rates of seizure‐freedom (81.6% vs. 57.1%, p = 0.032) and ASM discontinuation (44.4% vs. 6.3%, p = 0.006) were higher in the surgical group than in the nonsurgical group. Patients in the surgical group had a higher rate of seizure‐freedom with complete resection/disconnection than with subtotal resection (87.5% vs. 55.6%, p = 0.078), but with no statistically significant difference. In the nonsurgical group, more extensive lesions were associated with worse seizure outcomes. Cognition improved postoperatively in 90% of surgical patients. Significance: In patients with unilateral multilobar and hemispheric PMG, the age of seizure onset, the extent of the lesion and EEG features can help determine whether surgery should be performed early. Additionally, surgery could be more favorable for achieving seizure freedom and cognitive improvement sooner. Plain Language Summary: We aim to summarize clinical characteristics and compare the long‐term outcomes after surgical and nonsurgical (ASM) treatment to provide a basis for treatment decisions for patients with unilateral multilobar and hemispheric polymicrogyria (PMG)‐related epilepsy. We found that patients with unilateral hemispheric and multilobar PMG had significantly higher rates of seizure freedom and ASM discontinuation with surgical treatment than with nonsurgical treatment. In the surgical group, seizure outcomes were better in patients treated with complete resection/disconnection than in those treated with subtotal resection, but the difference was not statistically significant. [ABSTRACT FROM AUTHOR]

To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia (ITP), this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight (CyTOF). Thirty-six patients with ITP and nine healthy volunteers were enrolled in the study. As soluble immunomodulatory molecules, more sCD25 and sGalectin-9 were detected in ITP patients. On the cell surface, co-stimulatory molecules like ICOS and HVEM were observed to be upregulated in mainly central memory and effector T cells. In contrast, co-inhibitory molecules such as CTLA-4 were significantly reduced in Th1 and Th17 cell subsets. Taking a platelet count of 30×109 L−1 as the cutoff value, ITP patients with high and low platelet counts showed different T cell immune profiles. Antigen-presenting cells such as monocytes and B cells may regulate the activation of T cells through CTLA-4/CD86 and HVEM/BTLA interactions, respectively, and participate in the pathogenesis of ITP. In conclusion, the proteomic and soluble molecular profiles brought insight into the interaction and modulation of immune cells in the bone marrow of ITP. They may offer novel targets to develop personalized immunotherapies. [ABSTRACT FROM AUTHOR]

The spectral content of macroscopic neural activity evolves throughout development, yet how this maturation relates to underlying brain network formation and dynamics remains unknown. Here, we assess the developmental maturation of electroencephalogram spectra via Bayesian model inversion of the spectral graph model, a parsimonious whole-brain model of spatiospectral neural activity derived from linearized neural field models coupled by the structural connectome. Simulation-based inference was used to estimate age-varying spectral graph model parameter posterior distributions from electroencephalogram spectra spanning the developmental period. This model-fitting approach accurately captures observed developmental electroencephalogram spectral maturation via a neurobiologically consistent progression of key neural parameters: long-range coupling, axonal conduction speed, and excitatory:inhibitory balance. These results suggest that the spectral maturation of macroscopic neural activity observed during typical development is supported by age-dependent functional adaptations in localized neural dynamics and their long-range coupling across the macroscopic structural network. A major goal of computational neuroscience is to produce models with few parameters which can account for significant aspects of behavioral, neural or physiological data. The authors perform simulation-based inference on EEG spectral features with the Spectral Graph Model, and demonstrate that spectral maturation of the brain activity is an emergent phenomenon guided by age-dependent tuning of localized neuronal dynamics. [ABSTRACT FROM AUTHOR]

