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In this article, we explore multi-material additive manufacturing (MMAM) for conductive trace printing using molten metal microdroplets on polymer substrates to enhance digital signal transmission. Investigating microdroplet spread informs design rules for adjacent trace printing. We studied the effects of print distance on trace morphology and resolution, noting that printing distance showed almost no change in the printed trace pitch. Crosstalk interference between adjacent signal traces was analyzed across frequencies and validated both experimentally and through simulation; no crosstalk was visible for printed traces at input frequencies below 600 kHz. Moreover, we demonstrate printed trace reliability against thermal shock, whereby no discontinuation in conductive traces was observed. Our findings establish design guidelines for MMAM electronics, advancing digital signal transmission capabilities. [ABSTRACT FROM AUTHOR]

The technology to jet print metal lines with precise shape fidelity on diverse substrates is gaining higher interest across multiple research fields. It finds applications in additively manufactured flexible electronics, environmentally friendly and sustainable electronics, sensor devices for medical applications, and fabricating electrodes for solar cells. This paper provides an experimental investigation to deepen insights into the non-contact printing of solder lines using StarJet technology, eliminating the need for surface activation, substrate heating, curing, or post-processing. Moreover, it employs bulk metal instead of conventional inks or pastes, leading to cost-effective production and enhanced conductivity. The effect of molten metal temperature, substrate temperature, standoff distance, and printing velocity was investigated on polymer foils (i.e., PET sheets). Robust printing parameters were derived to print uniform, bulge-free, bulk metal lines suitable for additive manufacturing applications. The applicability of the derived parameters was extended to 3D-printed PLA, TPU, PA-GF, and PETG substrates having a much higher surface roughness. Additionally, a high aspect ratio of approx. 16:1 wall structure has been demonstrated by printing multiple metal lines on top of each other. While challenges persist, this study contributes to advancing additively manufactured electronic devices, highlighting the capabilities of StarJet metal jet-printing technology. [ABSTRACT FROM AUTHOR]

This paper presents layer‐by‐layer additive manufacturing (AM) of molten metal microdroplets and dielectric materials to fabricate multilayer hybrid circuit boards featuring interdigitated 3D capacitors. The printed metal lines have a low resistance of 5 mΩ/mm, 12 times lower than state‐of‐the‐art conductive inks. Exploiting the advantages of Sn‐based oxide as an ideal candidate for Electrical Energy Storage Systems (ESS), we successfully fabricated an out‐of‐plane capacitor module using a combination of polymer and metal materials. The fabrication process exhibited an exceptional aspect ratio of 16, illustrating the successful incorporation of 20 metal layers in the out‐of‐plane capacitor module. Q factor obtained for the 3D capacitor was in the range of 66–500. Additionally, a fully automated printing technique was employed to produce a multilayer hybrid electrical printed circuit board (PCB), eliminating the need for post‐processing. This streamlined approach presents an efficient and comprehensive solution for the one‐stop printing of intricate electrical circuits. © 2024 The Authors. IEEJ Transactions on Electrical and Electronic Engineering published by Institute of Electrical Engineer of Japan and Wiley Periodicals LLC. [ABSTRACT FROM AUTHOR]

Additive manufacturing (AM), so‐called 3D printing, has reshaped manufacturing technologies with attractive alternatives to the traditional centralized, subtractive‐based mass production. Further functionalities like multimaterial AM (MMAM) are essential for mainstream manufacturing. With MMAM of electrical traces, the traditional printed circuit board can be transformed to freeform 3D electronics using the entire volumetric space. Although research groups attempt MMAM for freeform 3D electronics, achieving easy integration of the electrical traces with high conductance into dielectric substrates in a streamlined and simplified process remains challenging. Herein, an in‐house developed printer, named Synkròtima, is demonstrated for one‐stop printing of 3D dielectric parts with fully embedded and structured conductive features via drop‐on‐demand printing of molten metal for the first time. Printed traces show 12 times lower electrical resistance of 5.7 m Ωm−1$5 \text{.7} \textrm{ } \text{m} \Omega \left(\text{m}\right)^{- 1}$ at 230 μm linewidth than the lines from conductive inks. Printed traces with 100 μm dot spacing reveal exemplary shape fidelity with a standard deviation of only 7 μm. Quantitative estimation of adhesion of metal traces to dielectric reveals a mean shear‐off force of 7.20 N which is half of what is obtained for reflow soldered electronics. Demonstrators with embedded functional electrical circuits, directly interconnected components, and 3D out‐of‐plane metal structures are printed via Synkròtima. [ABSTRACT FROM AUTHOR]

