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In this paper, we designed double V-shaped Al/Ni multilayer energy-containing microdevices with different V-angles, and we performed finite element modeling and simulation of the heat transfer process of the designed energy-containing microdevice. Temperature-dependent resistivity was introduced to effectively simulate the phase change during ignition. We simulated the temperature and current density distribution in the central region of the Al/Ni multilayer energy-containing microdevice and predicted the ignition voltage threshold for the specific device structure. Al/Ni multilayer energy-containing microdevices with different V-angles were prepared by electron beam evaporation technology, and ignition experiments on the prepared devices under the excitation of 47 μF capacitance were conducted. The experimental results show that the critical voltage of ignition increases with the increase in the V-angle, which verifies the correctness of the proposed finite element model. [ABSTRACT FROM AUTHOR]

Background: Previous research demonstrates that adopting, abandoning, and re-adopting (i.e., cycling) a healthy dietary pattern (HDP) improved, reverted, and re-improved cardiovascular disease (CVD) risk factors. In addition, changes in CVD risk factors are associated with dietary modifications of gut microbiota. Objective: We sought to assess the effects of cycling an HDP on gut microbiota and CVD risk factors. Methods: Retrospectively, we used data from a randomized controlled, crossover trial with three 3-week controlled dietary interventions, each separated by a 5-week period of participant-chosen, uncontrolled food intake. Seventeen participants (10 males, 7 females, age 26 ± 4 years old, BMI 23 ± 3 kg/m2) all consumed intervention diets that followed healthy U.S.-style dietary patterns. Gut microbiota composition and cardiovascular risk factors were measured before and after each HDP. Results: Repeatedly adopting and abandoning an HDP led to a cycling pattern of changes in the gut microbial community and taxonomic composition. During the HDP cycles, relative abundances of several bacterial taxa (e.g., Collinsella, Mediterraneibacter, Romboutsia, and Dorea) decreased and returned to baseline repeatedly. Similar HDP cycling occurred for multiple CVD risk factors (i.e., serum total cholesterol and LDL-C concentrations). Consistent negative associations were observed between changes in Mediterraneibacter or Collinsella and serum total cholesterol/HDL-C ratio. Conclusions: These results support previous findings that HDP cycling affected multiple CVD risk factors and expand the HDP cycling phenomenon to include several bacterial taxa. Young adults are encouraged to adopt and sustain a healthy dietary pattern to improve cardiovascular health, potentially through modifying gut microbiota composition. [ABSTRACT FROM AUTHOR]

The discovery of polar metals challenges long‐standing assumptions about the incompatibility between polar order and metallicity. However, despite recent progress, the mechanism allowing the coexistence of these supposedly forbidden properties remains unclear. Herein, carriers are introduced by constructing a symmetric polar/nonpolar interface in the KNbO3/BaTiO3 (KNO/BTO) superlattice (SL), enabling the coexistence of ferroelectric and metallic properties. A first‐principles analysis of the evolution of polar distortion and metallicity in the KNO/BTO SL under biaxial strain in the face to explore the dependence of the two at the microscopic level is performed. It is found that compressive strain enhances polarization distortion while reducing conductivity from three dimensions to two dimensions, indicating a weak coupling mechanism between carriers and polarization. Furthermore, it is shown that the presence of holes strengthens the TiO (NbO) covalent bonds, resulting in an unexpected enhancement of the polarization properties of the KNO/BTO SL. Therefore, it is proposed using the carrier screening effect and covalent bonding synergies as a framework for understanding the interaction between ferroelectricity and free carriers, rather than just a single factor therein. These results provide new theoretical insights for designing robust polar metals in perovskite ferroelectrics. [ABSTRACT FROM AUTHOR]

Throughout infancy, changes in growth and development are observed, including changes in nutritional requirements; at approximately 6 months of age, when complementary feeding begins, breastmilk and/or formula are no longer the sole source of energy and nutrients. Little is known about the impact of complementary feeding (CF) approaches used during this time on infant nutrition and growth. Baby-led weaning (BLW) has continued to gain popularity over the last two decades, emphasizing the importance of examining the adequacy of different CF methods. This narrative review of 19 studies from January 2010 to April 2024 aims to discuss the differences between BLW and conventional weaning (CW). The definition of BLW varied across studies, and no standard definition has been established. Though no differences in energy were reported, macronutrient and micronutrient intakes were variable between approaches, including for micronutrients such as iron and zinc. Of the few studies with growth data, results comparing BLW and CW were conflicting. Differences were seen in the demographics of parents who chose to follow BLW and breastfeeding prevalence and duration prior to complementary feeding. Additional research is needed to understand the impacts of BLW and CW on nutrient intakes and growth to inform recommendations for infant complementary feeding approaches. [ABSTRACT FROM AUTHOR]

Oxygen vacancies play a crucial role in stabilizing the ferroelectric phase in hafnium (Hf) oxide-based thin films and in shaping the evolution of their ferroelectric properties. In this study, we directly manipulated the oxygen vacancy concentration in Hf0.5Zr0.5O2−x (HZO) ferroelectric thin films in situ using oxygen plasma treatment. We scrutinized the variations in the ferroelectric properties of HZO films across different oxygen vacancy concentrations by integrating the findings from ferroelectric performance tests. Additionally, we elucidated the mechanism underlying the influence of oxygen vacancies on the coercive field and polarization properties of HZO ferroelectric films through the first-principles density functional theory (DFT) calculations. Finally, to study the impact of oxygen vacancies on the practical application of HZO ferroelectric synaptic devices, leveraging the plasticity of the ferroelectric polarization, we constructed a multilayer perceptron (MLP) network. We simulated its recognition accuracy and convergence speed under different oxygen vacancy concentrations in the MNIST recognition task. [ABSTRACT FROM AUTHOR]

