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Efficient wound repair with skin appendage regeneration following severe trauma poses a challenge due to the scarcity of skin grafts and decreased drug effectiveness in protease‐rich wound microenvironments. Here, a multifunctional artificial skin (NIR‐mFAS) with photothermal‐triggered drug delivery capabilities is designed to actively and comprehensively improve the regenerative potential of full‐thickness wounds. The antibacterial chitosan/silk fibroin hydrogel matrix of artificial skin, cross‐linked by electrostatic interactions, effectively encapsulates and sustains the release of epidermal growth factor (EGF) to accelerate re‐epithelialization and neovascularization by promoting the migration and proliferation of repair cells. Subsequently, the photothermal responsive polydopamine nanoparticles (PDA‐NPs) dispersed in the matrix enable precise control over the release of BMP4 under the irradiation of 1064 nm NIR, thereby inhibiting scarring by reducing myofibroblasts during the proliferative stage. Importantly, the concurrent controlled release of CHIR99021 can modulate cell fate by inducing the conversion of myofibroblasts into dermal papilla‐like cells, leading to hair follicle and sebaceous gland regeneration. The NIR‐mFAS functions as an advanced delivery system for achieving high‐quality wound healing with appendage regeneration and offers a smart therapeutic approach that can be applied to other treatments requiring coordinated delivery of multiple pharmacological agents. [ABSTRACT FROM AUTHOR]

In comparison to traditional graphite anode materials, Li metal anodes are distinguished by a high theoretical specific capacity and low redox potential, making Li an optimal anode material for next-generation high-energy-density batteries. However, the intrinsic high reactivity of lithium metal can readily lead to uneven deposition of Li+ during the cycling process, resulting in the formation of lithium dendrites and volume expansion problems accompanied by substantial safety hazards. To protect the Li metal anode, we combine a sol–gel strategy and a simple physical bonding method to construct a novel homogeneous melamine–formaldehyde resin nanosphere (MFNS) interlayer. The experimental results demonstrate that the abundant pyrrolic N and pyridinic N functional groups present in MFNSs exhibit a strong affinity and attraction to Li+. During the deposition process, the MFNS interlayer redistributes the inhomogeneous Li+ flux, resulting in a uniform distribution of Li+ and guiding the homogeneous nucleation and deposition of lithium metal. Thanks to the MFNS-covered Li anodes, the assembled symmetrical cell possesses a long life of 1560 h at 1 mA cm−2 with 1 mA h cm−2. Consequently, this work presents a novel stabilization strategy for the development and design of Li metal anodes. [ABSTRACT FROM AUTHOR]

A strategy was devised for the synthesis of SAPO-34, which involved a concentrated gel system-assisted two-step crystallization method. This strategy effectively controlled the size and morphology of SAPO-34. The successful synthesis of SAPO-34 crystals with micron-scale cubic morphology and nano-scale sheets were achieved using triethylamine as a low-cost template. The paper thoroughly examined the growth evolution that occurs during the crystallization process, and it delved into the factors such as gel concentration and crystallization conditions in the synthesis. Furthermore, potential theories regarding nucleation and growth mechanisms were suggested. A systematic study was conducted to examine how the morphology and acidity of SAPO-34 zeolites impact their catalytic performance. The results confirmed that the SAPO-34 with low silicon content and lamellar structure was successfully synthesized through a two-step crystallization within a gel system of H2O/Al2O3 = 30, with a thickness of approximately 50–300 nm. SAPO-34 nanosheets demonstrated a substantial enhancement in catalytic performance, with a catalytic life of 370 min and an 84.1% selectivity towards light olefins. [ABSTRACT FROM AUTHOR]

Aim: To evaluate the impact of non‐alcoholic fatty liver disease (NAFLD) presence and fibrosis risk on adverse outcomes in patients with type 2 diabetes and chronic kidney disease. Methods: Data were sourced from two longitudinal cohorts: 1172 patients from the National Health and Nutrition Examination Survey (NHANES) and 326 patients from the kidney biopsy cohort at the West China Hospital of Sichuan University. Cox regression estimated hazard ratios (HRs) for NAFLD and liver fibrosis concerning adverse clinical outcomes. Subsequently, a two‐sample Mendelian randomization study using genome‐wide association study statistics explored NAFLD's potential causal link to cardio‐cerebrovascular events. Results: In the NHANES cohort, NAFLD stood as an independent risk factor for various outcomes: overall mortality [HR 1.53 (95% confidence interval, CI 1.21‐1.95)], mortality because of cardio‐cerebrovascular diseases [HR 1.63 (95% CI 1.12‐2.37)], heart disease [HR 1.58 (95% CI 1.00‐2.49)], and cerebrovascular disease [HR 3.95 (95% CI 1.48‐10.55)]. Notably, advanced liver fibrosis, identified by a fibrosis‐4 (FIB‐4) score >2.67, exhibited associations with overall mortality, cardio‐cerebrovascular disease mortality and heart disease mortality. Within the kidney biopsy cohort, NAFLD correlated with future end‐stage kidney disease [ESKD; HR 2.17 (95% CI 1.41‐3.34)], while elevated FIB‐4 or NAFLD Fibrosis Scores predicted future ESKD, following full adjustment. Liver fibrosis was positively correlated with renal interstitial fibrosis and tubular atrophy in biopsies. Further Mendelian randomization analysis supported a causal relationship between NAFLD and cardio‐cerebrovascular events. Conclusions: In patients with type 2 diabetes and chronic kidney disease, the NAFLD presence and elevated FIB‐4 scores link to heightened mortality risk and ESKD susceptibility. Moreover, NAFLD shows a causal relationship with cardio‐cerebrovascular events. [ABSTRACT FROM AUTHOR]

Glycoproteins, representing a significant proportion of posttranslational products, play pivotal roles in various biological processes, such as signal transduction and immune response. Abnormal glycosylation may lead to structural and functional changes of glycoprotein, which is closely related to the occurrence and development of various diseases. Consequently, exploring protein glycosylation can shed light on the mechanisms behind disease manifestation and pave the way for innovative diagnostic and therapeutic strategies. Nonetheless, the study of clinical glycoproteomics is fraught with challenges due to the low abundance and intricate structures of glycosylation. Recent advancements in mass spectrometry‐based clinical glycoproteomics have improved our ability to identify abnormal glycoproteins in clinical samples. In this review, we aim to provide a comprehensive overview of the foundational principles and recent advancements in clinical glycoproteomic methodologies and applications. Furthermore, we discussed the typical characteristics, underlying functions, and mechanisms of glycoproteins in various diseases, such as brain diseases, cardiovascular diseases, cancers, kidney diseases, and metabolic diseases. Additionally, we highlighted potential avenues for future development in clinical glycoproteomics. These insights provided in this review will enhance the comprehension of clinical glycoproteomic methods and diseases and promote the elucidation of pathogenesis and the discovery of novel diagnostic biomarkers and therapeutic targets. [ABSTRACT FROM AUTHOR]

This article proposes a model‐free framework to solve the optimal control problem with an infinite‐horizon performance function for nonlinear systems with input constraints. Specifically, two Physics‐Informed Neural Networks (PINNs) that incorporate the knowledge of the Lyapunov stability theorem and the convergence conditions of the policy iteration algorithm are utilized to approximate the value function and control policy, respectively. Then, a Reinforcement Learning (RL) algorithm that does not require any first‐principles or data‐driven models of nonlinear systems is developed to iteratively learn a nearly optimal control policy. Furthermore, we provide a rigorous theoretical analysis showing the conditions that ensure the stability of closed‐loop systems with the control policy learned by RL and guarantee the convergence of the iteration algorithm. Finally, the proposed Physics‐Informed Reinforcement Learning (PIRL) method is applied to a chemical process example to demonstrate its effectiveness. [ABSTRACT FROM AUTHOR]