Background: Glutamatergic dysfunction has been implicated in sensory integration deficits in schizophrenia, yet how glutamatergic function contributes to behavioural impairments and neural activities of sensory integration remains unknown. Methods: Fifty schizophrenia patients and 43 healthy controls completed behavioural assessments for sensory integration and underwent magnetic resonance spectroscopy (MRS) for measuring the anterior cingulate cortex (ACC) glutamate levels. The correlation between glutamate levels and behavioural sensory integration deficits was examined in each group. A subsample of 20 pairs of patients and controls further completed an audiovisual sensory integration functional magnetic resonance imaging (fMRI) task. Blood Oxygenation Level Dependent (BOLD) activation and task-dependent functional connectivity (FC) were assessed based on fMRI data. Full factorial analyses were performed to examine the Group-by-Glutamate Level interaction effects on fMRI measurements (group differences in correlation between glutamate levels and fMRI measurements) and the correlation between glutamate levels and fMRI measurements within each group. Results: We found that schizophrenia patients exhibited impaired sensory integration which was positively correlated with ACC glutamate levels. Multimodal analyses showed significantly Group-by-Glutamate Level interaction effects on BOLD activation as well as task-dependent FC in a 'cortico-subcortical-cortical' network (including medial frontal gyrus, precuneus, ACC, middle cingulate gyrus, thalamus and caudate) with positive correlations in patients and negative in controls. Conclusions: Our findings indicate that ACC glutamate influences neural activities in a large-scale network during sensory integration, but the effects have opposite directionality between schizophrenia patients and healthy people. This implicates the crucial role of glutamatergic system in sensory integration processing in schizophrenia. [ABSTRACT FROM AUTHOR]

The Rh/BINAPa and ZSM-35(10) co-catalyzed tandem hydroformylation–acetalization of olefins has been developed. A series of olefins with various alcohols performed well in the process, affording the corresponding acetals with high regioselectivities (l/b ≥ 30.5) and excellent catalytic activities (TON of the Rh catalyst up to 4.3 × 104). Control experiments and DFT calculations indicated that the Rh/L11-catalyzed hydroformylation occurred in the solvent outside the molecular sieve, while the acetalization of intermediate aldehydes with alcohols takes place mainly in the interior of the molecular sieve. [ABSTRACT FROM AUTHOR]

A PPh3 modified-chitosan support was synthesized by the acid-mediated addition reaction of the tris(4-vinylphenyl)phosphane ligand (3vPPh3) and chitosan (CS). The material was loaded with Pd(OAc)2 to furnish a supported Pd catalyst (Pd/PPh3-CS), which was characterized by FT-IR, ICP-MS, TGA, XPS, SEM, TEM and N2 adsorption–desorption analysis. The catalyst showed a high catalytic activity, wide substrate compatibility and good recyclability in heterogeneous Suzuki–Miyaura cross coupling reactions. [ABSTRACT FROM AUTHOR]

Background: Patients with metabolic syndrome (MS) have a higher incidence of cardiovascular disease (CVD), but the possible mechanisms are not fully understood and further exploration of the possible factors influencing the high incidence of CVD in patients with MS is still needed. Objectives: This study aims to examine the association between fetal famine exposure and the risk of CVD in adulthood with MS. Methods: Of 13,744 MS patients free of CVD selected from the Kailuan Study in 2006 (referred as the baseline survey) were included in the study. China suffered a severe famine from 1959 to 1962, so the participants born during this period were classified as the uterine famine exposed group. All patients were born between January 1, 1949, and December 31, 1974. Based on the date of birth, all patients were divided into the no-exposed group (born between January 1, 1963, and December 31, 1974), uterine famine exposed group (born between January 1, 1959 and December 31, 1962), and childhood famine exposed group (born between January 1, 1949 and December 31, 1958). After following up to December 31, 2019, the weighted Cox regression analysis model was used to calculate the effect of early life famine exposure in MS individuals on the risk of CVD in adulthood. Results: During the 12.12 years of follow-up, the incidence of CVD was 5.87%, 10.13%, and 10.90% in the no-exposed group, uterine famine exposed group, and childhood famine exposed group, respectively. Compared with participants in the no-exposed group, the CVD risk and stroke risk increased in participants in the uterine famine exposed group (for CVD, HR: 1.32, 95% CI 1.04–1.67; for stroke, HR:1.37, 95% CI 1.05–1.79), but not in childhood famine exposed group. However, the increased CVD risks were only observed in females or smokers. No increased MI risks were observed for participants in the uterine famine exposed group or childhood famine exposed group. Conclusions: Our findings suggested that exposure to famine during uterine life might increase the risk of CVD in adulthood in participants with MS. [ABSTRACT FROM AUTHOR]

