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Building a fault-tolerant quantum computer will require vast numbers of physical qubits. For qubit technologies based on solid-state electronic devices1–3, integrating millions of qubits in a single processor will require device fabrication to reach a scale comparable to that of the modern complementary metal–oxide–semiconductor (CMOS) industry. Equally important, the scale of cryogenic device testing must keep pace to enable efficient device screening and to improve statistical metrics such as qubit yield and voltage variation. Spin qubits1,4,5 based on electrons in Si have shown impressive control fidelities6–9 but have historically been challenged by yield and process variation10–12. Here we present a testing process using a cryogenic 300-mm wafer prober13 to collect high-volume data on the performance of hundreds of industry-manufactured spin qubit devices at 1.6 K. This testing method provides fast feedback to enable optimization of the CMOS-compatible fabrication process, leading to high yield and low process variation. Using this system, we automate measurements of the operating point of spin qubits and investigate the transitions of single electrons across full wafers. We analyse the random variation in single-electron operating voltages and find that the optimized fabrication process leads to low levels of disorder at the 300-mm scale. Together, these results demonstrate the advances that can be achieved through the application of CMOS-industry techniques to the fabrication and measurement of spin qubit devices.Using a cryogenic 300-mm wafer prober, a new approach for the testing of hundreds of industry-manufactured spin qubit devices at 1.6 K provides high-volume data on performance, allowing optimization of the complementary metal–oxide–semiconductor (CMOS)-compatible fabrication process. [ABSTRACT FROM AUTHOR]

Cerebellar networks have traditionally been linked to sensorimotor control. However, a large body of evidence suggests that cerebellar functions extend to non-motor realms, such as fear-based emotional processing and that these functions are supported by interactions with a wide range of brain structures. Research related to the cerebellar contributions to emotional processing has focussed primarily on the use of well-constrained conditioning paradigms in both human and non-human subjects. From these studies, cerebellar circuits appear to be critically involved in both conditioned and unconditioned responses to threatening stimuli in addition to encoding and storage of fear memory. It has been hypothesised that the computational mechanism underlying this contribution may involve internal models, where errors between actual and expected outcomes are computed within the circuitry of the cerebellum. From a clinical perspective, cerebellar abnormalities have been consistently linked to neurodevelopmental disorders, including autism. Importantly, atypical adaptive behaviour and heightened anxiety are also common amongst autistic individuals. In this review, we provide an overview of the current anatomical, physiological and theoretical understanding of cerebellar contributions to fear-based emotional processing to foster further insights into the neural circuitry underlying emotional dysregulation observed in people with autism. [ABSTRACT FROM AUTHOR]

The paper describing sea level rise oscillations at Cape Hatteras, USA, by Parker (2012) has opened the discussion regarding if the velocity in a tide gauge record characterized by a quasi-60-year multi-decadal oscillation can be computed by linear fitting of 30 years of data in two ad hoc selected times and if acceleration can then be inferred by comparing these two values as proposed by Sallenger et al. (2012), or if this comparison is meaningless in that the 60-year time window is the minimum amount of time needed to evaluate the velocity in a record characterized by a quasi-60-year multi-decadal oscillation, and the acceleration has then to be computed as the time derivative of this velocity as suggested by Parker (2012a; b). For the specific case of The Battery, NY, it is shown here that the 60-year time window is the minimum time length needed to compute a velocity, and both the 60-year windows and the all data velocities are free of any acceleration at the present time. The 30-year time window velocity of 2009 is not representative of the present sea level rise, and the comparison of the 30-year time window velocity of 2009 and 1979 near a peak and a valley, respectively, of the 60-year multi-decadal oscillation to claim a present acceleration has no scientific background. [ABSTRACT FROM AUTHOR]

Background: Huntingtin (htt) protein is an essential regulator of nervous system function through its various neuroprotective and pro-survival functions, and loss of wild-type htt function is implicated in the etiology of Huntington's disease. While its pathological role is typically understood as a toxic gain-of-function, some neuronal phenotypes also result from htt loss. Therefore, it is important to understand possible roles for htt in other physiological circumstances. Objective: To elucidate the role of htt in the context of ethanol exposure, we investigated how loss of htt impacts behavioral and physiological responses to ethanol in Drosophila. Methods: We tested flies lacking htt for ethanol sensitivity and tolerance, preference for ethanol using capillary feeder assays, and recovery of mobility after intoxication. Levels of dopamine neurotransmitter and numbers of dopaminergic cells in brains lacking dhtt were also measured. Results: We found that dhtt-null flies are both less sensitive and more tolerant to ethanol exposure in adulthood. Moreover, flies lacking dhtt are more averse to alcohol than controls, and they recover mobility faster following acute ethanol intoxication. We showed that dhtt mediates these effects at least in part through the dopaminergic system, as dhtt is required to maintain normal levels of dopamine in the brain and normal numbers of dopaminergic cells in the adult protocerebrum. Conclusions: Our results demonstrate that htt regulates the physiological response to ethanol and indicate a novel neuroprotective role for htt in the dopaminergic system, raising the possibility that it may be involved more generally in the response to toxic stimuli. [ABSTRACT FROM AUTHOR]