Ionic memristors can emulate brain‐like functions of biological synapses for neuromorphic technologies. Apart from the widely studied excitatory‐excitatory and excitatory‐inhibitory synapses, reports on memristors with the inhibitory‐inhibitory synaptic behaviors remain a challenge. Here, the first biaxially inhibited artificial synapse is demonstrated, consisting of a solid electrolyte and conjugated microporous polymers bilayer as neurotransmitter, with the former serving as an ion reservoir and the latter acting as a confined transport. Due to the migration, trapping, and de‐trapping of ions within the nanoslits, the device poses inhibitory synaptic plasticity under both positive and negative stimuli. Remarkably, the artificial synapse is able to maintain a low level of stable nonvolatile memory over a long period of time (≈60 min) after multiple stimuli, with feature‐inferencing/‐training capabilities of neural node in neuromorphic computing. This work paves a reliable strategy for constructing nanochannel ionic memristive materials toward fully inhibitory synaptic devices. [ABSTRACT FROM AUTHOR]

Doping with various cations is considered to be a key method for inducing ferroelectricity in HfO2. However, previous studies often neglected the role of carriers introduced by heterovalent dopants. Here, using first-principles calculations, we show that carriers profoundly affect the stability of polar phases and advocate that carriers should be considered as a fundamental framework for understanding the origin of ferroelectricity in doped HfO2. Although doping with p-type elements that introduce holes can stabilize the polar phase, it is not sufficient to make them the ground state phase. However, when they are co-doped with an n-type V element, they not only stabilize the polar phase to the ground state, but also achieve charge neutrality through electron compensation. This is due to the formation of deep energy levels (electron–hole recombination centers) by V doping, similar to oxygen vacancies. Unlike oxygen vacancy compensation, which favors the formation of tetragonal phases, co-doping is more favorable for the formation of polar phases and the absence of structural defects. Our results contribute to the understanding of the origin of HfO2 ferroelectricity and provide a potential method for the preparation of HfO2-based films with excellent ferroelectric properties. [ABSTRACT FROM AUTHOR]

Resistive random access memory (RRAM) holds great promise for in-memory computing, which is considered the most promising strategy for solving the von Neumann bottleneck. However, there are still significant problems in its application due to the non-uniform performance of RRAM devices. In this work, a bilayer dielectric layer memristor was designed based on the difference in the Gibbs free energy of the oxide. We fabricated Au/Ta2O5/HfO2/Ta/Pt (S3) devices with excellent uniformity. Compared with Au/HfO2/Pt (S1) and Au/Ta2O5/Pt (S2) devices, the S3 device has a low reset voltage fluctuation of 2.44%, and the resistive coefficients of variation are 13.12% and 3.84% in HRS and LRS, respectively, over 200 cycles. Otherwise, the bilayer device has better linearity and more conductance states in multi-state regulation. At the same time, we analyze the physical mechanism of the bilayer device and provide a physical model of ion migration. This work provides a new idea for designing and fabricating resistive devices with stable performance. [ABSTRACT FROM AUTHOR]

A novel position-sensitive linear winding silicon drift detector (LWSDD) was designed and simulated. On the frontside (anode side), the collecting anodes were set on both sides of the detector, and an S-shaped linear winding cathode strip was arranged in the middle, which can realize independent voltage division and reduce the complexity of external bias resistor chain compared with the traditional linear silicon drift detector. The detectors were arranged in a butterfly shape, which increased the effective area of the detectors and improved the collection efficiency. The linear winding silicon drift detector can obtain one-dimensional position information by measuring the drift time of electrons. The 2D position information of the incident particle is obtained from the anodes coordinates of the readout signal. One-dimensional analytically exact solutions of electric potential and field were obtained for the first time for the linear winding silicon drift detector. The simulation results show that the electric potential distribution inside the detector is uniform, and the "drift channel" inside the detector points to the collecting anodes on both sides, which proves the reasonable and feasible design of the linear winding silicon drift detector. [ABSTRACT FROM AUTHOR]

In this study, a controllable equal-gap large-area silicon drift detector (L-SDD) is designed. The surface leakage current is reduced by reducing the SiO2-Si interface through the new controllable equal-gap design. The design of the equal gap also solves the problem whereby the gap widens due to the larger detector size in the previous SDD design, which leads to a large invalid area of the detector. In this paper, a spiral hexagonal equal-gap L-SDD of 1 cm radius is selected for design calculation, and we implement 3D modeling and simulation of the device. The simulation results show that the internal potential gradient distribution of the L-SDD is uniform and forms a drift electric field, with the direction of electron drift pointing towards the collecting anode. The L-SDD has an excellent electron drift channel inside, and this article also analyzes the electrical performance of the drift channel to verify the correctness of the design method of the L-SDD. [ABSTRACT FROM AUTHOR]

