Search

This clinical review summarises the pharmacological and anaesthetic properties of alfaxalone in the dog. Available pharmacokinetic‐pharmacodynamic data and factors affecting the induction dose have been reported. Furthermore, quality of induction and recovery after alfaxalone administration, the use of alfaxalone for total intravenous anaesthesia, and its effects on the cardio‐respiratory system, on laryngeal motion, on intraocular pressure and tear production have been evaluated. Finally, the use of alfaxalone in dogs undergoing caesarean section and the effect of intramuscular alfaxalone administration have been considered. [ABSTRACT FROM AUTHOR]

Objectives: To describe the prevalence, clinical findings and predictors of disease in dogs with cervical hyperaesthesia. Materials and Methods: Medical records of dogs referred for neurological investigation of cervical hyperaesthesia between 2009 and 2013 were retrospectively reviewed. Dogs were assigned to one of the following groups according to the final diagnosis: Non‐Neurologic, Brain, Cervical Spine, Multifocal, and Chiari‐like Malformation/Syringomyelia. Demographic data, clinical and neurological signs and laboratory findings were compared between groups using univariate analysis; predictors of disease location were assessed by multivariate analysis. Results: Final diagnostic allocations of the 185 records included in the study were as follows: 2.7% Non‐Neurologic, 2.2% Brain, 63.2% Cervical Spine, 22.2% Multifocal and 9.7% Chiari Malformation/Syringomyelia. Intervertebral disc extrusion and steroid‐responsive meningitis arteritis were the most common diseases. Compared to Multifocal dogs, those allocated a Cervical Spine diagnosis were older, heavier, more frequently ataxic and lame on a thoracic limb; furthermore, they were less frequently depressed or hyperthermic at presentation. Leucocytosis, neutrophilia and monocytosis were more frequent in dogs allocated a Multifocal diagnosis. Dogs with cervical hyperaesthesia older than 36 months and non‐hyperthermic at presentation were more likely to have a lesion of the cervical region rather than a multi‐focal disease. Clinical Significance: Although non‐specific, these results may be useful to guide clinicians in management of dogs presenting with cervical hyperaesthesia. Animal age and body temperature may support the suspicion of either focal or multi‐focal cervical spinal disease. [ABSTRACT FROM AUTHOR]

Objectives: To investigate the effect of 5% lidocaine patches on postoperative analgesia in dogs undergoing hemilaminectomy. Materials and Methods: Client‐owned dogs undergoing hemilaminectomy for a single acute intervertebral thoracolumbar disc extrusion were enrolled in this prospective, randomised, blinded clinical trial. Following methadone administration, anaesthesia was induced with propofol, and maintained with isoflurane in oxygen and fentanyl infusion, in both groups. After skin closure, two 1∙5 cm wide 5% lidocaine patch strips were attached along both sides of the wound in dogs allocated to Group L. In Group C, the two lidocaine patch strips were applied but the transparent isolating liner was not removed. Postoperatively, all dogs received a non‐steroidal anti‐inflammatory drug, gabapentin and diazepam. Methadone was administered according to the short form of Glasgow Composite Pain Scale with pain assessed every 2 hours for 48 hours by observers unaware of the treatment. Results: Thirty‐nine dogs completed the study. Demographic data, end‐expiratory fraction of isoflurane, fentanyl consumption, anaesthesia and surgical times were similar between groups. The number of dogs requiring postoperative methadone and the number of doses of methadone administered were not different between groups. No macroscopic skin reaction was noticed once the patches were removed. Clinical Significance: In this setting, 5% lidocaine patches did not provide additional postoperative analgesia in dogs undergoing hemilaminectomy. [ABSTRACT FROM AUTHOR]

The ISOLPHARM project explores the feasibility of exploiting an innovative technology to produce extremely high specific activity beta-emitting radionuclides as radiopharmaceutical precursors. This technique is expected to produce radiopharmaceuticals that are virtually mainly impossible to obtain in standard production facilities, at lower cost and with less environmental impact than traditional techniques. The groundbreaking ISOLPHARM method investigated in this project has been granted an international patent (INFN). As a component of the SPES (Selective Production of Exotic Species) project at the Istituto Nazionale di Fisica Nucleare–Laboratori Nazionali di Legnaro (INFN–LNL), a new facility will produce radioactive ion beams of neutron-rich nuclei with high purity and a mass range of 80–160 amu. The radioactive isotopes will result from nuclear reactions induced by accelerating 40 MeV protons in a cyclotron to collide on a target of UCx. The uranium in the target material will be 238U, yielding radioactive isotopes that belong to elements with an atomic number between 28 and 57. Isotope separation on line (ISOL) is adopted in the ISOLPHARM project to obtain pure isobaric beams for radiopharmaceutical applications, with no isotopic contaminations in the beam or subsequent trapping substrate. Isobaric contaminations may potentially affect radiochemical and radionuclide purity, but proper methods to separate chemically different elements can be developed. [ABSTRACT FROM AUTHOR]