Rationale: Himalayan marmot oil (SPO) has been used for pharmaceutical purposes for centuries, but its composition is still unclear. The bioactivity of SPO highly depends on the techniques used for its processing. This study focused on the comprehensive lipidomics of SPO, especially on the ones derived from dry rendering, wet rendering, cold pressing, and ultrasound‐assisted solvent extraction. Methods: We performed lipid profiling of SPO acquired by different extraction methods using ultrahigh‐performance liquid chromatography Q‐Exactive Orbitrap mass spectrometry, and 17 classes of lipids (2 BMPs, 12 LysoPCs, 9 LysoPEs, 41 PCs, 24 PEs, 23 Plasmenyl‐PCs, 10 Plasmenyl‐PEs, 10 MGs, 63 DGs, 187 TGs, 2 MGDGs, 3 Cer[NDS]s, 22 Cer[NS]s, 2 GlcCer[NS]s, 14 SMs, 14 CEs, and 6 AcylCarnitines) were characterized. Results: Fifty‐five lipids were differentially altered (VIP > 1.5, p < 0.05) between the extraction techniques, which can be used as potential biomarkers to differentiate SPO extracted by various methods. Additionally, the contents of oleic acid and arachidic acid were abundant in all samples that may suggest their medicinal values and are conducive to in‐depth research. Conclusions: These findings reveal the alterations of lipid profile and free fatty acid composition in SPO obtained with different extraction methods, providing a theoretical foundation for investigating its important components as functional factors in medicines and cosmetics. [ABSTRACT FROM AUTHOR]

Human action recognition based on optical and infrared video data is greatly affected by the environment, and feature extraction in traditional machine learning classification methods is complex; therefore, this paper proposes a method for human action recognition using Frequency Modulated Continuous Wave (FMCW) radar based on an asymmetric convolutional residual network. First, the radar echo data are analyzed and processed to extract the micro-Doppler time domain spectrograms of different actions. Second, a strategy combining asymmetric convolution and the Mish activation function is adopted in the residual block of the ResNet18 network to address the limitations of linear and nonlinear transformations in the residual block for micro-Doppler spectrum recognition. This approach aims to enhance the network's ability to learn features effectively. Finally, the Improved Convolutional Block Attention Module (ICBAM) is integrated into the residual block to enhance the model's attention and comprehension of input data. The experimental results demonstrate that the proposed method achieves a high accuracy of 98.28% in action recognition and classification within complex scenes, surpassing classic deep learning approaches. Moreover, this method significantly improves the recognition accuracy for actions with similar micro-Doppler features and demonstrates excellent anti-noise recognition performance. [ABSTRACT FROM AUTHOR]

The binding of peroxisome proliferator‐activated receptor γ (PPARγ) to the orphan nuclear receptor Nur77 facilitates the ubiquitination and degradation of Nur77, and leads to aberrant fatty acid uptake for breast cancer progression. Because of its crucial role in clinical prognosis, the interaction between Nur77 and PPARγ is an attractive target for anti‐breast‐cancer therapy. However, developing an inhibitor of the Nur77‐PPARγ interaction poses a technical challenge due to the absence of the crystal structure of PPARγ and its corresponding interactive model with Nur77. Here, ST‐CY14, a stapled peptide, is identified as a potent modulator of Nur77 with a KD value of 3.247 × 10−8 M by in silico analysis, rational design, and structural modification. ST‐CY14 effectively increases Nur77 protein levels by blocking the Nur77‐PPARγ interaction, thereby inhibiting lipid metabolism in breast tumor cells. Notably, ST‐CY14 significantly suppresses breast cancer growth and bone metastasis in mice. The findings demonstrate the feasibility of exploiting directly Nur77‐PPARγ interaction in breast cancer, and generate what to the best knowledge is the first direct inhibitor of the Nur77‐PPARγ interaction available for impeding fatty acid uptake and therapeutic development. [ABSTRACT FROM AUTHOR]

With the help of the high‐speed camera and self‐designed fixture, it was investigated that the effects of the impactors in a variety of shapes on the mechanical behavior and failure mode of carbon fiber‐reinforced polymer (CFRP) tubes with a range of inner diameter during the low‐velocity impact (LVI) of four impact energies. Then, the three‐dimensional digital image correlation (3D‐DIC) system was carried out to monitor the damage evolution of the LVI‐damaged specimens under compressive and flexural loading. In addition, the residual compressive and flexural strength of all kinds of cases were compared and discussed. The results show that the increase in wall thickness can improve the LVI, compression‐after‐impact (CAI), and flexure‐after‐impact performance. The failure mode of compression changes to brittle fracture failure at the impact circumferential region. The CAI strength of the specimen damaged by a flat impactor is 23.89% less than that of a hemispherical one, but there is little difference in flexural loading. Highlights: Mechanical behavior on in & post LVI of CFRP tubes varying wall thickness and impactor.Due to point‐line contact for flat impactor, two peak forces are in the F‐D curves.LVI property and residual strength are improved with the increase of wall thickness.Compressive failure mode is brittle fracture at the impact circumferential area.Flexure‐after‐impact strength mainly depends on the no‐impact surface of tubes. [ABSTRACT FROM AUTHOR]