Objective: The use of belimumab in treating lupus nephritis (LN) patients in China is still in its early stages. This retrospective comparative study aims to delineate the disease activity, associated therapies, clinical outcomes, and adverse events among LN patients treated with belimumab, reflecting real-world experience in southeastern China. Methods: From May 2020 to December 2023, 54 LN patients treated with belimumab and 42 LN patients treated with conventional therapy were enrolled. All patients had a follow-up period of more than 3 months. The general information, presenting clinical and laboratory data, and outcomes were collected and compared. Results: At 3 months of belimumab treatment, compared to baseline, there was a decrease in proteinuria from 74.1% to 64.8% (p < 0.001), a reduction in hematuria from 59.3% to 37.0% (p = 0.008), and an increase in partial or complete renal response from 53.7% to 75.9% (p < 0.001). The median SLEDAI score decreased from 10 to 5 (p < 0.001), and the proportion of patients achieving low lupus disease activity state (LLDAS) increased from 11.11% to 16.67% (p < 0.001) by the 3-month evaluation. Notably, there were significant reductions in oral corticosteroid dosages, with a median decrease from 30 to 17.5 mg/day (p < 0.001) by 3 months, and the proportion of patients requiring >5 mg/day of steroids decreased from 88.89% at baseline to 79.07% at six months (p < 0.001). Compared to the conventional therapy group, the belimumab group experienced a significant reduction in median steroid dosage and increased the proportion of patients achieving remission or LLDAS. The incidence of treatment-emergent adverse events (TEAEs) was significantly lower in the belimumab group (29.6% vs 52.4%, p = 0.024). Conclusion: These findings support the potential of belimumab to improve renal and serological parameters, reduce disease activity, lessen corticosteroid dependence, and decrease the risk of TEAEs, demonstrating its safety and efficacy as an adjunct therapy in LN management. [ABSTRACT FROM AUTHOR]

Purpose: Kawasaki disease (KD) is an acute systemic vasculitis that is associated with dysregulated immune responses. Monocytes play a central role in innate immunity. Our previous single-cell RNA sequencing of peripheral blood mononuclear cells (PBMC) revealed a new subset of monocytes in children with KD called L-Selectin+ classical monocytes (SELL+ CM). Therefore, we aimed to investigate the correlation between KD and SELL+ CM. Patients and Methods: Peripheral blood samples were collected from 81 KD patients, 18 febrile patients and 36 healthy children before treatment. Among them, ten KD patients were followed up, and samples were obtained before and after intravenous immunoglobulin (IVIG) treatment. Analysis of SELL+ CM was performed using flow cytometry. Additionally, ROC curve analysis was conducted to assess the diagnostic value of SELL+ CM for KD. Results: Classical monocytes (CM) expressed the highest levels of L-selectin in children with KD. The ratio of SELL+ CM in CM was significantly higher in KD patients than in febrile and healthy children. Following IVIG treatment, the ratio of SELL+ CM in CM showed a downward trend. The receiver operating characteristic (ROC) curve analysis (the area under the curve, AUC = 0.71) indicated the potential diagnostic value of SELL+ CM in KD. The correlation analysis suggested that SELL+ CM may serve as a new clinical index for patients with KD. Conclusion: In KD, the ratio of SELL+ CM in CM significantly increases during the acute phase, which may become a potential biomarker and help facilitate KD diagnosis based on clinical features. [ABSTRACT FROM AUTHOR]

It has been proven that Graph Neural Networks focus more on the majority class instances and ignore minority class instances when the class distribution is imbalanced. To address the class imbalance problems on graphs, most of the existing approaches rely on the availability of minority nodes in the training set, which may be scarce in extremely imbalanced situations and lead to overfitting. To tackle this issue, this paper proposes a novel oversampling-based Neighbor imbalanced-aware Graph Neural Networks, abbreviated as Nia-GNNs. Specifically, we propose a novel interpolation method that selects interpolated minority nodes from the entire dataset according to their predicted labels and similarity. Meanwhile, a class-wise interpolation ratio is applied to prevent the generation of out-of-domain nodes. Additionally, the generated minority nodes are inserted into the neighbor of minority nodes according to their neighbor distribution to balance the graph both neighborly and globally. Numerous experiments on different imbalanced datasets demonstrate the superiority of our method in classifying imbalanced nodes. [ABSTRACT FROM AUTHOR]

Zn metal anodes are usually subject to grave dendrite growth during platting/stripping, which dramatically curtails the lifespan of aqueous Zn‐ion batteries and capacitors. To address above problems, in our work, a novel phosphorus‐functionalized multichannel carbon interlayer was designed and covered on Zn anodes. The results demonstrated that the multichannel structure combined with the three‐dimensional meshy skeleton can provide more sufficient space for Zn deposition, thereby effectively inhibiting the growth of zinc dendrites. Meanwhile, theoretical calculations also confirmed that the P–C and P=O functional groups from phosphorus‐functionalized multichannel carbon interlayer have the decisive influence in reducing the zinc nucleation potential and depositing uniformly zinc. Concretely, the symmetrical battery assembled with phosphorus‐functionalized multichannel carbon interlayer‐covered Zn anodes possessed a long lifetime of 3300 h at 2 mA cm−2 with 1 mAh cm−2. Furthermore, the full cell with activated carbon cathodes exhibited a high specific capacity of 80.5 mAh g−1 and outstanding cycling stability without capacity decay after 15 000 cycles at a high current density of 5 A g−1. The superior electrochemical performance exceeded that of most reported papers. Consequently, our synthesized zincophilic interlayer with the unique structure has superior prospects for application in stabilizing zinc anodes and prolonging the lifespan of batteries. [ABSTRACT FROM AUTHOR]

The rise of rural e-commerce, accelerated by the COVID-19 pandemic, has driven agricultural development, resulting in a dual-channel model that combines offline supermarket docking with online e-commerce direct sales. Furthermore, given the perishable nature of most agricultural products, consumers exhibit a preference for high-quality logistics services. This paper analyses the dynamics of the agricultural supply chain, beginning with the "leading enterprises + farmers" production mode, and establishes two optimal decision-making models for online and offline dual-channel agricultural supply chains, incorporating logistics service levels. The first model considers centralised decision-making, where leading agricultural producers and community superstores make decisions simultaneously, aiming to maximise the overall profit of the supply chain. The second model addresses decentralised decision-making in which the producer, as the dominant player in a Stackelberg game, anticipates the reactions of retailers and sets the wholesale price, online sales price, and online logistics service level accordingly. Retailers, as followers, then determine the offline sales price and offline logistics service level based on the producer's decisions. Finally, we conduct a sensitivity analysis of the proposed models. Our findings reveal that as consumer focus on logistics service levels increases, the overall profit of the supply chain improves, and as the unit logistics cost corresponding to the level of logistics service increases, the marginal benefits of decreasing profit brought about by the increase in unit logistics cost also decrease. [ABSTRACT FROM AUTHOR]

Constrained multiobjective optimization problems (CMOPs) are widespread in reality. The presence of constraints complicates the feasible region of the original problem and increases the difficulty of problem solving. There are not only feasible regions, but also large areas of infeasible regions in the objective space of CMOPs. Inspired by this, this paper proposes a bidirectional coevolution method with reverse search (BCRS) combined with a two-stage approach. In the first stage of evolution, constraints are ignored and the population is pushed toward promising regions. In the second stage, evolution is divided into two parts, i.e., the main population evolves toward the constrained Pareto front (CPF) within the feasible region, while the reverse population approaches the CPF from the infeasible region. Then a solution exchange strategy similar to weak cooperation is used between the two populations. The experimental results on benchmark functions and real-world problems show that the proposed algorithm exhibits superior or at least competitive performance compared to other state-of-the-art algorithms. It demonstrates BCRS is an effective algorithm for addressing CMOPs. [ABSTRACT FROM AUTHOR]

