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The success of business firms and other organizations relies on the trustworthiness of reports and other documents prepared by management accountants. This study examines the personal ethical values and ethical value types of management accountants. Data were obtained from a survey of members of the Institute of Management Accountants (IMA). The survey, composed of the Rokeach Values Survey and demographic questions, was delivered by the IMA Research Lab to membership samples. Importantly, the results indicated that the highest-ranked values were consistent with values included in the IMA's Statement of Ethical Professional Practice. That management accountants hold high ethical values better enables them to provide reliable and meaningful work to business firms and other organizations. Another important finding is that older management accountants are more concerned with moral values than their younger colleagues. This finding has notable implications for the future of the profession. [ABSTRACT FROM AUTHOR]

SARS-CoV-2 infection during pregnancy was associated with maternal mortality and adverse birth outcomes in the pre-Omicron era, including a stillbirth rate of 5.6% in Botswana. We re-evaluated these outcomes in the Tsepamo Study during the Omicron era. We assessed maternal mortality and adverse birth outcomes for all singleton pregnancies from mid-November 2021 (the start of the Omicron era) to mid-August 2022 at nine Tsepamo sites, among individuals with documented SARS-CoV-2 screening PCR or antigen tests and known HIV status. Of 9,705 women routinely screened for SARS-CoV-2 infection at delivery (64% of deliveries at these sites), 373 (3.8%) tested positive. Women with HIV were as likely to test positive for SARS-CoV-2 (77/1833, 4.2%) as women without HIV (293/6981, 4.2%) (p = 1.0). There were 5 recorded maternal deaths (0.03%), one occurring in a woman with a positive SARS-CoV-2 test result. In contrast, maternal mortality was 3.7% and 0.1% in those with and without SARS-CoV-2, respectively, during the pre-Omicron era. In the Omicron era, there were no differences among infants exposed or unexposed to SARS-CoV-2 in overall adverse birth outcomes (28.1% vs 29.6%; aRR 1.0, 95%CI 0.8–1.1), severe adverse birth outcomes (11.9 vs 10.6%; aRR 1.1, 95%CI 0.8–1.5), preterm delivery (15.1% vs 14.9%; aRR 1.0, 95%CI 0.8–1.3), or stillbirth (1.9% vs 2.3%; aRR 0.8, 95%CI 0.4–1.7). Adverse outcomes among those exposed to both HIV and SARS-CoV-2 were similar to those exposed to HIV alone (31.2% vs. 33.1%; aRR 0.9, 95%CI 0.6–1.3; p = 0.5). Maternal mortality was far lower in Botswana during the Omicron era than in the pre-Omicron era, and adverse birth outcomes were no longer significantly impacted by exposure to SARS-CoV-2 either overall or with HIV co-exposure. Increased population immunity to SARS-CoV-2, less stress on the hospital systems in the Omicron era, and possible differences in viral pathogenicity may combine to explain these findings. [ABSTRACT FROM AUTHOR]

Human trafficking continues to be a profitable multi-billion dollar business. People are either callous toward human rights or they are unaware of the crime occurring. Many businesses may unknowingly facilitate human trafficking by providing services, such as transportation, hotels, or haircuts, or purchasing products from unfamiliar sources that secretly use forced labor. To be socially responsible, a business must establish effective enterprise governance policies that help prevent and detect trafficking. A business can incur legal fines, damage to its reputation, incur lost business, and be subject to litigation, all as a result of human trafficking. Worldwide, estimates are that 50 million people are being trafficked. Human trafficking is especially harmful to females, both adult women and girls, who comprise about 70 percent of all trafficking victims. Gender theory helps explain this disproportionate impact on women. This study provides an overview of human trafficking, an empirical analysis of the relationship of gender inequality to trafficking, and specific steps that a business can take to help prevent this crime, protect its reputation, and avoid fines and lost business. [ABSTRACT FROM AUTHOR]

Traditional methods of shielding fragile goods and human tissues from impact energy rely on isotropic foam materials. The mechanical properties of these foams are inferior to an emerging class of metamaterials called plate lattices, which have predominantly been fabricated in simple 2.5‐dimensional geometries using conventional methods that constrain the feasible design space. In this work, additive manufacturing is used to relax these constraints and realize plate lattice metamaterials with nontrivial, locally varying geometry. The limitations of traditional computer‐aided design tools are circumvented and allow the simulation of complex buckling and collapse behaviors without a manual meshing step. By validating these simulations against experimental data from tests on fabricated samples, sweeping exploration of the plate lattice design space is enabled. Numerical and experimental tests demonstrate plate lattices absorb up to six times more impact energy at equivalent densities relative to foams and shield objects from impacts ten times more energetic while transmitting equivalent peak stresses. In contrast to previous investigations of plate lattice metamaterials, designs with nonuniform geometric prebuckling in the out‐of‐plane direction is explored and showed that these designs exhibit 10% higher energy absorption efficiency on average and 25% higher in the highest‐performing design. [ABSTRACT FROM AUTHOR]