Hubs in the brain network are the regions with high centrality and are crucial in the network communication and information integration. Patients with schizophrenia (SCZ) exhibit wide range of abnormality in the hub regions and their connected functional connectivity (FC) at the whole-brain network level. Study of the hubs in the brain networks supporting complex social behavior (social brain network, SBN) would contribute to understand the social dysfunction in patients with SCZ. Forty-nine patients with SCZ and 27 healthy controls (HC) were recruited to undertake the resting-state magnetic resonance imaging scanning and completed a social network (SN) questionnaire. The resting-state SBN was constructed based on the automatic analysis results from the NeuroSynth. Our results showed that the left temporal lobe was the only hub of SBN, and its connected FCs strength was higher than the remaining FCs in both two groups. SCZ patients showed the lower association between the hub-connected FCs (compared to the FCs not connected to the hub regions) with the real-life SN characteristics. These results were replicated in another independent sample (30 SCZ and 28 HC). These preliminary findings suggested that the hub-connected FCs of SBN in SCZ patients exhibit the abnormality in predicting real-life SN characteristics. [ABSTRACT FROM AUTHOR]

Empathy is the ability to generate emotional responses (i.e., cognitive empathy) and to make cognitive inferences (i.e., affective empathy) to other people's emotions. Empirical evidence suggests that patients with bipolar disorder (BD) exhibit impairment in cognitive empathy, but findings on affective empathy are inconsistent. Few studies have examined the neural mechanisms of cognitive and affective empathy in patients with BD. In this study, we examined the empathy-related resting-state functional connectivity (rsFC) in BD patients. Thirty-seven patients with BD and 42 healthy controls completed the self-report Questionnaires of Cognitive and Affective Empathy (QCAE), the Yoni behavioural task, and resting-sate fMRI brain scans. Group comparison of empathic ability was conducted. The interactions between group and empathic ability on seed-based whole brain rsFC were examined. BD patients scored lower on the Online Simulation subscale of the QCAE and showed positive correlations between cognitive empathy and the rsFC of the dorsal Medial Prefrontal Cortex (dmPFC) with the lingual gyrus. The correlations between cognitive empathy and the rsFC of the temporal–parietal junction (TPJ) with the fusiform gyrus, the cerebellum and the parahippocampus were weaker in BD patients than that in healthy controls. These findings highlight the underlying neural mechanisms of empathy impairments in BD patients. [ABSTRACT FROM AUTHOR]

The damping ratio plays a main role in the vibration of membrane structures. In order to study the damping force of air application to membrane structures, this present paper investigated the vibration response of a membrane structure subjected to impact loads. Eight experiments with the application of different tension forces to a tension membrane structure were conducted, and the impact load was simulated using a rigid bullet with a certain velocity. The displacement data were obtained using a laser displacement meter. FEM was used to simulate the vibration, and the results had good agreement. The results show that the effect of air applied to a prestressed membrane was equivalent to viscous damping, and the damping force was determined using the air. The damping ratio was proportional to the density of the air over the density of the membrane. The parameter of the coefficient could be determined using the geometry of the structure. [ABSTRACT FROM AUTHOR]

Quantum transducers that can convert quantum signals from the microwave to the optical domain are a crucial optical interface for quantum information technology. Coherent microwave-to-optics conversions have been realized with various physical platforms, but all of them are limited to low efficiencies of less than 50%—the threshold of the no-cloning quantum regime. Here we report coherent microwave-to-optics transduction using Rydberg atoms and off-resonant scattering technique with an efficiency of 82 ± 2% and a bandwidth of about 1 MHz. The high conversion efficiency is maintained for microwave photons ranging from thousands to about 50, suggesting that our transduction is readily applicable to the single-photon level. Without requiring cavities or aggressive cooling for the quantum ground states, our results would push atomic transducers closer to practical applications in quantum technologies. The demonstration of high-efficiency coherent microwave-to-optics conversion could push atomic transducers closer to practical applications in quantum technologies. [ABSTRACT FROM AUTHOR]