Objectives To compare the lateral pre-iliac approach to the lumbar plexus combined with lumbar paravertebral sciatic nerve block, and the dorsal paravertebral approach to the lumbar plexus combined with sciatic nerve block in dogs. Methods Retrospective examination of case records of dogs that received the blocks and underwent pelvic limb orthopaedic surgery between 2010 and 2012. Success rate (intraoperative fentanyl consumption <2·1 µg/kg/hour), type and dose of local anaesthetic used, multiple of minimum alveolar concentration of volatile anaesthetic agent administered, incidence of intraoperative hypotension, postoperative methadone administration, postoperative contralateral limb paralysis and neurological complication at 6 weeks re-examination were analysed. Results Ninety-six and 95 records were retrieved in which lateral pre-iliac - lumbar paravertebral sciatic nerve and dorsal paravertebral - sciatic nerve were used, respectively. Success rates were 82·3% in lateral pre-iliac - lumbar paravertebral sciatic nerve and 74·7% in dorsal paravertebral - sciatic nerve groups. Bupivacaine, levobupivacaine and ropivacaine were used. Total local anaesthetic doses, intraoperative hypotension and postoperative methadone administered were similar between groups; minimum alveolar concentration multiple was significantly (P<0·001) lower in lateral pre-iliac - lumbar paravertebral sciatic nerve group. No neurological complications were noted. Clinical Significance Although success rates and perioperative analgesic requirements were not significantly different, the different exposure to anaesthetic agents suggests that the two techniques may not be equivalent. [ABSTRACT FROM AUTHOR]

O bjectives: To compare the analgesic and sedative effects of butorphanol and pethidine (meperidine) in dogs. M ethods: Twenty-eight female dogs undergoing ovariectomy (20) or ovariohysterectomy (8) were randomly divided into two groups. Pre-anaesthetic medication in group B consisted of 20 μg/kg intramuscular (im) acepromazine and 0·4 mg/kg butorphanol, while group P received 20 μg/kg acepromazine with 5 mg/kg pethidine. The resulting sedation (simple descriptive scale), propofol dose required to induce anaesthesia, several intraoperative cardiorespiratory variables and postoperative pain (Colorado Pain Scoring System) were compared between the two groups. A 0·2 mg/kg meloxicam dose was administered intravenously to all animals at the end of the 4 hours observation period, or earlier if the pain score was more than 13. R esults: Sedation scores, propofol induction doses and intraoperative cardiorespiratory variables were not different between groups. Postoperative pain scores were also similar although one dog in group B required rescue analgesia. Five dogs in group P vomited postoperatively. C linical S ignificance: Either butorphanol and pethidine, combined with acepromazine, produced reliable sedation and analgesia up to 4 hours after intramuscular injection in dogs. [ABSTRACT FROM AUTHOR]

Summary Reason for performing study: The recovery quality scoring systems (RQSSs) in current use have not been critically reviewed for reliability. Objective: To examine reliability (reproducibility) of 4 RQSSs when applied to a ranked series. Methods: A DVD incorporating the recordings of 9 horses recovering from general anaesthesia was evaluated by final year students over 5 days. On Day 1, each evaluator ranked recoveries from 1-9 (1 = best). Over the following 4 days, each evaluator scored the same recoveries using 4 different RQSSs (3 of them in common usage and previously published) applied in random order. The scores from each RQSS were ranked and plotted against the Day 1 ranking of each evaluator to establish the extent of agreement using generalisability theory. The same 9 recoveries were also ranked by 12 experienced equine anaesthetists and the Spearman Rank Correlation coefficient calculated to determine the agreement between experienced and inexperienced evaluators. Results: The recoveries were evaluated by 117 students. All 4 RQSSs were equally reliable with low (<4%) interobserver variability. The main (80%) source of total variation arose from differences between horses. The overall ranking within each RQSS was strongly correlated with Day 1 ranking. There was strong correlation (r = 0.983) between the students' ranking and that established by experienced anaesthetists. Interobserver reliability was similar with all 4 RQSSs. Conclusion: All 4 RQSSs studied were similarly reliable. Potential relevance: The selection of a universally acceptable RQSS from amongst the 4 examined can be based on criteria other than reliability, e.g. ease of use. This will facilitate wider scale multi-centre studies in recovery quality after anaesthesia in horses. [ABSTRACT FROM AUTHOR]

OBJECTIVE To evaluate intraoperative effects, complications, postoperative rescue analgesia requirement and presence of postoperative unilateral blockade after hypobaric spinal anaesthesia in dogs. METHODS Retrospective review of case records of dogs that underwent pelvic limb orthopaedic surgery and received hypobaric spinal anaesthesia. Cases that contained complete information on perioperative analgesia, end tidal anaesthetic agent, arterial blood pressure, postoperative urination, motor function and assessment at the sixth week re-examination were selected. RESULTS Twenty-four of forty-eight records were sufficiently complete to meet the selection criteria. Local anaesthetic dose and volume of the solution administered were 0 · 22 (±0 · 06) mg/kg and 0 · 16 (±0 · 05) mL/kg, respectively. Fentanyl was administered intraoperatively in seven dogs (29%); mean ± sd end-expired isoflurane was 1 · 09 ± 0 · 17%; hypotension was observed in nine dogs (37 · 5%). Unilateral blockade was documented in 18 dogs (75%); 6 dogs (25%) required methadone postoperatively; urinary retention was not observed. One dog developed steroid responsive meningitis arteritis. CLINICAL SIGNIFICANCE Hypobaric spinal anaesthesia achieved unilateral postoperative pelvic limb motor blockade in dogs, although bilateral block occurred in a proportion of animals; intraoperative hypotension was not infrequent. Fentanyl and postoperative methadone might be required to control nociception and pain, despite technical success in performing spinal anaesthesia. [ABSTRACT FROM AUTHOR]