Prior research has examined the relationship of religiosity to aspects of business risks, notably, the ethical environment in which business firms operate. Religiosity is connected to economic factors and societal factors. This study examines the relationship of religion-based ethics, specifically Judeo-Christian ethicality, in a country (measured by Judeo-Christian presence as a proportion of the population) to economic freedom, economic activity, gender equality, social progress, and corruption. Modern business firms, in efforts to embrace diversity, accommodate cultural factors such as religiosity, particularly so in multinational operations where diverse religions will be encountered. Findings show that Judeo-Christian ethicality has a positive relationship to factors connected to a society's sustainable business culture—that is, more economic freedom, higher economic activity, improved gender equality, better social progress, and lower corruption. [ABSTRACT FROM AUTHOR]

Mechanisms of cell reprogramming by pluripotency-related transcription factors or nuclear transfer seem to be mediated by similar pathways, and the study of the contribution of OCT4 and SOX2 in both processes may help elucidate the mechanisms responsible for pluripotency. Bovine fibroblasts expressing exogenous OCT4 or SOX2, or both, were analyzed regarding the expression of pluripotency factors and imprinted genes H19 and IGF2R, and used for in vitro reprogramming. The expression of the H19 gene was increased in the control sorted group, and putative iPSC-like cells were obtained when cells were not submitted to cell sorting. When sorted cells expressing OCT4, SOX2, or none (control) were used as donor cells for somatic cell nuclear transfer, fusion rates were 60.0% vs. 64.95% and 70.53% vs. 67.24% for SOX2 vs. control and OCT4 vs. control groups, respectively; cleavage rates were 66.66% vs. 81.68% and 86.47% vs. 85.18%, respectively; blastocyst rates were 33.05% vs. 44.15% and 52.06% vs. 44.78%, respectively. These results show that the production of embryos by NT resulted in similar rates of in vitro developmental competence compared to control cells regardless of different profiles of pluripotency-related gene expression presented by donor cells; however, induced reprogramming was compromised after cell sorting. [ABSTRACT FROM AUTHOR]

We sought to investigate whether SARS‐CoV‐2 was present, and to perform full‐length genomic sequencing, in a 5‐year‐old male crossbreed dog from Gaborone, Botswana that presented overt clinical signs (flu‐like symptoms, dry hacking cough and mild dyspnoea). It was only sampled a posteriori, because three adult owners were diagnosed with SARS‐CoV‐2 infection. Next‐generation sequencing based on Oxford Nanopore Technology (ONT) was performed on amplicons that were generated using a reverse transcriptase real‐time polymerase chain reaction (RT‐qPCR) of confirmed positive SARS‐CoV‐2 nasopharyngeal and buccal swabs, as well as a bronchoalveolar lavage with mean real cycle threshold (qCt) value of 36 based on the Nucleocapsid (N) gene. Descriptive comparisons to known sequences in Botswana and internationally were made using mutation profiling analysis and phylogenetic inferences. Human samples were not available. A near‐full length SARS‐CoV‐2 genome (∼90% coverage) was successfully genotyped and classified under clade 20 O and Pango‐Lineage AY.43 (Pango v.4.0.6 PLEARN‐v1.3; 2022‐04‐21), which is a sublineage of the Delta variant of concern (VOC) (formerly called B.1.617.2, first detected in India). We did not identify novel mutations that may be used to distinguish SARS‐CoV‐2 isolates from the dog and humans. In addition to Spike (S) region mutation profiling, we performed phylogenetic analysis including 30 Delta sequences publicly available reference also isolated from dogs. In addition, we performed another exploratory analysis to investigate the phylogenetic relatedness of sequence isolated from dog with those from humans in Botswana (n = 1303) as of 31 March 2022 and of same sublineage. Expectedly, the sequence formed a cluster with Delta sublineages – AY.43, AY.116 and B.1.617.2 – circulating in same time frame. This is the first documented report of human‐associated SARS‐CoV‐2 infection in a dog in Botswana. Although the direction of transmission remains unknown, this study further affirms the need for monitoring pets during different COVID‐19 waves for possible clinically relevant SARS‐CoV‐2 transmissions between species. [ABSTRACT FROM AUTHOR]