FeCo2O4/MoS2 binary composite catalysts were prepared by the hydrothermal method and calcination method. In this paper, the morphology and structure of the materials were characterized by means of SEM, EDS, XRD, and XPS. It was found that MoS2 has high activity and good stability in HER, and and it has more prospect than noble metal catalysts. In oxygen evolution chemical kinetics, its rich redox potential allowed it to adsorb OH− on (Co2+/Co3+, Fe2+/Fe3+) and enhanced the activity of OER. The cross-nanosheet structure of the FeCo2O4/MoS2 composite catalyst exposed more catalytic sites and accelerated charge transfer to achieve more efficient mass transfer. FeCo2O4/MoS2 as an anode and cathode was assembled into a two-electrode system in overall water splitting, which showed good catalytic activity. When the composite ratio of FeCo2O4 to MoS2 was 1:0.3, the composite catalyst had the best catalytic activity. The results show that when FeCo2O4/MoS2 is used as a cathode and anode to assemble an alkaline cell, respectively, the voltage for total water electrolysis is 1.59 V at a current density of 10 mA cm−2 in a 1 M KOH electrolyte, it can keep good stability in a 10 h test with electrolyzed water, and its current retention rate is 98.5%. [ABSTRACT FROM AUTHOR]

Superwetting aerogel is a promising alternative for the remediation of emulsified oily wastewater for its high porosity combined with extreme wettability enabled high separation performances to emulsion wastewater. However, it remains challenging for superwetting aerogels to accomplish high-performance dual separation to surfactant-stabilized oil-in-water (O/W) and water-in-oil (W/O) emulsions with high stability. Herein, an environmentally benign superamphiphilic composite aerogel was prepared by a green synthesis route that relied on the utilization of natural amphiphilic biomass. Collagen fibers (CFs) were utilized to construct the three-dimensional (3D) supramolecular skeleton of aerogel to provide high storage capacity of water/oil and outstanding capillary effect to boost the mass transfer. The two-dimensional (2D) lamellar structure of gelatin (Gel) was further grown on the skeleton of CFs aerogel to play the role for simultaneously enhanced demulsifying capability and spreading of emulsions. The as-prepared superamphiphilic aerogel enabled the separation of highly stable surfactant-stabilized O/W and W/O emulsions with high separation efficiency and flux. Excellent recycling performances and anti-fouling performance were also confirmed. Our investigations therefore demonstrated that the structural engineering of superamphiphilic aerogel is a promising way to realize high-performance dual separation of surfactant-stabilized O/W and W/O emulsion wastewater. [ABSTRACT FROM AUTHOR]

Background and hypothesis Acute kidney injury (AKI) could progress to chronic kidney disease (CKD) and the AKI-CKD transition has major clinical significance. A growing body of evidence has unveiled the role of pyroptosis in kidney injury. We postulate that GSDMD and GSDME exert cumulative effects on the AKI-CKD transition by modulating different cellular responses. Methods We established an AKI-CKD transition model induced by folic acid in wildtype (WT), Gsdmd −/−, Gsdme −/−, and Gsdmd −/− Gsdme −/− mice. Tubular injury, renal fibrosis and inflammatory responses were evaluated. In vitro studies were conducted to investigate the interplay among tubular cells, neutrophils, and macrophages. Results Double deletion of Gsdmd and Gsdme conferred heightened protection against AKI, mitigating inflammatory responses, including the formation of neutrophil extracellular traps (NETs), macrophage polarization and differentiation, and ultimately renal fibrosis, compared with wildtype mice and mice with single deletion of either Gsdmd or Gsdme. Gsdme , but not Gsdmd deficiency, shielded tubular cells from pyroptosis. GSDME-dependent tubular cell death stimulated NETs formation and prompted macrophage polarization towards a pro-inflammatory phenotype. Gsdmd deficiency suppressed NETs formation and subsequently hindered NETs-induced macrophage-to-myofibroblast transition (MMT). Conclusion GSDMD and GSDME collaborate to contribute to AKI and subsequent renal fibrosis induced by folic acid. Synchronous inhibition of GSDMD and GSDME could be an innovative therapeutic strategy for mitigating the AKI-CKD transition. [ABSTRACT FROM AUTHOR]

Microstructures have been proved as crucial factors for the sensing performance of flexible pressure sensors. In this study, polypyrrole (PPy)/sunflower pollen (SFP) (P/SFP) was prepared via the in situ growth of PPy on the surface of degreased SFP with a sea urchin-like microstructure; then, these P/SFP microspheres were sprayed onto a flat silk cocoon (FSC) to prepare a sensing layer P/SFP-FSC. PPy-FSC (P-FSC) was prepared as an electrode layer through the in situ polymerization of PPy on the FSC surface. The sensing layer P/SFP-FSC was placed between two P-FSC electrode layers to assemble a P/SFP-FSC pressure sensor together with a fork finger electrode. With 6 mg/cm2 of optimized sprayed P/SFP microspheres, the prepared flexible pressure sensor has a sensitivity of up to 0.128 KPa−1 in the range of 0–13.18 KPa and up to 0.13 KPa−1 in the range of 13.18–30.65 KPa, a fast response/recovery time (90 ms/80 ms), and a minimum detection limit as low as 40 Pa. This fabricated flexible P/SFP-FSC sensor can monitor human motion and can also be used for the encrypted transmission of important information via Morse code. In conclusion, the developed flexible P/SFP-FSC pressure sensor based on microstructure modification in this study shows good application prospects in the field of human–computer interaction and wearable electronic devices. [ABSTRACT FROM AUTHOR]

Background: Exploring the molecular mechanisms of primordial germ cell (PGC) migration and the involvement of gonadal somatic cells in gonad development is valuable for comprehending the origins and potential treatments of reproductive-related diseases. Methods: Diaphanous related formin 1 (Diaph1, also known as mDia1) was screened by analyzing publicly available datasets (ATAC-seq, DNase-seq, and RNA-seq). Subsequently, the CRISPR-Cas9 technology was used to construct Diaph1 knockout mice to investigate the role of Diaph1 in gonad development. Results: Based on data from public databases, a differentially expressed gene Diaph1, was identified in the migration of mouse PGC. Additionally, the number of PGCs was significantly reduced in Diaph1 knockout mice compared to wild type mice, and the expression levels of genes related to proliferation (Dicer1, Mcm9), adhesion (E-cadherin, Cdh1), and migration (Cxcr4, Hmgcr, Dazl) were significantly decreased. Diaph1 knockout also inhibited Leydig cell proliferation and induced apoptosis in the testis, as well as granulosa cell apoptosis in the ovary. Moreover, the sperm count in the epididymal region and the count of ovarian follicles were significantly reduced in Diaph1 knockout mice, resulting in decreased fertility, concomitant with lowered levels of serum testosterone and estradiol. Further research found that in Diaph1 knockout mice, the key enzymes involved in testosterone synthesis (CYP11A1, 3β-HSD) were decreased in Leydig cells, and the estradiol-associated factor (FSH receptor, AMH) in granulosa cells were also downregulated. Conclusions: Overall, our findings indicate that the knockout of Diaph1 can disrupt the expression of factors that regulate sex hormone production, leading to impaired secretion of sex hormones, ultimately resulting in damage to reproductive function. These results provide a new perspective on the molecular mechanisms underlying PGC migration and gonadal development, and offer valuable insights for further research on the causes, diagnosis, and treatment of related diseases. [ABSTRACT FROM AUTHOR]

