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6 results on '"Vassallo, Melanie"'

1. Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B100-Reactive CD4+ T-Regulatory Cells.

Author

Wolf, Dennis, Gerhardt, Teresa, Winkels, Holger, Michel, Nathaly Anto, Pramod, Akula Bala, Ghosheh, Yanal, Brunel, Simon, Buscher, Konrad, Miller, Jacqueline, McArdle, Sara, Baas, Livia, Kobiyama, Kouji, Vassallo, Melanie, Ehinger, Erik, Dileepan, Thamotharampillai, Ali, Amal, Schell, Maximilian, Mikulski, Zbigniew, Sidler, Daniel, and Kimura, Takayuki

Published
2020
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2. Regulatory CD4+ T Cells Recognize Major Histocompatibility Complex Class II Molecule–Restricted Peptide Epitopes of Apolipoprotein B.

Author

Kimura, Takayuki, Kobiyama, Kouji, Winkels, Holger, Tse, Kevin, Miller, Jacqueline, Vassallo, Melanie, Wolf, Dennis, Ryden, Christian, Orecchioni, Marco, Gange, Stephen J., Sidney, John, Sette, Alessandro, Ley, Klaus, Dileepan, Thamotharampillai, Jenkins, Marc K., James, Eddie A., Kwok, William W., Hanna, David B., Kaplan, Robert C., and Strickler, Howard D.

Published
2018
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3. A clinically applicable adjuvant for an atherosclerosis vaccine in mice.

Author

Kobiyama, Kouji, Vassallo, Melanie, Mitzi, Jessica, Winkels, Holger, Pei, Hong, Kimura, Takayuki, Miller, Jacqueline, Wolf, Dennis, and Ley, Klaus

Abstract

Abstract: Vaccination with MHC‐II‐restricted peptides from Apolipoprotein B (ApoB) with complete and incomplete Freund's adjuvant (CFA/IFA) is known to protect mice from atherosclerosis. This vaccination induces antigen‐specific IgG1 and IgG2c antibody responses and a robust CD4 T cell response in lymph nodes. However, CFA/IFA cannot be used in humans. To find a clinically applicable adjuvant, we tested the effect of vaccinating Apoe‐deficient mice with ApoB peptide P6 (TGAYSNASSTESASY). In a broad screening experiment, Addavax, a squalene‐based oil‐in‐water adjuvant similar to MF59, was the only adjuvant that showed similar efficacy as CFA/IFA. This was confirmed in a confirmation experiment for both the aortic arch and whole aorta analyzed by en face analysis after atherosclerotic lesion staining. Mechanistically, restimulated peritoneal cells from mice immunized with P6 in Addavax released significant amounts of IL‐10. Unlike P6 in CFA/IFA, vaccination with P6 in Addavax did not induce any detectable IgG1 or IgG2c antibodies to P6. These data suggest that squalene‐based adjuvants such as MF59 are good candidate adjuvants for developing a clinically effective atherosclerosis vaccine. [ABSTRACT FROM AUTHOR]

Published
2018
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4. Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry.

Author

Winkels, Holger, Ehinger, Erik, Vassallo, Melanie, Buscher, Konrad, Dinh, Huy Q., Kobiyama, Kouji, Hamers, Anouk A.J., Cochain, Clément, Vafadarnejad, Ehsan, Saliba, Antoine-Emmanuel, Zernecke, Alma, Pramod, Akula Bala, Ghosh, Amlan K., Anto Michel, Nathaly, Hoppe, Natalie, Hilgendorf, Ingo, Zirlik, Andreas, Hedrick, Catherine C., Ley, Klaus, and Wolf, Dennis

Published
2018
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6. Regulatory CD4+ T Cells Recognize Major Histocompatibility Complex Class II Molecule-Restricted Peptide Epitopes of Apolipoprotein B.

Author

Kimura, Takayuki, Kobiyama, Kouji, Winkels, Holger, Tse, Kevin, Miller, Jacqueline, Vassallo, Melanie, Wolf, Dennis, Ryden, Christian, Orecchioni, Marco, Dileepan, Thamotharampillai, Jenkins, Marc K, James, Eddie A, Kwok, William W, Hanna, David B, Kaplan, Robert C, Strickler, Howard D, Durkin, Helen G, Kassaye, Seble G, Karim, Roksana, and Tien, Phyllis C

Published
2018
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