In this study, we examine major cryptocurrencies, present notable fraud cases, describe fraud risks, and analyze cryptocurrency financial performance. People debate whether cryptocurrency is an investment opportunity, the new Dutch Tulip Bubble, or a giant Ponzi scheme. There have been a number of high-profile fraud cases associated with cryptocurrencies, such as the FTX scandal in late 2022, thereby making fraud a real concern to current and potential future investors. Regarding financial performance, cryptocurrencies experienced a major collapse in value in the most recent period of the study, about three times worse than the major stock market indices. While in prior periods, cryptocurrencies have significantly outperformed stock market indices, recent fraud cases and the extreme volatility of cryptocurrencies indicate that investing in cryptocurrencies comes with much higher risk than traditional stock market investments. The debate over the investment potential of cryptocurrencies continues, whether they have long term value or are simply the new Dutch Tulip Bubble. The study's findings will be useful to investors, regulators, and academic researchers regarding the cryptocurrency industry. [ABSTRACT FROM AUTHOR]

Thermal bubble-driven micro-pumps are an upcoming actuation technology that can be directly integrated into micro/mesofluidic channels to displace fluid without any moving parts. These pumps consist of high power micro-resistors, which we term thermal micro-pump (TMP) resistors, that locally boil fluid at the resistor surface in microseconds creating a vapor bubble to perform mechanical work. Conventional fabrication approaches of thermal bubble-driven micro-pumps and associated microfluidics have utilized semiconductor micro-fabrication techniques requiring expensive tooling with long turn around times on the order of weeks to months. In this study, we present a low-cost approach to rapidly fabricate and test thermal bubble-driven micro-pumps with associated microfluidics utilizing commercial substrates (indium tin oxide, ITO, and fluorine doped tin oxide, FTO, coated glass) and tooling (laser cutter). The presented fabrication approach greatly reduces the turn around time from weeks/months for conventional micro-fabrication to a matter of hours/days allowing acceleration of thermal bubble-driven micro-pump research and development (R&D) learning cycles. [ABSTRACT FROM AUTHOR]

In 1494, the first printed book on double-entry accounting was written by Franciscan Friar Luca Pacioli, later called the Father of Accounting. He would become close friends with Leonardo da Vinci, the iconic symbol of the Renaissance. This study analyzes simultaneously the lives of Pacioli and Leonardo, using a 'biographical lens' approach, incorporating older research and more recent work, to shed new light on their lives and contributions, providing a glimpse of how they became friends, where their lives intersected, some interests they shared, and how each contributed to the other's work. Preparers and users of financial information are indebted to Luca Pacioli for his monumental role in the development of accounting. His friend, Leonardo, made myriad contributions to art and science, notably world-famous paintings such as the Last Supper. Pacioli and Leonardo changed the course of history with their exceptional contributions, sometimes collaborating, to their respective fields. [ABSTRACT FROM AUTHOR]

The Princess Marina Hospital in Gaborone, Botswana, had an outbreak of COVID-19 from early August 2020. The aim of this paper was to describe the outbreak investigation. The investigation's specific objectives were to describe the COVID-19 cases in terms of person, place, and time (PPT) and to determine measures to prevent further transmission of the infection. The data reported herein were collected over a 3-month period from beginning of August to end of October 2020. The investigation included all COVID-19 cases i.e. both patients and healthcare workers. It followed the steps of an outbreak investigation. These included assembling an investigation team comprising both the hospital and DHMT staff. All the wards reported their confirmed cases to the infection control team who in turn prepared line lists and case reports. Epicurves were produced from date of positive result. A total of 193 cases were reported, of which 110 (57.0%) were patients and 83 (43.0%) were healthcare workers. The median age was 35 years. Females accounted for 154 (79.8%) participants. Most of the wards were affected. The wards with the highest numbers of cases were female medical ward (39), emergency department (24), gynecology ward (17), and pediatric medical ward (10). Control measures included restricting movement into the hospital as well as clinical screening at all entry points. Furthermore, all patients were tested before admission into the wards. Surveillance of COVID-19 cases was continued beyond the 3 months reported in this paper. COVID-19 can spread rapidly in hospital settings affecting both patients and healthcare workers. Outbreak investigations including describing cases in terms of person, place, and time are critical if the most effective and efficient control measures are to be implemented. [ABSTRACT FROM AUTHOR]