Zwitterionic catalysis is powerful in simultaneously activating electrophiles and nucleophiles in organic transformations; however, its potential in polymerizations remains untapped. Herein, a zwitterionic catalytic model for ring-opening polymerization (ROP) is introduced and a series quaternary ammonium carboxylate zwitterionic catalysts have been designed and evaluated in the ROPs of cyclic esters. Among the zwitterionic catalysts, L -carnitine, a commercially available and inexpensive natural product, showed the optimal catalytic performance. ROPs of L -lactide (L -LA), trimethylene carbonate, δ-valerolactone and ε-caprolactone were successful. PLLA was prepared with controlled molecular weight (1.4 to 21.2 kg mol−1) and narrow dispersion (Đ 1.02 to 1.21). The zwitterionic catalytic mechanism is proposed where quaternary ammonium and hydroxyl cooperatively activated the carbonyl of monomers, while the carboxylic anion activated the chain-end/initiator. NMR titrations validated the bifunctional activation mechanism. Organocatalysts of zwitterionic nature provide a new design tool for wider scope investigation of catalytic polymerizations. [ABSTRACT FROM AUTHOR]

Due to the impact of global environment and climate change, determining how to ensure food production and reduce food loss has become an important research topic for many countries, especially developing countries, and can provide key information for China's grain harvest management. This article mainly examines the impact of harvesting period on rice yield, the existence of latent losses, and their management value. From 2019 to 2022, our team conducted experiments on the growth curve of rice grains, plants, and populations to investigate the existence of latent losses by establishing the relationship between the standard moisture weight and the days after heading. The results showed that the weight of the rice gradually decreased as the harvest time was delayed, and there were latent losses, of which the dry matter loss was about 3.5%. With the addition of grain shattering loss, the latent loss rate was about 7.0%. In summary, if rice management is strengthened, including harvesting at the optimal time, 4.67% of the loss can be recovered. The timing of the harvest significantly impacts rice yield. Understanding the process and causes of new types of rice losses, increasing the basis for judging the timely harvest period, and providing the best management measures can prevent the post-harvest losses caused by traditional methods and increase the amount of fertile land available. [ABSTRACT FROM AUTHOR]

Background: Postoperative delirium (POD) and cognitive dysfunction (POCD) are common complications following thoracic surgery, particularly in patients aged 65 years and above. These complications can significantly affect recovery and increase healthcare costs. This study investigates the effects of low-dose S-ketamine on reducing POD and POCD in this patient demographic. Methods: In this retrospective cohort study, medical records of patients aged ≥ 65 years who underwent elective thoracic surgery from January 2019 to August 2023 were reviewed. Patients were categorized into S-ketamine and Control groups based on intraoperative S-ketamine exposure. POD was assessed using the Confusion Assessment Method (CAM), while cognitive function was evaluated using the Montreal Cognitive Assessment (MoCA) at baseline, 1 week, 1 month, and 6 months post-surgery. Intraoperative and postoperative parameters, including hemodynamic stability, blood loss, pain scores, and ICU stay length, were also recorded. Results: The study comprised 140 participants, with 70 in each group. The S-ketamine group demonstrated a significantly lower incidence of POD at 7 days post-surgery (12.0% vs. 26.7%, P < 0.001), and reduced POCD at 1 month (18.7% vs. 36.0%, P < 0.05) and 6 months (10.7% vs. 21.3%, P < 0.05). The Ketamine group had a significantly higher median MoCA score compared to the Control group both at 1 month (P = 0.021) and 6 months (P = 0.007). Adverse events, such as infection, bleeding, and respiratory failure, showed no significant differences between the groups, suggesting a safe profile for S-ketamine. Conclusion: Administering low-dose S-ketamine during thoracic surgery in patients aged 65 years and above significantly reduces the incidence of POD and POCD, highlighting its neuroprotective potential. These findings advocate for the inclusion of S-ketamine in anesthetic protocols to improve postoperative outcomes and reduce healthcare costs in this patient population. [ABSTRACT FROM AUTHOR]

Titanium silicon molecular zeolite (TS-1) plays an important role in catalytic reactions due to its unique nanostructure. The straight channel on TS-1 was parallel to the orientation of the short b-axis and directly exposed to the aperture of the 10-member ring with a diameter of 0.54 nm × 0.56 nm. This structure could effectively reduce the diffuse restriction of bulk organic compounds during the oxidative desulfurization process. As a kind of cationic polymer electrolyte, polydimethyldiallyl ammonium chloride (PDDA) contains continuous [C8H16N+Cl−] chain segments, in which the Cl− could function as an effective structure-directing agent in the synthesis of nanomaterials. The chain of PDDA could adequately interact with the [0 1 0] plane in the preparation process of zeolite, and then the TS-1 nanosheet with short b-axis thickness (6 nm) could be obtained. The pore structure of the TS-1 nanosheet is controlled by regulating the content of PDDA. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), N2 physical adsorption analysis, infrared absorption spectrum and ultraviolet–visible spectrum were used to determine the TS-1. The thinner nanosheets exhibit excellent catalytic performance in oxidative desulfurization of dibenzothiophene (DBT), in which the removal rate could remain at 100% after three recycles. Here, the TS-1 nanosheet with short b-axis thickness has a promising future in catalytic reactions. [ABSTRACT FROM AUTHOR]

Objective: To analyze the clinical features and gene mutations in four families with hereditary protein C (PC) deficiency and explore their association with vascular thromboembolism. Methods: The clinical data of four patients with PC deficiency were retrospectively analyzed. Venous blood samples were collected from the four affected patients and their family members, and relevant coagulation indexes and thrombin production and inhibition tests were performed. PCR was used to amplify and directly sequence the PROC gene of the probands. Software analysis was conducted to assess the conservativeness and pathogenicity of the mutated loci. Protein models were constructed to analyze the spatial structure before and after the mutation. Results: Thrombin generation and inhibition assays demonstrated impaired anticoagulation in all four probands. Proband 1 and 4 presented clinically with pulmonary embolism and lower extremity deep vein thrombosis (DVT), Proband 2 with cerebral infarction, and Proband 3 with DVT. Genetic analysis revealed the presence of the following mutations: c.541T > G heterozygous missense mutation, c.577-579delAAG heterozygous deletion mutation, c.247-248insCT heterozygous insertion mutation, c.659G > A heterozygous missense mutation, and a new variant locus c.1146_1146delT heterozygous deletion mutation in the four probands, respectively. In particular, c.1146_1146delT heterozygous deletion mutations not reported previously. Conservativeness and pathogenicity analyses confirmed that most of these amino acid residues were conserved, and all the mutations were found to be pathogenic. Analysis of protein modeling revealed that these mutations induced structural alterations in the protein or led to the formation of truncated proteins. According to the American College of Medical Genetics and Genomics (ACMG) classification criteria and guidelines for genetic variants, c.1146_1146delT was rated as pathogenic (PVS1 + M2 + PM4 + PP1 + PP3 + PP4). Conclusion: The identified mutations are likely associated with decreased PC levels in each of the four families. The clinical manifestations of hereditary PC deficiency exhibit considerable diversity. [ABSTRACT FROM AUTHOR]