In a STOC 1976 paper, Schaefer proved that it is PSPACE-complete to determine the winner of the so-called Maker-Breaker game on a given set system, even when every set has size at most 11. Since then, there has been no improvement on this result. We prove that the game remains PSPACE-complete even when every set has size 6. [ABSTRACT FROM AUTHOR]

Background: Esophageal perforation is a serious and potentially life-threatening medical emergency. Given multiple etiologies and varying clinical presentations of the perforated esophagus, the diagnosis is commonly delayed, complicating expeditious and optimal intervention.Methods: We thoroughly reviewed the latest literature on the subject and herein describe the various treatment strategies in varying settings.Results: Treatment depends on multiple factors including the cause and location of the perforation, the time interval between the inciting event and presentation to the managing clinician, the overall medical stability of the patient, comorbidities including pre-existent esophageal pathology or prior foregut operations, and both the location and extent of extra-esophageal fluid collections. Because of these various considerations, determining the best diagnostic and therapeutic approach requires considerable clinical experience and judgment on the part of the physician. Management principles include (1) adequate fluid resuscitation; (2) expeditious administration of appropriate broad-spectrum antibiotics; (3) repair, occlusion, exclusion, diversion, or exteriorization of the perforation site; (4) drainage of extraluminal fluid collections; (5) relief of distal obstruction; and (6) nutritional support.Conclusions: For decades, operative intervention has been the mainstay of therapy for esophageal perforation. More recently, endoscopic therapies, including stenting, clipping, suturing, or endoscopic vacuum therapy, have been introduced, expanding the clinician's therapeutic armamentarium while supplanting surgical approaches in many cases. With further experience and introduction of novel therapies, the management of esophageal perforation undoubtedly will continue to evolve. [ABSTRACT FROM AUTHOR]

Background: Mutations in the postsynaptic transmembrane protein neuroligin-3 are highly correlative with autism spectrum disorders (ASDs) and intellectual disabilities (IDs). Fear learning is well studied in models of these disorders, however differences in fear response behaviours are often overlooked. We aim to examine fear behaviour and its cellular underpinnings in a rat model of ASD/ID lacking Nlgn3. Methods: This study uses a range of behavioural tests to understand differences in fear response behaviour in Nlgn3−/y rats. Following this, we examined the physiological underpinnings of this in neurons of the periaqueductal grey (PAG), a midbrain area involved in flight-or-freeze responses. We used whole-cell patch-clamp recordings from ex vivo PAG slices, in addition to in vivo local-field potential recordings and electrical stimulation of the PAG in wildtype and Nlgn3−/y rats. We analysed behavioural data with two- and three-way ANOVAS and electrophysiological data with generalised linear mixed modelling (GLMM). Results: We observed that, unlike the wildtype, Nlgn3−/y rats are more likely to response with flight rather than freezing in threatening situations. Electrophysiological findings were in agreement with these behavioural outcomes. We found in ex vivo slices from Nlgn3−/y rats that neurons in dorsal PAG (dPAG) showed intrinsic hyperexcitability compared to wildtype. Similarly, stimulating dPAG in vivo revealed that lower magnitudes sufficed to evoke flight behaviour in Nlgn3−/y than wildtype rats, indicating the functional impact of the increased cellular excitability. Limitations: Our findings do not examine what specific cell type in the PAG is likely responsible for these phenotypes. Furthermore, we have focussed on phenotypes in young adult animals, whilst the human condition associated with NLGN3 mutations appears during the first few years of life. Conclusions: We describe altered fear responses in Nlgn3−/y rats and provide evidence that this is the result of a circuit bias that predisposes flight over freeze responses. Additionally, we demonstrate the first link between PAG dysfunction and ASD/ID. This study provides new insight into potential pathophysiologies leading to anxiety disorders and changes to fear responses in individuals with ASD. [ABSTRACT FROM AUTHOR]

Objectives: Approximately 20-40% of patients with locally advanced esophageal cancer will achieve a pathologic complete response (ypCR) following neoadjuvant chemoradiotherapy (nCRT). Predicting ypCR based on a clinical complete response (ycCR) has been a challenge. This study assessed the correlation between ycCR and ypCR, as determined from esophagectomy specimens.Methods: Patients undergoing esophagectomy following nCRT at three major institutions between 2005 and 2018 were reviewed. Restaging, including PET/CT, endoscopy with biopsy, and esophageal ultrasound (EUS), was performed to determine ycCR.Results: Six hundred sixty patients were included, with 93.3% with esophageal adenocarcinoma histology. Six hundred fifty-eight of these patients underwent PET, 304 EUS, and 584 underwent a biopsy. Following nCRT, 148 (22.4%) were found to have a ypCR. Only 12/32 (37.5%) determined to have a ycCR were found to have a ypCR, while 136/628 (21.6%) with a non-ycCR were found to have a ypCR (p 0.075). Individual modality PPV was 28% for PET, 54% for EUS, and 26% for biopsy. When PET was combined with EUS, 168 reports were concordant and the PPV of ypCR was 50%, though the number of patients was low (1/2). With all 3 re-staging modalities combined, the PPV and NPV both rose to 100%.Conclusions: Current restaging tools cannot reliably predict ypCR after nCRT. While multimodal restaging appears to be a more accurate predictor of ypCR than any testing modality alone, patients cannot reliably be advised to avoid an esophagectomy on the assumption that ycCR predicts ypCR at this time. [ABSTRACT FROM AUTHOR]

