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The article presents a case study of a 78-year-old man, who was diagnosed with acquired erythropoietic protoporphyria (EPP). The man was subjected to medical examinations including blood, biochemical, and histopatological tests that reveal late onset symptoms and moderate anaemia and suspicion of acquired EPP. The man was treated with erythropoiesis-stimulating agent (ESA), darbepoetin alfa, and oral glycyrrhizin.

Hopping dynamics in glass has been known for quite a long time. In contrast, hopping dynamics in smectic-A (SmA) and hexatic smectic-B (HexB) liquid crystals (LC) has been observed only recently. The hopping in SmA phase occurs among the smectic layers (one-dimensionally), while hopping in HexB phase occurs inside the layers (two-dimensionally). The hopping dynamics in SmA and HexB liquid crystal phases is investigated by parallel soft-core spherocylinders, while three-dimensional hopping dynamics in inherent glassy states is investigated by systems of Weeks--Chandler--Andersen (WCA) spheres. The temperature dependence of diffusion coefficients of hopping in SmA phase can be described by the Arrhenius equation characteristic of activation process. In HexB LC phase, the diffusion coefficients saturate at higher temperatures. In a system of WCA spheres, the values and temperature dependence of diffusion coefficients depend on the observed states. [ABSTRACT FROM AUTHOR]

Using molecular dynamics (MD) simulation, we simulate the structural change of a telomeric DNA by β-decay of substituted tritium to helium-3. The configuration of the telomeric DNA is obtained by removing TRF2 protein from the TRF2-Dbd-DNA complex (Protein Data Bank ID is 3SJM). We assume that hydrogens (H) of guanines in the telomeric DNA are replaced to helium-3. Since this replacement of the H atoms to the 3He atoms changes the charge distribution significantly, the charge distribution used in the MD simulation for the modified guanine is obtained by the density functional theory calculations. We adopt, as the MD simulation, nanoscale molecular dynamics code with CHARMM36 force field using Langevin thermostat and Nosé–Hoover Langevin piston to control the temperature and pressure of the system, respectively. Moreover, changing both the number of replaced guanine N and the temperature of the system T, we calculate the root mean square deviation RMSD to quantify the dependence of the durability of the telomeric DNA on the β-decays. From the MD simulation, it is found that as N or T becomes larger, the RMSD of the DNA becomes also larger. Namely, it denotes that as the intensity of the β-decays becomes larger or as the temperature is increased, the DNA structure becomes more fragile. [ABSTRACT FROM AUTHOR]