Depressive disorder is a severe and complex mental illness. There are a few anti-depressive medications that can reduce depressive symptoms, but with adverse or side effects. GaoYou-13 (GY-13), commonly known as Areca Thirteen Pill, is a traditional medicine for depression treatment with significant clinical impact. However, the molecular mechanism of GY-13 has not been fully elucidated. This study aimed to explore and explain the action and mechanism of GY-13 in treatment for depression. SD male rats were stimulated differently daily for 42 days to construct a depression rat model and divided into six groups: the control, CUMS model, GY-13L, GY-13 M, GY-13H, and FLUO. The body weight of was measured on day 7, 14, 21, 28, 35, and 42 or different days, and the behavioral tests (Open-field test, Sucrose preference test, Morris water maze) were made alongside. After the rats were decapitated, the rat brains were stained with Nissl or H&E dyes. The serums of TNF-α and IL-1β were tested. The protein of p-IKKα, p-IкBα, and p-NFкBp65 was traced. Then nano-LC–MS/MS analysis was made to detect the mechanism of GY-13. The active ingredients, drug targets, and key pathways of GY-13 in treating depression were analyzed through network pharmacology and molecular docking. With immunohistochemistry, quantitative RT-PCR, and western-blot techniques, the therapeutic mechanism of GY-13 was traced and analyzed. This study revealed that GY-13 significantly enhances autonomous and exploratory behavior, sucrose consumption, learning and memory ability, and hippocampal neuronal degeneration, which inhibits inflammation. In addition, omics analysis showed several proteins were altered in the hippocampus of rats following CUMS and GY-13 treatment. Bioinformatics analysis and network pharmacology revealed the antidepressant effects of GY-13 are related to the chemokine/chemokine receptor axis. Immunohistochemistry, western blotting and RT-PCR assay further support the findings of omics analysis. We highlighted the importance of the chemokine/chemokine receptor axis in the treatment of depression, as well as showed GY-13 can be used as a novel targeted therapy for depression treatment. [ABSTRACT FROM AUTHOR]

Purpose: Joint destruction is a major burden and an unsolved problem in rheumatoid arthritis (RA) patients. We designed an intra-articular mesoporous silica nanosystem (MSN-TP@PDA-GlcN) with anti-inflammatory and joint protection effects. The nanosystem was synthesized by encapsulating triptolide (TP) in mesoporous silica nanoparticles and coating it with pH-sensitive polydopamine (PDA) and glucosamine (GlcN) grafting on the PDA. The nano-drug delivery system with anti-inflammatory and joint protection effects should have good potency against RA. Methods: A template method was used to synthesize mesoporous silica (MSN). MSN-TP@PDA-GlcN was synthesized via MSN loading with TP, coating with PDA and grafting of GlcN on PDA. The drug release behavior was tested. A cellular inflammatory model and a rat RA model were used to evaluate the effects on RA. In vivo imaging and microdialysis (MD) system were used to analyze the sustained release and pharmacokinetics in RA rats. Results: TMSN-TP@PDA-GlcN was stable, had good biocompatibility, and exhibited sustained release of drugs in acidic environments. It had excellent anti-inflammatory effects in vitro and in vivo. It also effectively repaired joint destruction in vivo without causing any tissue toxicity. In vivo imaging and pharmacokinetics experiments showed that the nanosystem prolonged the residence time, lowered the Cmax value and enhanced the relative bioavailability of TP. Conclusions: These results demonstrated that MSN-TP@PDA-GlcN sustained the release of drugs in inflammatory joints and produced effective anti-inflammatory and joint protection effects on RA. This study provides a new strategy for the treatment of RA. [ABSTRACT FROM AUTHOR]