Review of: Investigative Aesthetics: Conflicts and Commons in the Politics of Truth, Matthew Fuller and Eyal Weizman (2021) London: Verso, 272 pp., ISBN 978-1-78873-908-5, p/bk, £14.99 [ABSTRACT FROM AUTHOR]

During sleep, the widespread coordination of neuronal oscillations across both cortical and subcortical brain regions is thought to support various physiological functions. However, how sleep-related activity within the brain's largest sensorimotor structure, the cerebellum, is multiplexed with well-described sleep-related mechanisms in regions such as the hippocampus remains unknown. We therefore simultaneously recorded from the dorsal hippocampus and three distinct regions of the cerebellum (Crus I, lobule VI, and lobules II/III) in male mice during natural sleep. Local field potential (LFP) oscillations were found to be coordinated between these structures in a sleep stage-specific manner. During non-REM sleep, prominent ε frequency coherence was observed between lobule VI and hippocampus, whereas non-REM-associated hippocampal sharp-wave ripple activity evoked discrete LFP modulation in all recorded cerebellar regions, with the shortest latency effects in lobule VI. We also describe discrete phasic sharp potentials (PSPs), which synchronize across cerebellar regions and trigger sharp-wave ripple suppression. During REM, cerebellar ε phase significantly modulated hippocampal theta frequency, and this effect was greatest when PSPs were abundant. PSPs were phase-locked to cerebellar ε oscillation peak and hippocampal theta oscillation trough, respectively. Within all three cerebellar regions, prominent LFP oscillations were observed at both low (ε,,4Hz) and very high frequencies (;250Hz) during non-REM and REM sleep. Intracerebellar cross-frequency analysis revealed that ε oscillations modulate those in the very high-frequency range. Together, these results reveal multiple candidate physiological mechanisms to support "offline," bidirectional interaction within distributed cerebello-hippocampal networks. [ABSTRACT FROM AUTHOR]

We provide a complete picture of the extent to which amplification of success probability is possible for randomized algorithms having access to one NP oracle query, in the settings of two-sided, onesided, and zero-sided error. We generalize this picture to amplifying one-query algorithms with q-query algorithms, and we show our inclusions are tight for relativizing techniques. [ABSTRACT FROM AUTHOR]

We present OH observations made in Amazonas, Brazil during the Green Ocean Amazon campaign (GoAmazon2014/5) from February to March of 2014. The average diurnal variation of OH peaked with a midday (10:00–15:00) average of 1.0 × 106 (±0.6 × 106) molecules cm−3. This was substantially lower than previously reported in other tropical forest photochemical environments (2–5 × 106 molecules cm−3) while the simulated OH reactivity was lower. The observational data set was used to constrain a box model to examine how well current photochemical reaction mechanisms can simulate observed OH. We used one near‐explicit mechanism (MCM v3.3.1) and four condensed mechanisms (i.e., RACM2, MOZART‐T1, CB05, CB6r2) to simulate OH. A total of 14 days of analysis shows that all five chemical mechanisms were able to explain the measured OH within instrumental uncertainty of 40% during the campaign in the Amazonian rainforest environment. Future studies are required using more reliable NOx and VOC measurements to further investigate discrepancies in our understanding of the radical chemistry in the tropical rainforest. Key Points: OH observations with a chemical ionization mass spectrometer during the GoAmazon2014/5 study were lower than some previous studiesBox model simulations of OH were carried out with five different chemical mechanismsObserved and model‐predicted OH concentrations agree to within measurement uncertainty of 40% [ABSTRACT FROM AUTHOR]

We investigate the power of randomness in two-party communication complexity. In particular, we study the model where the parties can make a constant number of queries to a function that has an efficient one-sided-error randomized protocol. The complexity classes defined by this model comprise the Randomized Boolean Hierarchy, which is analogous to the Boolean Hierarchy but defined with one-sidederror randomness instead of nondeterminism. Our techniques connect the Nondeterministic and Randomized Boolean Hierarchies, and we provide a complete picture of the relationships among complexity classes within and across these two hierarchies. In particular, we prove that the Randomized Boolean Hierarchy does not collapse, and we prove a query-to-communication lifting theorem for all levels of the Nondeterministic Boolean Hierarchy and use it to resolve an open problem stated in the paper by Halstenberg and Reischuk (CCC 1988) which initiated the study of this hierarchy. [ABSTRACT FROM AUTHOR]

The molecular mechanisms that produce the full array of neuronal subtypes in the vertebrate nervous system are incompletely understood. Here, we provide evidence of a global temporal patterning program comprising sets of transcription factors that stratifies neurons based on the developmental time at which they are generated. This transcriptional code acts throughout the central nervous system, in parallel to spatial patterning, thereby increasing the diversity of neurons generated along the neuraxis. We further demonstrate that this temporal program operates in stem cell−derived neurons and is under the control of the TGFβ signaling pathway. Targeted perturbation of components of the temporal program, Nfia and Nfib, reveals their functional requirement for the generation of late-born neuronal subtypes. Together, our results provide evidence for the existence of a previously unappreciated global temporal transcriptional program of neuronal subtype identity and suggest that the integration of spatial and temporal patterning mechanisms diversifies and organizes neuronal subtypes in the vertebrate nervous system. How is the full array of neuronal subtypes in the vertebrate nervous system produced? This study reveals a temporal transcriptional program that diversifies neuronal subtype identity throughout the nervous system and operates in parallel with spatial patterning mechanisms. [ABSTRACT FROM AUTHOR]

