416 results on '"Wang Yanfei"'
Search Results
2. An novel finite difference dispersion error elimination mechanism in the Lax–Wendroff high‐order time discretization.
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Liang, Wenquan and Wang, Yanfei
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FINITE differences ,DIFFERENCE operators ,GEOPHYSICAL prospecting ,TIME management ,FINITE difference time domain method ,ACOUSTICS - Abstract
Time domain finite difference methods have been widely used for wave‐equation modelling in exploration geophysics over many decades. When using time domain finite difference methods, it is desirable to use a larger time step so as to save numerical simulation time. The Lax–Wendroff method is one of the well‐known methods to allow larger time step without increasing the time grid dispersion. However, the Lax–Wendroff method suffers from more time consumption because there are more spatial derivatives required to be approximated by the finite difference operators. We propose a new finite difference scheme for the Lax–Wendroff method so as to reduce the numerical simulation time. Then we determine the finite difference operator coefficients and analyse the dispersion error of the proposed finite difference scheme for the Lax–Wendroff method. At last, we apply the proposed finite difference scheme for the Lax–Wendroff method to different velocity models. The numerical simulation results indicate that the proposed finite difference scheme for the Lax–Wendroff method can effectively suppress time grid dispersion and is more efficient compared to the traditional finite difference scheme for the Lax–Wendroff method. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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3. DrugFormer: Graph‐Enhanced Language Model to Predict Drug Sensitivity.
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Liu, Xiaona, Wang, Qing, Zhou, Minghao, Wang, Yanfei, Wang, Xuefeng, Zhou, Xiaobo, and Song, Qianqian
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LANGUAGE models ,KNOWLEDGE graphs ,ACUTE myeloid leukemia ,DRUG resistance ,DRUG recall - Abstract
Drug resistance poses a crucial challenge in healthcare, with response rates to chemotherapy and targeted therapy remaining low. Individual patient's resistance is exacerbated by the intricate heterogeneity of tumor cells, presenting significant obstacles to effective treatment. To address this challenge, DrugFormer, a novel graph‐augmented large language model designed to predict drug resistance at single‐cell level is proposed. DrugFormer integrates both serialized gene tokens and gene‐based knowledge graphs for the accurate predictions of drug response. After training on comprehensive single‐cell data with drug response information, DrugFormer model presents outperformance, with higher F1, precision, and recall in predicting drug response. Based on the scRNA‐seq data from refractory multiple myeloma (MM) and acute myeloid leukemia (AML) patients, DrugFormer demonstrates high efficacy in identifying resistant cells and uncovering underlying molecular mechanisms. Through pseudotime trajectory analysisunique drug‐resistant cellular states associated with poor patient outcomes are revealed. Furthermore, DrugFormer identifies potential therapeutic targets, such as COX8A, for overcoming drug resistance across different cancer types. In conclusion, DrugFormer represents a significant advancement in the field of drug resistance prediction, offering a powerful tool for unraveling the heterogeneity of cellular response to drugs and guiding personalized treatment strategies. [ABSTRACT FROM AUTHOR]
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- 2024
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4. A case report of mediastinal extramedullary hematopoiesis: imaging, pathological and thoracoscopic biopsy correlation.
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Yao, Fengbo, Li, Dingbiao, Wang, Ying, Wang, Yanfei, and Lv, Yongchang
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EXTRAMEDULLARY hematopoiesis ,NEEDLE biopsy ,SURGICAL diagnosis ,ERYTHROPOIESIS ,BONE marrow - Abstract
Objective: To summarize the clinical features, imaging characteristics, and surgical diagnosis and treatment experience of mediastinal extramedullary hematopoiesis. Methods: By summarizing and analyzing the case data and reviewing the literature, one case of posterior mediastinal extramedullary hematopoiesis on thoracoscopic biopsy in our department was summarized. Conclusion: Posterior mediastinal extramedullary hematopoiesis is a response to failure of bone marrow erythropoiesis, which is relatively rare clinically, and diagnosis requires a combination of patient history and imaging, puncture biopsy or thoracoscopic excisional biopsy can provide a pathological diagnosis, and surgical complete resection is the main treatment modality. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Production and characterization of homologous protoporphyrinogen IX oxidase (PPO) proteins: Evidence that small N-terminal amino acid changes do not impact protein function.
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Wang, Cunxi, Zheng, Meiying, Est, Chandler, Lawal, Remi, Liang, Wenguang, Korasick, David A., Rau, Michael J., Saracco, Scott A., Johnson, Virginia, Wang, Yanfei, White, Tommi, Li, Wenze, Zhang, Jun, Gu, Xin, and Liu-Gontarek, Flora
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PROTOPORPHYRINOGEN oxidase ,AMINO acid sequence ,ESCHERICHIA coli ,PEPTIDES ,STRUCTURAL models - Abstract
Transgenic soybean, cotton, and maize tolerant to protoporphyrinogen IX oxidase (PPO)-inhibiting herbicides have been developed by introduction of a bacterial-derived PPO targeted into the chloroplast. PPO is a membrane-associated protein with an intrinsic tendency for aggregation, making expression, purification, and formulation at high concentrations difficult. In this study, transgenic PPO expressed in three crops was demonstrated to exhibit up to a 13 amino acid sequence difference in the N-terminus due to differential processing of the chloroplast transit peptide (CTP). Five PPO protein variants were produced in and purified from E. coli, each displaying equivalent immunoreactivity and functional activity, with values ranging from 193 to 266 nmol min
-1 mg-1 . Inclusion of an N-terminal 6xHis-tag or differential processing of the CTP peptide does not impact PPO functional activity. Additionally, structural modeling by Alphafold, ESMfold, and Openfold indicates that these short N-terminal extensions are disordered and predicted to not interfere with the mature PPO structure. These results support the view that safety studies on PPO from various crops can be performed from a single representative variant. Herein, we report a novel and robust method for large-scale production of PPO, enabling rapid production of more than 200 g of highly active PPO protein at 99% purity and low endotoxin contamination. We also present a formulation that allows for concentration of active PPO to > 75 mg/mL in a buffer suitable for mammalian toxicity studies. [ABSTRACT FROM AUTHOR]- Published
- 2024
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6. Expression of GLOD4 in the Testis of the Qianbei Ma Goat and Its Effect on Leydig Cells.
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Wang, Jinqian, Chen, Xiang, Sun, Wei, Tang, Wen, Chen, Jiajing, Zhang, Yuan, Li, Ruiyang, and Wang, Yanfei
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LEYDIG cells ,GENE expression ,CELLULAR control mechanisms ,CELL cycle ,TESTOSTERONE regulation - Abstract
Simple Summary: Glyoxalase domain-containing protein 4 (GLOD4), a member of the glyoxalase gene family, is widely expressed in Leydig cells and its primary function within the Leydig cells remains unknown. GLOD4 expression in other species is often associated with functions such as cell proliferation, cell cycle, and detoxification. We therefore explored the relevant elements of Leydig cells. We speculate that GLOD4 may regulate testicular development and spermatogenesis by increasing the number of Leydig cells and regulation of testosterone secretion. The expression pattern of GLOD4 in the testis and its regulatory effect on testicular cells was explored in goats to enhance our understanding of spermatogenesis and improve reproduction in breeding rams. In this study, we demonstrated the localization of GLOD4 in testicular cells using immunohistochemistry and subcellular localization analyses. Subsequently, we analyzed the GLOD4 expression pattern in four age-based groups (0, 6, 12, and 18 months old) using real-time quantitative polymerase chain reaction (qRT-PCR) and protein blotting. Finally, we performed GLOD4 silencing and overexpression studies in Leydig cells (LCs) and explored the effects on cell proliferation, the cell cycle, steroid hormone secretion and the expression of candidate testosterone hormone-regulated genes. GLOD4 was mainly expressed in Leydig cells, and the subcellular localization results showed that the GLOD4 protein was mainly localized in the cytoplasm and nucleus. Silencing of GLOD4 significantly suppressed the mRNA expression levels of the testosterone secretion-related genes CYP11A1, 3β-HSD, and CYP17A1 and the mRNA expression levels of cell cycle-related genes CDK6, PCNA, and Cyclin E. Moreover, the cell cycle was blocked at the G2/M phase after GLOD4 silencing, which significantly suppressed testosterone secretion. In contrast, GLOD4 overexpression significantly increased the mRNA expression levels of the testosterone secretion-related genes CYP11A1, 3β-HSD, and CYP17A1 and increased the expression of the cell cycle-related genes CDK6, PCNA, and Cyclin E. Moreover, GLOD4 overexpression promoted the cell cycle from G0/G1 phases to enter the S phase and G2/M phases, promoted the secretion of testosterone. Taken together, our experimental results indicate that GLOD4 may affect the development of cells in Qianbei Ma goats of different ages by influencing the cell cycle, cell proliferation, and testosterone hormone synthesis. These findings enhance our understanding of the functions of GLOD4 in goats. [ABSTRACT FROM AUTHOR]
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- 2024
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7. AntiFormer: graph enhanced large language model for binding affinity prediction.