Chronic wound healing remains challenging due to the oxidative microenvironment. Prussian blue (PB) nanoparticles exhibiting multiple antioxidant enzyme-like activities have attracted widespread attention, while their antioxidant efficacy remains unsatisfied. Herein, ultrasmall calcium-enriched Prussian blue nanoparticles (CaPB NPs) are simply constructed with high yields for the wound repair application. Owing to the ultrasmall size and synergistic effect of the generated dual active sites, the CaPB NPs exhibit prominent antioxidase-like activities, protecting cells from oxidative stress-induced damage. In addition to the effect of Ca on regulating keratinocyte and fibroblast growth, it has been demonstrated that the administration of CaPB NPs obviously promoted wound closure as well as collagen deposition and neovascularization in the full-thickness wound defect model in mice. Importantly, the CaPB NP treatment can effectively up-regulate the expression levels of anti-inflammatory cytokines and vascular endothelial growth factors to remodel the wound microenvironment, thereby accelerating the wound healing process. Overall, this work reveals that metal atom substitution is an effective strategy to construct ultrasmall and high-catalytic-performance PB-based nanozymes and further potentiate their effectiveness for chronic wound management. [ABSTRACT FROM AUTHOR]

In deep neural network (DNN) accelerators, it is expensive to transfer model parameters from the main memory to the processing elements. Data movement accounts for a large number of the inference latency and energy consumption. In this paper, we present three position-based techniques to compress the DNN model parameters. The techniques could lead to significant energy and performance improvement. The three presented compression techniques are lossless. The first technique takes into consideration the regularly repeat property of the DNN weights to compress them. The second technique saves the relative distance between weights instead of the weights to compress the model. The third technique applies Huffman coding on the relative distance based on the second technique. The proposed techniques are assessed on several DNNs. The results show that, the first technique could decrease 38% of latency and 36% energy, respectively. The second technique could decrease 41% of latency and 39% energy, respectively. The third technique could decrease 45% of latency and 43% energy, respectively. Applying Huffman code could achieve additional 7% reduction in both latency and energy based on the second technique. [ABSTRACT FROM AUTHOR]

Hafnium dioxide (HfO2)-based ferroelectric films are highly desirable due to their excellent compatibility with CMOS technology, good scalability, low operating voltage, and moderate polarization strength. However, the preparation of HfO2-based ferroelectric films inevitably introduces oxygen vacancies, which, under the influence of electric fields, redistribute and cause the awakening and fatigue phenomena of the films, ultimately resulting in the loss of ferroelectric performance. In this study, Hf0.5Zr0.5O2 (HZO) thin films were grown using atomic layer deposition (ALD) technology, and the influence of using different metal electrodes (W, Pt) as the top and bottom electrodes on the electrical properties of the HZO films was investigated. The leakage current of the W/HZO/W capacitor was the lowest, and the initial 2Pr at 3 V was 41.4 μC/cm2, much higher than those of the W/HZO/Pt (15.7 μC/cm2) and Pt/HZO/Pt (7.6 μC/cm2) capacitors. As the number of electric field cycles gradually increased to 104, the 2Pr values of the three capacitors changed. At this point, the 2Pr value of the W/HZO/W capacitor was 53.9 μC/cm2, and the characteristic fatigue curve was flatter, indicating a weaker wake-up effect. These results indicate that the W electrode material can effectively promote the formation of the ferroelectric phase, reduce oxygen vacancies, and suppress the wake-up effect. [ABSTRACT FROM AUTHOR]

High‐performance stretchable optoelectronic synaptic transistor arrays are key units for constructing and mimicking simulated neuromorphic vision systems. In this study, ultra‐low power consumption and low‐operation‐voltage stretchable all‐carbon optoelectronic synaptic thin film transistors (TFTs) using sorted semiconducting single‐walled carbon nanotubes (sc‐SWCNTs) modified with CdSe/ZnS quantum dots as active layers on ionic liquid‐based composite elastomer substrates are first reported. The resulting stretchable TFT devices show enhancement‐mode characteristics with excellent electrical properties (such as the record on/off ratios up to 105, negligible hysteresis, and small subthreshold swing), excellent mechanical tensile properties (such as the only 12.4% and 6.4% degradations of the carrier mobility after 20% vertical and horizontal strain stretching), and optoelectronic synaptic plasticity (for the recognition of Morse codes) with ultra‐low power consumptions (15.38 aJ) at the operating voltage from −1 to 0.2 V. At the same time, the designed nonvolatile conductance of the stretchable SWCNT optoelectronic synapse thin film transistors (SSOSTFTs) stimulated by UV light and the bending angle are first used to simulate stretchable neuromorphic vision systems (including the functions of the crystalline lens and optic cone cells as bionic eyes) for detecting the atmospheric environment with a record accuracy of 95.1% as a bionic eye. [ABSTRACT FROM AUTHOR]

Mushrooms contain multiple essential nutrients and health-promoting bioactive compounds, including the amino acid L-ergothioneine. Knowledge of the chemical composition of different mushroom varieties will aid research on their health-promoting properties. We compared the metabolomes of fresh raw white button, crimini, portabella, lion's mane, maitake, oyster, and shiitake mushrooms using untargeted liquid chromatography mass spectrometry (LC/MS)-based metabolomics. We also quantified amino acid concentrations, including L-ergothioneine, a potential antioxidant which is not synthesized by plants or animals. Among the seven mushroom varieties, more than 10,000 compounds were detected. Principal Component Analysis indicated mushrooms of the same species, Agaricus Bisporus (white button, portabella, crimini), group similarly. The other varieties formed individual, distinct clusters. A total of 1344 (520 annotated) compounds were detected in all seven mushroom varieties. Each variety had tens-to-hundreds of unique-to-mushroom-variety compounds. These ranged from 29 for crimini to 854 for lion's mane. All three Agaricus bisporus varieties had similar amino acid profiles (including detection of all nine essential amino acids), while other varieties had less methionine and tryptophan. Lion's mane and oyster mushrooms had the highest concentrations of L-ergothioneine. The detection of hundreds of unique-to-mushroom-variety compounds emphasizes the differences in chemical composition of these varieties of edible fungi. [ABSTRACT FROM AUTHOR]