This article presents a fully integrated Cryo-CMOS system on chip (SoC) for quantum computing. The proposed SoC integrates a radio frequency (RF) pulse modulator for qubit state manipulation, a multi-tone signal generator and a coherent receiver for qubit state readout, and 22 DACs for high-speed voltage pulsing of qubit gates. By adopting frequency division multiplexing and direct digital synthesis (DDS), the RF pulse modulator can control up to 16 qubits over a single RF line, and the readout receiver can detect the state of up to six qubits simultaneously. The proposed SoC also integrates a microcontroller for low latency on-chip signal processing and increased flexibility in implementing quantum instruction sets. A detailed analysis of qubit-state readout fidelity and the impact of finite DAC resolution on two-qubit gate fidelity is also included in this article, together with an electrical specification summary. The SoC is implemented in Intel’s 22 nm FFL fin field-effect transistor (FinFET) process, and it is characterized both at room and 4 K temperatures. The performance of each specific block is measured, with the readout characterized in a loop-back configuration. Generation of the control signals required for a full Rabi oscillation experiment is also demonstrated. This article also describes the cryogenic thermalization techniques used to integrate the SoC in the dilution refrigerator and shows temperature measurements during operation. [ABSTRACT FROM AUTHOR]

Seizures can emerge from multiple or large foci in temporal lobe epilepsy, complicating focally targeted strategies such as surgical resection or the modulation of the activity of specific hippocampal neuronal populations through genetic or optogenetic techniques. Here, we evaluate a strategy in which optogenetic activation of medial septal GABAergic neurons, which provide extensive projections throughout the hippocampus, is used to control seizures. We utilized the chronic intrahippocampal kainate mouse model of temporal lobe epilepsy, which results in spontaneous seizures and as is often the case in human patients, presents with hippocampal sclerosis. Medial septal GABAergic neuron populations were immunohistochemically labelled and were not reduced in epileptic conditions. Genetic labelling with mRuby of medial septal GABAergic neuron synaptic puncta and imaging across the rostral to caudal extent of the hippocampus, also indicated an unchanged number of putative synapses in epilepsy. Furthermore, optogenetic stimulation of medial septal GABAergic neurons consistently modulated oscillations across multiple hippocampal locations in control and epileptic conditions. Finally, wireless optogenetic stimulation of medial septal GABAergic neurons, upon electrographic detection of spontaneous hippocampal seizures, resulted in reduced seizure durations. We propose medial septal GABAergic neurons as a novel target for optogenetic control of seizures in temporal lobe epilepsy. [ABSTRACT FROM AUTHOR]

Review of: Investigative Aesthetics: Conflicts and Commons in the Politics of Truth, Matthew Fuller and Eyal Weizman (2021) London: Verso, 272 pp., ISBN 978-1-78873-908-5, p/bk, £14.99 [ABSTRACT FROM AUTHOR]

Small unmanned aerial systems provide a versatile platform for covering large areas quickly. By adding sensors to drones, imagery of large areas can be taken for a variety of applications. Traditionally, single fixed staring systems or gimballed sensors are used to take this imagery. Both options require a compromise between field of view (FOV), resolution, scanning speed, and flight path to properly perform the desired task. If more than one sensor is integrated onto the drone, a wide FOV can be covered without a scanning gimbal and obtain higher resolution than a traditional wide FOV staring system. Presented is a multi-camera design approach based on a constraining ground sample distance for a wide area coverage (WAC) system. This design approach can be used for any imaging bands. A figure of merit (FoM) is derived to quantify and compare the performance of the WAC systems in the visible (0.4 to 0.7 μm), short wave infrared (1.0 to 1.7 μm), and longwave infrared (8 to 14 μm) for both good and bad visibility conditions. The performance of three optimized and fabricated WAC systems is compared and tested through the FoM and flight testing. [ABSTRACT FROM AUTHOR]

Ultrasound promises to be a rapid, radiation-free alternative to chest X-ray for the diagnosis of rib fractures in blunt chest trauma, and this promise has been raised repeatedly over the last decade. Results have been encouraging, and reviews have consistently concluded that ultrasound appears to be the superior diagnostic modality. However, authors have stopped short of recommending changes in practice, and chest X-ray remains the recommended study in both Canadian and American radiology guidelines. In this narrative review, a search of three primary databases was performed to consider the current balance of evidence and discuss concerns that have, thus far, weighed against the broad application of ultrasound in this role. This review suggests that the potential applications for ultrasound in rib fracture diagnosis warrant its consideration for expanded use from emergency rooms to athletics venues. [ABSTRACT FROM AUTHOR]

