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One of the core questions of quantum physics is how to reconcile the unitary evolution of quantum states, which is information-preserving and time-reversible, with evolution following the second law of thermodynamics, which, in general, is neither. The resolution to this paradox is to recognize that global unitary evolution of a multi-partite quantum state causes the state of local subsystems to evolve towards maximum-entropy states. In this work, we experimentally demonstrate this effect in linear quantum optics by simultaneously showing the convergence of local quantum states to a generalized Gibbs ensemble constituting a maximum-entropy state under precisely controlled conditions, while introducing an efficient certification method to demonstrate that the state retains global purity. Our quantum states are manipulated by a programmable integrated quantum photonic processor, which simulates arbitrary non-interacting Hamiltonians, demonstrating the universality of this phenomenon. Our results show the potential of photonic devices for quantum simulations involving non-Gaussian states. The emergence of relaxation in unitarily evolving systems can be seen as a paradox, but not once the distinction between local and global dynamics is considered. Here, the authors use photons in an integrated optical interferometer to show that, for a system evolving unitarily on a global level, single-mode measurements converge to those of a thermal state. [ABSTRACT FROM AUTHOR]

Quantum key distribution (QKD) allows secret key exchange between two users with unconditional security. For QKD to be widely deployed, low cost and compactness are crucial requirements alongside high performance. Currently, the majority of QKD systems demonstrated rely on bulk intensity and phase modulators to generate optical pulses with precisely defined amplitude and relative phase difference—i.e., to encode information as signal states and decoy states. However, these modulators are expensive and bulky, thereby limiting the compactness of QKD systems. Here, we present and experimentally demonstrate a novel optical transmitter design to overcome this disadvantage by generating intensity- and phase-tunable pulses at GHz clock speeds. Our design removes the need for bulk modulators by employing directly modulated lasers in combination with optical injection locking and coherent interference. This scheme is, therefore, well suited to miniaturization and photonic integration, and we implement a proof-of-principle QKD demonstration to highlight potential applications. [ABSTRACT FROM AUTHOR]

The specific function of the epithelium as critical barrier between the intestinal lumen and the organism's internal microenvironment is reflected by permanent maintenance of intercellular junctions and cellular polarity. The intestinal epithelial cells are responsible for absorption of nutritional components, facing mechanical stress and a changing oxygen supplementation via blood stream. Oxygen itself can regulate the barrier and the absorptive function of the epithelium. Therefore, we compared the dish cell culture, the transwell-like membrane culture and the oxygen enriched air-liquid interface (ALI) culture. We demonstrated strong influence of the different culture conditions on morphology and function of intestinal porcine epithelial cell lines in vitro. ALI culture resulted in a significant increase in cell number, epithelial cell layer thickness and expression as well as apical localisation of the microvilli-associated protein villin. Remarkable similarities regarding the morphological parameters were observed between ALI cultures and intestinal epithelial cells in vivo. Furthermore, the functional analysis of protein uptake and degradation by the epithelial cells demonstrated the necessity of sufficient oxygen supply as achieved in ALI cultures. Our study is the first report providing marked evidence that optimised oxygen supply using ALI cultures directly affects the morphological differentiation and functional properties of intestinal epithelial cells in vitro. [ABSTRACT FROM AUTHOR]

Signal amplification is ubiquitous in the control of physical systems, and the ultimate performance limit of amplifiers is set by quantum physics. Increasing the amplitude of an unknown quantum optical field, or any harmonic oscillator state, must introduce noise. This linear amplification noise prevents perfect copying of the quantum state, enforces quantum limits on communications and metrology, and is the mechanism preventing the increase of entanglement via local operations. Non-deterministic versions of ideal cloning and local entanglement increase (distillation) are allowed, suggesting the possibility of non-deterministic noiseless linear amplification. Here we introduce, and experimentally demonstrate, such a noiseless linear amplifier for quantum states of the optical field, and use it for distillation of field-mode entanglement. This simple but powerful circuit enables practical devices for enhancing quantum technologies. The idea of noiseless amplification unifies approaches to cloning and distillation, and will find applications in quantum metrology and communications. [ABSTRACT FROM AUTHOR]