Search

Purpose: Meditative movement (MM) practices are increasingly being studied, including examination of the potential for these modalities to contribute to weight management.Methods: A search was conducted for randomized controlled trials testing one or both of two forms of MM, Tai Chi and Qigong, reporting effects on changes in body composition. Data from these studies were extracted and tabled, and a meta-analysis of studies with inactive control conditions was conducted. Risk of bias was assessed, and seven RCTs had a low risk of bias. Sources of bias include publication bias and selection of English only.Results: Publications meeting inclusion criteria yielded 24 studies (N = 1621 participants). Significant improvements in body composition, primarily body mass index, were noted for 41.7% of studies. A synthesis table describes the distribution of design factors, including type of comparison condition (inactive vs. active) and baseline body composition status (whether or not overweight/obese). A meta-analysis was conducted on 12 studies with inactive controls (using a random effects model) finding a small-to-medium treatment effect (SMD = − 0.388, CI = [− 0.732, − 0.044], t = 2.48, p < 0.03) for TC or QG interventions with a high level of heterogeneity.Conclusions: Tai Chi and Qigong show demonstrable effects on body composition, when compared to inactive control conditions. Systematic evaluation and valid conclusions regarding the impact of Tai Chi and Qigong on body composition outcomes will require more targeted study designs and control of comparison conditions. [ABSTRACT FROM AUTHOR]

Volume crime offences such as domestic burglary are commonly assessed for forensic opportunities by the first attending officer present at the scene. Conversely, less serious volume crime offences such as thefts from motor vehicles are very frequent and are routinely assessed for forensic opportunities by the victim talking to the police over the telephone. It is not clear whether this difference in attendance policy leads to differences in the types and quantity of forensic material recovered. The current study explored whether there was a benefit to evidence recovery for attended as opposed to non-attended assessments. Five hundred thefts from motor vehicles offences recorded by Northamptonshire Police (UK) between 14 January 2010 and 28 February 2011 were analysed; 250 were attended forensic assessments and 250 were non-attended assessments. Significant differences were found between the two scenarios, with attended assessments more likely to yield DNA, property and trace substance material. Conversely, fingerprints were more likely to be recovered at non-attended assessments. Despite the fruitful findings of the current study, future research would benefit from establishing the methods used by the first attending officer and forensic investigator when assessing and gathering evidence. Similarly, it is unclear whether these differences in forensic material are reflected in the identification of an offender and subsequently in the solving of the crime. [ABSTRACT FROM PUBLISHER]

In order to investigate the role of pre-trial attitudes about forensic science in juror decision-making, a previous study demonstrated the predictive validity of the Forensic Evidence Evaluation Bias Scale (FEEBS), using a murder trial scenario, which featured ambiguous prosecution DNA evidence. The current study validates the FEEBS using two new crime types and the conditions include a manipulation of the presence of DNA evidence in the trial scenario. The FEEBS successfully predicted mock jurors' perceptions of the probative value of DNA evidence for both robbery and sexual assault trials. The two subscales of the FEEBS were demonstrated to have different predictive ability depending on the presence or absence of DNA evidence. A confirmatory factor analytic technique was used to validate the underlying two-factor structure of the FEEBS, as previously proposed. These results are discussed with reference to theCSI Effectliterature, and the potential for improvement to less empirically supportedvoir direquestioning techniques. [ABSTRACT FROM PUBLISHER]

Car key burglary has recently become the focus of empirical investigation as offenders, no longer able to steal vehicles without first obtaining their keys, resort to 'burgling' target properties. Research surrounding the modus operandi of these offenses is beginning to emerge; however, little attention has been paid to investigating the characteristics of car key burglary offenders. Challenging the assumption that car key burglary offenses are perpetrated by regular burglars, this study aims to differentiate between offenders. Logistic regression analysis of 110 car key and 110 regular burglary offenders revealed that car key burglars are more likely to have previous vehicle theft convictions and are also more likely to be detected on information supplied to the police than regular burglars. Regular burglars are more likely to have previous shoplifting convictions. It was concluded that car key burglars are a distinct sample of offenders and the implications of these findings are discussed. [ABSTRACT FROM AUTHOR]