Marine low clouds strongly influence global climate, and their radiative effects are particularly susceptible to the concentration of cloud condensation nuclei (CCN). One major source of CCN is the condensational growth of pre-CCN particles, and sulfate has long been considered the major condensing species in the remote marine boundary layer. While some studies have suggested that secondary organic species can contribute to particle growth, its importance remains unclear. Here we present the first long-term observational evidence that organics play an important role in particle growth over remote oceans. To the contrary of traditional thinking, sulfate dominated condensational growth for only a small (∼18 %) fraction of the 62 observed growth events, even fewer than the organic-dominated events (24 %). During most (58 %) growth events, the major condensing species included both organics and sulfate. Potential precursors of the secondary organics are volatile organic compounds from ocean biological activities and those produced by the air–sea interfacial oxidation. Our results indicate that the condensation of secondary organics contributes strongly to the growth of pre-CCN particles and thereby the CCN population over remote oceans. [ABSTRACT FROM AUTHOR]

Background: The relationship between individual complications and esophagectomy mortality is unclear. The influence of comorbidities on the impact of complications on operative mortality is also unknown. We sought to assess the impact of individual complications and the effect of coexisting comorbidities on operative mortality following esophagectomy.Methods: All gastric conduit esophagectomies performed for cancer from 2008 to 2017 in the Society of Thoracic Surgery database were identified. Chi square was utilized to identify postoperative events associated with operative mortality. Multivariable logistic regression analysis was performed, utilizing postoperative events, to determine the risk-adjusted effect on operative mortality for each postoperative event. To assess the effect of preoperative comorbidities, a second logistic regression analysis was performed, incorporating preoperative characteristics.Results: Of 11,943 esophagectomy patients, 63.9% had a postoperative event and 3.3% died, which did not change over the study period. The postoperative events with the highest impact on operative mortality were respiratory distress syndrome (OR 7.48 (95% CI 5.23-10.7)), reintubation (OR 6.55 (4.61-9.30)), and renal failure (OR 5.97 (4.08-8.75)). Anastomotic leak requiring reoperation was associated with increased operative mortality (OR 1.48 (1.03-2.14)), but medically managed leak was not. Incorporating preoperative characteristics into the operative mortality model had little effect on odds ratio for death for individual postoperative events.Conclusions: In the Society of Thoracic Surgery database, 64% of patients suffer postoperative events and 3.3% die following esophagectomy. The independent association of certain postoperative events with mortality is an objective method of terming a complication "major" and may aid efforts to reduce mortality. [ABSTRACT FROM AUTHOR]

For any n-bit boolean function f, we show that the randomized communication complexity of the composed function f o gn, where g is an index gadget, is characterized by the randomized decision tree complexity of f. In particular, this means that many query complexity separations involving randomized models (e.g., classical vs. quantum) automatically imply analogous separations in communication complexity. [ABSTRACT FROM AUTHOR]

Marine low clouds strongly influence global climate, and their radiative effects are particularly susceptible to the concentration of cloud condensation nuclei (CCN). One major source of CCN is condensational growth of pre-CCN particles, and sulfate has long been considered the major condensing species in remote marine boundary layer. While some studies suggested that secondary organic species can contribute to the particle growth, its importance remains unclear. Here we present the first long-term observational evidence that organics play an important role in particle growth over remote oceans. To the contrary of traditional thinking, sulfate dominated condensational growth for only a small (~18 %) fraction of the 62 observed growth events, even fewer than the organic-dominated events (24 %). During most (58 %) growth events, the major condensing species included both organics and sulfate. Potential precursors of the secondary organics are volatile organic compounds from ocean biological activities and those produced by the air-sea interfacial oxidation. Our results indicate that the condensation of secondary organics contributes strongly to the growth of pre-CCN particles, and thereby the CCN population over remote oceans. [ABSTRACT FROM AUTHOR]

Background: Thoracic surgeons have been incorporating enhanced recovery after surgery (ERAS) protocols into their practices, not only to reduce narcotic usage but also to improve complication rates and decrease lengths of stay. Here, we describe the utility of a regional block technique that can be used for patients undergoing urgent or elective thoracic surgical procedures or suffering from rib fractures.Methods: We report our initial one-year experience with these erector spinae plane (ESP) blocks.Results: ESP blocks were placed in 42 patients. The procedure was performed by a trained team of anesthesiologists and certified nurse practitioners. It included placement of a catheter on the ipsilateral chest, followed by a 20 ml of 0.2% ropivacaine bolus and continuous infusion. Patients were then followed by the regional team, as long as the catheter was in place. While it had some technical challenges, the block was effective in 83.3% of patients with no reported mortality or major complications. However, given the confounding factors of the study (such as simultaneous implementation of ERAS protocol) and heterogeneity of the patient population, a control group was difficult to ascertain and meaningful opioid consumption analysis was difficult to perform.Conclusions: Regional blocks, such as the ESP block, complement fundamental ERAS principles and serve as an adjunct to the available armamentarium for non-narcotic ways to control pain in thoracic surgical and chest trauma patients. Continued collaboration between the thoracic surgeons and anesthesiologists is needed for its success. [ABSTRACT FROM AUTHOR]

Review of: Documents of Doubt: The Photographic Conditions of Conceptual Art, Heather Diack (2020) Minneapolis, MN: University of Minnesota Press, 296 pp., ISBN 978-1-51790-757-0, p/bk, $30.00 [ABSTRACT FROM AUTHOR]

Authors would like to correct the incorrect author references in the online published article. [ABSTRACT FROM AUTHOR]