A theoretical model for simulating ionizing radiation effects on negative capacitance field-effect transistors (NCFETs) with a metal–ferroelectric–insulator–semiconductor (MFIS) structure was established. Based on the model, the effects of total ionizing dose (TID) and dose rate on the surface potential, ferroelectric capacitance, voltage amplification factor, and transfer characteristics of NCFETs were investigated. The simulation results demonstrated that, with the increase in total dose, the curves of surface potential versus gate voltage and driving current versus gate voltage shift left significantly, resulting in the point of voltage amplification shifting left. Meanwhile, with the increase in dose rate, the amplitude of both the surface potential and driving current decreases slightly. Meanwhile, the derived result indicated that relatively thin ferroelectric thickness can effectively reduce the effect of TID. It is expected that this model can be helpful for analyzing the radiation effects of NCFETs. [ABSTRACT FROM AUTHOR]

Objective. To investigate the application effect of 24 h dynamic electrocardiogram in the diagnosis of asymptomatic myocardial ischemia with arrhythmia in elderly patients with coronary heart disease. Methods. A total of 206 elderly patients suspected of coronary heart disease (CHD) with asymptomatic myocardial ischemia and arrhythmia were selected as the research subjects. 24 h dynamic electrocardiogram and conventional electrocardiogram examinations were conducted. Coronary angiography was used as the gold standard to observe the performance of the two examination methods in the diagnosis of asymptomatic myocardial ischemia with arrhythmia in elderly patients with CHD. Results. Coronary angiography showed 174 positive cases and 32 negative cases among the 206 patients. The diagnostic results of a conventional electrocardiogram showed 150 positive cases and 20 negative cases. Its sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were 86.21%, 62.50%, 82.52%, 92.59%, and 45.45%, respectively. The diagnostic results of 24 h dynamic electrocardiograms showed 168 positive cases and 29 negative cases. Its sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were 96.55%, 96.63%, 95.63%, 98.25%, and 82.86%, respectively. The above results indicated that 24 h dynamic electrocardiogram was significantly better (P < 0.05). The detection rate of arrhythmia types by 24-hour dynamic electrocardiogram was significantly higher than that of conventional electrocardiogram (P < 0.05). Conclusion. 24 h dynamic electrocardiogram is helpful for the diagnosis of asymptomatic myocardial ischemia with arrhythmia in elderly patients with CHD and can improve the detection rate, thereby providing a basis for clinical diagnosis and treatment. [ABSTRACT FROM AUTHOR]

Biological neurons encode signals through firing voltage spike trains having unique temporal patterns, enabling efficient information representation and processing. Realization of these rich neuronal firing characteristics in a single electronic device, without circuitry and software assistance, promise compact and functional neuromorphic hardware for advanced artificial intelligence applications. Here, a Pt/Co3O4‐x/ITO‐based ionic memristor is reported that can faithfully produce voltage spike trains exhibiting diverse temporal patterns of biological neurons, under electric current stimulation. The spiking behaviors stem from the redistribution of ions in the device, governed by the current induced electric field and Joule heating effects. Tonic, phasic, burst, and adaptive firing patterns of neurons are demonstrated. Particularly, the adaptive firing characteristics allow the memristor to reduce the response to invariant current stimulation and to respond to current changes with enhanced sensitivity, implementing neuronal adaptive coding function. Integrating such memristors with pressure sensors yields an artificial tactile sensory system that can adaptively perceive small pressure variations in the presence of strong static pressure backgrounds, enabling accurate identification of touched objects in ever‐changing environments. This work opens up an avenue toward advanced neuromorphic hardware for smart neural prosthetics and bionic robotics applications. [ABSTRACT FROM AUTHOR]

In-sensor computing can simultaneously output image information and recognition results through in-situ visual signal processing, which can greatly improve the efficiency of machine vision. However, in-sensor computing is challenging due to the requirement to controllably adjust the sensor's photosensitivity. Herein, it is demonstrated a ternary cationic halide Cs0.05FA0.81MA0.14 Pb(I0.85Br0.15)3 (CsFAMA) perovskite, whose External quantum efficiency (EQE) value is above 80% in the entire visible region (400–750 nm), and peak responsibility value at 750 nm reaches 0.45 A/W. In addition, the device can achieve a 50-fold enhancement of the photoresponsibility under the same illumination by adjusting the internal ion migration and readout voltage. A proof-of-concept visually enhanced neural network system is demonstrated through the switchable photosensitivity of the perovskite sensor array, which can simultaneously optimize imaging and recognition results and improve object recognition accuracy by 17% in low-light environments. [ABSTRACT FROM AUTHOR]

Nanowire structures with high-density interfaces are considered to have higher radiation damage resistance properties compared to conventional bulk structures. In the present work, molecular dynamics (MD) is conducted to investigate the irradiation effects and mechanical response changes of GaAs nanowires (NWs) under heavy-ion irradiation. For this simulation, single-ion damage and high-dose ion injection are used to reveal defect generation and accumulation mechanisms. The presence of surface effects gives an advantage to defects in rapid accumulation but is also the main cause of dynamic annihilation of the surface. Overall, the defects exhibit a particular mechanism of rapid accumulation to saturation. Moreover, for the structural transformation of irradiated GaAs NWs, amorphization is the main mode. The main damage mechanism of NWs is sputtering, which also leads to erosion refinement at high doses. The high flux ions lead to a softening of the mechanical properties, which can be reflected by a reduction in yield strength and Young's modulus. [ABSTRACT FROM AUTHOR]

