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A high-yielding, ligand-free, palladium-catalyzed isocy-anide insertion reaction for the synthesis of phthalazino[1,2-6]quin-azolinones from the readily obtainable quinazolinones has been developed. Easily handled and relatively low-cost palladium(II) ac-etate was used as the catalyst, without an additional ligand. Prepa-ration of the quinazolinones involved the cascade reaction of isatoic anhydrides, phenylhydrazines and 2-bromobenzaldehyde catalyzed by p-toluenesulfonic acid in one pot. This novel protocol may be ap-plicable for the synthesis of other important ring-fused heterocyclic compounds. [ABSTRACT FROM AUTHOR]

A new route for the synthesis of novel spirooxindoles from isocyanides, dialkyl acetylenedicarboxylates, and N-substituted isatylidene derivatives through [3+2] cycloaddition has been developed. This method has several advantages, such as high regioselectivity, high yields, readily available starting materials, and one-pot operations. The synthetic alkyne-containing spirooxindoles could also be used in the selective synthesis of triazolecontaining spirocyclic compounds using a copper azide-alkyne cycloaddition (CuAAC) reaction. [ABSTRACT FROM AUTHOR]

Ytterbium perfluorooctanesulfonate [Yb(OPf)3] catalyses the highly efficient synthesis of acylals from aldehydes and acetic anhydride in a fluorous biphase system (FBS) composed of toluene and perfluorodecalin. The fluorous phase containing the fluorous catalyst is easily separated and can be reused several times without significant loss of catalytic activity. [ABSTRACT FROM AUTHOR]