Tissue engineering is gaining use to investigate the application of its techniques for infertility treatment. The use of pluripotent embryonic cells for in vitro production of viable spermatozoa in testicular scaffolds is a promising strategy that could solve male infertility. Due to cell–extracellular matrix (ECM) interactions, here we aim to investigate the differentiation of embryoid bodies (EBs) in cultured into decellularized rat testis scaffolds. Decellularized testis (P = 0.019) with a low concentration of gDNA (30.58 mg/ng tissue) was obtained by sodium dodecyl sulfate perfusion. The structural proteins (collagens type I and III) and the adhesive glycoproteins of ECM (laminin and fibronectin) were preserved according to histological and scanning electron microscopy (SEM) analyses. Then, decellularized rat testis were cultured for 7 days with EB, and EB mixed with retinoic acid (RA) in non-adherent plates. By SEM, we observe that embryonic stem cells adhered in the decellularized testis ECM. By immunofluorescence, we verified the positive expression of HSD17B3, GDNF, ACRV-1, and TRIM-36, indicating their differentiation using RA in vitro, reinforcing the possibility of EB in male germ cell differentiation. Finally, recellularized testis ECM may be a promising tool for future new approaches for testicular cell differentiation applied to assisted reproduction techniques and infertility treatment. Abbreviations: ACRV-1: Acrosomal vesicle protein 1; ATB: Penicillin-streptomycin; DAPI: 4,6-Diamidino-2-phenylindole; EB: Embryoid bodies; ECM: Extracellular matrix; ESCs: Pluripotent embryonic stem cells; GAGs: Glycosaminoglycans; gDNA: Genomic DNA; GDNF: Glial cell line-derived neurotrophic factor; H&E: Hematoxylin and eosin; HSD17B3: 17-beta-Hydroxysteroid dehydrogenase type 3; PBS: Phosphate-buffered saline; PGCLCs: Primordial germ-cell-like cells; RA: Retinoic acid; SDS: Sodium dodecyl sulfate; SEM: Scanning electron microscopy; SSCs: Spermatogonial stem cells; TRIM-36: Tripartite Motif Containing 36; [ABSTRACT FROM AUTHOR]

The cellular reprogramming into pluripotency is influenced by external and internal cellular factors, such as in vitro culture conditions (e.g., environmental oxygen concentration), and the aging process. Herein, we aimed to generate and maintain equine iPSCs (eiPSCs) derived from fibroblasts of a horse older than 20 years and to evaluate the effect of different levels of oxygen tension (atmospheric 20% O2, 5% O2, or 20% to 5% O2) on these cells. Fibroblasts were reprogrammed, and putative eiPSCs were positive for positive alkaline phosphatase detection; they were positive for pluripotency-related genes OCT4, REX1, and NANOG; immunofluorescence-positive staining was presented for OCT4 and NANOG (all groups), SOX2 (groups 5% O2 and 20% to 5% O2), and TRA-1-60, TRA-1-81, and SSEA-1 (only in 20% O2); they formed embryoid bodies; and there is spontaneous differentiation in mesoderm, endoderm, and ectoderm embryonic germ layers. In addition to the differences in immunofluorescence analysis results, the eiPSC colonies generated at 20% O2 presented a more compact morphology with a well-defined border than cells cultured in 5% O2 and 20% to 5% O2. Significant differences were also observed in the expression of genes related to glucose metabolism, mitochondrial fission, and hypoxia (GAPDH, GLUT3, MFN1, HIF1α, and HIF2α), after reprogramming. Our results show that the derivation of eiPSCs was not impaired by aging. Additionally, this study is the first to compare high and low oxygen cultures of eiPSCs, showing the generation of pluripotent cells with different profiles. Under the tested conditions, the lower oxygen tension did not favor the pluripotency of eiPSCs. This study shows that the impact of oxygen atmosphere has to be considered when culturing eiPSCs, as this condition influences the pluripotency characteristics. [ABSTRACT FROM AUTHOR]