During heavy-ion experiments, the single-event gate rupture (SEGR) effects can still be observed in the vertical double-diffused power MOSFET (VDMOS) with radiation-hardened cells. Fault analysis demonstrates that the hot spots locate at the termination of the VDMOS. Then, several mitigation solutions for termination structure are discussed comprehensively by means of TCAD simulations. Finally, a combined hardness method with horizontally extending P+ region and adding floating N+ region is proposed. It is effective to reduce the electric field of gate oxide to below the calculated critical field, without additional masks and process steps. [ABSTRACT FROM AUTHOR]

The origin of the converse magnetoelectric (CME) effect in the Nb‐doped BaTiO3 (NBTO) polar metal is investigated by density functional theory. Unlike the Fe doping system, where the magnetic moment is chiefly contributed by eg orbitals of the Fe atom, the magnetic moment of the NBTO system is mainly contributed by the dxz/dyz orbitals of Ti (Nb) atoms and highly depends on the polarization intensity. When the in‐plane compressive strain η ≤ −2%, the magnetic moment of the NBTO system is zero because electrons predominantly occupy the dxy orbitals. However, the switching process of the ferroelectric polarization induces a strong CME effect with significant magnetic moment changes. Especially, the magnetic moment changes in the NBTO system with the compressive strain η ≤ −2%, which is dozens of times of that of the unstrained NBTO system. These results are useful for designing new ultrafast and low‐power information storage devices with remarkable electrically controlled magnetism. [ABSTRACT FROM AUTHOR]

By applying non-equilibrium molecular dynamics simulation, it is demonstrated that the thermal conductivity of the reported Si/Ge core-shell nanowires (NWs) can be further reduced by shell doping. The thermal conductivity of Si/Ge0.6Si0.4 core-shell NWs is only about 66% of that of Si/Ge core-shell NWs. By analyzing the participation ratios of eigenmodes, it is revealed that the large reduction in the thermal conductivity of Si/Ge0.6Si0.4 core-shell NWs stems from the strong localization of the phonon modes from 1.0 THz to 2.0 THz and the modes from 9.0 THz to 16.0 THz due to both impurity scattering and interface scattering associated with peculiar structure of shell doped silicon NWs. [ABSTRACT FROM AUTHOR]

Background: Astaxanthin is a red lipophilic carotenoid that is often undetectable in human plasma due to the limited supply in typical Western diets. Despite its presence at lower than detectable concentrations, previous clinical feeding studies have reported that astaxanthin exhibits potent antioxidant properties.Objective: We examined astaxanthin accumulation and its effects on gut microbiota, inflammation, and whole-body metabolic homeostasis in wild-type C57BL/6 J (WT) and β-carotene oxygenase 2 (BCO2) knockout (KO) mice.Methods: Six-wk-old male and female BCO2 KO and WT mice were provided with either nonpurified AIN93M (e.g., control diet) or the control diet supplemented with 0.04% astaxanthin (wt/wt) ad libitum for 8 wk. Whole-body energy expenditure was measured by indirect calorimetry. Feces were collected from individual mice for short-chain fatty acid assessment. Hepatic astaxanthin concentrations and liver metabolic markers, cecal gut microbiota profiling, inflammation markers in colonic lamina propria, and plasma samples were assessed. Data were analyzed by 3-way ANOVA followed by Tukey's post hoc analysis.Results: BCO2 KO but not WT mice fed astaxanthin had ∼10-fold more of this compound in liver than controls (P < 0.05). In terms of the microbiota composition, deletion of BCO2 was associated with a significantly increased abundance of Mucispirillum schaedleri in mice regardless of gender. In addition to more liver astaxanthin in male KO compared with WT mice fed astaxanthin, the abundance of gut Akkermansia muciniphila was 385% greater, plasma glucagon-like peptide 1 was 27% greater, plasma glucagon and IL-1β were 53% and 30% lower, respectively, and colon NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome activation was 23% lower (all P < 0.05) in male KO mice than the WT mice.Conclusions: Astaxanthin affects the gut microbiota composition in both genders, but the association with reductions in local and systemic inflammation, oxidative stress, and improvement of metabolic homeostasis only occurs in male mice. [ABSTRACT FROM AUTHOR]

The γ‐ray total dose radiation effects on Zr‐doped HfO2 (HfZrO) and Al‐doped HfO2 (HfAlO) ferroelectric thin films are comparatively studied. The J–E, P–E,C–V, εr–f curves and fatigue characteristics of both HfZrO and HfAlO thin films are measured and analyzed with the increasing total dose from 0 to 5 Mrad (Si). The remnant polarization (Pr) values of both HfZrO and HfAlO thin films first decrease and then increase with the increasing total dose. A competitive mechanism between the pinned domains and increasing polarization switching charges induced by radiation is proposed to explain this phenomenon. This work presents doped HfO2 film with great radiation tolerance for nuclear and aerospace applications. [ABSTRACT FROM AUTHOR]

