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Helical polycarbodiimides with either naphthalene or anthracene side chains display chiroptical switching properties in solution and the solid state. This interesting chiroptical switching occurs due to the expansion and contraction of the helical backbone and the simultaneous reorientation of the aromatic side chains. Herein, we modified the aliphatic side-chain structure to induce the switching behavior in simple phenyl substituted polycarbodiimides. The polymerization of 1-hexynyl-5-phenylcarbodiimide introduced a terminal alkyne appended to the polymer backbone. By using the CLICK reaction, we were able to attach steric bulky branched alkyl groups to poly(N-phenyl)-N′-(n-branched alkyl) carbodiimide (P-1B). To increase the solubility and modulate the aliphatic sidechain packing of the polymer, 1-hexynyl-5-phenylcarbodiimide was copolymerized with phenyl octadecyl carbodiimide in different mole ratios. IR spectra and Specific Optical Rotation (SOR) studies showed these simple phenyl polymers show temperature driven solution state switching between two and sometimes three conformational states akin to what was only previously observed in polymers with polyaromatic side chains. In addition, one of the copolymers, P-2B, synthesized from the 50/50 mole feed ratio of the branched monomer and phenyl octadecyl carbodiimide showed solid-state sensing of various volatile organic compounds (VOCs) and solvent vapor. [ABSTRACT FROM AUTHOR]

The aim of the present work is to formulate and evaluate in situ oral topical gels of poorly water soluble drug Bifonazole based on temperature induced systems for the treatment of oral candidiasis. Bifonazole is poorly water soluble and low permeable drug means it's belongs to BCS Class IV. Due to its poor water solubility, it necessary to enhance solubility in water by make complex with Beta- Cyclodextrin (Drug to bCyclo Dextrine ratio is 1:1). After in situ gel preparation done by using Poloxamer (10% and 15%w/w) along with carbopol 934 (0.2 to 1.0% w/w) and Bifonazole — β CD complex (1%w/w). The formulations were evaluated for physiochemical parameter, gelation Temperature, viscosity, gel strength, content uniformity mucoadhesive force, Diffusion Study. [ABSTRACT FROM AUTHOR]