The cellular reprogramming into pluripotency is influenced by external and internal cellular factors, such as in vitro culture conditions (e.g., environmental oxygen concentration), and the aging process. Herein, we aimed to generate and maintain equine iPSCs (eiPSCs) derived from fibroblasts of a horse older than 20 years and to evaluate the effect of different levels of oxygen tension (atmospheric 20% O2, 5% O2, or 20% to 5% O2) on these cells. Fibroblasts were reprogrammed, and putative eiPSCs were positive for positive alkaline phosphatase detection; they were positive for pluripotency-related genes OCT4, REX1, and NANOG; immunofluorescence-positive staining was presented for OCT4 and NANOG (all groups), SOX2 (groups 5% O2 and 20% to 5% O2), and TRA-1-60, TRA-1-81, and SSEA-1 (only in 20% O2); they formed embryoid bodies; and there is spontaneous differentiation in mesoderm, endoderm, and ectoderm embryonic germ layers. In addition to the differences in immunofluorescence analysis results, the eiPSC colonies generated at 20% O2 presented a more compact morphology with a well-defined border than cells cultured in 5% O2 and 20% to 5% O2. Significant differences were also observed in the expression of genes related to glucose metabolism, mitochondrial fission, and hypoxia (GAPDH, GLUT3, MFN1, HIF1α, and HIF2α), after reprogramming. Our results show that the derivation of eiPSCs was not impaired by aging. Additionally, this study is the first to compare high and low oxygen cultures of eiPSCs, showing the generation of pluripotent cells with different profiles. Under the tested conditions, the lower oxygen tension did not favor the pluripotency of eiPSCs. This study shows that the impact of oxygen atmosphere has to be considered when culturing eiPSCs, as this condition influences the pluripotency characteristics. [ABSTRACT FROM AUTHOR]

Orchestrated events, including extensive changes in epigenetic marks, allow a somatic nucleus to become totipotent after transfer into an oocyte, a process termed nuclear reprogramming. Recently, several strategies have been applied in order to improve reprogramming efficiency, mainly focused on removing repressive epigenetic marks such as histone methylation from the somatic nucleus. Herein we used the specific and non-toxic chemical probe UNC0638 to inhibit the catalytic activity of the histone methyltransferases EHMT1 and EHMT2. Either the donor cell (before reconstruction) or the early embryo was exposed to the probe to assess its effect on developmental rates and epigenetic marks. First, we showed that the treatment of bovine fibroblasts with UNC0638 did mitigate the levels of H3K9me2. Moreover, H3K9me2 levels were decreased in cloned embryos regardless of treating either donor cells or early embryos with UNC0638. Additional epigenetic marks such as H3K9me3, 5mC, and 5hmC were also affected by the UNC0638 treatment. Therefore, the use of UNC0638 did diminish the levels of H3K9me2 and H3K9me3 in SCNT-derived blastocysts, but this was unable to improve their preimplantation development. These results indicate that the specific reduction of H3K9me2 by inhibiting EHMT1/2 during nuclear reprogramming impacts the levels of H3K9me3, 5mC, and 5hmC in preimplantation bovine embryos. [ABSTRACT FROM AUTHOR]

Purpose Cybercrime is a prevalent and serious threat to publicly traded companies. Defending company information systems from cybercrime is one of the most important aspects of technology management. Cybercrime often not only results in stolen assets and lost business but also damages a company's reputation, which in turn may affect the company's stock market value. This is a serious concern to company managers, financial analysts, investors and creditors. This paper aims to examine the impact of cybercrime on stock prices of a sample of publicly traded companies.Design/methodology/approach Financial data were gathered on companies that were reported in news stories as victims of cybercrime. The market price of the company's stock was recorded for several days before the news report and several days after. The percentage change in the stock price was compared to the change in the Dow Jones Industrial average to determine whether the stock price increased or decreased along with the rest of the market.Findings Stock prices were negatively affected in all time periods examined, significantly so in one period.Practical implications This paper describes cases concerning cybercrime, thereby bringing attention to the value of cybersecurity in protecting computers, identity and transactions. Cyber security is necessary to avoid becoming a victim of cybercrime. Specific security improvements and preventive measures are provided within the paper. Preventive measures are generally less costly than repairs after a cybercrime.Originality/value This is an original manuscript that adds to the literature regarding cybercrime and preventive measures. [ABSTRACT FROM AUTHOR]

Copyright of Études Inuit Studies is the property of Centre interuniversitaire d'etudes et de recherches autochtones (CIERA) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Miss Julie via Manda Björling, 1906-1912: Embodiment, Conceptual Blending, and Reception. [Extracted from the article]