The 0-1 knapsack problem (KP) is a classic NP-hard problem and could be handled by swarm intelligence algorithms. However, most of these algorithms might be trapped in the local optima as the scale increases. Hybrid rice optimization (HRO) is a novel swarm intelligence algorithm inspired by the breeding process of Chinese three-line hybrid rice, its population is classified into three types such as the maintainer, restorer and sterile line and several stages including hybridization, selfing and renewal are implemented. In this paper, a modified HRO algorithm is proposed for the complicated large-scale 0-1 KP. A dynamic step is introduced in the renewal stage to balance the exploration and exploitation phases. Moreover, HRO is combined with binary ant colony optimization (BACO) algorithm to compose the parallel model and serial model for enhancing the convergence speed and search efficiency. In the parallel model, HRO and BACO are independently implemented on two subpopulations and communicate during each iteration. In the serial model, BACO is embedded in HRO as an operator to update the maintainer line. The experimental results on 0-1 KPs of different scales and correlations demonstrate the outperformance of the parallel model and serial model. [ABSTRACT FROM AUTHOR]

Background: Cornell assessment of pediatric delirium (CAPD) showed advantage in diagnosis of pediatric delirium in Chinese critically ill patients. But its performance in surgical patients is still unclear. The present study was designed to validate the diagnostic performance of CAPD in surgical pediatric patients.Methods: This is a prospective validation study. Pediatric patients who underwent selective surgery and general anesthesia were enrolled. Primary outcome was the incidence of delirium within postoperative three days. CAPD Chinese version was used to evaluate if the patient had delirium one time per day. At the meantime, a psychiatrist employed Diagnostic and Statistical Manual of Mental Disorders fifth edition to diagnose delirium, which was the "gold standard", and the result was considered as reference standard. Sensitivity, specificity and area under receiver operating characteristic (ROC) curve were calculated to investigate the performance of CAPD.Results: A total of 170 patients were enrolled. Median age was 4 years old. As diagnosed by psychiatrist, 23 (13.5 %) patients experienced at least one episode of delirium during the follow-up period. When diagnostic threshold was set at 9, CAPD showed the optimal sensitivity (87.0 %, 95 %CI 65.3 %-96.6 %) and specificity (98.0 %, 95 %CI 93.7 %-99.5 %) in comparison with other diagnostic thresholds. ROC analysis showed that CAPD was a good delirium assessment instrument with area under curve of 0.911 (95 % CI 0.812 to 1.000, P < 0.001). Agreement between CAPD and reference standard was 0.849 (Kappa coefficient, P < 0.001).Conclusions: This study found that Cornell assessment of pediatric delirium could be used as an effective instrument in diagnosis of delirium in pediatric surgical patients.Trial Registration: www.chictr.org.cn Identifier: ChiCTR-DDD-17,012,231, August 3, 2017. [ABSTRACT FROM AUTHOR]

Alteration of empathy is common in patients with psychiatric disorders. Reliable and valid assessment tools for measuring empathy of clinical samples is needed. The Questionnaire of Cognitive and Affective Empathy (QCAE) is a newly-developed instrument to capture cognitive and affective components of empathy. This study aimed to validate the QCAE and compared self-reported empathy between clinical groups with varied psychiatric diagnoses and healthy sample. The present study performed factor analysis for the QCAE on clinical samples in the Chinese setting (n = 534), including patients with schizophrenia (n = 158), bipolar disorder (n = 213) and major depressive disorder (n = 163). Internal consistency, internal correlation and convergent validity was examined in the subsample (n = 361). Group comparison among patients with schizophrenia, bipolar disorder, major depressive disorder and healthy controls (n = 107) was conducted to assess the discriminant validity. Our results indicated acceptable factor model, good reliability and validity of the QCAE. Impaired cognitive empathy was found in clinical samples, especially in patients with schizophrenia, while higher affective empathy was found in patients with bipolar disorder and major depressive disorder. The QCAE is a useful tool in assessing empathy in patients with varied psychiatric diagnoses. [ABSTRACT FROM AUTHOR]