Herein, visible‐light‐induced metal‐free three‐component amidoheteroarylation of alkenes with quinoxalin‐2(1H)‐ones and N‐sulfonylaminopyridinium salts is developed. This protocol involves a radical relay process in which the N‐centered radicals undergo chemoselective addition to alkenes to form an alkyl radical that selectively combines with heteroarenes, leading to the formation of C−C and C−N bonds in one step under mild reaction conditions. The involved high efficiency and selectivity, wide substrate scope, and excellent functional‐group compatibility demonstrate the practicability of the developed protocol. [ABSTRACT FROM AUTHOR]

Grounded in the cultural context of Chinese filial piety, this study employs structural equation model to analyze survey data from elderly participants. It explores the effect and path of progeny–parents family travel on the elderly's sense of well-being and examines the mediating roles of generational interaction, optimistic emotion, and psychological resilience. The findings indicate that progeny–parents family travel positively influences the well-being of the elderly, with generational interaction, optimistic emotion, and psychological resilience serving as intermediary roles. Theoretically, this study enriches the localized perspective of family travel's psychological and behavioral impact on the elderly. It elucidates the spillover effects of family travel within the framework of filial piety culture, delineates the mechanisms by which family travel enhances elderly well-being, and offers theoretical insights for businesses to develop customized family travel products and services. [ABSTRACT FROM AUTHOR]

Single-cell omics technologies enable molecular characterization of diverse cell types and states, but how the resulting transcriptional and epigenetic profiles depend on the cell's genetic background remains understudied. We describe Monopogen, a computational tool to detect single-nucleotide variants (SNVs) from single-cell sequencing data. Monopogen leverages linkage disequilibrium from external reference panels to identify germline SNVs and detects putative somatic SNVs using allele cosegregating patterns at the cell population level. It can identify 100 K to 3 M germline SNVs achieving a genotyping accuracy of 95%, together with hundreds of putative somatic SNVs. Monopogen-derived genotypes enable global and local ancestry inference and identification of admixed samples. It identifies variants associated with cardiomyocyte metabolic levels and epigenomic programs. It also improves putative somatic SNV detection that enables clonal lineage tracing in primary human clonal hematopoiesis. Monopogen brings together population genetics, cell lineage tracing and single-cell omics to uncover genetic determinants of cellular processes. Monopogen identifies single-nucleotide variants in single-cell sequencing data. [ABSTRACT FROM AUTHOR]

To enhance the precision of evaluating the operational status of SF6 high-voltage circuit breakers (HVCBs) and devise judicious maintenance strategies, this study introduces an operational state assessment method for SF6 HVCBs grounded in the integrated data-driven analysis (IDDA) model. The relative degradation weight (RDW) is introduced as a metric for quantifying the relative significance of distinct indicators concerning the operational condition of SF6 HVCBs. A data-driven model, founded on critical factor stability (CFS), is formulated to convert environmental indicators into quantitative computations. Furthermore, an optimized fuzzy inference (OFI) system is devised to streamline the system architecture and enhance the processing speed of continuous indicators. Ultimately, the efficacy of the proposed model is substantiated through validation, and results from instance analyses underscore that the presented approach not only attains heightened accuracy in assessment compared to extant analytical methodologies but also furnishes a dependable foundation for prioritizing maintenance sequences across diverse components. [ABSTRACT FROM AUTHOR]

In this work, we have performed extensive swarm-intelligence structures searching simulations on the RbBSi compounds within the pressure range from 0 to 100 GPa. We have proposed three different phases of RbBSi, of which the stability, the electronic structure and the potential superconductivity were calculated by first-principles calculations. All predicted phases are thermodynamically and dynamically stable within the studied pressure range. The bands of the three phases crossing the Fermi level indicate the structures are all metallic. In addition, P4/nmm-RbBSi is a superconductor with Tc of 14.4 K at ambient pressure. This work extends the understanding and potential application of alkali metal boron-silicide compounds in the field of superconductor. [ABSTRACT FROM AUTHOR]

To ensure a stable and reliable power supply, the valid and timely response of protective relays are indispensable. Through the prevention of fault expansions, potential equipment damage or system collapse can be averted, where their setting is one vital prerequisite for such effective implementations. However, the increasing complexity of distribution power systems results in more challenges for protection tuning strategies. Ergo, this paper presents an ensemble that combines the independent factor evaluation (IFE) and quantum genetic optimization (QGO) models to further optimize the performance of relays according to their distributed tuning environment. In this ensemble, both near and far-end fault characteristics can be incorporated. In the first stage, the IFE dimensional reduction model is deployed for massive heterogeneous input data, where the statistical independence of input signals is calculated, the linear transformation matrix to decouple mixed signals is found, the linear combination of such signals is formed, and the non-Gaussian property to sort them is established. This can ameliorate the following calculation efficiency under those high-dimensional data scenarios. Subsequently, the QGO model is designed to further improve relay settings, where qubit representation is built to reduce required chromosomes, the linear superposition of the optimal solution probability in different states is implemented for a better diversity and convergence performance, and a self-adaption quantum gate is established to dynamically update the qubit chromosome groups and two-state solution combinations. Lastly, an empirical case study is presented, which validates the enhanced convergence, accuracy, and rapidity of the proposed ensemble. [ABSTRACT FROM AUTHOR]

This article develops a safe reinforcement learning (SRL) algorithm for optimal control of nonlinear systems with input constraints. First, we design a novel performance index function by taking advantage of control Lyapunov‐barrier functions (CLBF) with inherent safety and stability properties to ensure closed‐loop stability and safety during operation under the optimal control policy. Additionally, since it is challenging to represent the CLBF‐based value function as an explicit function of process states, neural networks (NNs) are used to approximate the value function using the process operational data that indicate safe and unsafe operations. Theoretical results on the stability, safety, and optimality of the SRL algorithm are developed, accounting for the approximation error of the NN‐based value function. Finally, the efficacy of the proposed safe optimal control scheme is shown using an application to a chemical process example. [ABSTRACT FROM AUTHOR]

Adult lung resident stem/progenitor cells, including P63+ progenitor cells, have demonstrated the capacity for regeneration of lung epithelium in preclinical models. Here, we report a clinical trial of intrapulmonary P63+ progenitor cell transplantation in 28 participants with stage II to IV chronic obstructive pulmonary disease (COPD). Autologous P63+ progenitor cells were isolated from the airway basal layer of participants in the intervention group via bronchoscopic brushing, cultured for 3 to 5 weeks, and then transplanted back into the lungs via bronchoscopy at 0.7 × 106 to 5.2 × 106 cells per kilogram of body weight. Twenty patients were evaluable at the end of the study (intervention group, n = 17; control group, n = 3). No grade 3 to 5 adverse events (AEs) or serious AEs occurred. Although bronchoscopy-associated AEs were recorded in participants in the intervention group, other AEs were not substantial different between groups. Twenty-four weeks after transplantation, participants in the intervention group displayed improvement in gas transfer capacity [diffusing capacity of the lung for carbon monoxide (DLCO) change from baseline: +18.2%], whereas the control group experienced a decrease (DLCO change from baseline: −17.4%; P = 0.008). Furthermore, participants in the intervention group showed >30-meter increase in walking distance within 6 minutes. Transcriptomic analysis of progenitor cells isolated from responding and nonresponding individuals in the intervention group showed that higher expression of P63 was associated with treatment efficacy. In conclusion, transplantation of cultured P63+ lung progenitor cells was safe and might represent a potential therapeutic strategy for COPD. Editor's summary: Chronic obstructive pulmonary disease (COPD) results in damage to both the airways and the lung parenchyma, but a treatment that potentially reverses this damage in patients has not yet been identified. Building on previous preclinical work, Wang and colleagues conducted an early, open-label clinical trial of autologous P63+ lung progenitor cells for the treatment of patients with COPD. Cells were collected during bronchoscopy, expanded over several weeks, and then were administered back into the patients' lungs, again by bronchoscopy. The treated group showed improvements in the diffusing capacity of the lung for carbon monoxide and the 6-minute walk distance at 24 weeks' follow-up, supporting further clinical studies of P63+ lung progenitor cells for the treatment of COPD. —Melissa L. Norton [ABSTRACT FROM AUTHOR]