Prior research indicates that a business firm benefits when it includes social media in the firm's marketing mix. Social media links a firm to consumers, investors, workers, suppliers, lenders, and other stakeholders. Social media platforms range from older platforms, such as Facebook and Twitter, to more recent platforms, such as Google+ and Instagram. Identifying the social networking sites that are most beneficial to a firm and its customers can be a challenge. The present study empirically analyzes the use of social media by major technology firms to determine which platforms the firms use and whether use varies according to company size (total revenue). Results will be of meaningful to business leaders and firm managers in the technology industry, as well as to academicians who study the effect of emerging technologies, specifically social media, on technology firms. From an ethical perspective, firms must disseminate information that is dependable and correct; social media provides an efficient means for firms to distribute information to customers, investors, and others. [ABSTRACT FROM AUTHOR]

The Canadian experience in removing the ceiling on federally insured mortgage loans provides a good illustration of the structural implications of the ceiling. After the ceiling was removed, the ratio of the conventional mortgage rate to the NHA rate fell from 112.8 percent to 103.0 percent, indicating that the ceiling provided a benefit of approximately 10 percent of the conventional mortgage rate for NHA borrowers. On the other hand, the ceiling substantially reduced the availability of this credit since the proportion of financial institution mortgage lending for new residential construction that was federally insured almost doubled after the ceiling was removed. Moreover, this reduction in availability fell primarily on low income borrowers since the proportion of NHA loans going to the bottom third of the income distribution rose from approximately 13 percent to 30 percent after the ceiling was removed. Thus, the removal of the rate ceiling on federally insured mortgage loans increased the cost of this credit by approximately 10 percent of the conventional mortgage rate, but substantially increased the availability of this credit, especially for low income borrowers. [ABSTRACT FROM AUTHOR]

Finally, Fair argues that the mortgage market has an asymmetrical effect on the housing market, exercising a greater restraining than stimulating influence. This point is often made about monetary policy in general on the ground that "you can lead a horse to water but you can't make him drink." However, one must be very careful when making this argument to distinguish between movements along a curve and movements of the curve. For a given set of builder expectations as to future sales and profit margins, higher mortgage costs or less favourable borrowing terms reduce housing starts by reducing the return on rental dwellings and the saleability of owner-occupancy dwellings, while a subsequent decline in mortgage costs and improvement in borrowing terms stimulate housing starts analogously. However, ordinarily borrowing terms improve and rates decline when there is a reduction in the overall rate of growth of the economy, while borrowing terms become more stringent and rates increase when economic activity increases. Since variations in the rate of growth of economic activity are likely to affect builder expectations, the apparent asymmetrical effect of the mortgage market on housing starts is more likely to come from a coincident shift in expectations than from a pure asymmetry in the mortgage market. [ABSTRACT FROM AUTHOR]

The article examines the impact of price and interest rate expectations on the demand for money in Canada. The authors present a demand function for money and estimate it in logarithmic fashion using quarterly observations from January, 1955 to December, 1967. Data include yields on Canadian government securities of three different maturities, and two separate measures for money. Results indicate that interest rates and income significantly affect the demand for real cash balances. Expectations for interest rates and prices were also significant factors.

The article investigates how the effect of changes in money supply affects nominal interest rates through changes in the real rate of interest and through changes in the expected rate of inflation. The article also empirically estimates these effects of money on interest rates. The article discusses the effects of money on short, medium and long-term interest rates and derive the real yield curve. One of the conclusions resulting from the article's study is that unexpected monetary changes have a significant but temporary impact on real interest rates, with the greatest impact occurring on the short-end of the market. Several other conclusions are also presented.

The growing number of students whose primary language does not match the language of their schools and a steadily growing performance gap has prompted widespread attention to support emergent literacy gains for those students. This study randomly assigned schools in a Southwestern U.S. state with English language learners (ELLs) in kindergarten and first grade to an experimental computer‐assisted instruction (CAI) condition or a ‘business as usual’ control. The study tracked ELLs performance over one academic year using a nationally normed standardised reading test. The results demonstrated first‐grade students in the experimental condition demonstrated greater gains compared with the control students in the domains of vocabulary, phonics, phonological awareness and text comprehension. Gains for kindergarten were less consistent; however, the lowest language proficient students using CAI experienced greater gains in vocabulary when compared with controls. Results extend prior studies targeting ELL students' reading skill development with targeted CAI interventions. What is already known about this topic English language learners (ELLs) face additional struggles in gaining literacy proficiency in the early grades. Computer‐assisted instruction (CAI) programs support learning for non‐ELLs, provided the instructional materials target specific literacy needs directly. Efficacy of CAIs (and any instructional program) is dependent upon the match between learner needs, classroom curriculum and programmatic features. What this paper adds Large randomised control trial testing the effects of a CAI on ELL literacy development in kindergarten and first‐grade students. Measures of progressive learner development in critical literacy skills using a nationally normed measure of reading achievement. Explicit attention to the levels of language proficiency intersecting with the use of the CAI to identify interaction effects Implications for theory, policy or practice Computer‐assisted instruction support for second language learners can be effective for targeted literacy gains, provided the program materials support critical literacy needs. Use of CAI may be instrumental to support emergent literacy given the ability to capitalise on the proposed pedagogical interventions for second language learners. Stress the importance of maintaining attention to the existing language skills of second language learners when examining the efficacy of literacy interventions. [ABSTRACT FROM AUTHOR]