This study aims to identify quantitatively the level of increased stress in civilian crime scene investigators (CSIs) whilst they were performing a variety of tasks as part of their normal duties. Mean above-average resting heart rate was used as the quantitative measure of physiological changes, recorded once a second for 12 CSIs during a working shift of 8 hours over a period of 7 days. Each CSI maintained an activity log of their work which enabled the physiological readings to be aligned to tasks undertaken. As well as physical stress, results show that CSIs undergo psychosocial stress during the examination of routine crime scenes such as domestic burglary and vehicle examination. Increased levels of stress diminished between scene visits. Reasons for increased stress reactivity at routine crime scenes are considered and opportunities for further work discussed. This study demonstrates quantitatively the stress undergone by civilian CSIs and questions the effect this might have on the effective recovery of forensic material from the crime scene as well as the welfare of the CSI. [ABSTRACT FROM AUTHOR]

As a result of the mandatory introduction in 1998 of electronic immobilisers in all new vehicles, car crime has evolved so that criminals resort to stealing vehicle keys during domestic burglaries in order to steal the vehicle subsequently. This new offence is referred to as 'car key burglary'. Building upon previous research (Shaw, Smith, & Bond, 2010), car key burglary data provided by Northamptonshire Police from 1 January 2008 to 31 December 2009 was analysed to identify the crime-scene characteristics that can differentiate a car key burglary from a regular domestic burglary. Significant differences were found between car key burglaries and regular domestic burglaries pertaining to the security of the property and the types of items stolen, with secure premises and items likely to be left in a vehicle overnight (such as satellite navigation systems, in-car DVD players and mobile telephones) being more indicative of car key burglary. The implications of these findings are considered and the limitations discussed in terms of the current methods of recording police data. Suggestions as to how police data recording might be amended to facilitate a better understanding of car key burglary are considered. [ABSTRACT FROM AUTHOR]

Previous research has shown that as crime scene location deprivation increases (lower socioeconomic status), the recovery of forensic material, principally DNA and fingerprints, also increases. However, this increase does not result in more crimes being solved by forensic means. In this study, we analyze stolen vehicle data and find a statistically significant positive association between deprivation and the amount of forensic material that matched either the victim or an associate of the victim on a criminal database. The nature of this association was investigated further by inspecting recovered stolen vehicles to establish whether the condition of a stolen vehicle and the tidiness of its interior influenced the recovery of forensic material that was attributed to the victim or an associate. Contradictory results suggest that other factors may contribute to understanding the association between the recovery of victim- or associate-attributable forensic material and crime scene location deprivation. [ABSTRACT FROM AUTHOR]

The most widely accepted model of juror decision making acknowledges the importance of both the case-specific information presented in the courtroom, as well as the prior general knowledge and beliefs held by each juror. The studies presented in this paper investigated whether mock jurors could differentiate between evidence of varying strengths in the absence of case information and then followed on to determine the influence that case context (and therefore the story model) has on judgments made about the strength of forensic DNA evidence. The results illustrated that mock jurors correctly identified various strengths of evidence when it was not presented with case information; however, the perceived strength of evidence was significantly inflated when presented in the context of a criminal case, particularly when the evidence was of a weak or ambiguous standard. These findings are discussed in relation to the story model, and the potential implications for real juries. [ABSTRACT FROM AUTHOR]

Since the mandatory introduction in 1998 of electronic immobilisers in all vehicles, new cars are impossible to start without their keys. Some offenders have thus resorted to stealing car keys during domestic burglaries in order to steal the car—a relatively new phenomenon referred to as ‘car key burglaries’. With these crimes becoming an increasing problem in the UK, it is imperative that they are recorded accurately in order to identify the true scope of this problem and tackle it effectively. As yet, no universal definition of a car key burglary exists according to which all police constabularies can work, leading to inconsistencies in the recording of these types of crimes. Car key burglary data recorded by Northamptonshire Police was examined and analysed, and significant differences were found between car key and regular domestic burglaries. These differences pertained to the time of day at which the offence occurred, the neighbourhood in which the offence occurred and the search of the property by the offender. The implications of these findings are discussed, as well as limitations of the study, and possible directions for future research that may allow the police to record a domestic burglary more accurately as a car key burglary. [ABSTRACT FROM AUTHOR]