Aims: To predict the vagus nerve stimulation (VNS) efficacy for pediatric drug‐resistant epilepsy (DRE) patients, we aim to identify preimplantation biomarkers through clinical features and electroencephalogram (EEG) signals and thus establish a predictive model from a multi‐modal feature set with high prediction accuracy. Methods: Sixty‐five pediatric DRE patients implanted with VNS were included and followed up. We explored the topological network and entropy features of preimplantation EEG signals to identify the biomarkers for VNS efficacy. A Support Vector Machine (SVM) integrated these biomarkers to distinguish the efficacy groups. Results: The proportion of VNS responders was 58.5% (38/65) at the last follow‐up. In the analysis of parieto‐occipital α band activity, higher synchronization level and nodal efficiency were found in responders. The central‐frontal θ band activity showed significantly lower entropy in responders. The prediction model reached an accuracy of 81.5%, a precision of 80.1%, and an AUC (area under the receiver operating characteristic curve) of 0.838. Conclusion: Our results revealed that, compared to nonresponders, VNS responders had a more efficient α band brain network, especially in the parieto‐occipital region, and less spectral complexity of θ brain activities in the central‐frontal region. We established a predictive model integrating both preimplantation clinical and EEG features and exhibited great potential for discriminating the VNS responders. This study contributed to the understanding of the VNS mechanism and improved the performance of the current predictive model. [ABSTRACT FROM AUTHOR]

The galvanic dissolved oxygen sensor finds widespread applications in multiple critical fields due to its high precision and excellent stability. As its core sensing components, the oxygen-permeable membrane, electrode, and electrolyte significantly impact the sensor's performance. To systematically investigate the comprehensive effects of these core sensing components on the performance of galvanic dissolved oxygen sensors, this study selected six types of oxygen-permeable membranes made from two materials (Perfluoroalkoxy Polymer (PFA) and Fluorinated Ethylene Propylene Copolymer (FEP)) with three thicknesses (0.015 mm, 0.03 mm, and 0.05 mm). Additionally, five concentrations of KCl electrolyte were configured, and four different proportions of lead–tin alloy electrodes were chosen. Single-factor and crossover experiments were conducted using the OxyGuard dissolved oxygen sensor as the experimental platform. The experimental results indicate that under the same membrane thickness conditions, PFA membranes provide a higher output voltage compared to FEP membranes. Moreover, the oxygen permeability of FEP membranes is more significantly affected by temperature. Furthermore, the oxygen permeability of the membrane is inversely proportional to its thickness; the thinner the membrane, the better the oxygen permeability, resulting in a corresponding increase in sensor output voltage. When the membrane thickness is reduced from 0.05 mm to 0.015 mm, the sensor output voltage for PFA and FEP membranes increases by 86% and 74.91%, respectively. However, this study also observed that excessively thin membranes might compromise measurement accuracy. In a saturated, dissolved oxygen environment, the sensor output voltage corresponding to the six oxygen-permeable membranes used in the experiment exhibits a highly linear inverse relationship with temperature (correlation coefficient ≥ 98%). Meanwhile, the lead–tin ratio of the electrode and electrolyte concentration have a relatively minor impact on the sensor output voltage, demonstrating good stability at different temperatures (coefficient of variation ≤ 0.78%). In terms of response time, it is directly proportional to the thickness of the oxygen-permeable membrane, especially for PFA membranes. When the thickness increases from 0.015 mm to 0.05 mm, the response time extends by up to 2033.33%. In contrast, the electrode material and electrolyte concentration have a less significant effect on response time. To further validate the practical value of the experimental results, the best-performing combination of core sensing components from the experiments was selected to construct a new dissolved oxygen sensor. A performance comparison test was conducted between this new sensor and the OxyGuard dissolved oxygen sensor. The results showed that both sensors had the same response time (49 s). However, in an anaerobic environment, the OxyGuard sensor demonstrated slightly higher accuracy by 2.44%. This study not only provides a deep analysis of the combined effects of oxygen-permeable membranes, electrodes, and electrolytes on the performance of galvanic dissolved oxygen sensors but also offers scientific evidence and practical guidance for optimizing sensor design. [ABSTRACT FROM AUTHOR]

Efficiently querying multiple spatial datasets is a challenging task in geoscience. The majority of spatial processing techniques use minimum bounding box (MBB) to approximate neighbouring spatial objects and and place them adjacent in the spatial index. However, due to the existence of redundant space in MBB of these methods, this problem can significantly reduce the query efficiency. In this paper, we propose a novel two-stage adaptive method of clipping the bounding box in spatial query, called IB-CBB (Intersection Based Clipped Bounding Boxes). The first stage employs a clipped bounding box, which records the redundant spatial spaces within the bounding box of the spatial index by calculating the clip points. As a result, the computational complexity of indexed child nodes in the query process is reduced. The second stage optimizes the above query algorithm by judging the intersection of the query box and the MBB of index node, significantly reducing the query time. Experiments demonstrate that IB-CBB outperforms the baseline method in terms of reducing the computational time. [ABSTRACT FROM AUTHOR]