Growing evidence suggests an alerting effect of monochromatic blue light on brain activity. Little is known about the moderation of those effects by timing and duration of exposure. The present electroencephalography (EEG) study examined such moderations on delta, theta, alpha1, alpha2, and beta EEG bands. A counterbalanced repeated-measures design was applied. The 16-hr daytime period was divided into three sessions: 07:00-12:20, 12:20-17:40, and 17:40-23:00 (timing of exposure). Two light conditions comparable in luminance but differing in wavelength were applied, namely polychromatic white light and monochromatic blue light (460 nm). There were two durations of exposure—the shorter one lasting 30 min and the longer one lasting 4 hrs. Thirty male students participated in the study. Four factors analyses of variance (ANOVAs, for light conditions, timing of exposure, duration of exposure, and brain area) were performed on each EEG band. Results indicated an alerting effect of short exposure to monochromatic blue light at midday and in the evening, which was demonstrated by a decrease in lower frequency bands (alpha1, delta, and theta, respectively). Long exposure to blue light may have a reverse effect, especially in the morning and at midday, when increases in lower frequency bands (theta in the morning and theta and alpha1 at midday) were observed. It can be concluded that the daytime effect of monochromatic blue light on EEG activity depends on timing and duration of exposure. [ABSTRACT FROM AUTHOR]

Objectives: Existing research has documented that shiftwork consequences may depend on the shift system parameters. Fast rotating systems (1-3 shifts of the same kind in a row) and day work have been found to be less disruptive biologically and socially than slower rotating systems and afternoon and night work. The aim of this study was to compare day workers and shift workers of different systems in terms of rotation speed and shifts worked with regard to work-family and family-work positive and negative spillover, marital communication style, job satisfaction and health.Material and Methods: Employees (N = 168) of the maintenance workshops of transportation service working different shift systems (day shift, weekly rotating 2 and 3‑shift system, and fast rotating 3-shift system) participated in the study. They completed the Work- Family Spillover Questionnaire, Marital Communication Questionnaire, Minnesota Job Satisfaction Questionnaire and the Physical Health Questionnaire (a part of the Standard Shiftwork Index).Results: The workers of quicker rotating 3-shift systems reported significantly higher scores of family-to-work facilitation (F(3, 165) = 4.175, p = 0.007) and a higher level of constructive style of marital communication (Engagement F(3, 165) = 2.761, p = 0.044) than the workers of slower rotating 2-shift systems. There were no differences between the groups of workers with regard to health and job satisfaction.Conclusions: A higher level of work-family facilitation and a more constructive style of marital communication were found among the workers of faster rotating 3-shift system when compared to the workers of a slower rotating 2-shift system (afternoon, night). This may indicate that the fast rotating shift system in contrary to the slower rotating one is more friendly for the work and family domains and for the relationship between them. Int J Occup Med Environ Health 2017;30(1):121-131. [ABSTRACT FROM AUTHOR]

The neural system is one of the earliest systems to develop and the last to be fully developed after birth. This study presents a detailed description of organogenesis of the central nervous system (CNS) at equine embryonic/fetal development between 19 and 115 days of pregnancy. The expression of two important biomarkers in the main structure of the nervous system responsible for neurogenesis in the adult individual, and in the choroid plexus, was demonstrated by Nestin and glial fibrillary acid protein (GFAP) co-labeling. In the 29th day of pregnancy in the undifferentiated lateral ventricle wall, the presence of many cells expressing Nestin and few expressing GFAP was observed. After the differentiation of the lateral ventricle wall zones at 60 days of pregnancy, the subventricular zone, which initially had greater number of Nestin cells, began to show higher numbers of GFAP cells at 90 days of pregnancy. A similar pattern was observed for Nestin and GFAP cells during development of the choroid plexus. This study demonstrates, for the first time, detailed chronological aspects of the equine central nervous system organogenesis associated with downregulation of Nestin and upregulation of GFAP expression. [ABSTRACT FROM AUTHOR]

The article presents a comment on the article "Housing Choice and Relative Tenure Prices," by William B. Brueggeman and Richard B. Peiser, published in the November 1979 issue of the "Journal of Financial and Quantitative Analysis." The author takes issue with the fact that the authors overlooked the more interesting and difficult implications of their work, such as why a bias for home ownership exists, are markets imperfect and what is the length of lag time in adjustment, what impact does taxation have on the bias, what is the impact of changing prices and expectation on the bias and adjustment process, and what are the consequences of joint investment-consumption aspects of ownership.