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Wang, Qing, Feng, Yuzhou, Wang, Yanfei, Li, Bo, Wen, Jianguo, Zhou, Xiaobo, and Song, Qianqian
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SARS-CoV-2 ,LANGUAGE models ,SOMATIC mutation ,IMMUNOREGULATION ,ANTIBODY formation - Abstract
Antibodies play a pivotal role in immune defense and serve as key therapeutic agents. The process of affinity maturation, wherein antibodies evolve through somatic mutations to achieve heightened specificity and affinity to target antigens, is crucial for effective immune response. Despite their significance, assessing antibody–antigen binding affinity remains challenging due to limitations in conventional wet lab techniques. To address this, we introduce AntiFormer, a graph-based large language model designed to predict antibody binding affinity. AntiFormer incorporates sequence information into a graph-based framework, allowing for precise prediction of binding affinity. Through extensive evaluations, AntiFormer demonstrates superior performance compared with existing methods, offering accurate predictions with reduced computational time. Application of AntiFormer to severe acute respiratory syndrome coronavirus 2 patient samples reveals antibodies with strong neutralizing capabilities, providing insights for therapeutic development and vaccination strategies. Furthermore, analysis of individual samples following influenza vaccination elucidates differences in antibody response between young and older adults. AntiFormer identifies specific clonotypes with enhanced binding affinity post-vaccination, particularly in young individuals, suggesting age-related variations in immune response dynamics. Moreover, our findings underscore the importance of large clonotype category in driving affinity maturation and immune modulation. Overall, AntiFormer is a promising approach to accelerate antibody-based diagnostics and therapeutics, bridging the gap between traditional methods and complex antibody maturation processes. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Blatant benevolence or hidden scheming? The effects of leader leniency on employee discretionary outcomes.
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Zhu, Yu, Mei, Wenjuan, Nong, Meilan, Wang, Yanfei, and Hua, Liwen
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PATH analysis (Statistics) ,GRATITUDE ,ORGANIZATIONAL citizenship behavior ,TEST methods ,BENEVOLENCE ,ANALYSIS of variance ,SCHOLARS - Abstract
Leniency, the act of lessening or removing a negative consequence for misconduct, is a means of addressing workplace misconduct. Although existing research has highlighted that the lenient reaction generally brings benefits, scholars have recently challenged this positive view of leniency by noting its negative outcomes. Drawing upon the attribution theory, we propose that the effects of leader leniency depend on subordinates' relational attributions of such lenient behavior. We conducted an experiment (Study 1, N = 229) and a multi-source and multi-wave survey (Study 2, N = 268). Study 1 used ANOVA analysis and Study 2 used path analysis and bias-corrected bootstrap method to test the model. Results showed that when the subordinate relational attribution is low, leader leniency will trigger subordinate gratitude and increase organizational citizenship behavior. Conversely, when the subordinate relational attribution is high, leader leniency will induce subordinate psychological entitlement, fueling workplace deviance. Our research provides new insight into understanding the losses and gains of leader leniency and identifies the role of relational attribution in the effects of leader leniency. Finally, we discuss our theoretical contributions and practical implications. [ABSTRACT FROM AUTHOR]
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- 2024
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9. Endovascular thrombectomy versus medical management on outcomes with infarct volumes more than 70 mL.
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Han, Nannan, Zhang, Xiaobo, Zhang, Yu, Liu, Yu, Ma, Haojun, Ge, Hanming, Wang, Yanfei, Li, Shilin, Yan, Xudong, Li, Tengfei, Wu, Yulun, Ma, Juan, Shi, Wenzhen, Zhang, Gejuan, Tian, Ye, and Chang, Mingze
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ENDOVASCULAR surgery ,MAGNETIC resonance imaging ,CEREBRAL circulation ,ISCHEMIC stroke ,COHORT analysis - Abstract
Objective: Endovascular thrombectomy (EVT) in patients with large infarct volume remains controversial. The aim of this study is to compare clinical outcomes between EVT and medical management in acute large vessel occlusion with infarct volumes larger than 70 mL on diffusion‐weighted magnetic resonance imaging (DWI). Methods: A prospective observational cohort study was conducted, including patients with anterior cerebral circulation occlusion due to ischemic stroke with infarct volumes larger than 70 mL within 24 h of onset between July 2018 and June 2023. Eligible patients were divided into two groups: the EVT group and the medical management (non‐EVT) group. The main outcomes were functional independence and mortality at 90 days. To assess clinical endpoints, we selected variables including age, NIHSS score, infarct volume, and occlusion location for 1:1 propensity score (PS) matching and PS adjustment using inverse probability of treatment weighting (IPTW). Results: Among the 131 identified patients (mean [SD] age, 69.9 [13.7] years; 58 female), the median infarct volume was 123.6 mL. Of these patients, 75 (57.3%) underwent EVT. After PS adjustment, EVT was not associated with functional independence (10.9% vs. 10.9%; p = 1.000) or mortality (43.5% vs. 47.8%; p = 0.675). Additionally, after PS adjustment using IPTW, EVT was also not associated with a functional independence (15.8% vs. 13.7%; p = 0.767) or mortality (46.8% vs. 44.0%; p = 0.762). Conclusion: This study provides real‐world evidence regarding infarct volumes larger than 70 mL, indicating that EVT does not provide benefits compared to medical management alone when considering age, NIHSS score, infarct volume, and occlusion location. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Steering benzyl alcohol electrooxidation coupled with hydrogen evolution via hetero‐interface construction.
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Du, Xin, Xie, Wenfu, Wang, Yanfei, Li, Hao, Li, Jinze, Li, Yang, Song, Yuke, Li, Zhenhua, Lee, Jin Yong, and Shao, Mingfei
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BENZYL alcohol ,ELECTROLYTIC cells ,BENZOIC acid ,STANDARD hydrogen electrode ,ACTIVATION energy ,DENSITY functional theory ,ALCOHOL oxidation ,ELECTROLYTIC reduction - Abstract
It is still a challenge to develop electrocatalyst for the efficient adsorption and conversion of organic molecule in aqueous media. Herein, a hetero‐interface structure based on CuO@Ni(OH)2 is rationally designed to enhance the performance of benzyl alcohol oxidation to benzoic acid. A high Faradaic efficiency of 99% and the yield of 3.09 mmol cm−2 h−1 are achieved at 1.70 V versus reversible hydrogen electrode, outperforming the previously reported electrocatalysts. Furthermore, a membrane‐free flow electrolyzer was assembled based on CuO@Ni(OH)2 hetero‐interface, exhibiting a much high yielding of benzoic acid (6.73 mmol cm−2 h−1) and hydrogen (0.35 L cm−2 h−1) with excellent stability. Both experimental data and density functional theory calculations verify that the electron is tend to accumulate at the hetero‐interface, thus accelerating the adsorption of reactant and intermediate and reducing the energy barrier of the conversion of benzyl alcohol to benzoic acid. [ABSTRACT FROM AUTHOR]
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- 2024
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11. Spatial-diffusion characters and emission reduction strategy for motor vehicle pollutants on expressway.
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Yao, Shengyong, Niu, Siyu, Hasan, Mohammad Kamrul, Bian, Zixiang, Hao, Yunhong, Wang, Yanfei, Li, Shuning, Ding, Ru, Ji, Chenfei, and Li, Duoduo
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ELECTRIC vehicles ,GREENHOUSE gas mitigation ,MOTOR vehicles ,RURAL roads ,FREIGHT & freightage ,POLLUTANTS - Abstract
This research tries to establish the emissions diffusion model of high-speed motor vehicles on the Capital Ring Expressway (CRE) around Beijing, China, applying the MOVES and the CALPUFF models. Data required for this study have been collected from different sources. The results show that small buses and large trucks have the highest pollutant emissions on the CRE. The pollutants like CO and HC mainly comes from gasoline vehicles, while NOx, PM10 and PM2.5 comes from diesel vehicles. The average concentrations of the diffusion of CO, NOx, CH4, PM10, and PM2.5 along with the CRE are 6.5 mg/m3, 2.3 mg/m3, 0.27 mg/m3, 0.055 mg/m3 and 0.056 mg/m3 respectively. The results of this study have practical significance and influence on the emission reduction and concentration control strategies under different circumstances, and put forward suggestions on changing transportation modes, strengthening supervision and so on. It has produced a number of recommendations for the policy makers including (1) active promotion of new energy vehicles on expressways, (2) strategic change of the mode of passenger and freight transportation on expressways, (3) strengthen traffic management and supervision of motor vehicles on expressways, and (4) strengthen vegetation protection in rural and ecologically sound areas along the route. [ABSTRACT FROM AUTHOR]
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- 2024
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12. Characteristics of the O(1 S) to O(1 D) 557.7 nm green emission observed in an argon plasma jet.
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Zhao, Shuai, Wang, Yanfei, Zhu, Ximing, and Sobota, Ana
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ARGON plasmas ,PLASMA jets ,ELECTRON temperature ,GLOW discharges ,ELECTRON density ,EMISSION spectroscopy ,ELECTRIC fields - Abstract
An extensive study on the green auroral emission characterization is presented based on a single dielectric barrier discharge geometry argon plasma jet driven by a kHz sine voltage. The plasma was generated by using 99.999% pure argon and the observed 557.7 nm green line resulted from the excited O(
1 S) state. An optical emission spectroscopy method using line ratios of argon was used to obtain the electron density and electron temperature under different conditions in the downstream region. The characteristics of discharge and green emission with variations in interelectrode distance, applied voltage (power) and flow rate are discussed. The spatially diffuse distribution of O(1 S), owing to its long lifetime, is shown by the short exposure imaging. Two discharge regimes are presented, accompanied by two distinct branches of the green emission intensity, with a clear conclusion that the 557.7 nm emission is favored in the low electron temperature environment. In this work, the intense and diffuse green plume only forms when the downstream electron density is approximately lower than 1 × 1014 cm−3 and the electron temperature is lower than 1.1 eV. By charging the two electrodes in two opposite ways, it is shown that the green emission from oxygen is favored in the case where the electric field and the electron drift are not continuous. [ABSTRACT FROM AUTHOR]- Published
- 2024
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13. Preparation of (Ti0.2Zr0.2Hf0.2Nb0.2Ta0.2)C high‐entropy ceramic nanopowders via liquid‐phase precursor.