Objective To analyse the trend of COPD patients' inpatient costs and its influencing factors in the context of the reform of DRG, and to provide reference for the reasonable control of COPD inpatient costs. Methods ITSA were used to analyse the trend of COPD patients' inpatient costs in a tertiary general hospital from 2018 to 2022, and univariate analysis, stepwise regression analysis and RFM were used to analyse the factors influencing the inpatient costs and the degree of significance of COPD patients' inpatient costs after the official operation of the DRG. Results The results of ITSA showed that the overall inpatient costs of COPD patients decreased significantly and by an average of 1.82% per month during the DRG operation stage; the integrated medical service fee, drug fee, and consumable fee all showed a decreasing trend during the DRG operation stage, by an average of 1.06%, 1.67%, and 4. 98% per month, respectively, but the proportion of the integrated medical service fee increased compared with that before the DRG reform by 7.18%; The stepwise regression results showed that the number of hospital days (β = 0.584), admission status (β = 0.294), whether surgery (β = 0.125), whether traditional Chinese medicine (β = 0.084), and drug share ratio (β = 0.099) had a statistically significant impact on COPD hospitalisation costs (P < 0.05); and the results of the Random Forest model analysis showed that hospital days, admission status, drug share ratio were the most important factors influencing COPD hospitalisation costs, status, and medication ratio were the key factors affecting COPD hospitalisation costs. Conclusion DRG can effectively promote medical institutions to strengthen cost management and reduce the economic burden of disease. Hospitals should further reduce the cost of COPD and the economic burden of patients by reducing the number of inpatient days, strengthening the management of critically ill patients, and promoting the rational use of drugs. [ABSTRACT FROM AUTHOR]

Objective This study aims to investigate the mortality among HIV/AIDS patients receiving antiretroviral therapy (ART) in Fangchenggang City, Guangxi Province, and to identify associated factors with AIDS-related and non-AIDS-related deaths, providing scientific evidence for reducing AIDS mortality. Methods We collected data from the National Comprehensive AIDS Prevention and Control Information System. These data included socio-demographic and follow-up records of 2 728 HIV-1 infected individuals receiving Antiretroviral Therapy (ART) treatment in Fangchenggang City from January 1, 2005 to July 5, 2022. This dataset included socio-demographic and follow-up records during the specified period, providing a comprehensive insight into the therapeutic responses, survival rates, and potential associated complications among ART-treated HIV/AIDS patients within Fangchenggang City. Socio-demographic and follow-up data were analyzed using the cumulative incidence function (CIF) under a competing risk framework and the Fine-Gray subdistribution hazard regression model to assess the associated factors with both AIDS-related and non-AIDS-related deaths. Results With an average follow-up period of 6.7 person-years, 295 cases experienced AIDS-related death with a mortality rate of 1.06/100 person-years, while 227 cases died from non-AIDS-related causes, with a mortality rate of 1.2/100 person-years. Under consideration of competing risks, the cumulative incidence of AIDS-related death at 1 year, 5 years, and 13 years post-diagnosis was 2.5%, 8.5%, and 15.0%, respectively. The factors associated with a higher risk of AIDS-related death included: age 60 years or older (aHR = 1.5, 95% CI: 1.05~2.15), current spouse's infection status unknown/not investigated (aHR = 1.39, 95 % CI: 1.03~1.90), history of prophylactic treatment for opportunistic infections (aHR = 1.4, 95% CI: 1.06~1.84), and occurrence of opportunistic infections or tumors (aHR = 1.65, 95% CI: 1.12~2.45) . On the contrary, factors associated with a lower risk of AIDS-related death included: being female (aHR = 0.61, 95% CI: 0.49~0.90), initial treatment regimen containing EFV (aHR = 0.41, 95% CI: 0.25~0.68), having changed the treatment regimen (aHR = 0.19, 95% CI: 0.12~0.29), first CD4 cell count ≥ 200 cells/µL (aHR = 0.30, 95% CI: 0.20~0.45), initial viral load (VL) between 50 to 1000 copies/ml (aHR = 0.31, 95% CI: 0.18-0.54), and VL < 50 copies/ml (aHR = 0.61, 95% CI: 0.44~0.84). Regarding non-AIDS related deaths, passive detection (aHR = 1.41, 95% CI: 1.0~1.98), uninvestigated/unknown spouse's infection status (aHR = 1.40, 95% CI: 1.01~1.95), and first CD4 cell count ≥200 cells/ (JLL (aHR = 1.68, 95% CI: 1.27~2.22) were found to be associated with increased risk. In contrast, lower risk factors included being female (aHR = 0.55, 95 % CI: 0.37-0.81), having experienced a change in antiviral treatment regimen post-initiation (aHR = 0.33, 95%CI :0.21-0.50), initial treatment regimens containing EFV (aHR = 0.55, 95% CI: 0.34-0.88), and NVP (aHR = 0.50, 95% CI: 0.3-0.83). Conclusion The mortality rate among HIV/AIDS patients receiving ART in Fangchenggang City is relatively low. This study underscores the importance of preventing and treating opportunistic infections or tumors for improving the survival of HIV/AIDS patients. HIV/AIDS care clinics should particularly focus on monitoring and following up on female patients, older patients, and those detected passively, enhancing medication adherence, expanding HIV testing among key populations, and thereby striving to reduce the mortality rate among AIDS patients. [ABSTRACT FROM AUTHOR]