Background: Accurate diagnosis of delirium is very important for prevention and treatment. Present study was designed to validate the 3-Minute Diagnostic Interview for CAM-defined Delirium Chinese version (3D-CAM-CN) in surgical ICU patients. Methods: In this prospective diagnostic study, the 3D-CAM was translated into Chinese with culture adaption. Two interviewers (Roles A and B) independently administrated 3D-CAM-CN assessment in adult patients from postoperative days 1 to day 3. At the meantime, a panel of psychiatrists diagnosed delirium according to the Diagnostic and Statistical Manual of Mental Disorders-fifth edition as the reference standard. The sensitivity and specificity were calculated to analyze the diagnostic character of the 3D-CAM-CN. Kappa coefficient was used to evaluate interrater reliability. Results: Two hundred forty-five adult patients were assessed for at least 2 days, resulting a total of 647 paired-assessments. When compared with the reference standard, the sensitivity and specificity of the 3D-CAM-CN assessment were 87.2 and 96.7%, respectively, by Role A and 84.6 and 97.4%, respectively, by Role B, with good interrater reliability (Kappa coefficient = 0.82, P < 0.001). It also performed well in patients with mild cognitive impairment, with the sensitivity from 85.7 to 100% and the specificity from 95.7 to 96.4%. Conclusion: Our results showed that the 3D-CAM-CN can be used as a reliable and accurate instrument for delirium assessment in surgical patients. Trial registration: This trail was approved by the Clinical Research Ethic Committee of Peking University First Hospital (No. 2017–1321) and registered on Chinese clinical trial registry on July 6, 2017 (ChiCTR-OOC-17011887). [ABSTRACT FROM AUTHOR]

The article titled "One‐Stop Hybrid Printing of Bulk Metal and Polymer for 3D Electronics" presents a new hybrid printer that combines metal and polymer materials in a 3D structure. The printer uses drop-on-demand printing to create electrically conductive metal features with a high aspect ratio and low resistance. This technology allows for the integration of metal elements into 3D polymer designs, opening up new possibilities for design and manufacturing. The authors of the article are Zhe Shu and a team of researchers. [Extracted from the article]

Background: Accessory breast cancer is very rare, particularly in men. Male accessory breast cancer on the abdominal wall has not been documented in the scientific literature so far. We describe a case of male accessory breast cancer on the abdominal wall. Case presentation: We describe a male patient suffering a swelling and erosive, enlarged, and hardened abdominal wall mass with pain due to abdominal wall accessory breast cancer. The patient had no obvious disease history, and the initial clinical symptom was a small mass on the abdominal wall. B-ultrasound revealed a solid subcutaneous nodule in the right abdomen with a size of ~2.8 × 2.5 × 1.5 cm. The abdominal wall tumor resection was performed with local anesthesia. Pathological testing revealed a grade II infiltrating ductal carcinoma derived from the accessory mammary gland (right abdominal wall) with neuroendocrine characteristics, showing ER (100% strong positive), PR (100% strong positive), HER-2 (-), ki67 (40% positive), Syn (+), CgA (+), and GCDFP15 (+). Conclusion: Nonaxillary accessory breast cancer in males is very rare, with no obvious clinical manifestations, and could be easily ignored. This disease requires great attention from clinicians. [ABSTRACT FROM AUTHOR]

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Many molecular epidemiological studies have been performed to explore the association between MTHFR C677T polymorphism and cancer risk in diverse populations. However, the results were inconsistent. Hence, we performed a meta-analysis to investigate the association between cancer risk and MTHFR C677T (150,086 cases and 200,699 controls from 446 studies) polymorphism. Overall, significantly increased cancer risk was found when all eligible studies were pooled into the meta-analysis. In the further stratified and sensitivity analyses, significantly increased breast cancer risk was found in Asians and Indians, significantly decreased colon cancer risk was found, significantly decreased colorectal cancer risk was found in male population, significantly increased gastric cancer risk was found in Caucasians and Asians, significantly increased hepatocellular cancer risk was found in Asians, significantly decreased adult acute lymphoblastic leukemia (AALL) risk was found in Caucasians, significantly decreased childhood acute lymphoblastic leukemia (CALL) risk was found in Asians, and significantly increased multiple myeloma and NHL risk was found in Caucasians. In summary, this meta-analysis suggests that MTHFR C677T polymorphism is associated with increased breast cancer, gastric cancer, and hepatocellular cancer risk in Asians, is associated with increased gastric cancer, multiple myeloma, and NHL risk in Caucasians, is associated with decreased AALL risk in Caucasians, is associated with decreased CALL risk in Asians, is associated with increased breast cancer risk in Asians, is associated with decreased colon cancer risk, and is associated with decreased colorectal cancer risk in male population. Moreover, this meta-analysis also points out the importance of new studies, such as Asians of HNC, Asians of lung cancer, and Indians of breast cancer, because they had high heterogeneity in this meta-analysis ( I > 75 %). [ABSTRACT FROM AUTHOR]