We study problems in randomized communication complexity when the protocol is only required to attain some small advantage over purely random guessing, i.e., it produces the correct output with probability at least ϵ greater than one over the codomain size of the function. Previously, Braverman and Moitra (in: Proceedings of the 45th symposium on theory of computing (STOC), ACM, pp 161–170, 2013) showed that the set-intersection function requires Θ (ϵ n) communication to achieve advantage ϵ . Building on this, we prove the same bound for several variants of set-intersection: (1) the classic “tribes” function obtained by composing with And (provided 1 / ϵ is at most the width of the And), and (2) the variant where the sets are uniquely intersecting and the goal is to determine partial information about (say, certain bits of the index of) the intersecting coordinate. [ABSTRACT FROM AUTHOR]

Aerosols alter Earth's radiative budget both directly and indirectly through interaction with clouds. Continuous observations are required to reduce the uncertainties in climate models associated with atmospheric processing and the interactions between aerosols and clouds. Field observations of aerosols are a central component of the Atmospheric Radiation Measurement (ARM) Facility's global measurements. The ARMmission goal is to ''provide the climate research community with strategically located in situ and remote sensing observatories designed to improve the understanding and representation, in climate and earth system models, of clouds and aerosols as well as their interactions and coupling with the Earth's surface.'' Since 1996, ARM has met this goal by operating Aerosol Observing Systems (AOS) for in situ measurement of aerosols. Currently the five ARM AOSs are the most comprehensive field deployable aerosol systems in the United States. The AOS suite includes seven measurement classes: number concentration, size distribution, chemical composition, radiative and optical properties, hygroscopicity, trace gases, and supporting meteorological conditions. AOSs are designed as standardized measurement platforms to enable intercomparison across the ARM Facility for regional process studies within a global context. The instrumentation and measurement capabilities of the ARMAOSs, along with a history of their design and field deployments are presented here. [ABSTRACT FROM AUTHOR]

Background: Despite the increased risk for nodal disease, definitive endoscopic resection is being increasingly offered for lesions invasive into the submucosa based on the success with intramucosal tumors. The aim of this study was to evaluate survival after esophagectomy alone for confirmed submucosal tumors after endoscopic resection.Methods: Patients from seven centers in the USA who underwent esophagectomy for submucosal tumors removed with endoscopic resection were analyzed. Nodal involvement was correlated with recurrence and survival.Results: We identified 23 patients with submucosal esophageal adenocarcinoma. Esophagectomy was performed at a median of 2 months (Interquartile range 1-3) after the endoscopic resection. There was no postoperative mortality. Positive nodal disease was seen in 26 % of patients on final pathology. At a median of 37 months (Interquartile range 25-55), 91 % of patients were alive and free of disease. The disease-specific 5-year survival was 88 %. Disease-specific 5-year survival was 67 % in patients with positive nodal metastases and 100 % in those without (p = 0.159).Conclusions: Esophagectomy is curative in the majority of patients with submucosal tumors even in the presence of nodal metastases. These data serve as a benchmark for comparison when considering extending the indications for therapeutic endoscopic resection for submucosal tumors in the future. [ABSTRACT FROM AUTHOR]

We prove that the PNP-type query complexity (alternatively, decision list width) of any Boolean function f is quadratically related to the PNP-type communication complexity of a lifted version of f. As an application, we show that a certain "product" lower bound method of Impagliazzo and Williams (CCC 2010) fails to capture PNP communication complexity up to polynomial factors, which answers a question of Papakonstantinou, Scheder, and Song (CCC 2014). [ABSTRACT FROM AUTHOR]

Background: Deep Learning (DL) has advanced the state-of-the-art capabilities in bioinformatics applications which has resulted in trends of increasingly sophisticated and computationally demanding models trained by larger and larger data sets. This vastly increased computational demand challenges the feasibility of conducting cutting-edge research. One solution is to distribute the vast computational workload across multiple computing cluster nodes with data parallelism algorithms. In this study, we used a High-Performance Computing environment and implemented the Downpour Stochastic Gradient Descent algorithm for data parallelism to train a Convolutional Neural Network (CNN) for the natural language processing task of information extraction from a massive dataset of cancer pathology reports. We evaluated the scalability improvements using data parallelism training and the Titan supercomputer at Oak Ridge Leadership Computing Facility. To evaluate scalability, we used different numbers of worker nodes and performed a set of experiments comparing the effects of different training batch sizes and optimizer functions. Results: We found that Adadelta would consistently converge at a lower validation loss, though requiring over twice as many training epochs as the fastest converging optimizer, RMSProp. The Adam optimizer consistently achieved a close 2nd place minimum validation loss significantly faster; using a batch size of 16 and 32 allowed the network to converge in only 4.5 training epochs. Conclusions: We demonstrated that the networked training process is scalable across multiple compute nodes communicating with message passing interface while achieving higher classification accuracy compared to a traditional machine learning algorithm. [ABSTRACT FROM AUTHOR]

We show that deterministic communication complexity can be superlogarithmic in the partition number of the associated communication matrix. We also obtain near-optimal deterministic lower bounds for the Clique vs. Independent Set problem, which in particular yields new lower bounds for the log-rank conjecture. All of these results follow from a simple adaptation of a communication-to-query simulation theorem of Raz and McKenzie [Combinatorica, 19 (1999), pp. 403-435] together with lower bounds for the analogous query complexity questions. [ABSTRACT FROM AUTHOR]

