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This study divided the volunteers into healthy skin non sensitive individuals and oily skin sensitive individuals through self-evaluation questionnaire and measurement of sebum secretion. The physiological parameters of facial skin were measured by non-invasive methods and the skin microbiome was analyzed by 16S rRNA high-throughput sequencing. Research has found that compared with the healthy skin, the hydration content and b-value of oily sensitive skin are significantly reduced (P<0.05), while the TEWL, sebum, hemoglobin, and skin roughness are significantly increased (P<0.05), and the pore area is significantly increased (P<0.05). The analysis of skin microbiota diversity shows a significant decrease in Sobs index (P<0.05) and Shannon index (P<0.001), resulting in a decrease in microbiota diversity. The species composition analysis shows that the abundance of Cutibacterium and Staphylococcus genera increases significantly, while the abundance of Rhodococcus and Pseudomonas genera decreases significantly (P<0.001). Spearman correlation analysis shows that sebum is positively correlated with the genera Cutibacterium and Staphylococcus, while negatively correlated with other genera. At the same time, Cutibacterium always shows the opposite correlation with other bacteria genera. This study indicates that the occurrence of oily sensitive skin is closely related to the changes in skin microbiota, and Cutibacterium is an important genus that affects the overall stability of the skin microbiota. This study provides a scientific basis for the development of skincare products for oily sensitive skin populations. [ABSTRACT FROM AUTHOR]

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Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals that has caused tremendous economic losses worldwide. In this study, we designed a chimeric nanoparticles (CNPs) vaccine that displays the predominant epitope of the serotype O foot-and-mouth disease virus (FMDV) VP1 131-160 on the surface of MS2 phage. The recombinant protein was expressed in Escherichia Coli and can self-assemble into CNPs with diameter at 25–30 nm in vitro. A tandem repeat peptide epitopes (TRE) was prepared as control. Mice were immunized with CNPs, TRE and commercialized synthetic peptide vaccines (PepVac), respectively. The ELISA results showed that CNPs stimulated a little higher specific antibody levels to PepVac, but was significantly higher than the TRE groups. Moreover, the results from specific IFN-γ responses and lymphocyte proliferation test indicated that CNP immunized mice exhibited significantly enhanced cellular immune response compared to TRE. These results suggested that the CNPs constructed in current study could be a potential alternative vaccine in future FMDV control. [ABSTRACT FROM AUTHOR]

The article discusses a study which investigated the development of a synthetic peptide-based immunochromatographic strip for differentiation of serotype O foot-and-mouth disease virus (FMDV)-infected pigs from vaccinated pigs. The study involved the synthesis of five peptides designed from the amino acid sequences of nonstructural proteins (NSP) of FMDV. For the test and control lines, staphylococcal protein A and rabbit against peptide-conjugated olvalbumin antibody immunoglobulin G were blotted on the nitrocellulose membrane.

Neutrophils and macrophages in cattle express a novel class of immunoglobulin Fc receptor, specific for bovine IgG2, termed boFcγ2R. In cows, the ability of neutrophils to kill immunoglobulin-opsonized microorganisms appears to depend largely on this subclass. Although related to other mammalian FcγRs, boFcγ2R belongs to a novel gene family that includes the human killer Ig-like receptor and FcαRI (CD89) proteins. In this study, we describe the presence and characterization of this novel class of FcγR in sheep. The comparative analysis of this novel FcγR has allowed us to begin an exploration of some immunological characteristic of ruminants. [ABSTRACT FROM AUTHOR]