1. Perfusion-weighted imaging with dynamic contrast enhancement (PWI/DCE) morphologic, qualitative, semiquantitative, and radiomics features predicting undifferentiated pleomorphic sarcoma (UPS) treatment response.
- Author
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Valenzuela, R. F., Duran-Sierra, E., Canjirathinkal, M., Amini, B., Torres, K. E., Benjamin, R. S., Ma, J., Wang, W. L., Hwang, K. P., Stafford, R. J., Wu, C., Zarzour, A. M., Bishop, A. J., Lo, S., Madewell, J. E., Kumar, R., Murphy Jr, W. A., and Costelloe, C. M.
- Abstract
Undifferentiated pleomorphic sarcoma (UPS) is the largest subgroup of soft tissue sarcomas. This study determined the value of perfusion-weighted imaging with dynamic-contrast-enhancement (PWI/DCE) morphologic, qualitative, and semiquantitative features for predicting UPS pathology-assessed treatment effect (PATE). This retrospective study included 33 surgically excised extremity UPS patients with pre-surgical MRI. Volumetric tumor segmentation from PWI/DCE was obtained at Baseline (BL), Post-Chemotherapy (PC), and Post-Radiation Therapy (PRT). The surgical specimens’ PATE separated cases into Responders (R) (≥ 90%, 16 patients), Partial-Responders (PR) (89 − 31%, 10 patients), and Non-Responders (NR) (≤ 30%, seven patients). Seven semiquantitative kinetic parameters and maps were extracted from time-intensity curves (TICs), and 107 radiomic features were derived. Statistical analyses compared R vs. PR/NR. At PRT, 79% of R displayed a “Capsular” morphology (P = 1.49 × 10
-7 ), and 100% demonstrated a TIC-type II (P = 8.32 × 10-7 ). 80% of PR showed “Unipolar” morphology (P = 1.03 × 10-5 ), and 60% expressed a TIC-type V (P = 0.06). Semiquantitative wash-in rate (WiR) was able to separate R vs. PR/NR (P = 0.0078). The WiR radiomics displayed significant differences in the first_order_10 percentile (P = 0.0178) comparing R vs. PR/NR at PRT. The PWI/DCE TIC-type II curve, low WiR, and “Capsular” enhancement represent PRT patterns typically observed in successfully treated UPS and demonstrate potential for UPS treatment response assessment. [ABSTRACT FROM AUTHOR]- Published
- 2024
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