Titanium nitride (TiN) film is a remarkable material for a variety of applications ranging from superhard coating to superconducting quantum devices, which can be easily oxidized when it works in the atmosphere. However, the study of its oxidation effect on the crystal and electronic structures of epitaxial TiN films is rare as yet. Here, we coherently synthesize TiN epitaxial films on MgO single crystal substrates via reactive magnetron sputtering and, then, dope oxygen into these films via a controllable oxidation process. The crystal and electronic structures are characterized by high-resolution x-ray diffraction, x-ray photoelectron spectra, and Raman spectra. It is revealed that the crystal structure remains to be of the rocksalt type in these films even with heavy oxygen doping. The data of temperature-dependent electrical transport measurements indicate that the superconducting critical temperature (kinetic inductance) decreases (increases) from 4.6 K (0.672 pH/□) in the pristine TiN film to 3.4 K (1.13 pH/□) in the film with a maximum oxygen doping level. Our work provides a controllable way to tune the superconductivity of TiN films, which enables the flexibility to engineer the resultant performance of TiN-based superconducting quantum devices. [ABSTRACT FROM AUTHOR]

Although health benefits of the Dietary Approaches to Stop Hypertension (DASH) diet are established, it is not understood which food compounds result in these benefits. We used metabolomics to identify unique compounds from individual foods of a DASH-style diet and determined if these Food-Specific Compounds (FSC) are detectable in urine from participants in a DASH-style dietary study. We also examined relationships between urinary compounds and blood pressure (BP). Nineteen subjects were randomized into 6-week controlled DASH-style diet interventions. Mass spectrometry-based metabolomics was performed on 24-hour urine samples collected before and after each intervention and on 12 representative DASH-style foods. Between 66–969 compounds were catalogued as FSC; for example, 4-hydroxydiphenylamine was found to be unique to apple. Overall, 13–190 of these FSC were detected in urine, demonstrating that these unmetabolized food compounds can be discovered in urine using metabolomics. Although linear mixed effects models showed no FSC from the 12 profiled foods were significantly associated with BP, other endogenous and food-related compounds were associated with BP (N = 16) and changes in BP over time (N = 6). Overall, this proof of principle study demonstrates that metabolomics can be used to catalog FSC, which can be detected in participant urine following a dietary intervention. [ABSTRACT FROM AUTHOR]

The original article can be found online at https://doi.org/10.1007/s11227-023-05339-4.Correction to: The Journal of Supercomputinghttps://doi.org/10.1007/s11227-023-05339-4In this article, the author name Minghua Tang was incorrectly written as Minging Tang.The original article has been corrected.Publisher's NoteSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.By Minghua Tang; Enrico Russo and Maurizio PalesiReported by Author; Author; Author [Extracted from the article]

The oxygen ion (O2−) loss effect during resistive switching (RS) cycles will inevitably lead to endurance degradation or even failure in oxide-based memristive devices. In this Letter, we propose an effective way to recover the cycling-induced endurance failed HfOx based memristive devices by utilizing oxygen plasma treatment (OPT). In the as-fabricated Pt/HfOx/Pt devices, a negative SET event is observed after consecutive normal RS cycles and eventually triggers endurance failure. The appearance of the intermediate resistance state at the initial stage of the negative SET cycle indicates a prominent reduction of the migration barrier of O2−, which accounts for the occurrence of negative SET after increasing cycles. Then, we recover the devices from endurance failure by moderate OPT, which can supply the available O2− in RS cycles. More importantly, the first recovered devices after endurance failure can be recovered again through OPT, which better proves the validity of the recovery method. This study could provide an effective approach for understanding and addressing the cycling-induced endurance failure issue in oxide-based memristive devices. [ABSTRACT FROM AUTHOR]

Background: To compare and characterize the gut microbiota in women of childbearing age from sub-Saharan Africa (the Democratic Republic of the Congo, DRC) and South Asia (India), in relation to dietary intakes. Methods: Women of childbearing age were recruited from rural DRC and India as part of the Women First (WF) preconception maternal nutrition trial. Findings presented include fecal 16S rRNA gene-based profiling of women in the WF trial from samples obtained at the time of randomization, prior to initiation of nutrition intervention and to conception. Results: Stool samples were collected from 217 women (DRC n = 117; India n = 100). Alpha diversity of the gut microbiota was higher in DRC than in India (Chao1: 91 ± 11 vs. 82 ± 12, P = 6.58E-07). The gut microbial community structure was not significantly affected by any demographical or environmental variables, such as maternal BMI, education, and water source. Prevotella, Succinivibrio , and Roseburia were at relatively high abundance without differences between sites. Bifidobacterium was higher in India (4.95 ± 1.0%) than DRC (0.3 ± 0.1%; P = 2.71E-27), as was Lactobacillus (DRC: 0.2 ± 0.0%; India: 1.2 ± 0.1%; P = 2.39E-13) and Faecalibacterium (DRC: 6.0 ± 1.7%; India: 8.4 ± 2.9%; P = 6.51E-7). Ruminococcus was higher in DRC (2.3 ± 0.7%) than in India (1.8 ± 0.4%; P = 3.24E-5) and was positively associated with consumption of flesh foods. Succinivibrio was positively associated with dairy intake in India and fish/insects in DRC. Faecalibacterium was positively associated with vitamin A-rich fruits and vegetables. Overall, these observations were consistent with India being primarily vegetarian with regular fermented dairy consumption and DRC regularly consuming animal-flesh foods. Conclusion: Consumption of animal-flesh foods and fermented dairy foods were independently associated with the gut microbiota while demographic variables were not, suggesting that diet may have a stronger association with microbiota than demographic characteristics. [ABSTRACT FROM AUTHOR]

Nanoscale magnetization modulation by electric field enables the construction of low-power spintronic devices for information storage applications and, etc. Electric field-induced ion migration can introduce desired changes in the material's stoichiometry, defect profile, and lattice structure, which in turn provides a versatile and convenient means to modify the materials' chemical-physical properties at the nanoscale and in situ. In this review, we provide a brief overview on the recent study on nanoscale magnetization modulation driven by electric field-induced migration of ionic species either within the switching material or from external sources. The formation of magnetic conductive filaments that exhibit magnetoresistance behaviors in resistive switching memory via foreign metal ion migration and redox activities is also discussed. Combining the magnetoresistance and quantized conductance switching of the magnetic nanopoint contact structure may provide a future high-performance device for non-von Neumann computing architectures. [ABSTRACT FROM AUTHOR]