The purpose of the meta‐analysis was to evaluate and compare the surgical site infection (SSI) risk factors in patients with colorectal cancer (CC). The results of this meta‐analysis were analysed, and the odds ratio (OR) and mean difference (MD) with 95% confidence intervals (CIs) were calculated using dichotomous or contentious random or fixed‐effect models. For the current meta‐analysis, 23 examinations spanning from 2001 to 2023 were included, encompassing 89 859 cases of CC. Clean‐contaminated surgical site wounds had significantly lower infections (OR, 0.36; 95% CI, 0.20–0.64, p < 0.001) compared to contaminated surgical site wounds in patients with CCs. Males had significantly higher SSIs (OR, 1.18; 95% CI, 1.12–1.24, p < 0.001) compared to females in patients with CC. American Society of Anesthesiology score ≥3 h had a significantly higher SSI (OR, 1.42; 95% CI, 1.18–1.71, p < 0.001) compared to <3 score in patients with CCs. Body mass index ≥25 had significantly higher SSIs (OR, 1.54; 95% CI, 1.11–2.14, p = 0.01) compared to <25 in patients with CCs. The presence of stoma creation had a significantly higher SSI rate (OR, 2.28; 95% CI, 1.37–3.79, p = 0.001) compared to its absence in patients with CC. Laparoscopic surgery had significantly lower SSIs (OR, 0.68; 95% CI, 0.59–0.78, p < 0.001) compared to open surgery in patients with CC. The presence of diabetes mellitus had a significantly higher SSI rate (OR, 1.24; 95% CI, 1.15–1.33, p < 0.001) compared to its absence in patients with CCs. No significant difference was found in SSI rate in patients with CCs between <3 and ≥3 h of operative time (OR, 1.07; 95% CI, 0.75–1.51, p = 0.72), between the presence and absence of blood transfusion (OR, 1.60; 95% CI, 0.69–3.66, p = 0.27) and between the presence and absence of previous laparotomies (OR, 1.47; 95% CI, 0.93–2.32, p = 0.10). The examined data revealed that contaminated wounds, male sex, an American Society of Anesthesiology score ≥3 h, a body mass index ≥25, stoma creation, open surgery and diabetes mellitus are all risk factors for SSIs in patients with CC. However, operative time, blood transfusion and previous laparotomies were not found to be risk factors for SSIs in patients with CC. However, given that several comparisons had a small number of chosen research, consideration should be given to their values. [ABSTRACT FROM AUTHOR]

Adolescent idiopathic scoliosis (AIS) is a three-dimensional spinal deformity that is associated with low bone mineral density (BMD). Vitamin D (Vit-D) supplementation has been suggested to improve BMD in AIS, and its outcomes may be related to genetic factors. The present study aimed to (a) investigate the synergistic effect between a low BMD-related gene (wingless-related integration site 16, WNT16) and two important Vit-D pathway genes (Vit-D receptor, VDR, and Vit-D binding protein, VDBP) on serum Vit-D and bone qualities in Chinese AIS patients and healthy adolescents, and (b) to further investigate the effect of ablating Wnt16 on the cortical bone quality and whether diets with different dosages of Vit-D would further influence bone quality during the rapid growth phase in mice in the absence of Wnt16. A total of 519 girls (318 AIS vs. 201 controls) were recruited, and three selected single-nucleotide polymorphisms (SNPs) (WNT16 rs3801387, VDBP rs2282679, and VDR rs2228570) were genotyped. The serum 25(OH)Vit-D level was significantly associated with VDBP rs2282679 alleles (OR = −4.844; 95% CI, −7.521 to −2.167, p < 0.001). Significant multi-locus models were identified by generalized multifactor dimensionality reduction (GMDR) analyses on the serum 25(OH)Vit-D level (p = 0.006) and trabecular area (p = 0.044). In the gene-edited animal study, Wnt16 global knockout (KO) and wildtype (WT) male mice were provided with different Vit-D diets (control chow (1000 IU/Kg) vs. Vit-D-deficient chow (Nil in Vit-D) vs. high-dose Vit-D chow (20,000 IU/Kg)) from 4 weeks to 10 weeks old. Wnt16 global KO mice had significantly lower serum 25(OH)Vit-D levels and higher liver Vdbp mRNA expression levels than WT mice. In addition, Wnt16 global KO mice showed a decrease in bone density, cortical thickness and cortical area compared with WT mice. Interestingly, high-dose Vit-D chow led to lower bone density, cortical thickness, and cortical area in WT mice, which were less obvious in Wnt16 global KO mice. In conclusion, WNT16 may regulate the serum 25(OH)Vit-D level and bone qualities, which might be associated with VDBP expression. Further investigations with a larger sample size and wider spectrum of scoliosis severity are required to validate our findings regarding the interaction between WNT16 and Vit-D status in patients with AIS. [ABSTRACT FROM AUTHOR]

Purpose: For fixed or hinged single cables, the vibration equation is well developed. However, the form of boundary constraints between fixed and hinged is used extensively for the single cable in practical engineering, such as the restraint of struts between multi-span cables. As the struts with different lengths and stiffness are placed in the single cable, the mode shape of the multi-span cables is affected significantly. Moreover, with the decrease in the aspect ratio of single-span cable, the effect of the cable bending stiffness cannot be overlooked. The above effects in single and multi-span cables are studied in the proposed model. Methods: The vibration equation of the multi-span cable is developed in two steps. To establish the vibration equation of the single cable with general elastic constraint, the constraints at the ends of the strut are simplified as the compression springs that can bear the pressure. The bending springs that can consider the bending stiffness are also set at both ends simultaneously, then the vibration equation of the single cable with a general elastic constraint can be derived. For a multi-span cable structure, the strut is simplified into the elastic constraints of a single-span cable. By combining the aforementioned vibration equations of single-span cables which have general constraints, the vibration equation of multi-span cables can be established. Results: The vibration frequency equations of m span multi-span cable with constraint stiffness are established, and the objective function optimization algorithm is validated. Conclusion: The analytical solution of the multi-span cable vibration equation in this paper is then validated by the comparison with the multi-span cable vibration model established by the finite element method. The comparison demonstrated that the proposed method is valid and practical. [ABSTRACT FROM AUTHOR]