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Xie, Chenyi, Miao, Huaming, Wan, Fan, Wang, Yanfei, Li, Duan, and Liu, Rongjun
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FIBER-reinforced ceramics ,CERAMICS ,METALLIC composites ,CERAMIC powders ,ETHYLENE glycol - Abstract
Using citric acid, ethylene glycol, ZrOCl2·8H2O, HfOCl2·8H2O, TiCl4, NbCl5, and TaCl5 as raw materials, the (Ti0.2Zr0.2Hf0.2Nb0.2Ta0.2)C high‐entropy ceramic precursor was prepared by Pechini coordination polymerization method. The precursor and pyrolysis products were analyzed and characterized by different methods. The results showed that the precursor formed a chelate structure, which greatly improved the stability of the precursor, and was clear and transparent with moderate viscosity (30–50 mPa·s). At a low pyrolysis temperature of 1600°C, single‐phase (Ti0.2Zr0.2Hf0.2Nb0.2Ta0.2)C high‐entropy ceramic nanopowders with a ceramic yield of 50.8% can be obtained. The high‐entropy ceramic powder has high purity, a particle size of about 140–200 nm, and uniform element distribution. It is suitable for introduction into fiber‐reinforced ceramic matrix composite by precursor infiltration and pyrolysis (PIP) process. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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14. Limited protection of pneumococcal vaccines against emergent Streptococcus pneumoniae serotype 14/ST876 strains.
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Lan, Yinle, Liu, Lin, Hu, Dongping, Ge, Lihong, Xiang, Xi, Peng, Minfei, Fu, Ying, Wang, Yanfei, Li, Shuxian, Chen, Yan, Jiang, Yan, Tu, Yuexing, Vidal, Jorge E., Yu, Yunsong, Chen, Zhimin, and Wu, Xueqing
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NASOPHARYNX microbiology ,CARRIER state (Communicable diseases) ,GENOMICS ,MICROBIAL sensitivity tests ,PHYLOGENY ,DATA analysis ,RESPIRATORY infections ,RESEARCH funding ,SEROTYPES ,VACCINE effectiveness ,POLYMERASE chain reaction ,TERTIARY care ,CHILDREN'S hospitals ,CHEST X rays ,STREPTOCOCCUS ,CHI-squared test ,FEVER ,LONGITUDINAL method ,PNEUMOCOCCAL vaccines ,ONE-way analysis of variance ,STATISTICS ,STREPTOCOCCAL diseases ,COLLECTION & preservation of biological specimens ,DATA analysis software ,HOSPITAL care of children ,SEQUENCE analysis - Abstract
Purpose: Streptococcus pneumoniae (Spn) is a major cause of child death. We investigated the epidemiology of S. pneumoniae in a pediatric fever clinic and explored the genomics basis of the limited vaccine response of serotype 14 strains worldwide. Methods: Febrile disease and pneumonia were diagnosed following criteria from the WHO at the end of 2019 at a tertiary children's hospital. Spn was isolated by culture from nasopharyngeal (NP) swabs. The density was determined by lytA-base qPCR. Isolates were serotyped by Quellung and underwent antimicrobial susceptibility testing. Whole-genome sequencing was employed for molecular serotyping, MLST, antibiotic gene determination, SNP calling, recombination prediction, and phylogenetic analysis. Results: The presence of pneumococcus in the nasopharynx (87.5%, 7/8, p = 0.0227) and a high carriage (100%, 7/7, p = 0.0123) were significantly associated with pneumonia development. Living with siblings (73.7%, 14/19, p = 0.0125) and non-vaccination (56.0%, 28/50, p = 0.0377) contributed significantly to the Spn carriage. Serotype 14 was the most prevalent strain (16.67%, 5/30). The genome analysis of 1497 serotype 14 strains indicated S14/ST876 strains were only prevalent in China, presented limited vaccine responses with higher recombination activities within its cps locus, and unique variation patterns in the genes wzg and lrp. Conclusion: With the lifting of the one-child policy, it will be crucial for families with multiple children to get PCV vaccinations in China. Due to the highly variant cps locus and distinctive variation patterns in capsule shedding and binding proteins genes, the prevalent S14/ST876 strains have shown poor response to current vaccines. It is necessary to continue monitoring the molecular epidemiology of this vaccine escape clone. [ABSTRACT FROM AUTHOR]
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- 2024
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15. Evaluation of different screening tools as the first step of the GLIM framework: A cross‐sectional study of Chinese cancer patients in an outpatient setting.
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Wang, Yanfei, Liu, Ziqi, Zhang, Hong, Wang, Yunyi, Chen, Xiaoyan, Lu, Wenqi, Fang, Yu, Peng, Zhi, and Liu, Wei
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- 2024
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16. Preparation of phosphinimide and its adsorption of uranium in aqueous solution.
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Liu, Zengcheng, Wang, Zhongchao, and Wang, Yanfei
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URANIUM ,AQUEOUS solutions ,RADIOACTIVE elements ,LANGMUIR isotherms ,METAL ions ,SORBENTS - Abstract
The phosphinimide materials described in this paper were synthesized by polymerization precipitation. The properties of complexes coordinated with metal ions can be used as adsorbents for the adsorption of radioactive elements by using ligands such as imide and phosphorus groups. Then, the synthetic phosphinimide was characterized in detail by FT-IR, SEM, EDS and XPS, and its morphology and structural changes were studied. In addition, the effects of the material on the removal of uranium(VI) from aqueous solutions at different pH, sorbent doses, contact times, initial concentrations, and temperatures were studied. The experimental data shows that the adsorption process can fit the pseudo-second-order kinetic model well, which is in line with the Langmuir isotherm model. The thermodynamic study of adsorption shows that the adsorption process is a spontaneous endothermic process. In addition, at a temperature of 303.15 K and pH = 6, the maximum adsorption of uranium(VI) by phosphinimide in 25 min can reach 234.6 mg g
−1 , and a removal rate of 97.75%. [ABSTRACT FROM AUTHOR]- Published
- 2024
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17. How and when leader voice solicitation facilitates innovative behavior: the role of pride and collectivism orientation.
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Li, Xingxin, Wang, Yanfei, Zhu, Yu, and Zheng, Lixun
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Purpose: Drawing on affective events theory (AET), this study aims to investigate how and when leader voice solicitation affects employees' innovative behavior. Specifically, this study proposes that leader voice solicitation evokes employees' feelings of pride, which subsequently motivate employees' innovative behavior. Moreover, collectivism orientation plays a moderating role in this process. Design/methodology/approach: This study collected 251 supervisor–subordinate dyadic data in two phases and employed structural equational modeling (SEM) to test the hypotheses. Findings: The results revealed that employees' feelings of pride mediate the positive relationship between leader voice solicitation and employees' innovative behavior. Collectivism orientation intensifies the mediated relationship. Originality/value: This study extends the potential outcome variables of leader voice solicitation. Moreover, it introduces a novel theoretical perspective to explore the impact of leader voice solicitation on employees. Importantly, this study examines the mediating effect of pride and the moderating effect of collectivism orientation, deepening the understanding of how and when leader voice solicitation affects innovative behavior. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Co-Amorphization of Acemetacin with Basic Amino Acids as Co-Formers for Solubility Improvement and Gastric Ulcer Mitigation.
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Hou, Jiayue, Zhao, Peixu, Wang, Yanfei, Jiang, Xiwei, and Fu, Qiang
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STOMACH ulcers ,FOURIER transform infrared spectroscopy ,MOLECULAR spectroscopy ,X-ray powder diffraction ,AMINO acids ,DIFFERENTIAL scanning calorimetry ,DRUG solubility - Abstract
Acemetacin (ACM) is a new non-steroidal anti-inflammatory drug with anti-inflammatory, analgesic, and antipyretic effects. However, the poor water solubility and gastrointestinal side effects limit its use. Recently, the co-amorphous (CAM) strategy has attracted great interest to improve solubility for poorly water-soluble drugs, and basic amino acids have the potential to protect the gastrointestinal tract. In order to develop a highly efficient and low-toxic ACM formulation, we prepared ACM CAM systems, with basic amino acids (lysine, arginine, and histidine) as co-formers, using a cryo-milling method. The solid-state behaviors of the ACM CAM systems were characterized by polarizing light microscopy, differential scanning calorimetry, and powder X-ray diffraction. Fourier transform infrared spectroscopy and molecular docking were carried out to understand the formation mechanism. Moreover, the gastro-protective effects of ACM CAM systems were evaluated in a rat gastric ulcer model. The results demonstrated that the CAM systems improved the dissolution rates of ACM compared with the neat amorphous counterpart. Furthermore, ACM CAM systems are significantly effective in mitigating the ACM-induced gastric ulcer in rats, and the ulcer inhibition rates were almost 90%. More importantly, this study provided a useful method for mitigating drug-induced gastrointestinal damage and broadened the applications of drug–amino acid CAM systems. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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19. Enhanced Renal Carcinoma Treatment via Synergistic Photothermal/Photodynamic Therapy Using Hittorf's Phosphorus‐Decorated Polymeric Carbon Nitride Heterostructure.