We investigated electric-field modulation of ferromagnetic resonance (FMR) in Ni81Fe19 (NiFe)/Bi3.15Nd0.85Ti2.99Mn0.01O12 (BNTM) heterostructures at room temperature. BNTM thin films were deposited on a Pt (111)/Ti/SiO2/Si (100) substrate by the sol-gel method. The strain effect is produced by the electric field applied to the BNTM layer, which results in the FMR spectrum shift by tuning of the magnetic anisotropy of the NiFe microstrip devices. A strain-induced magnetic anisotropy change of 332 fJ/Vm is obtained by analyzing the experimental FMR spectra. We discussed an influence on spin orbit torques by applying an electric field to a ferroelectric (FE) layer via coupling to polarization with FMR experiments evidencing. The torque ratios τa/τb increased at first and then declined from the positive to negative electric field. As the value of the applied electric field changes from 129 kV/cm to 0 kV/cm, the variation of the torque ratios τa/τb (the field-like torque τa and damping-like torque τb) is about 0.07. Our results reported in this work demonstrate a route to realize a large magneto-electric coupling effect at room temperature and provide some insights into possible applications of the ferromagnetic/FE device. [ABSTRACT FROM AUTHOR]

Background: Protein intake from cow milk-based infant formula has been associated with rapid weight gain and increased adiposity, but the effect of protein from complementary foods has not been prospectively evaluated, and the effect of protein from sources other than formula during complementary feeding is not clear. Objective: The aim of this study was to directly compare the effect of protein from 2 common complementary food sources, meat and dairy, on infant growth and weight trajectory. Design: Healthy term, formula-fed infants were recruited from the metro Denver area, matched by sex and race/ethnicity and randomly assigned to a meat or a dairy complementary food group from 5 to 12 mo of age. Total protein intake during this 7-mo intervention was ~3 g ⋅ kg-1⋅d-1 for both groups. Intakes of infant formula, cereal, fruit, and vegetables were ad libitum. Caregivers also completed 3-d diet records at 5, 10, and 12 mo of age. Anthropometric measures were obtained during monthly home visits, and blood samples were collected at 5 and 12 mo of age. Results: Sixty-four infants completed the intervention (meat: n = 32; dairy: n = 32). The average total protein intake (mean ± SD) increased from 2.01 ± 0.06 g ⋅ kg-1 ⋅ d-1 at 5 mo to 3.35 ± 0.12g⋅kg-1 ⋅ d-1 at 12 mo and did not differ between groups. Over time, weight and weight-for-age z score increased by 0.48 ± 0.07. However, there was a significant group-by-time interaction for both length-for-age z score (LAZ) and weight-for-length z score (WLZ). Post hoc analysis showed that LAZ increased in the meat group (+0.33 ± 0.09; P = 0.001 over time) and decreased in the dairy group (-0.30 ± 0.10; P = 0.0002 over time); WLZ significantly increased in the dairy group (0.76 ± 0.21; P = 0.000002 over time) compared with the meat group (0.30 ± 0.17; P = 0.55 over time). Insulin-like growth factor I and insulin-like growth factor-binding protein 3 both increased over time without group differences. Conclusions: Protein source may have an important role in regulating growth. In these formula-fed older infants, meat- and dairy-based complementary foods led to distinct growth patterns, especially for length. [ABSTRACT FROM AUTHOR]

A Schottky barrier rectifier was fabricated with a (100)-oriented \beta -Ga2O3 substrate grown by the edge-defined film-fed method. The Sn-doped \beta -Ga2O3 substrate had an effective donor concentration of approximately 2\times 10^17 cm−3. High performance parameters were obtained, such as a high forward current (421 A/cm2 at 2 V), low ON-resistance (2.9 \textm\Omega \cdot cm2), and short reverse recovery time (20 ns). Furthermore, the dynamic behavior of the device is characterized through test on the half-wave rectification of ac voltages at different frequency. The diode worked well at 100 kHz. At the end of the letter, we discuss how Ga2O3 Schottky rectifier can operate at high frequency. [ABSTRACT FROM AUTHOR]

For 2D mesh based Network-on-Chip (NoC), the prohibited turns of routing algorithms should be repetitively distributed in order for the routing algorithms to be implemented by logic-based circuit. In this paper, we aim to exploit the designing space for logic-based routing algorithms, and propose new logic-based routing algorithms that outperform the state-of-the-art counterparts. Toward this direction, we firstly construct all routing algorithms for $5 \times 5$ 2D mesh topology. Then we select those routing algorithms which have repetitive prohibited turns across both the network rows and columns. In addition, we chose those routing algorithms that have smaller routing pressures than Odd-Even routing algorithm. Then the routing algorithms for 2D mesh topology ranging from $6 \times 6$ to $15 \times 15$ are respectively constructed according to the prohibited turns distribution of the selected routing algorithms. Two routing algorithms that have smaller routing pressures than Odd-Even routing algorithm are obtained for all considered networks. The obtained logic-based routing algorithms are called as Repetitive Turn Model (RTM). Simulation results show that RTM could achieve up to 51% performance improvement as compared to Odd-Even routing algorithm. [ABSTRACT FROM AUTHOR]