Justice on Demand: True Crime in the Digital Streaming Era, Tanya Horeck (2019) Detroit: Wayne State University Press, 240 pp., ISBN 978-0-81434-063-9, p/bk, $34.99 [ABSTRACT FROM AUTHOR]

Introduction: Endoscopic resection (ER) has revolutionized the staging and therapy of superficial esophageal adenocarcinoma. Pathologic evaluation allows an assessment of the risk of lymph node metastases based on tumor characteristics. The aim of this study was to assess the inter-observer variability in pathologic assessment of ER specimens of esophageal adenocarcinoma.Methods: We performed a retrospective study on ER specimens of superficial esophageal adenocarcinoma from four US institutions. Original endoscopic resection slides were re-reviewed by two blinded, experienced (study) gastrointestinal pathologists for the depth of tumor invasion, tumor grade, and the presence of lymphovascular invasion (LVI). Discordance was considered present only when both study pathologists disagreed with the original report.Results: There were 25 ER specimens reviewed for this study, and discordance occurred in 12 of the 25 specimens (48%) for the depth of tumor invasion. In most cases (83%), the discordance was related to overstaging a true T1a lesion. We found that only 38% of true T1a lesions were correctly staged for depth of invasion. Less commonly discordance was secondary to understaging a true T1b lesion. There was concordance between the two study pathologists in 22/25 cases (88%) on the depth of invasion. Discordance was present for tumor grade in 8/18 cases (44%) and for LVI in 4/16 cases (25%). Concordance between the study pathologists was 80% for tumor grade and 88% for LVI.Conclusions: There was an alarmingly high rate of discordance (48%) between the study pathologists and the original pathology assessment for the depth of tumor invasion in ER specimens. This was particularly common for lesions called T1b on the original pathology report. Since critical decisions are made regarding esophageal preservation or esophagectomy on the basis of the pathologic interpretations of ER specimens, it behooves surgeons to understand the inter-observer variability. Review of ER specimens by an experienced GI pathologist is recommended to ensure that patients receive the appropriate treatment for superficial esophageal adenocarcinoma. [ABSTRACT FROM AUTHOR]

We prove several results which, together with prior work, provide a nearly-complete picture of the relationships among classical communication complexity classes between P and PSPACE, short of proving lower bounds against classes for which no explicit lower bounds were already known. Our article also serves as an up-to-date survey on the state of structural communication complexity.Among our new results we show that MA⊈ZPPNP[1], that is, Merlin-Arthur proof systems cannot be simulated by zero-sided error randomized protocols with one NP query. Here the class ZPPNP[1] has the property that generalizing it in the slightest ways would make it contain AM∩coAM, for which it is notoriously open to prove any explicit lower bounds. We also prove that US⊈ZPPNP[1], where US is the class whose canonically complete problem is the variant of set-disjointness where yes-instances are uniquely intersecting. We also prove that US⊈coDP, where DP is the class of differences of two NP sets. Finally, we explore an intriguing open issue: Are rank-1 matrices inherently more powerful than rectangles in communication complexity? We prove a new separation concerning PP that sheds light on this issue and strengthens some previously known separations. [ABSTRACT FROM AUTHOR]

We exhibit an n-node graph whose independent set polytope requires extended formulations of size exponential in Ω (n= log n). Previously, no explicit examples of n-dimensional 0=1-polytopes were known with extension complexity larger than exponential in Θ(√n). Our construction is inspired by a relatively little-known connection between extended formulations and (monotone) circuit depth. [ABSTRACT FROM AUTHOR]

During the Observations and Modeling of the Green Ocean Amazon (GoAmazon2014/5) campaign, size-resolved cloud condensation nuclei (CCN) spectra were characterized at a research site (T3) 60 km downwind of the city of Manaus, Brazil, in central Amazonia for 1 year (12 March 2014 to 3 March 2015). Particle hygroscopicity (κCCN) and mixing state were derived from the size-resolved CCN spectra, and the hygroscopicity of the organic component of the aerosol (κorg) was then calculated from κCCN and concurrent chemical composition measurements. The annual average κCCN increased from 0.13 at 75 nm to 0.17 at 171 nm, and the increase was largely due to an increase in sulfate volume fraction. During both wet and dry seasons, κCCN, κorg, and particle composition under background conditions exhibited essentially no diel variations. The constant κorg of ~0:15 is consistent with the largely uniform and high O: C value (~0:8), indicating that the aerosols under background conditions are dominated by the aged regional aerosol particles consisting of highly oxygenated organic compounds. For air masses strongly influenced by urban pollution and/or local biomass burning, lower values of κorg and organic O: C atomic ratio were observed during night, due to accumulation of freshly emitted particles, dominated by primary organic aerosol (POA) with low hygroscopicity, within a shallow nocturnal boundary layer. The O: C, κorg, and κCCN increased from the early morning hours and peaked around noon, driven by the formation and aging of secondary organic aerosol (SOA) and dilution of POA emissions into a deeper boundary layer, while the development of the boundary layer, which leads to mixing with aged particles from the residual layer aloft, likely also contributed to the increases. The hygroscopicities associated with individual organic factors, derived from PMF (positive matrix factorization) analysis of AMS (aerosol mass spectrometry) spectra, were estimated through multivariable linear regression. For the SOA factors, the variation of the κ value with O: C agrees well with the linear relationship reported from earlier laboratory studies of SOA hygroscopicity. On the other hand, the variation in O: C of ambient aerosol organics is largely driven by the variation in the volume fractions of POA and SOA factors, which have very different O: C values. As POA factors have hygroscopicity values well below the linear relationship between SOA hygroscopicity and O: C, mixtures with different POA and SOA fractions exhibit a steeper slope for the increase in κorg with O: C, as observed during this and earlier field studies. This finding helps better understand and reconcile the differences in the relationships between κorg and O: C observed in laboratory and field studies, therefore providing a basis for improved parameterization in global models, especially in a tropical context. [ABSTRACT FROM AUTHOR]