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Guan, Chen, Li, Chenyu, Yang, Chengyu, Yang, Dongjiang, Zhang, Lixue, Xu, Lingyu, Liu, Ke, Zhang, Ningxin, Li, Tianyang, Song, Zhuo, Che, Lin, Wang, Yanfei, Zhang, Liwei, Li, Daohao, Zhu, Yukun, and Xu, Yan
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NITRIDES ,PHOTODYNAMIC therapy ,RENAL cell carcinoma ,REACTIVE oxygen species ,ABSORPTION spectra ,CARCINOMA - Abstract
Nanostructured heterojunctions offer a promising solution to overcome the limitations of narrow absorption spectra, limited penetration depths, and potential harm to healthy cells in phototherapy for clear cell renal cell carcinoma (ccRCC) treatment with nanomaterials. In this study, a heterostructure (PCN@HP) by decorating Hittorf's phosphorus nanorods onto biocompatible polymeric carbon nitride (PCN), enabling excitation by NIR light is designed. Compared with PCN and HP alone, the synthesized heterostructure generated localized heat upon broad absorption spectra of irradiation, boosting charge migration and separation, generating cytotoxic reactive oxygen species (ROS). Then, via in vitro and in vivo experiments, it is confirmed that the NIR‐mediated PCN@HP heterojunction is a safe and effective approach for synchronous photothermal and photodynamic therapy treatment of ccRCC. Collectively, the PCN@HP heterojunction holds great potential as a non‐invasive synergistic, dual‐mode therapeutic nanomedicine for efficient tumor nano‐therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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20. On the mechanism of wogonin against acute monocytic leukemia using network pharmacology and experimental validation.
- Author
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Wang, Xixi, Wang, Yanfei, Chen, Jing, Wang, Qinyao, Liu, Zhongjian, Yin, Yijie, Yang, Tonghua, Shen, Tao, and Sa, Yalian
- Abstract
Wogonin is a natural flavone compound from the plant Scutellaria baicalensis, which has a variety of pharmacological activities such as anti-cancer, anti-virus, anti-inflammatory, and immune regulation. However, the potential mechanism of wogonin remains unknown. This study was to confirm the molecular mechanism of wogonin for acute monocytic leukemia treatment, known as AML-M5. The potential action targets between wogonin and acute monocytic leukemia were predicted from databases. The compound-target-pathway network and protein-protein interaction network (PPI) were constructed. The enrichment analysis of related targets and molecular docking were performed. The network pharmacological results of wogonin for AML-M5 treatment were verified using the THP-1 cell line. 71 target genes of wogonin associated with AML-M5 were found. The key genes TP53, SRC, AKT1, RELA, HSP90AA1, JUN, PIK3R1, and CCND1 were preliminarily found to be the potential central targets of wogonin for AML-M5 treatment. The PPI network analysis, GO analysis and KEGG pathway enrichment analysis demonstrated that the PI3K/AKT signaling pathway was the significant pathway in the wogonin for AML-M5 treatment. The antiproliferative effects of wogonin on THP-1 cells of AML-M5 presented a dose-dependent and time-dependent manner, inducing apoptosis, blocking the cell cycle at the G2/M phase, decreasing the expressions of CCND1, CDK2, and CyclinA2 mRNA, as well as AKT and p-AKT proteins. The mechanisms of wogonin on AML-M5 treatment may be associated with inhibiting cell proliferation and regulating the cell cycle via the PI3K/AKT signaling pathway. [ABSTRACT FROM AUTHOR]
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- 2024
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21. Insights into how carbon chain length and branch position of alcohol solvents affect solid–liquid thermodynamic behavior of form I of probucol.
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Zhang, Rong, Wang, Wei, Li, Jiaqi, Xu, Shijie, and Wang, Yanfei
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THERMODYNAMICS ,SOLVENTS ,MOLE fraction ,STERIC hindrance ,ENERGY density ,CARBON - Abstract
To address the problem that how straight-chain and branched solvent affect the solubility of active pharmaceutical ingredient, in this work, the molar fraction solubility of form I of probucol in five alcohols with straight and branched alcohols was determined by gravimetric method ranging from 278.15 to 323.15 K. The results showed that the equilibrium solubility of probucol is temperature-dependent and increased monotonically with temperature. More importantly, our findings show that the solubility of probucol rose as the number of straight-chain carbons grew and that it is more soluble in straight-chain alcohols than in branched alcohols with an equivalent carbon count. Furthermore, we conclude that the solubility of probucol in various solvents in straight-chain alcohols is co-dominated by solvent polarity and cohesive energy density, while in branched alcohols, the solubility of PBL is co-dominated by steric hindrance and temperature. Then, three thermodynamic models were employed to correlate the experimental solubility data and derive the dissolution thermodynamic properties of PBL. Our results indicated that except for ethanol, the dissolution process of PBL in other alcohols is enthalpy-driven and spontaneous, while in the case of ethanol, the dissolution of PBL transforms from entropy-driven to enthalpy-driven. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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22. Joint Gravity and Magnetic Inversion Using CNNs' Deep Learning.
- Author
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Bai, Zhijing, Wang, Yanfei, Wang, Chenzhang, Yu, Caixia, Lukyanenko, Dmitry, Stepanova, Inna, and Yagola, Anatoly G.
- Subjects
ARTIFICIAL neural networks ,CONVOLUTIONAL neural networks ,INVERSION (Geophysics) ,DEEP learning ,GRAVITY ,MACHINE learning ,MAGNETIC fields - Abstract
Enhancing the reliability of inversion results has always been a prominent issue in the field of geophysics. In recent years, data-driven inversion methods leveraging deep neural networks (DNNs) have gained prominence for their ability to address non-uniqueness issues and reduce computational costs compared to traditional physically model-driven methods. In this study, we propose a GMNet machine learning method, i.e., a CNN-based inversion method for gravity and magnetic field data. This method relies more on data-driven training, and in the prediction phase after the model is trained, it does not heavily depend on a priori assumptions, unlike traditional methods. By forward modeling gravity and magnetic fields, we obtain a substantial dataset to train the CNN model, enabling the direct mapping from field data to subsurface property distribution. Applying this method to synthetic data and one-field data yields promising inversion results. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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23. P‐4.29: The Research on Virtual Reality Field Based on Gesture Recognition.
- Author
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Zhang, Junshuai, Wang, Yanfei, and Wang, Lijun
- Subjects
CONVOLUTIONAL neural networks ,GESTURE ,VIRTUAL reality - Abstract
In recent years, gesture recognition technology has been increasingly used in the field of virtual reality. Applying gesture recognition technology to the field of virtual reality is an important method to improve the immersion of virtual reality. This article introduces the main algorithms of vision‐based gesture recognition technology, such as convolutional neural network (CNN), introduces interactive devices widely used in virtual reality applications, and finally systematically analyzes the application of gesture recognition technology in virtual reality such as emergency rescue and education training. The current application status in real fields and prospects for future development. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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24. P‐4.4: Research on Key Technologies for Psychological Relief Based on Virtual Reality Exposure Therapy.
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Wang, Yanfei and Wang, Lijun
- Subjects
VIRTUAL reality therapy ,PSYCHOTHERAPY ,COGNITIVE therapy ,TREATMENT effectiveness ,PEOPLE with mental illness ,REFLEXES ,DECOMPRESSION (Physiology) - Abstract
In the context of China's rapid development and accelerated pace of life, people generally face increased pressure, leading to a sharp increase in psychological problems. More than half of the population is sub‐healthy, and patients with mental illness are also increasing year by year. Mental stress is a common cause of psychological and physiological disorders, triggering emergency stress states. Psychotherapy has been developing as an important intervention method, and psychological relief based on relaxation and stress reduction has gradually become a research hotspot. Behavioral therapy and cognitive therapy are common psychological treatments, while relaxation induction methods include breathing training, meditation, music, etc. Virtual reality technology is used in psychological research to improve therapeutic effects. Among them, virtual reality exposure therapy (VRET), which treats anxiety by creating virtual scenes, has attracted attention. And in virtual reality exposure therapy treatment, the patient's psychological state can be grasped by monitoring these physiological reactions. This article will discuss the key technologies for psychological decompression based on VRET, aiming to gain an in‐depth understanding of its principles, applications, etc. [ABSTRACT FROM AUTHOR]
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- 2024
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25. Caffeine Ameliorates Age-Related Hearing Loss by Downregulating the Inflammatory Pathway in Mice.
- Author
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Zhang, Xiaolin, Cao, Ruijuan, Li, Changye, Zhao, Hongchun, Zhang, Ruyi, Che, Juan, Xie, Jinwen, Tang, Na, Wang, Yanfei, Liu, Xiuzhen, and Zheng, Qingyin
- Published
- 2024
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26. How and When Observed Illegitimate Tasks Affect Observers' Work Withdrawal and Helping Behavior.
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Wang, Yanfei, Mei, Wenjuan, Zhu, Yu, and Chen, Yuan
- Abstract
Prior research has primarily focused on the victims' perspectives, while research to date has overlooked the impact of illegitimate tasks from observers' perspective. Drawing upon deontic justice theory, this study investigates how observers react to observed illegitimate tasks, and examines how these reactions are influenced by the observer's sense of deontic justice and moderated by their empathic concern. This study carried out an experiment and a three-wave survey. Results showed that observed illegitimate tasks decreased observers' sense of deontic justice, thereby promoting work withdrawal behavior, and helping behavior. Furthermore, our findings revealed that observers' empathic concern strengthened these direct and indirect connections. This study further discusses implications and suggests avenues for subsequent studies. [ABSTRACT FROM AUTHOR]
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- 2024
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27. The crystal structure of tetrakis(μ2-(1H-benzimidazole-2-methoxo-κ2N,O:O:O)-(n-butanol-κO)-chlorido)-tetranickel(II), C48H68Cl4N8O8Ni4.