Study Design: Retrospective cohort study Objectives: The goal of this study was to determine the clinical characteristics of patients with primary spinal osteosarcoma and to construct a practical clinical prediction model for patients to achieve an accurate prediction of overall survival. Methods: This study included 230 patients diagnosed between 2004-2015 from the Surveillance, Epidemiology, and End Results database. Independent risk factors were screened in the training set using Cox regression algorithms, and a prognostic model was developed. Internal and external validation sets were used to test the nomogram model's calibration, discrimination, and clinical utility. A risk classification system based on the nomogram was developed and validated. Results: Four independent prognostic factors were identified, and based on this a nomogram model was developed for predicting patient prognosis. The C-index of the training set was.737, while that of the validation set was.693. The time-varying area under the curve values was greater than.720 in both cohorts. The calibration curves proved that the prediction model has high prediction accuracy. The decision curve analysis showed that the nomogram is clinically useful. A risk classification system was established, which allows all patients to be divided into two different risk groups. Conclusions: A nomogram and risk classification system was developed for patients with primary spinal osteosarcoma to accurately predict overall patient survival and achieve risk stratification of patient mortality. These tools are expected to play an important role in clinical practice, informing clinicians in making decisions. [ABSTRACT FROM AUTHOR]

Background: The purpose of this study was to analyze myopic regression after corneal refractive surgery (CRS) in civilian pilots and to explore the factors that may cause long-term myopic regression. Methods: We included civilian pilots who had undergone CRS to correct their myopia and who had at least 5 years of follow-up. We collected retrospective data and completed eye examinations and a questionnaire to assess their eye habits. Results: A total of 236 eyes were evaluated in this study. 211 eyes had Intrastromal ablations (167 eyes had laser in situ keratomileusis, LASIK, 44 eyes had small incision lenticule extraction, SMILE) and 25 eyes had subepithelial ablations (15 eyes had laser epithelial keratomileusis, LASEK and 10 eyes had photorefractive keratectomy, PRK). The mean preoperative spherical equivalent (SE) was − 2.92 ± 1.11 D (range from − 1.00 to -5.00 D). A total of 56 eyes (23.6%) suffered from myopic regression after CRS. Comparisons of individual and eye characteristics between the regression and non-regression groups revealed statistically significant differences in age, cumulative flight time, postoperative SE (at 6 months and current), uncorrected visual acuity (UCVA), accommodative amplitude (AA), positive relative accommodation (PRA), postoperative period, types of CRS and eye habits. Generalized propensity score weighting (GPSW) was used to balance the distribution of covariates among different age levels, types of CRS, cumulative flying time, postoperative period and continuous near-work time. The results of GPS weighted logistic regression demonstrated that the associations between age and myopic regression, types of CRS and myopic regression, continuous near-work time and myopic regression were significant. Cumulative flying time and myopic regression, postoperative period and myopic regression were no significant. Specifically, the odds ratio (OR) for age was 1.151 (P = 0.022), and the OR for type of CRS was 2.769 (P < 0.001). The OR for continuous near-work time was 0.635 with a P value of 0.038. Conclusions: This is the first report to analyze myopic regression after CRS in civilian pilots. Our study found that for each year increase in age, the risk of civilian pilots experiencing myopic regression was increased. Intrastromal ablations had a lower risk of long-term myopia regression than subepithelial ablations. There is a higher risk of myopic progression with continuous near-work time > 45 min and poor accommodative function may be related factors in this specific population. [ABSTRACT FROM AUTHOR]