We describe the implementation of an OPT plate to perform optical projection tomography (OPT) on a commercial wide-field inverted microscope, using our open-source hardware and software. The OPT plate includes a tilt adjustment for alignment and a stepper motor for sample rotation as required by standard projection tomography. Depending on magnification requirements, three methods of performing OPT are detailed using this adaptor plate: a conventional direct OPT method requiring only the addition of a limiting aperture behind the objective lens; an external optical-relay method allowing conventional OPT to be performed at magnifications >4x; a remote focal scanning and region-of-interest method for improved spatial resolution OPT (up to ~1.6 μm). All three methods use the microscope’s existing incoherent light source (i.e. arc-lamp) and all of its inherent functionality is maintained for day-to-day use. OPT acquisitions are performed on in vivo zebrafish embryos to demonstrate the implementations’ viability. [ABSTRACT FROM AUTHOR]

During the Observations and Modeling of the Green Ocean Amazon (GoAmazon2014/5) campaign, size-resolved cloud condensation nuclei (CCN) spectra were characterized at a research site (T3) 60 km downwind of the city of Manaus, Brazil, in central Amazonia for one year (12 March 2014 to 3 March 2015). Particle hygroscopicity (κCCN) and mixing state were derived from the size-resolved CCN spectra, and the hygroscopicity of the organic component of the aerosol (κorg) was then calculated from κCCN and concurrent chemical composition measurements. The annual average κCCN increased from 0.13 at 75 nm to 0.17 at 171 nm, and the increase was largely due to an increase in sulfate volume fraction. During both wet and dry seasons, κCCN, κorg, and particle composition under background conditions exhibited essentially no diel variations. The constant κorg of ~ 0.15 is consistent with the largely uniform and high O : C value (~ 0.8), indicating that the aerosols under background conditions are dominated by the aged regional aerosol particles consisting of highly oxygenated organic compounds. For air masses strongly influenced by urban pollution and/or local biomass burning, lower values of κorg and organic O : C atomic ratio were observed during night, due to accumulation of freshly emitted particles, dominated by primary organic aerosol (POA) with low hygroscopicity, within a shallow nocturnal boundary layer. The O : C, κorg, and κCCN increased from the early morning hours and peaked around noon, driven by the formation and aging of secondary organic aerosol (SOA) and dilution of POA emissions into a deeper boundary layer, while the development of the boundary layer, which leads to mixing with aged particles from the residual layer aloft, likely also contributed to the increases. The hygroscopicities associated with individual organic factors, derived from PMF analysis of AMS spectra, were estimated through multi-variable linear regression. For the SOA factors, the variation of the κ value with O : C agrees well with the linear relationship reported from earlier laboratory studies of SOA hygroscopicity. On the other hand, the variation in O:C of ambient aerosol organics is largely driven by the variation in the volume fractions of POA and SOA factors, which have very different O : C values. As POA factors have hygroscopicity values well below the linear relationship between SOA hygroscopicity and O:C, mixtures with different POA and SOA fractions exhibit a steeper slope for the increase of κorg with O : C, as observed during this and earlier field studies. This finding helps better understand and reconcile the differences in the relationships between κorg and O : C observed in laboratory and field studies, therefore providing a basis for improved parameterization in global models, especially in a tropical context. [ABSTRACT FROM AUTHOR]

The influence of the local terrestrial environment on nocturnal atmospheric CO measurements at a 329-m television transmitter tower (and a component of a CO monitoring network) was estimated with a tracer release experiment and a subsequent simulation of the releases. This was done to characterize the vertical transport of emissions from the surface to the uppermost tower level and how it is affected by atmospheric stability. The tracer release experiment was conducted over two nights in May of 2009 near the Department of Energy's Savannah River Site (SRS) in South Carolina. Tracer was released on two contrasting nights-slightly stable and moderately stable-from several upwind surface locations. Measurements at the 329-m level on both nights indicate that tracer was able to mix vertically within a relatively short (∼24 km) distance, implying that nocturnal stable conditions do not necessarily prevent vertical dispersion in the boundary layer and that CO measurements at the tower are at least partly influenced by nearby emissions. A simulation of the tracer release is used to calculate the tower footprint on the two nights to estimate the degree to which the local domain affects the tower readings. The effect of the nocturnal boundary layer on the area sampled by the tower can be seen clearly, as the footprints were affected by changes in stability. The contribution of local sources to the measurements at the tower was minimal, however, suggesting that nocturnal concentrations at upper levels are contributed mostly by regional sources. [ABSTRACT FROM AUTHOR]