- Author
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Wang, Yanfei, He, Xiujuan, Mao, Qian, and Ji, Jinlan
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CRYSTAL structure - Abstract
C
48 H68 Cl4 N8 O8 Ni4 , tetragonal, I41 /a (no. 88), a = 16.9137(5) Å, c = 19.5028(13) Å, V = 5579.2(5) Å3 , Z = 4, Rgt (F) = 0.0391, wRref (F2 ) = 0.1221, T = 293 K. [ABSTRACT FROM AUTHOR]- Published
- 2024
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28. The impact of massive EV charging on distribution lines.
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Chen, Wenwen, Wang, Yanfei, Huang, Yuchen, Chen, Yongjin, Luo, Shun, and Deng, Meiling
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- 2024
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29. Revealing chronic disease progression patterns using Gaussian process for stage inference.
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Wang, Yanfei, Zhao, Weiling, Ross, Angela, You, Lei, Wang, Hongyu, and Zhou, Xiaobo
- Abstract
Objective The early stages of chronic disease typically progress slowly, so symptoms are usually only noticed until the disease is advanced. Slow progression and heterogeneous manifestations make it challenging to model the transition from normal to disease status. As patient conditions are only observed at discrete timestamps with varying intervals, an incomplete understanding of disease progression and heterogeneity affects clinical practice and drug development. Materials and Methods We developed the Gaussian Process for Stage Inference (GPSI) approach to uncover chronic disease progression patterns and assess the dynamic contribution of clinical features. We tested the ability of the GPSI to reliably stratify synthetic and real-world data for osteoarthritis (OA) in the Osteoarthritis Initiative (OAI), bipolar disorder (BP) in the Adolescent Brain Cognitive Development Study (ABCD), and hepatocellular carcinoma (HCC) in the UTHealth and The Cancer Genome Atlas (TCGA). Results First, GPSI identified two subgroups of OA based on image features, where these subgroups corresponded to different genotypes, indicating the bone-remodeling and overweight-related pathways. Second, GPSI differentiated BP into two distinct developmental patterns and defined the contribution of specific brain region atrophy from early to advanced disease stages, demonstrating the ability of the GPSI to identify diagnostic subgroups. Third, HCC progression patterns were well reproduced in the two independent UTHealth and TCGA datasets. Conclusion Our study demonstrated that an unsupervised approach can disentangle temporal and phenotypic heterogeneity and identify population subgroups with common patterns of disease progression. Based on the differences in these features across stages, physicians can better tailor treatment plans and medications to individual patients. [ABSTRACT FROM AUTHOR]
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- 2024
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30. Molecular Insights into the Synergistic Effects of Putrescine and Ammonium on Dinoflagellates.
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Wang, Yanfei and Coyne, Kathryn J.
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POLYAMINES ,PUTRESCINE ,AMMONIUM ,NITROGEN compounds ,DINOFLAGELLATES ,CELL death - Abstract
Ammonium and polyamines are essential nitrogen metabolites in all living organisms. Crosstalk between ammonium and polyamines through their metabolic pathways has been demonstrated in plants and animals, while no research has been directed to explore this relationship in algae or to investigate the underlying molecular mechanisms. Previous research demonstrated that high concentrations of ammonium and putrescine were among the active substances in bacteria-derived algicide targeting dinoflagellates, suggesting that the biochemical inter-connection and/or interaction of these nitrogen compounds play an essential role in controlling these ecologically important algal species. In this research, putrescine, ammonium, or a combination of putrescine and ammonium was added to cultures of three dinoflagellate species to explore their effects. The results demonstrated the dose-dependent and species-specific synergistic effects of putrescine and ammonium on these species. To further explore the molecular mechanisms behind the synergistic effects, transcriptome analysis was conducted on dinoflagellate Karlodinium veneficum treated with putrescine or ammonium vs. a combination of putrescine and ammonium. The results suggested that the synergistic effects of putrescine and ammonium disrupted polyamine homeostasis and reduced ammonium tolerance, which may have contributed to the cell death of K. veneficum. There was also transcriptomic evidence of damage to chloroplasts and impaired photosynthesis of K. veneficum. This research illustrates the molecular mechanisms underlying the synergistic effects of the major nitrogen metabolites, ammonium and putrescine, in dinoflagellates and provides direction for future studies on polyamine biology in algal species. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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31. COV2Var, a function annotation database of SARS-CoV-2 genetic variation.
- Author
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Feng, Yuzhou, Yi, Jiahao, Yang, Lin, Wang, Yanfei, Wen, Jianguo, Zhao, Weiling, Kim, Pora, and Zhou, Xiaobo
- Published
- 2024
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32. The Wheat Endophyte Epicoccum layuense J4-3 Inhibits Fusarium graminearum and Enhances Plant Growth.
- Author
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Nzabanita, Clement, Zhang, Lihang, Wang, Yanfei, Wang, Shuangchao, and Guo, Lihua
- Subjects
PLANT growth ,FUSARIUM ,ENDOPHYTIC fungi ,MYCOSES ,BIOLOGICAL pest control agents ,FUNGAL cultures - Abstract
Fungal endophytes are well-known for their ability to promote plant growth and hinder fungal diseases, including Fusarium head blight (FHB) caused by Fusarium graminearum. This study aimed to characterize the biocontrol efficacy of strain J4-3 isolated from the stem of symptomless wheat collected from Heilongjiang Province, China. It was identified as Epicoccum layuense using morphological characteristics and phylogenetic analysis of the rDNA internal transcribed spacer (ITS) and beta-tubulin (TUB). In a dual culture assay, strain J4-3 significantly inhibited the mycelial growth of F. graminearum strain PH-1 and other fungal pathogens. In addition, wheat coleoptile tests showed that lesion symptoms caused by F. graminearum were significantly reduced in wheat seedlings treated with hyphal fragment suspensions of strain J4-3 compared to the controls. Under field conditions, applying spore suspensions and culture filtrates of strain J4-3 with conidial suspensions of F. graminearum on wheat spikes resulted in the significant biocontrol efficacy of FHB. In addition, wheat seedlings previously treated with spore suspensions of strain J4-3 before sowing successfully resulted in FHB reduction after the application of conidial suspensions of F. graminearum at anthesis. More importantly, wheat seedlings treated with hyphal fragments and spore suspensions of strain J4-3 showed significant increases in wheat growth compared to the controls under greenhouse and field conditions. Overall, these findings suggest that E. layuense J4-3 could be a promising biocontrol agent (BCA) against F. graminearum, causing FHB and a growth-promoting fungus in wheat. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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33. Investigation on the structural characteristics and polymorphic transformation mechanism of polymorphic hydrates: a case of minodronic acid monohydrate.
- Author
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Gao, Xuefei, Zhu, Liang, Dong, Chenglin, Wang, Xiaoning, Zhao, Wenli, Zhao, Xiaoyu, and Wang, Yanfei
- Subjects
POLYMORPHIC transformations ,METHANE hydrates ,HYDROGEN bonding interactions ,HYDROGEN bonding ,DYNAMIC simulation ,ACTIVATION energy - Abstract
The polymorphism of Minodronic acid (MDA) monohydrates (form D and form E) was investigated in this work. The results revealed that the main difference lies in the discrepancy of hydrogen bonds in two polymorphisms. In addition, the atoms-in-molecules (AIM) analysis was conducted to assess the strength of hydrogen bonds. The hydrogen bonds in form D were estimated as electrostatic, while the corresponding hydrogen bonds in form E were partially covalent type. Then the polymorphic transformation mechanism was investigated by experiments coupled with molecular dynamic simulations. As the conformation of the water molecule transforms from Form D to Form E, the hydrogen bond interaction between water and MDA molecules gradually becomes stronger. The observations were consistent with the results obtained from molecular dynamic simulations. The energy barriers of the path I were in line with the simulation results. This indicates the reliability of the polymorphic transformation mechanism of the MDA monohydrates. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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34. Hepatocyte nuclear factor 1B deletion, but not intragenic mutation, might be more susceptible to hypomagnesemia.
- Author
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Wang, Yanfei, Xiao, Xiaoyu, Lin, Qiuqiu, Song, Rong, Wang, Xiaozhou, Liang, Yiji, Chen, Jingsong, Luan, Xiaojun, Zhou, Zhiguang, Xiao, Yang, Xue, Yaoming, and Hu, Jingyi
- Subjects
HEPATOCYTE nuclear factors ,MATURITY onset diabetes of the young ,HYPOMAGNESEMIA ,MAGNETIC resonance imaging ,CYSTIC kidney disease - Abstract
Aims: HNF1B syndrome is caused by defects in the hepatocyte nuclear factor 1B (HNF1B) gene, which leads to maturity‐onset diabetes of the young type 5 and congenital organ malformations. This study aimed to identify a gene defect in a patient presenting with diabetes and severe diarrhea, while also analyzing the prevalence of hypomagnesemia and its correlation with the HNF1B genotype. Materials and Methods: Whole exome sequencing was used to identify responsible point mutations and small indels in the proband and their family members. Multiplex ligation‐dependent probe amplification was carried out to identify HNF1B deletions. Furthermore, an analysis of published data on 539 cumulative HNF1B cases, from 29 literature sources, was carried out to determine the correlation between the HNF1B genotype and the phenotype of serum magnesium status. Results: Using multiplex ligation‐dependent probe amplification, we identified a de novo heterozygous HNF1B deletion in the patient, who showed dorsal pancreas agenesis and multiple kidney cysts, as detected by magnetic resonance imaging. Magnesium supplementation effectively alleviated the symptoms of diarrhea. Hypomagnesemia was highly prevalent in 192 out of 354 (54.2%) patients with HNF1B syndrome. Compared with patients with intragenic mutations, those with HNF1B deletions were more likely to suffer from hypomagnesemia, with an odds ratio of 3.1 (95% confidence interval 1.8–5.4). Conclusions: Hypomagnesemia is highly prevalent in individuals with HNF1B syndrome, and those with HNF1B deletion are more susceptible to developing hypomagnesemia compared with those with intragenic mutations. The genotype–phenotype associations in HNF1B syndrome have significant implications for endocrinologists in terms of genotype detection, treatment decisions and prognosis assessment. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
