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Your search keyword '"Syh-Yuan Hwang"' showing total 3 results
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3 results on '"Syh-Yuan Hwang"'

1. Chemical Constituents from Flueggea virosa and the Structural Revision of Dehydrochebulic Acid Trimethyl Ester.

Author

Chih-Hua Chao, Ying-Ju Lin, Ju-Chien Cheng, Hui-Chi Huang, Yung-Ju Yeh, Tian-Shung Wu, Syh-Yuan Hwang, and Yang-Chang Wu

Subjects
FLUEGGEA, TERPENES, IN vitro studies, EUPHORBIACEAE, CELL-mediated cytotoxicity, X-ray diffraction
Abstract

In an attempt to study the chemical constituents from the twigs and leaves of Flueggea virosa, a new terpenoid, 9(10→20)-abeo-ent-podocarpane, 3β,10α-dihydroxy-12-methoxy-13- methyl-9(1010→20)-abeo-ent-podocarpa-6,8,11,13-tetraene (1), as well as five known compounds were characterized. Their structures were elucidated on the basis of spectroscopic analysis. In addition, the structure of dehydrochebulic acid trimethyl ester was revised as (2S,3R)-4E-dehydrochebulic acid trimethyl ester based on a single-crystal X-ray diffraction study. The in vitro anti-hepatitis C virus (anti-HCV) activity and cytotoxicity against Huh7.5 cells for the isolated compounds were evaluated. [ABSTRACT FROM AUTHOR]

Published
2016
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2. 5β,19-Epoxycucurbitane Triterpenoids from Momordica charantia and Their Anti-Inflammatory and Cytotoxic Activity.

Author

Chia-Ching Liaw, Hui-Chi Huang, Ping-Chun Hsiao, Li-Jie Zhang, Zhi-Hu Lin, Syh-Yuan Hwang, Feng-Lin Hsu, and Yao-Haur Kuo

Subjects
FRUIT, SPECTRUM analysis, TERPENES, CLINICAL pathology, CYTOTOXINS, BIOLOGICAL assay, INFLAMMATION, MEDICINAL plants, MEDICAL research, NITRIC oxide, PAIN, RESEARCH funding, TUMORS, IN vitro studies, EQUIPMENT & supplies, THERAPEUTICS
Abstract

Five new 5β,19-epoxycucurbitane triterpenoids, taikugausins A-E (1-5), together with 5β,19-epoxy-25-methoxycucurbita-6,23-diene-3β, 19-diol (6), have been isolated and characterized from the 70% EtOH extract of the fresh fruits of Momordica charantia. The chemical structures of compounds 1-6 were elucidated on the basis of extensive spectroscopic analyses, especially 2D NMR (HMQC, HMBC, and NOESY) experiments and HRESIMS data. The relationship between NMR chemical shifts and the configuration of C-19 with an OMe group in 5β,19-epoxycucurbitane are described. Among them, compounds 3 and 4 exhibited remarkable anti-inflammatory activities by the inhibition of nitric oxide production at the concentration of 10 μg/mL. In addition, 3 and 4 also showed moderate cytotoxicity against WiDr, Hep G2, MCF-7, and HEp-2 human tumor cell lines. [ABSTRACT FROM AUTHOR]

Published
2015
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3. Two Anti-inflammatory Steroidal Saponins from Dracaena angustifolia Roxb.

Author

Hui-Chi Huang, Ming-Kuem Lin, Syh-Yuan Hwang, Tsong-Long Hwang, Yao-Haur Kuo, Chi-I Chang, Chung-Yi Ou, and Yueh-Hsiung Kuo

Subjects
STEROID saponins, SPECTRUM analysis, ANTI-inflammatory agents, SUPEROXIDES, NEUTROPHILS
Abstract

Two new steroidal saponins, named drangustosides A-B (1-2), together with eight known compounds 3-10 were isolated and characterized from the MeOH extract of Dracaena angustifolia Roxb. The structures of compounds were assigned based on 1D and 2D NMR spectroscopic analyses, including HMQC, HMBC, and NOESY. Compounds 1 and 2 showed anti-inflammatory activity by superoxide generation and elastase release by human neutrophils in response to fMLP/CB. [ABSTRACT FROM AUTHOR]

Published
2013
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