Simple Summary: LncRNAs are involved in HNSCC carcinogenesis, progression, and metastasis. In this study, we identified a novel lncRNA, named MASCC1 (Metastasis-Associated Squamous Cell Carcinoma 1), which was highly expressed in metastatic HNSCC and correlated with poor prognosis. In vitro, MASCC1 knockdown (KD) inhibited HNSCC cell proliferation, migration, invasion, and tumor sphere formation while promoting apoptosis. In vivo, MASCC1 KD suppressed HNSCC tumor formation and lymph node metastasis. Mechanistically, MASCC1 acted as a competing endogenous RNA (ceRNA) to sponge miR-195, regulating Cyclin D1, BCL-2, and YAP1 expression. Moreover, miR-195 overexpression rescued the effects of MASCC1 overexpression on the biological behaviors of HNSCC in vitro and in vivo. Our results show that lncRNA MASCC1 functions as an oncogene and is involved in HNSCC progression and metastasis, providing a potential target for HNSCC treatment. The altered expression of long noncoding RNAs (lncRNAs) is associated with human carcinogenesis. We performed a high-throughput analysis of lncRNA expression in strictly selected pairs of metastatic head and neck squamous cell carcinoma (HNSCC) and non-metastatic HNSCC samples. We identified a novel lncRNA, which was highly expressed in metastatic HNSCC, named Metastasis Associated Squamous Cell Carcinoma 1 (MASCC1), for further study. Using qRT-PCR, we further compared MASCC1 expression in 60 HNSCC samples. The results show that high expression of MASCC1 in patients with HNSCC was related to poor prognosis. In vitro, MASCC1 knockdown (KD) inhibited HNSCC proliferation, migration, invasion, and tumor sphere formation, while promoting apoptosis. In vivo, MASCC1 KD inhibited HNSCC growth and lymph node metastasis. Mechanistically, MASCC1 acted as a competing endogenous RNA (ceRNA) by binding to miR-195, subsequently regulating the expression of Cyclin D1, BCL-2, and YAP1. Moreover, miR-195 overexpression rescued the effects of MASCC1 on the biological behaviors of HNSCC. Taken together, our results suggest that MASCC1 is a novel oncogene that can predict the prognosis of patients with HNSCC and is a potential therapeutic target for HNSCC intervention. [ABSTRACT FROM AUTHOR]

The construction of the underwater Internet of Things (UIoT) is crucial to marine resource development, environmental observation, and tactical surveillance. The underwater optical wireless communication (UOWC) system with its large bandwidth and wide coverage facilitates the high-capacity information interconnection within the UIoT networks over short and medium ranges. To enhance the coverage characteristics of the UOWC system, an optimized lemniscate-compensated layout of light-emitting diode (LED) array is proposed in this paper, which can ameliorate the received optical power and reliability at the receiving terminal. Compared with traditional circular and rectangular layouts, the received optical power and bit error rate (BER) performance of the proposed system are analyzed based on the Monte Carlo simulation method. The analysis results show that the proposed LED array achieves a smaller peak power deviation and mean square error of the received optical power under three typical seawater environments. Furthermore, the proposed LED-array scheme supports a better BER performance of the UOWC system. For example, in turbid seawater with a transmission depth of 9.5 m, the BER of the proposed LED array layout is 1 × 10−7, which is better than the BER of 3.5 × 10−6 and 1 × 10−4 under the other two traditional light source layouts. [ABSTRACT FROM AUTHOR]

Optical manometry is a highly promising method for measuring pressure. However, its wider application is limited by the lower sensitivity and influenced by environmental factors. Herein, multi‐mode optical pressure sensors based on Eu2+‐doped Li4SrCa(SiO4)2 phosphors suitable for a variety of complex pressure‐measuring environments are designed. The phosphors contain two separate luminescence centers at 443 nm (EuSr) and 584 nm (EuCa), respectively. In the lower pressure range, the emission peak undergoes a massive redshift of 5.19 nm GPa−1 of EuCa, which is 14× better than commercially available ruby sensors. In order to improve the pressure response range and the accuracy of pressure measurement, for the first time, a new approach in the pressure readout method in which single Eu2+ ions doping based on fluorescence intensity ratio (FIR) pressure measurement is realized in designed materials. Meanwhile, the measured full width at half maximum (FWHM) as an indicator of pressure sensor performance also reveals that the sensing performance is d FWHM/d P ≈ 1.23 nm GPa−1 and d FWHM/d P ≈ 0.84 nm GPa−1 for EuSr and EuCa positions, respectively. Additionally, the structural stability of the phosphor is confirmed by in situ Raman spectrum. The above results indicate that the Li4SrCa(SiO4)2:0.04Eu2+ phosphor is a good candidate for multi‐mode optical pressure sensors. [ABSTRACT FROM AUTHOR]

The interaction of domain structure and defects in ferroelectric thin films has been studied for decades. However, the role of dislocations and thermal stability of microstructures is still poorly studied. By combining transmission electron microscopy, x-ray diffraction experiments, and phase-field simulations, we show that dislocation pairs induced by post-annealing above 550 °C provide a stress field stabilizing a domains in 30 nm thick tetragonal PbTiO3 films on SrTiO3 substrate, initially exhibiting pure c domains. Based on phase-field simulations, we further discuss the effects of single dislocations and dislocation pairs on the nucleation of a-domains and the occurrence of non-ferroelastic 180° domains. Dislocations, and the possibility to tune them using an appropriate thermal annealing process, offer a path for modulating the domains and domain wall states and, thus, the physical properties of ferroelectric films. [ABSTRACT FROM AUTHOR]

Ocean currents, mechanical collisions and electronic damage can cause faults in an autonomous underwater vehicle (AUV), including sensors and thrusters. For such problems, this paper designs a fault-tolerant controller that is independent of the results of the fault diagnosis. An adaptive reaching law is developed based on sliding mode control to shorten convergence times. For the chattering phenomenon, a weighted hyperbolic tangent function is adopted instead of the traditional sign function in sliding mode control. Simulations are carried out when thruster and sensor fail under the condition of ocean current disturbance, model uncertainty and sensor noise. Comparative simulation results show that the proposed method can accelerate the convergence speed of the state point and improve the trajectory tracking effect of the AUV. Consequently, the effectiveness of the proposed method is confirmed. [ABSTRACT FROM AUTHOR]

This paper investigates the AUV region-tracking control problem with measurement noise and transient and steady-state constraints. To achieve the fluctuation of AUV tracking error within an expected region while satisfying the transient and steady-state performance constraints, this paper proposes an improved nonlinear tracking error transformation method. This method converts the tracking error into a new virtual error variable through nonlinear conversion, thus transforming the above performance requirements for the tracking error into boundedness requirements for the new virtual error variable. In addition, aiming at the problem of measurement noise causing strong fluctuation of the control signal, this paper proposes a finite-time AUV control method based on a two-stage command filter. This method utilizes a finite-time sliding mode differentiator to filter the virtual control signal during the derivation of the control law using the backstepping technique. In light of the signal loss incurred by two-stage filtering and its potential impact on system stability, a finite-time compensator is designed to compensate the signal loss and achieve finite-time stability of the closed-loop system. Finally, simulations conducted using ODIN AUV demonstrate that the proposed method exhibits smooth control signal and low energy consumption characteristics. Furthermore, the tracking error meets the requirements for both transient and steady-state performance, as well as regional tracking. [ABSTRACT FROM AUTHOR]

In this paper, a millimeter‐wave broadband high‐efficiency power amplifier (PA) for Ka‐band (26–32 GHz) using 0.15‐μm GaAs pseudomorphic high‐electron‐mobility transistor process is proposed. The PA utilizes a three‐stage cascade structure and adopts an RC series feedback network, which expands the bandwidth and ensures the circuit stability. To improve the output power and efficiency of the circuit, a tree‐like transistor structure is proposed. The power amplifier, it can provide 23.6 dBm output P1dB with 33.1% power‐added efficiency at 28 GHz with high linearity. The maximum small signal gain can reach 27 dB with 3‐dB bandwidth from 24 to 33 GHz for the measured results. [ABSTRACT FROM AUTHOR]