35. Adsorption of uranium(VI) in aqueous solution by tetraphenyldithiodiphosphonate.
- Author
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Liu, Zengcheng, Wang, Yanfei, Xu, Yufen, and Peng, Tianqiong
- Subjects
URANIUM ,AQUEOUS solutions ,ADSORPTION (Chemistry) ,LANGMUIR isotherms ,ADSORPTION capacity ,ELECTRON mobility - Abstract
Tetraphenyldithiodiphosphonate is synthesized by polymerization precipitation. The P = S bond of the material has strong polarity, which is conducive to improving the electron mobility of the complex and inhibiting the accumulation between molecules. The synthesized tetraphenyldithiodiphosphonate is characterized by FT-IR, SEM, XPS and XRD. In addition, the pseudo-second-order kinetic model is used to simulate the experimental data well, and the adsorption process conforms to the Langmuir isotherm model. Thermodynamic studies of adsorption have shown that the adsorption process is essentially a spontaneous endothermic process. At room temperature, tetraphenyldithiodiphosphonate demonstrates a maximum adsorption capacity for uranium(VI) reaching 398.8 mg g
−1 . [ABSTRACT FROM AUTHOR]- Published
- 2024
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- View/download PDF
36. A multivariable model of ultrasound and clinicopathological features for predicting axillary nodal burden of breast cancer: potential to prevent unnecessary axillary lymph node dissection.
- Author
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Yang, Lei, Gu, Yifan, Wang, Bing, Sun, Ming, Zhang, Lei, Shi, Lei, Wang, Yanfei, Zhang, Zheng, and Yin, Yifei
- Subjects
AXILLARY lymph node dissection ,BREAST cancer ,LOGISTIC regression analysis ,CLINICAL pathology ,ULTRASONIC imaging ,BREAST surgery - Abstract
Background: To develop a clinical model for predicting high axillary nodal burden in patients with early breast cancer by integrating ultrasound (US) and clinicopathological features. Methods and materials: Patients with breast cancer who underwent preoperative US examination and breast surgery at the Affiliated Hospital of Nantong University (centre 1, n = 250) and at the Affiliated Hospital of Jiangsu University (centre 2, n = 97) between January 2012 and December 2016 and between January 2020 and March 2022, respectively, were deemed eligible for this study (n = 347). According to the number of lymph node (LN) metastasis based on pathology, patients were divided into two groups: limited nodal burden (0–2 metastatic LNs) and heavy nodal burden (≥ 3 metastatic LNs). In addition, US features combined with clinicopathological variables were compared between these two groups. Univariate and multivariate logistic regression analysis were conducted to identify the most valuable variables for predicting ≥ 3 LNs in breast cancer. A nomogram was then developed based on these independent factors. Results: Univariate logistic regression analysis revealed that the cortical thickness (p < 0.001), longitudinal to transverse ratio (p = 0.001), absence of hilum (p < 0.001), T stage (p = 0.002) and Ki-67 (p = 0.039) were significantly associated with heavy nodal burden. In the multivariate logistic regression analysis, cortical thickness (p = 0.001), absence of hilum (p = 0.042) and T stage (p = 0.012) were considered independent predictors of high-burden node. The area under curve (AUC) of the nomogram was 0.749. Conclusion: Our model based on US variables and clinicopathological characteristics demonstrates that can help select patients with ≥ 3 LNs, which can in turn be helpful to predict high axillary nodal burden in early breast cancer patients and prevent unnecessary axillary lymph node dissection. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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- View/download PDF
37. Properties of Heat-Assisted pH Shifting and Compounded Chitosan from Insoluble Rice Peptide Precipitate and Its Application in the Curcumin-Loaded Pickering Emulsions.
- Author
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Yang, Zhenyu, Li, Zhiying, Xu, Zitong, Kong, Zhihao, Qiao, Xin, Zhang, Liwen, Dai, Lei, Wang, Yanfei, Sun, Qingjie, McClements, David Julian, and Xu, Xingfeng
- Subjects
PEPTIDES ,QUARTZ crystal microbalances ,EMULSIONS ,CHEMICAL stability ,FOOD emulsifiers ,CHITOSAN ,CHITIN - Abstract
Curcumin exhibits antioxidant and antitumor properties, but its poor chemical stability limits its application. Insoluble peptide precipitates formed by proteolysis of rice glutelin are usually discarded, resulting in resource waste. The coupled treatment of heat-assisted pH shifting and compounded chitosan (CS) was used to fabricate rice peptide aggregate–chitosan complexes (RPA–CS). The structure, interfacial behavior, emulsion properties, and digestibility of curcumin-loaded RPA–CS Pickering emulsions were investigated. Increasing the CS concentration led to lower interfacial tension but larger particle size, and the three-phase contact angle of the RPA–CS complexes approached 90°. Quartz crystal microbalance with dissipation (QCM–D) indicated that RPA–CS complexes with 6 g·kg
−1 of CS (RPA–CS6 ) had the highest K1 (0.592 × 106 Hz−1 ) and K4 (0.487 × 106 Hz−1 ), suggesting that the softest interfacial layers were formed. The solid–liquid balance of RPA–RPA–CS emulsions was lower than 0.5, declaring that they had more elastic behavior than that of RPA emulsions. RPA–RPA–CS4 -and RPA–CS6 emulsions had better storage stability, lower FFA release (79.8% and 76.3%, respectively), and higher curcumin bioaccessibility (65.2% and 68.2%, respectively) than RPA emulsions. This study showed that a low-value insoluble rice peptide precipitate could be used as a valuable emulsifier in foods, which may increase the economics and sustainability of the food supply. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
38. When and why does prosocial rule-breaking behavior fall into dilemma? A moral balancing perspective.
- Author
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Zhu, Yu, Nong, Meilan, Wang, Yanfei, and Ma, Jie
- Subjects
PROSOCIAL behavior ,ORGANIZATIONAL citizenship behavior ,EMPLOYEE benefits ,INSTITUTIONAL environment ,DILEMMA - Abstract
Existing research has demonstrated that prosocial rule-breaking behavior (PSRB) generates positive outcomes for employees and organizations. However, scholars know little about the potential dark side of PSRB. This article draws upon the moral balance model to explore the potential double-edged sword effect of PSRB. We propose that when the rules climate is high, employees who engage in prosocial rule-breaking behavior will perceive the loss of moral credits and increase organizational citizenship behavior. Furthermore, when the rules climate is low, employees who engage in prosocial rule-breaking behavior will produce psychological entitlement, fueling counterproductive behavior. Results from an experiment and a multisource field study support our hypotheses. Our research provides new insight into understanding the perils and benefits of employees' prosocial rule-breaking behavior and reveals the importance of exploring organizational moral climate in this distinct process. Finally, implications for theory and implementation are discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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- View/download PDF
39. Structure and mechanism of a eukaryotic ceramide synthase complex.
- Author
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Xie, Tian, Fang, Qi, Zhang, Zike, Wang, Yanfei, Dong, Feitong, and Gong, Xin
- Subjects
CERAMIDES ,ENDOPLASMIC reticulum ,DRUG target ,SYNTHASES ,METABOLIC disorders ,HETERODIMERS - Abstract
Ceramide synthases (CerS) catalyze ceramide formation via N‐acylation of a sphingoid base with a fatty acyl‐CoA and are attractive drug targets for treating numerous metabolic diseases and cancers. Here, we present the cryo‐EM structure of a yeast CerS complex, consisting of a catalytic Lac1 subunit and a regulatory Lip1 subunit, in complex with C26‐CoA substrate. The CerS holoenzyme exists as a dimer of Lac1‐Lip1 heterodimers. Lac1 contains a hydrophilic reaction chamber and a hydrophobic tunnel for binding the CoA moiety and C26‐acyl chain of C26‐CoA, respectively. Lip1 interacts with both the transmembrane region and the last luminal loop of Lac1 to maintain the proper acyl chain binding tunnel. A lateral opening on Lac1 serves as a potential entrance for the sphingoid base substrate. Our findings provide a template for understanding the working mechanism of eukaryotic ceramide synthases and may facilitate the development of therapeutic CerS modulators. Synopsis: In eukaryotes, ceramide synthase is a multispan enzyme in the endoplasmic reticulum membrane. Here, structural and biochemical studies of the yeast Lac1‐Lip1 complex provide new insight into its substrate binding and molecular mechanism. The cryo‐EM structure of the yeast Lac1‐Lip1 complex bound to C26‐CoA substrate reveals that the holoenzyme exists as a dimer of heterodimers.Lac1 contains a hydrophilic reaction chamber and a hydrophobic tunnel that bind the CoA moiety and C26‐acyl chain of C26‐CoA, respectively.Lip1 interacts with both the transmembrane region and the last luminal loop of Lac1 to maintain the acyl chain binding tunnel.A lateral opening in the membrane‐embedded region of Lac1 serves as a potential entry site for the sphingoid base substrate. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
