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1. Synthesis of benzooxepane-fused cyclobutene derivatives via Pd-catalyzed cascade reactions of haloarenes and diynylic ethers.

Author

Shugao Zhu, Wenliang Huang, Shihan Liu, Rongjing Yu, Yufeng Ma, Hong Wang, Rui Zhang, Bin Liu, Yu Lan, and Ruwei Shen

Subjects
ARYL halides, ETHERS, ISOMERIZATION, RING formation (Chemistry)
Abstract

A tandem palladium-catalyzed Sonogashira coupling, propargyl-allenyl isomerization, and [2+2] cycloaddition sequence between electrondeficient haloarenes and 1,8-diynylic ethers is developed. The reaction shows good functional tolerance and proceeds under mild conditions to provide a new profile of benzooxepane-fused cyclobutene derivatives in moderate to high yields with high selectivity. The reaction mechanism is validated both by experimental studies and DFT calculations. [ABSTRACT FROM AUTHOR]

Published
2024
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