The human cerebellum is engaged in a broad array of tasks related to motor coordination, cognition, language, attention, memory, and emotional regulation. A detailed cerebellar atlas can facilitate the investigation of the structural and functional organization of the cerebellum. However, existing cerebellar atlases are typically limited to a single imaging modality with insufficient characterization of tissue properties. Here, we introduce a multifaceted cerebellar atlas based on high-resolution multimodal MRI, facilitating the understanding of the neurodevelopment and neurodegeneration of the cerebellum based on cortical morphology, tissue microstructure, and intra-cerebellar and cerebello-cerebral connectivity. [ABSTRACT FROM AUTHOR]

As a widely considerable target in chemical biology and pharmacological research, rat sarcoma (RAS) gene mutations play a critical driving factor in several fatal cancers. Despite the great progress of RAS subtype‐specific inhibitors, rapid acquired drug resistance could limit their further clinical applications. Proteolysis targeting chimera (PROTAC) has emerged as a powerful tool to handle "undruggable" targets and exhibited significant therapeutic benefit for the combat of drug resistance. Owing to unique molecular mechanism and binding kinetics, PROTAC is expected to become a feasible strategy to break the bottleneck of classical RAS inhibitors. This review aims to discuss the current advances of RAS inhibitors and especially focus on PROTAC strategy targeting RAS mutations and their downstream effectors for relevant cancer treatment. [ABSTRACT FROM AUTHOR]

BACKGROUND: Chlorantraniliprole (CAP) is a diamide insecticide with high efficacy against many pest insects, including the black cutworm, Agrotis ipsilon. Agrotis ipsilon is a serious pest causing significant yield losses in crops. Glutathione‐S‐transferases (GSTs) belong to a family of metabolic enzymes that can detoxify a wide range of pesticides. However, little is known about the functions of GSTs in CAP tolerance in A. ipsilon. RESULTS: A cDNA sequence (designated AiGSTu1) encoding an unclassified GST was identified from A. ipsilon. AiGSTu1 is highly expressed during the 3rd‐instar larval and the pupal stages. Most of the mRNA transcripts were found in larval Malpighian tubules. Exposure to CAP strongly enhanced AiGSTu1 expression, GST activity, hydrogen peroxide (H2O2) and malondialdehyde levels in larvae. H2O2 treatment upregulated the transcription level of AiGSTu1, suggesting that CAP‐induced oxidative stress may activate AiGSTu1 expression. The activity of recombinant AiGSTu1 was inhibited by CAP in a dose‐dependent manner. Metabolism assay results demonstrated that AiGSTu1 is capable of depleting CAP. Overexpression of AiGSTu1 enhanced the tolerance of Escherichia coli cells to H2O2 and the oxidative stress inducer, cumene hydroperoxide. Silencing of AiGSTu1 by RNA interference increased the susceptibility of A. ipsilon larvae to CAP. CONCLUSION: The findings of this study provide valuable insights into the potential role of AiGSTu1 in CAP detoxification and will improve our understanding of CAP tolerance in A. ipsilon. © 2023 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

Two-dimensional layered metal dichalcogenides have given rise to considerable interest in electronics and optoelectronics fields because of their excellent physical and chemical properties and promising applications. Tin disulfide (SnS2) is an important member of them due to its environment-friendly and resource-rich characteristics. Here, a series of in situ electrical transport experiments and photocurrent measurements under high pressure have been performed to investigate the electrical and opto-electrical properties of 4H-SnS2. With increasing pressure, the electrical resistivity of 4H-SnS2 decrease significantly, leading to a transition from semiconducting to metallic state above 58.6 GPa. The increase in pressure results in a substantial enhancement in photoelectric activity, indicating the extensive potential of utilizing pressure as a trigger for in situ optoelectronic applications. Combined with our previous results of x-ray diffraction and optical absorption at high pressure, pressure-induced structural distortion, bandgap narrowing, metallization, and enhancement of photoelectric activity of 4H-SnS2 are tunable and reversible, which are of great significance for both fundamental research and device design. [ABSTRACT FROM AUTHOR]