40. Agent-based model: A method worthy of promotion in Library and Information Science.
- Author
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Su, Peng, Chen, Meihua, and Wang, Yanfei
- Subjects
INFORMATION science ,LIBRARY science ,ARTIFICIAL intelligence ,INTELLIGENT agents ,ACTIVE learning - Abstract
Agent-based model (ABM) is a branch of artificial intelligence. Its specialty is to construct a complex macro-system model by describing the perception, decision, learning and action of micro-agents. This method is widely used in many fields from natural science to social science. We discuss ABM by collecting relevant academic papers which apply to the field of Library and Information Science (LIS). This article systematically reviews how ABM is applied to the LIS field and argues that ABM can provide an exploratory tool with quantifiability, repeatability, interpretability, contingency, adaptability and other types of advantages. Finally, it is pointed out that this method is a research tool worthy of careful exploration. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
41. Research Progress on Debranched Starch: Preparation, Characterization, and Application.
- Author
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Wang, Deda, Zhao, Mei, Wang, Yanfei, Mu, Hongyan, Sun, Cong, Chen, Haihua, and Sun, Qingjie
- Subjects
PULLULANASE ,STARCH ,DEGREE of polymerization ,CRYSTAL structure ,MOLECULAR weights ,GRANULATION ,POLYMERIZATION - Abstract
Debranched starch (DBS) with shorter chain length can be obtained by hydrolysing native starches with debranching enzymes, which allows to improve or create new functional properties that favourable for specific application requirement. In present review, the botanical source, treatment approaches prior to or post debranching reaction, and the debranching processes for preparing DBS were extensively discussed. The structural and physicochemical properties of DBS, such as molecular weight distribution, crystalline profile, solubility, gel capacity, and thermal stability determined were demonstrated. The polymerization degree of DBS depends significantly on the crystalline structure, granule size, and morphology of the botanical origin, and are greatly correlated with the debranching enzyme and hydrolysis time. Gelatinization, solvent precipitation, drying, and crystallization would greatly influence the physicochemical properties of DBS. DBS also has impact in designing health-related food and carriers for delivering functional agents. Moreover, the modified products based on DBS have great potential in food and pharmaceutical applications. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
42. SiC modified self‐healing ytterbium disilicate materials for potential environmental barrier coating application.
- Author
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Du, Jinping, Wang, Yanfei, Wan, Fan, Li, Junsheng, Li, Duan, and Liu, Rongjun
- Subjects
SELF-healing materials ,YTTERBIUM ,SILICON carbide ,WATER vapor ,SURFACE coatings ,OXIDIZING agents ,PUNCTUALITY - Abstract
Environmental barrier coatings (EBCs) are crucial to the reliability and durability of SiCf/SiC composite components seeking applications in hot sections of next‐generation advanced aero‐engines. The cracks initiated and developed in EBCs owing to various reasons during service greatly undermine their lifespans. To address this problem, in this work, silicon carbide (SiC) in the forms of particles and whiskers with various amounts have been introduced to ytterbium disilicate (Yb2Si2O7), the mainstream EBC topcoat materials, so as to gain some self‐healing potential. The results reveal that, the SiC inclusions in Yb2Si2O7 in the presence of ytterbium monosilicate (Yb2SiO5) can trigger the following reactions. Specifically, SiC self‐healing agents are oxidized to form viscous SiO2, which actively reacts with Yb2SiO5 upon encountering it, forming Yb2Si2O7. This has brought twofold beneficial effects including ① silicon supplementation of disilicate topcoat, whose silicon element tends to be "dragged out" by water vapor, leading to the deterioration of thermal mismatch; as well as ② crack self‐healing resulting from the volume expansion induced by the above reactions. Then the two aspects of self‐healing agents, namely the "promptness" and "sustainability," have been discussed in detail. The former is unveiled to be more pertinent to the repairing of large cracks, whilst the latter is more relevant to the self‐healing of tiny cracks at initiation or early stage of propagation. The current work sheds some lights on the design and development of more durable and robust EBCs with self‐healing capability. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
43. Magnetic Ag3PO4/CoFe2O4 Z-scheme heterojunction material for photocatalytic decomposition of ofloxacin.
- Author
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Ye, Hongyong, Xia, Lingyun, Wang, Yanfei, Zhou, Hao, Xie, Xinying, Zuo, Guangling, and Wu, Keliang
- Abstract
A magnetic composite catalyst, Ag
3 PO4 /CoFe2 O4 , was successfully synthesized using a combination of solvothermal and hydrothermal techniques with CoFe2 O4 as the base material. The crystal structure, morphology and properties of the Ag3 PO4 /CoFe2 O4 composite catalyst were characterized by various instrumental analysis methods. The photocatalytic activity of this composite catalyst was evaluated using ofloxacin (OFX) degradation. The study revealed that the Z-type heterojunction structure was formed by loading the body-centered cubic Ag3 PO4 onto the surface of spinel cobalt ferrite CoFe2 O4 , and this structure can accelerate the recombination of invalid electron–hole pairs and facilitate the separation of valid charge carriers. The visible light catalytic activity of Ag3 PO4 /CoFe2 O4 composite catalyst was found to have improved significantly. The degradation effect of Ag3 PO4 /CoFe2 O4 composite catalyst on OFX was significantly better than that of pure Ag3 PO4 and CoFe2 O4 , with 4% Ag3 PO4 /CoFe2 O4 showing the best possible effect. The degradation rate of OFX could reach up to 95.9% under visible light for 2.5 h, and the degradation process followed the first-order kinetic reaction model. The magnetic properties of the Ag3 PO4 /CoFe2 O4 composite catalyst make it easy to enable magnetic separation, recovery, and recycling of the catalyst without secondary contamination after the reaction. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
44. Hsa_circ_0102899 promotes epithelial–mesenchymal transition in non-small cell lung cancer.
- Author
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Wang, YanFei, He, JieMing, Liang, YongXue, and Xiong, DaLin
- Abstract
Objective: The significance of circular RNAs (circRNAs) has been identified in the progression of non-small cell lung cancer (NSCLC). Consistently, our study probed the functional actions of hsa_circ_0102899 (circ_0102899) in NSCLC cells. Methods: circ_0102899 expression was checked in NSCLC tissues, as well as its correlation with clinical characteristics of patients, Using A459 cells, transfection to alter gene expression was performed, thus measuring the changes of proliferation, apoptosis, migration, and apoptosis, as well as epithelial–mesenchymal transition (EMT)-related proteins. circ_0102899's effects in vivo were validated by tumor xenograft assay. Finally, the regulatory mechanism of circ_0102899 was investigated. Results: circ_0102899 indicated a high-expression level in NSCLC tissues which was associated with NSCLC tumor characteristics. Functionally, circ_0102899 knockdown not only inhibited the growth and EMT process of NSCLC cells, but also inhibited tumor formation in vivo. In terms of the regulatory mechanism, circ_0102899 had a binding to miR-885-5p to target eukaryotic translation initiation factor 4γ2 (EIF4G2). circ_0102899 mediated miR-885–5/EIF4G2 axis to accelerate the process of cell malignant behavior in NSCLC. Conclusion: circ_0102899 promotes EMT and metastasis in NSCLC by regulating the miR-885-5p/EIF4G2 axis. [ABSTRACT FROM AUTHOR]
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- 2023
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45. The Functional Prognosis of Rescue Conscious Sedation During Mechanical Thrombectomy on Patients with Acute Anterior Circulation Ischemic Stroke: A Single-Center Retrospective Study.
- Author
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Li, Shilin, Zhang, Yu, Zhang, Xiaobo, Zhang, Gejuan, Han, Nannan, Ma, Haojun, Ge, Hanming, Zhao, Yong, Zhang, Leshi, Wang, Yanfei, Shi, Wenzhen, Ma, Xiaojuan, Tian, Yizhuo, Xiao, Yixuan, Niu, Yinuo, Qiao, Lin, and Chang, Mingze
- Subjects
ISCHEMIC stroke ,CONSCIOUS sedation ,THROMBECTOMY ,PROGNOSIS ,INTRACRANIAL hemorrhage ,POSTOPERATIVE nausea & vomiting - Abstract
Introduction: Based on real-world case data, this study intends to explore and analyze the impact of rescue conscious sedation (CS) on the clinical outcomes of patients with anterior circulation acute ischemic stroke (AIS) receiving mechanical thrombectomy (MT). Methods: This retrospective study enrolled patients with anterior circulation AIS who received MT and were treated with either single local anesthesia (LA) or rescue CS during MT between January 2018 and October 2021. We used univariate and multivariate logistic regression methods to compare the impact of LA and CS on the clinical outcomes of patients with AIS who received MT, including the mRS at 90 days, the incidence of poststroke pneumonia (PSP), the incidence of symptomatic intracranial cerebral hemorrhage (sICH), and the mortality rate. Results: We reviewed 314 patient cases with AIS who received MT. Of all patients, 164 met our search criteria. Eighty-nine patients received LA, and 75 patients received rescue CS. There was no significant difference between the two groups in the 90-day good prognosis (45.3% vs. 51.7%, p = 0.418) and mortality (17.3% vs. 22.5%, p = 0.414). Compared with the LA group, the incidence of postoperative pneumonia in the rescue CS group (44% vs. 25.8%, p = 0.015) was more significant. Multivariate stepwise logistic regression analysis revealed that intraoperative remedial CS was independently associated with PSP following MT. In a subgroup analysis, rescue CS was found to significantly increase the incidence of PSP in patients with dysphagia (OR = 7.307, 95% CI 2.144–24.906, p = 0.001). As the severity of the National Institutes of Health Stroke Scale (NIHSS) increased, intraoperative rescue CS was found to increase the risk of PSP (OR = 1.155, 95% CI 1.034–1.290, p = 0.011) by 5.1% compared to that of LA (OR = 1.104, 95% CI 1.013–1.204, p = 0.024). Conclusion: Compared to LA, rescue CS during MT does not significantly improve the 90 days of good prognosis and reduce the incidence of sICH and mortality in patients with anterior circulation AIS. However, it has a significantly increased risk of poststroke pneumonia (PSP), particularly in patients with dysphagia. [ABSTRACT FROM AUTHOR]
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- 2023
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46. Progress of cross-scale mechanics in additive manufacturing technology for aeronautical application.