Collection and interpretation of forensic intelligence (primarily through DNA and fingerprint identifications) is an integral part of the investigation of criminal offenses ranging from burglary and vehicle crime to major crime. The forensic contribution depends not only on the successful recovery of material, but also the ability to identify potential offenders and apply this intelligence to solve the crime. This study examines burglary and vehicle crimes investigated by Northamptonshire Police (U.K.) by analyzing relationships between deprivation of a crime location and the recovery and identification of DNA and fingerprint material. The results show that, for stolen vehicles, although significantly more forensic material (both DNA and fingerprints) is recovered and identified in more deprived neighborhoods, this does not lead to a corresponding increase in solved cases. These findings are considered in relation to previous studies, which have advocated the prioritization of resources at crime scenes most likely to yield forensic material. [ABSTRACT FROM AUTHOR]

We evaluated the safety and efficacy of the purine nucleoside analogue, clofarabine, in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL). Six patients with DLBCL (n = 5) or MCL (n = 1) and a median age of 68 years were treated with 40 mg/m2 clofarabine IV over 2 h for 5 days, repeated every 28 days, for 1-2 cycles. The overall response rate was 50% (complete response = 1, complete response unconfirmed = 1, partial response = 1). Median progression-free survival was 3.5 months (range 1.5-10 months) and the median overall survival was 7.8 months (range 3-31 months). Grade 3-4 neutropenia and thrombocytopenia was universal, with a median of 34 (range 19-55) and 77 (range 0-275) days required for neutrophil and platelet recovery. Grade 3 non-hematologic toxicities included transaminitis, febrile neutropenia, non-neutropenic infections and orthostatic hypotension. Further accrual to the study was terminated due to prolonged Grade 3-4 myelosuppression and orthostatic hypotension in five of six patients. Clofarabine exhibits evidence of single agent activity in relapsed or refractory DLBCL. However, further study with novel administration schedules that maintain this efficacy and limit toxicity is warranted. [ABSTRACT FROM AUTHOR]

Treatment options for chronic lymphocytic leukaemia (CLL) are limited and eventually fail because of the development of toxicities or drug resistance. Thus, identification of new therapeutic strategies and targets is a high priority. The semisynthetic geldanamycin derivative 17-allylamino-17-demethoxygeldanamycin (17-AAG) inhibits heat shock protein 90 (Hsp90) binding to client proteins, thereby leading to their degradation. We demonstrate that at biologically active and clinically attainable levels (1 μmol/l), 17-AAG treatment of CLL B cells in vitro causes modest apoptosis as well as decreased AKT protein levels. Given the potential activation of AKT following antibody therapy in CLL, we evaluated the combination of 17-AAG and rituximab. These agents produced synergistic cytotoxicity of CLL cells in vitro. However, rituximab-mediated antibody-dependent cellular cytotoxicity was modestly reduced with 17-AAG, and complement-dependent cytotoxicity was not altered. We conclude that the combination of Hsp90 inhibitors with therapeutic antibodies, such as rituximab may represent a novel strategy to enhance therapeutic response in CLL. Furthermore, our data indicates that AKT and Hsp70 protein levels are relevant pharmacodynamic endpoints to monitor the in vivo effect of 17-AAG therapy. [ABSTRACT FROM AUTHOR]

A letter to the editor is presented in response to the article "Prolonged myelosuppression with clofarabine in the treatment of patients with relapsed or refractory, aggressive non-Hodgkin lymphoma" in the April 2009 issue.

The article offers information on the "Natural Areas Journal" and its new editor, Ron Hiebert. It says that "Natural Areas Journal" has served the natural community since 1980 as a depository of the most science-based information on natural areas management. Hiebert is the current director of Colorado Plateau Cooperative Ecosystem Studies Unit and served the journal as an associate editor in the 1980s and 1990s. Meanwhile, the author appreciates the people who are committed to the journal.