Nd/Zr-cosubstituted bismuth titanate (BNTZ, x = 0, 0.05, 0.1, 0.3, and 0.5) thin films have been fabricated by chemical solution deposition and their polarization hysteresis loops, leakage current, and capacitance butterfly loops investigated. Results show that, at Zr content of x = 0.1, both capacitance and remanent polarization can be greatly improved. The BNTZ film also exhibits fatigue-free, excellent leakage current characteristics ( I ≈ 9.44 × 10 A) at applied voltage of 3 V. High-quality c-axis-oriented BNTZ films with improved electrical properties were fabricated; this finding supports the feasibility of engineering polarization rotation in ferroelectric bismuth titanate (as suggested theoretically by Roy et al. in Appl. Phys. Lett. 102:182901, ). [ABSTRACT FROM AUTHOR]

A transparent, flexible graphene field effect transistor (GFET) based on ferroelectric gate is demonstrated. In this device, the single layer graphene was fabricated by chemical vapor deposition method, and transferred to the polyethylene terephthalate substrate. Then the poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) ferroelectric polymer layer film was used as the gate dielectric for the graphene FET. Based on the P(VDF-TrFE)/graphene heterojunction FET, Hall Bar structure was fabricated. The transport properties of the graphene channel at low temperature and retention characteristics at different temperature are investigated in detail. These special properties indicated that the GFET might be useful for many particular applications, such as a non-volatile memories, flexible electronic devices and phototransistors. [ABSTRACT FROM AUTHOR]

Network-on-Chip (NoC) has been made the communication infrastructure for many-core architecture. NoC are subject to congestion, which is claimed to be avoided by many researchers. However, there is no completely understanding of congestion in literature, which hinders its solution. Toward this direction, we firstly carry out study on congestion in this paper. We find that congestion usually occurs at a portion of nodes in a local network region. Moreover, local congestion will significantly decrease system performance and mostly impact some particular communication pairs. Then we attempt to solve local congestion by addressing different local region size, based on Divide-Conquer approach and routing pressure. It avoids congestion in every local region by keeping routing pressure of every local region minimum. Using different local region size will create different routings. Our study shows that the local region size is closely related with the routing performance. When local region size is 5 × 5 the optimal routing performance of large size network could be achieved. [ABSTRACT FROM AUTHOR]

Ferroelectric random access memory (FeRAM) is a promising candidate to substitute static random access memory (SRAM) in lookup table (LUT) design due to its high density, high speed operation, anti-radiation and non-volatility. Ferroelectric gate field effect transistors (FeFETs) have been extensively studied and its usage in memory elements and basic analog circuit configurations has gained much interests. Here, we propose a novel architecture of FeFET-based LUT. An improved timing mode of FeRAM chip is analyzed to satisfy the performance of the FeFET-based LUT. Decoder, driver circuit and sensitive amplifier for FeFET array are also proposed. All the simulation results show that the proposed LUT works properly when the frequency reaches 500 MHz at 0.3 V differential input signal. [ABSTRACT FROM AUTHOR]

The usage of ferroelectric-gate field effect transistors (FeFET) in digital circuits has typically been its applications in memory. The use of FeFET to implement logic circuits is neither completely understood nor extensively studied. This paper presents simulations of electrical properties of a single FeFET and the resulting behavioral characterizations of FeFET-based basic logic circuits in a commercially available TCAD environment. The all-FeFET current mirror, CMOS inverter, 2-input-NAND and 2-input-NOR logic circuits show almost the same electrical characteristics as standard MOSFET ones, except for the negligible clockwise hysteresis under the condition of low voltage supply. Moreover, the all-FeFET current mode sensitive amplifier whose component units were all-FeFET common-source amplifier, current mirror and differential amplification, also works reasonably. [ABSTRACT FROM AUTHOR]

A structurally simple, highly reactive chlorinating reagent, N-chloro-N-fluorobenzenesulfonylamine (CFBSA), was conveniently prepared from inexpensive Chloramine B in high yield. A wide range of substrates were chlorinated with it to obtain products in good to high yields and appropriate selectivity. [ABSTRACT FROM AUTHOR]

This paper presents a fully integrated reconfigurable all-band RF transceiver for GPS/GLONASS/ Galileo/Beidou in 55-nm CMOS. The transceiver incorporates three low-IF receivers (RXs) and one direct up-conversion BPSK transmitter (TX), which can be configured to receive any two global navigation satellite system (GNSS) signals or switched to process the Chinese Beidou(I) signals. A switching module is integrated to provide the connectivity between different RF front-end and IF channel (IFC), which will effectively simplify the design complexity of the IFC and save power consumption, while the GNSS signals are received. A flexible frequency plan with two frequency synthesizers is utilized to satisfy different local oscillator requirements of the transceiver. An optimized automatic frequency calibration scheme using an error compensation logic enables fast and high-precision calibration process for optimum phase-locked loop operation. Several digitally assisted calibration modules are integrated to ensure that the chip performance only shows a weak process, voltage and temperature (PVT) dependence. While drawing about 21.5–30.2 mA per RX channel from a 1.2-V supply, the RXs achieve an image rejection ratio more than 49 dB after I/Q mismatch calibration, an automatic gain control range of 88 dB, and an input-referred 1 dB compression point of better than −25 dBm with a minimum noise figure of about 2 dB. The output power of the TX is about 5 dBm with about 6% error vector magnitude (EVM) and 30-mA current from a 1.2-V supply. The whole transceiver consumes a die area of 2.8 \times 3~mm^2 . [ABSTRACT FROM AUTHOR]