Kawasaki disease can be combined with liver injury. As a mainstay treatment for Kawasaki disease, aspirin may cause liver injury. This study aimed to compare the safety and effectiveness of clopidogrel versus aspirin in Kawasaki disease with mild-to-moderate liver injury. This study retrospectively analysed 166 children with Kawasaki disease combined with mild-to-moderate liver injury. The children treated with clopidogrel were less likely to have aggravated liver injury than those treated with aspirin (n = 2/100 vs. n = 13/66, P < 0.001). The initial alanine aminotransferase value of the clopidogrel group was higher (131.5 [98.5, 167.5] vs. 96 [72, 133], P < 0.001), while the time of alanine aminotransferase recovery to normal was similar (5 [4, 7] vs. 4 [3, 7], P = 0.179). No significant fever differences observed between groups: 7.5 [6, 9] for aspirin vs. 7 [6, 8] for clopidogrel group, P = 0.064. The probability of nonresponse to intravenous immunoglobulin (n = 29/100 vs. n = 30/66, P = 0.030) and the days of hospitalization (n = 6 [4, 9] vs. n = 7 [5, 10], P = 0.007) in the clopidogrel group were less than those in the aspirin group. In conclusion, the application of clopidogrel is potentially superior to aspirin in Kawasaki disease combined with mild-to-moderate liver injury. [ABSTRACT FROM AUTHOR]

Tin oxide (SnO2) is a traditional gas-sensitive semiconductor with excellent response to various gases. However, its sensor performances are attenuated by the utility factor during gas diffusion in the sensing body. Therefore, the rational design of microstructure of devices is attractive and necessary because it may provide a sensible and controllable microstructure, which facilitates gas diffusion and inhibits the utility factor. Herein, the mesoporous tin oxide (MPTD) quantum dot thin film for H2S gas sensors is prepared by a facile route, which creates a mesoporous microstructure for thin films by the thermal decomposition of NH4Cl. The pore size of the thin films is controlled to be 19.36–40.13 nm. The mesoporous microstructure exhibits enhanced gas-sensing properties amounting to a 30-fold increase in response and 1/3 reduction in recovery time in H2S detection at room temperature (25 °C), with a limit of detection of 0.4 ppm. To determine the importance of sensor parameters such as pore size, film thickness, and grain size, an eXtreme Gradient Boosting (XGBoost) algorithm model was developed to examine the feature importance of each parameter on the gas-sensing performance of the MPTD sensors. The visual illustration of parameter importance is revealed to facilitate the optimization of technical preparation parameters as well as the rational design of semiconductor gas sensors. [ABSTRACT FROM AUTHOR]

The development of cooperative relationships among project participants makes relationship norms an important governance mechanism to promote cooperative behavior. However, the research on relationship norms mostly ignored the project network environment established by project participants. A static project network cannot accurately reflect the actual project network state from the perspective of network embeddedness, but the research on the mechanism of cooperative behavior from the perspective of dynamic network embeddedness is limited. Therefore, this study overcame the limitation of static analysis. This paper divided the implementation process of construction projects into early, middle, and late phases. The theoretical model of network embeddedness, relationship norms, and cooperative behavior was tested using sample data from 716 surveys regarding the three phases from China to determine the mechanism of the effect of network embeddedness on cooperative behavior. The research results show that network embeddedness (including structural embeddedness and relational embeddedness) has a direct impact on cooperative behavior. The results also indicate that network embeddedness has an indirect impact on cooperative behavior through relationship norms. Additionally, the results further indicate that the direct and indirect effects of network embeddedness on cooperative behavior are different in different phases of construction projects. With the advance of construction projects, the influence of relational embeddedness increases, whereas the effect of structural embeddedness decreases. The research results deepen the understanding of relationship norms in construction projects and make up for the lack of research on cooperative behavior in construction projects from the perspective of dynamic networks. The research results also provide enlightenment for project participants to fully utilize the network relationships in different phases of construction projects, stimulate the establishment of relationship norms, and promote cooperation. This is helpful to improve the cooperative construction management mode. [ABSTRACT FROM AUTHOR]

Researchers have been focusing on the potential of using plant polyphenols for promoting human health and have identified that the problems of poor stability, poor solubility, and low bioavailability of polyphenols in practical applications need to be urgently solved. The nanoemulsion delivery system has a small droplet size and good stability, thus is an excellent polyphenol delivery system with promising applications. Nanoemulsion-encapsulated polyphenols show improved stability, in vivo bioavailability, bioaccessibility, and antioxidant and antitumor activities, making it more suitable for application in the food industry. This paper reviews the current research on the classification and role of polyphenols, novel technologies for the preparation of polyphenol nanoemulsions, and the mechanism of nanoemulsion encapsulation and its effects on various properties of polyphenols. Based on the current problems posed when using polyphenol nanoemulsions, emulsion optimization scheme is proposed. Overall, the application status and potential use of polyphenol nanoemulsions in the food industry were explored. The findings of this study provide insights into future application directions of polyphenol nanoemulsions. [ABSTRACT FROM AUTHOR]

Purpose: Autoimmune retinopathy (AIR) is a group of autoimmune retinal diseases that can cause blindness. The purpose of this study is to investigate the profiles of serum antiretinal antibodies (ARAs) and cytokines and their association with disease diagnosis as well as clinical features in AIR. Methods: The patients with presumed para (p) and non-paraneoplastic (np) AIR diagnosis, the patients with retinitis pigmentosa and bilateral uveitis as disease controls, and healthy subjects were prospectively enrolled. Western blotting and Luminex multiple cytokine assay/enzyme linked immunosorbent assay were used to determine the presence of serum ARAs and the concentration of cytokines, respectively. Kruskal–Wallis or chi square test was applied to compare the profiles of ARA and cytokines among various groups. The multilevel mixed-effect regression was used to investigate the association of ARA or cytokines with clinical features. Results: No significant difference in the band number and subtypes of serum ARAs was found between AIR patients and their controls. AIR patients had higher concentration of serum IFN-ɤ, CXCL9, or CXCL10 than non-AIR controls. A positive correlation was found between increased number of ARAs and elevated TNF-α in np-AIR patients. Elevated pro-inflammatory cytokines or ARA subtypes (antibody against recoverin and α-enolase) were associated with worse retinal functions or anatomy, including visual acuity, visual field, ERG parameters, and central retinal thickness. Conclusions: The data of our study demonstrate that detection of serum ARAs has limited value in the diagnosis of AIR. Th1-type cytokines/chemokines or specific ARA subtypes are associated with pathogenesis and disease severity of the AIR. [ABSTRACT FROM AUTHOR]

Background: The application of virtual reality (VR) in gastroscopic operation teaching can be safe and effective, but the advantages can be realized only when students accept and use it. This study aims to identify the factors influencing Chinese clinical medical postgraduates on their intention to use the 3D gastroscopic model constructed based on VR technology using Unified Theory of Acceptance and Use of Technology (UTAUT) model. Students' demographic factors are also taken into consideration. Methods: All methods were carried out in accordance with relevant guidelines. Data were collected from clinical medical postgraduates students in China using stratified sampling. A total of 292 questionnaires including valid responses were used in this study. Data were processed using Amos 24.0 and SPSS 26.0 software and the statistical analysis technique was based on structural equation modeling (SEM). Results: The results showed that different from the mediator of home location and year of clinical learning, mediator of gender, university kind and graduate degree did not affect the behavioral intention. In addition, performance expectancy, facilitating condition, and social influence directly and indirectly have effect on behavioral intention. Also, the significance between social influence and performance expectancy, social influence and effort expectancy were verified. Conclusions: This study manifested that the proposed framework based on the UTAUT had explanatory power to identify the factors influencing the students' behavioral intention to use the 3D gastroscopic model constructed based on VR technology. Whereas, an important variable of effort expectancy in the frame of the SEM were not certified, thereby indicating that particular attention should be paid to this variable by universities and teachers before applying 3D gastroscopic model constructed based on VR technology in teaching. Added preparatory work is required such as explaining the basic knowledge of the operating steps of VR model and make students adequately understand its accessibility, which can probably improve the intentions of them to use it. The positive effects of social influence on performance expectancy and effort expectancy we proposed was also verified in this study, which provided a direction for future research. [ABSTRACT FROM AUTHOR]