Search

Discontinuous Galerkin (DG) method is presented for numerical modeling of melt migration in a chemically reactive and viscously deforming upwelling mantle column at local chemical equilibrium. DG methods for both advection and elliptic equations provide a robust and efficient solution to the problems of melt migration in the asthenospheric upper mantle. Assembling and solving the elliptic equation is the major bottleneck in these computations. To address this issue, adaptive mesh refinement and local time-stepping methods have been proposed to improve the computational wall time. The robustness of DG methods is demonstrated through two benchmark problems by modeling detailed structure of high-porosity dissolution channels and compaction dissolution waves. [ABSTRACT FROM AUTHOR]

In 1988 we reported two sisters with bilateral exudative retinopathy of Coats' type, sparse hair, dystrophic nails and primeval splashes of intracranial calcification. We now provide an update on this family documenting the occurrence of skeletal defects comprising abnormal bone marrow, osteopenia and sclerosis with a tendency to fractures, a mixed cerebellar and extrapyramidal movement disorder, infrequent epileptic seizures, leucodystrophic changes and post-natal growth failure. Additionally, we present two previously unreported individuals from Ireland and Switzerland with the identical disorder which is characteristerised by a unique pattern and distribution of brain calcification. Since our original publication a number of other authors have described, frequently as a new' syndrome, cases with a variable combination of the same features observed in our patients. We review this literature to further characterise the Tolmie-Browne-McGettrick-Stephenson syndrome which may include pancytopenia as a major finding and encompass cases previously described by Revesz, Gouti_res, Sazgar and possibly Labrune. Tolmie-Browne-McGettrick-Stephenson syndrome is likely an autosomal recessive progressive microangiopathy. The possible phenotypic overlap with dyskeratosis congenita might provide a clue to the molecular aetiology of this multisystem disorder. [ABSTRACT FROM AUTHOR]