- Author
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YU Zhijie, XU Bihan, WANG Xiangying, SUN Qixing, and WANG Yanfei
- Subjects
METAL microstructure ,STRESS fractures (Orthopedics) ,INHOMOGENEOUS materials ,WEAR resistance ,STRUCTURAL design - Abstract
The application of metal additive manufacturing technology and products in the aviation field requires optimized structural design at macroscale and precise manufacture control at microscale. As one of the typical features of additive manufacture, microstructure inevitably affects the material performance. The research has shown that the uniformity, plasticity, and fatigue fracture characteristics of additive manufacturing materials are often inferior to traditional materials, while their strength, hardness, wear resistance, and some microscale properties are often better than traditional materials. The size effect in the micro/nano-scale and the heterogeneous characteristics of materials have a significant impact on metal materials with microstructures. Under different microstructures, materials can achieve a better balance between strength and ductility, which is also applicable to additively manufactured metals. Therefore, the process characteristics of additive manufacturing and the heterogeneities introduced by human design are both expected to significantly improve the comprehensive performance of metals, which have important guiding value for the application of metal additive manufacturing in the aviation field. However, since many of the mechanism of these phenomena are still unclear, the strength-ductility synergistic and antagonistic relationships with other properties of the materials are also worth further research. [ABSTRACT FROM AUTHOR]
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- 2023
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47. A bibliometric review on electric vehicle (EV) energy efficiency and emission effect research.
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Yao, Shengyong, Bian, Zixiang, Hasan, Mohammad Kamrul, Ding, Ru, Li, Shuning, Wang, Yanfei, and Song, Shulei
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ENERGY consumption ,AUTOMOBILE emissions ,SCIENTIFIC knowledge ,BIBLIOMETRICS ,ELECTRIC vehicle industry - Abstract
Electric vehicles have received extensive attention due to their unique energy efficiency and good emission reduction effects. While a large-scale of electric vehicles are gradually replacing traditional fuel vehicles, it is necessary to ensure the energy efficiency of electric vehicles and the effectiveness of their emission reduction effects. This study conducted a bibliometric analysis of scientific publications on energy efficiency and emission reduction effects of electric vehicles from 2003 to 2022, using a variety of bibliometric tools such as R Studio, biblioshiny and VOSviewer. The results showed the gradual elimination of traditional energy vehicles, where electric vehicles play an important role in connecting energy efficiency and emission control. The results also showed the top publication outlets, citations trackers, authors with thematic evaluation of energy efficiency and emission reduction effects of electric vehicles. The contribution of the study is manifold. The academic contribution of the present study is the bibliometric analysis which will help academicians to get a quick overview of the most popular journals, top collaborators, documents, authors, and scientific knowledge structure. Secondly, policy makers, environmentalists, researchers, and academician will definitely get a pathway how they should go for future research. Finally, this study suggests more researches trend to focus on the sales of electric vehicles, automobile exhaust emissions, sensitivity analysis of electric vehicles, energy storage analysis to improve the energy efficiency of electric vehicles, and V2G related to the energy efficiency of electric vehicle clusters. [ABSTRACT FROM AUTHOR]
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- 2023
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48. Hexarelin alleviates apoptosis on ischemic acute kidney injury via MDM2/p53 pathway.
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Guan, Chen, Li, Chenyu, Shen, Xuefei, Yang, Chengyu, Liu, Zengying, Zhang, Ningxin, Xu, Lingyu, Zhao, Long, Zhou, Bin, Man, Xiaofei, Luo, Congjuan, Luan, Hong, Che, Lin, Wang, Yanfei, and Xu, Yan
- Abstract
Introduction: Hexarelin exhibits significant protection against organ injury in models of ischemia/reperfusion (I/R)-induced injury (IRI). Nevertheless, the impact of Hexarelin on acute kidney injury (AKI) and its underlying mechanism remains unclear. In this study, we investigated the therapeutic potential of Hexarelin in I/R-induced AKI and elucidated its molecular mechanisms. Methods: We assessed the protective effects of Hexarelin through both in vivo and in vitro experiments. In the I/R-induced AKI model, rats were pretreated with Hexarelin at 100 μg/kg/d for 7 days before being sacrificed 24 h post-IRI. Subsequently, kidney function, histology, and apoptosis were assessed. In vitro, hypoxia/reoxygenation (H/R)-induced HK-2 cell model was used to investigate the impact of Hexarelin on apoptosis in HK-2 cells. Then, we employed molecular docking using a pharmmapper server and autodock software to identify potential target proteins of Hexarelin. Results: In this study, rats subjected to I/R developed severe kidney injury characterized by tubular necrosis, tubular dilatation, increased serum creatinine levels, and cell apoptosis. However, pretreatment with Hexarelin exhibited a protective effect by mitigating post-ischemic kidney pathological changes, improving renal function, and inhibiting apoptosis. This was achieved through the downregulation of conventional apoptosis-related genes, such as Caspase-3, Bax and Bad, and the upregulation of the anti-apoptotic protein Bcl-2. Consistent with the in vivo results, Hexarelin also reduced cell apoptosis in post-H/R HK-2 cells. Furthermore, our analysis using GSEA confirmed the essential role of the apoptosis pathway in I/R-induced AKI. Molecular docking revealed a strong binding affinity between Hexarelin and MDM2, suggesting the potential mechanism of Hexarelin’s anti-apoptosis effect at least partially through its interaction with MDM2, a well-known negative regulator of apoptosis-related protein that of p53. To validate these findings, we evaluated the relative expression of MDM2 and p53 in I/R-induced AKI with or without Hexarelin pre-administration and observed a significant suppression of MDM2 and p53 by Hexarelin in both in vivo and in vitro experiments. Conclusion: Collectively, Hexarelin was identified as a promising medication in protecting apoptosis against I/R-induced AKI. [ABSTRACT FROM AUTHOR]
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- 2023
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49. Hospitalized patients received furosemide undergoing acute kidney injury: the risk and prediction tool.
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Guan, Chen, Li, Chenyu, Xu, Lingyu, Che, Lin, Wang, Yanfei, Yang, Chengyu, Zhang, Ningxin, Liu, Zengying, Zhao, Long, Zhou, Bin, Man, Xiaofei, Luan, Hong, and Xu, Yan
- Subjects
ACUTE kidney failure ,HOSPITAL patients ,FUROSEMIDE ,PROPENSITY score matching ,CONGESTIVE heart failure ,KIDNEY transplantation - Abstract
Purpose: Furosemide, a frequently prescribed diuretic for managing congestive heart failure and edema, remains a topic of debate regarding its potential risk of inducing acute kidney injury (AKI) in patients. Consequently, this study aims to examine the occurrence of hospital-acquired AKI (HA-AKI) in hospitalized patients who are administered furosemide and to investigate potential risk factors associated with this outcome. Methods: This study encompassed a cohort of 22374 hospitalized patients who either received furosemide treatment or not from June 1, 2012, to December 31, 2017. Propensity score matching was employed to establish comparability between the two groups regarding covariates. Subsequently, a nomogram was constructed to predict the probability of AKI occurrence among patients who underwent furosemide treatment. Results: The regression analysis identified the single-day total dose of furosemide as the most significant factor for AKI, followed by ICU administration, estimated glomerular filtration rate, antibiotic, statin, NSAIDs, β-blockers, proton pump inhibitor, chronic kidney disease, and 7 other indicators. Subgroup analysis revealed a synergistic effect of furosemide with surgical operation, previous treatment with β-blockers, ACEI/ARB and antibiotics, leading to an increased risk of AKI when used in combination. Subsequently, a visually represented prognostic nomogram was developed to predict AKI occurrence in furosemide users. The predictive accuracy of the nomogram was assessed through calibration analyses, demonstrating an excellent agreement between the nomogram predictions and the actual likelihood of AKI, with a probability of 77.40%. Conclusions: Careful consideration of factors such as dosage, concurrent medication use, and renal function of the patient is necessary for clinical practice when using furosemide. Our practical prognostic model for HA-AKI associated with furosemide use can be utilized to assist clinicians in making informed decisions about patient care and treatment. [ABSTRACT FROM AUTHOR]
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- 2023
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50. The crystal structure of catena-poly[(μ2-2H-1,2,3-triazole-4,5-dicarboxylato-κ2O, O′)-(μ2-1,3-bis((1H-imidazol-1-yl)methyl)benzene-κ2N,N′) zinc(II)], C18H15N7O4Zn
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Mao, Qian, Wang, Yanfei, Zhang, Zhonghua, and Ji, Jinlan
- Subjects
CRYSTAL structure - Abstract
C
18 H15 N7 O4 Zn, triclinic, P 1 ‾ (no. 2), a = 9.1100(8) Å, b = 10.6451(7) Å, c = 12.0479(8) Å, α = 95.238(5)∘ , β = 112.154(7)∘ , γ = 112.971(7)∘ , V = 956.56(13) Å3 , Z = 2, Rgt (F) = 0.0264, wRref (F2 ) = 0.0731, T = 298 K. [ABSTRACT FROM AUTHOR]- Published
- 2023
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