Search

Your search keyword '"Srn1"' showing total 3 results
Start Over Descriptor "Srn1" Database Complementary Index
3 results on '"Srn1"'

1. Denitrative Hydroxylation of Unactivated Nitroarenes.

Author

Duff, Lee, Meakin, Harry, Richardson, Adam, Greener, Andrew J., Smith, George W. A., Ocaña, Ivan, Chechik, Victor, and James, Michael J.

Subjects
NITROAROMATIC compounds, HYDROXYLATION, RADICAL anions
Abstract

A one-step method for the conversion of nitroarenes into phenols under operationally simple, transition-metal-free conditions is described. This denitrative functionalization protocol provides a concise and economical alternative to conventional three-step synthetic sequences. Experimental and computational studies suggest that nitroarenes may be substituted by an electron-catalysed radical-nucleophilic substitution (SRN1) chain mechanism. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

2. Regioselective Suzuki-Miyaura Reaction: Application to the Microwave-promoted Synthesis of 4,7-Diarylquinazolines.

Author

Kabri, Youssef, Verhaeghe, Pierre, Gellis, Armand, and Vanelle, Patrice

Subjects
MICROWAVES, ORGANOBORON compounds, PALLADIUM, ORGANIC synthesis, BINDING sites
Abstract

New diarylquinazolines displaying pharmaceutical potential were synthesized in high yields from 4,7-dichloro-2-(2-methylprop-1-enyl)-6-nitroquinazoline by using microwave-promoted regioselective Suzuki-Miyaura cross-coupling reactions. [ABSTRACT FROM AUTHOR]

Published
2010
Full Text
View/download PDF

3. Access to Original Vinylic Chlorides in the Quinazoline Series via a Monoelectronic Transfer Reaction Approach.

Author

Maillard-Boyer, Martine, Castera-Ducros, Caroline, Verhaeghe, Pierre, Sifredi, France, Rathelot, Pascal, and Vanelle, Patrice

Subjects
QUINAZOLINE, HETEROCYCLIC compounds, AROMATIC compounds, CHLORIDES, PHARMACEUTICAL biotechnology, MOLECULAR biology, BIOCHEMISTRY, CANCER chemotherapy, CHEMICAL biology, THERAPEUTICS
Abstract

series of new quinazoline derivatives bearing a vinylic chloride group on the 2-position was prepared by using a consecutive SRN1 / ERC1 radical strategy. [ABSTRACT FROM AUTHOR]

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results