Extracting information efficiently from game/simulation-based assessment (G/ SBA) logs requires two things: a well-structured log file and a set of analysis methods. In this report, we propose a generic data model specified as an extensible markup language ( XML) schema for the log files of G/ SBAs. We also propose a set of analysis methods for identifying useful information from the log files and implement the methods in a package in the Python programming language, glassPy. We demonstrate the data model and glassPy with logs from a game-based assessment, SimCityEDU. [ABSTRACT FROM AUTHOR]

Mouse models are widely employed to study mitochondrial inheritance, which have implications to several human diseases caused by mutations in the mitochondrial genome (mtDNA). These mouse models take advantage of polymorphisms between the mtDNA of the NZB/BINJ and the mtDNA of common inbred laboratory (i.e., C57BL/6) strains to generate mice with two mtDNA haplotypes (heteroplasmy). Based on PCR followed by restriction fragment length polymorphism (PCR-RFLP), these studies determine the level of heteroplasmy across generations and in different cell types aiming to understand the mechanisms underlying mitochondrial inheritance. However, PCR-RFLP is a time-consuming method of low sensitivity and accuracy that dependents on the use of restriction enzyme digestions. A more robust method to measure heteroplasmy has been provided by the use of real-time quantitative PCR (qPCR) based on allelic refractory mutation detection system (ARMS-qPCR). Herein, we report an ARMS-qPCR assay for quantification of heteroplasmy using heteroplasmic mice with mtDNA of NZB/BINJ and C57BL/6 origin. Heteroplasmy and mtDNA copy number were estimated in germline and somatic tissues, providing evidence of the reliability of the approach. Furthermore, it enabled single-step quantification of heteroplasmy, with sensitivity to detect as low as 0.1% of either NZB/BINJ or C57BL/6 mtDNA. These findings are relevant as the ARMS-qPCR assay reported here is fully compatible with similar heteroplasmic mouse models used to study mitochondrial inheritance in mammals. [ABSTRACT FROM AUTHOR]

Animal breeders have made widespread use of assisted reproductive technologies to accelerate genetic improvement programs aimed at obtaining more, better and cheaper food products. Selection approaches have traditionally focused on Mendel's laws of inheritance using parental phenotypic characteristics and quantitative genetics approaches to choose the best parents for the next generation, regardless of their gender. However, apart from contributing DNA sequence variants, male and female gametes carry parentalspecific epigenetic marks that play key roles during pre- and post-natal development and growth of the offspring. We herein review the epigenetic anomalies that are associated with artificial reproductive technologies in current use in animal breeding programs. For instance, we demonstrate that bovine embryos and fetuses derived by in vitro culture and somatic cell nuclear transfer show epigenetic anomalies in the differentially methylated regions controlling the expression of some imprinted genes. Although these genomic imprinting errors are undetected in the somatic tissues after birth, further research is warranted to examine potential germ cell transmission of epimutations and the potential risks of reproducing cattle using artificial reproductive technologies. [ABSTRACT FROM AUTHOR]

The story of 'Jessie Brown' emerged within a faux eyewitness account to the socalled Indian Mutiny of 1857. Subsequently elaborated and distributed via a 'global republic of performance' (including journalism, ballad poetry, musical compositions, dioramas, exhibitions and stage spectacles), Jessie Brown exposed class- and ethnic-based dissonances within the British imperialist project. The culmination of this process was the elaborate 'contemporaneous drama' Jessie Brown; or, The Relief of Lucknow (1858), by Dion Boucicault. Due to ongoing developments in a real-world colonial conflict, Boucicault employed melodramatic elements non-formulaically, including a sonically enhanced, proto-cinematic tableau vivant in lieu of a conventional dramatic resolution. This article augments the study of nineteenth-century literature by developing a 'global republic of performance' model used to analyse and account for the Jessie Brown phenomenon in its various media elaborations. [ABSTRACT FROM AUTHOR]