Recently, most background modeling approaches represent distributions of background changes by using parametric models such as Gaussian mixture models. Because of significant illumination changes and dynamic moving backgrounds with time, variations of background changes are hard to be modeled by parametric background models. Moreover, how to efficiently and effectively update parameters of parametric models to reflect background changes remains a problem. In this paper, we propose a novel coarse-to-fine detection theory algorithm to extract foreground objects on the basis of nonparametric background and foreground models represented by binary descriptors. We update background and foreground models by a first-in–first-out strategy to maintain the most recent observed background and foreground instances. As shown in the experiments, our method can achieve better foreground extraction results and fewer false alarms of surveillance videos with lighting changes and dynamic backgrounds in both collected and CDnet 2012 benchmark data sets. [ABSTRACT FROM AUTHOR]

A strength of microfluidic chip laboratories is the rapid heat transfer that, in principle, enables a very homogeneous temperature distribution in chemical processes. In order to exploit this potential, we present an integrated chip system where the temperature is precisely controlled and monitored at the microfluidic channel level. This is realized by integration of a luminescent temperature sensor layer into the fluidic structure together with inkjet-printed micro heating elements. This allows steering of the temperature at the microchannel level and monitoring of the reaction progress simultaneously. A fabrication procedure is presented that allows for straightforward integration of thin polymer layers with optical sensing functionality in microchannels of glass-polydimethylsiloxane (PDMS) chips of only 150 μm width and 29 μm height. Sensor layers consisting of polyacrylonitrile and a temperature-sensitive ruthenium tris-phenanthroline probe with film thicknesses of about 0.5 to 6 μm were generated by combining blade coating and abrasion techniques. Optimal coating procedures were developed and evaluated. The chip-integrated sensor layers were calibrated and investigated with respect to stability, reproducibility, and response times. These microchips allowed observation of temperature in a wide range with a signal change of around 1.6 % per K and a maximum resolution of around 0.07 K. The device is employed to study temperature-controlled continuous micro flow reactions. This is demonstrated exemplarily for the tryptic cleavage of coumarin-modified peptides via fluorescence detection. [Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]

Articular cartilage is a thin complex tissue that covers the bony ends of joints. Changes in the composition and structure of articular cartilage will cause degeneration, which may further lead to osteoarthritis. Decreased stiffness is one of the earliest symptoms of cartilage degeneration and also represents the imperfect quality of repaired cartilage. An optical coherence tomography (OCT)-based air-jet indentation system was recently developed in our group to measure the mechanical properties of soft tissues. In this study, this system was applied to quantify the change of mechanical properties of articular cartilage after degeneration induced by enzymatic digestions. Forty osteochondral disks ( n == 20 × 2) were prepared from bovine patellae and treated with collagenase and trypsin digestions, respectively. The apparent stiffness of the cartilage was measured by the OCT-based air-jet indentation system before and after the degeneration. The results were also compared with those from a rigid contact mechanical indentation and an ultrasound water-jet indentation. Through the air-jet indentation, it was found that the articular cartilage stiffness dropped significantly by 84%% ( p < 0.001) and 63%% ( p < 0.001) on average after collagenase and trypsin digestions, respectively. The stiffness measured by the air-jet indentation system was highly correlated ( R > 0.8, p < 0.001) with that from the other two indentation methods. This study demonstrated that the OCT-based air-jet indentation can be a useful tool to quantitatively assess the mechanical properties of articular cartilage, and this encourages us to further develop a miniaturized probe suitable for arthroscopic applications. [ABSTRACT FROM AUTHOR]

In this study, optical coherence tomography (OCT) with an axial resolution of 15 μm was used to investigate the depth and degeneration dependences of the refractive index (RI) of articular cartilage collected from bovine patellae in vitro. Eighteen disks of articular cartilage with a diameter of 6.35 mm harvested from different patellae were successfully prepared. Each disk was cut into two halves and three horizontal cartilage slices (n = 18 × 2 × 3) with an approximately equal thickness of 0.5 mm were further prepared from each half disk. The cartilage slices were digested by two different enzymes, collagenase and trypsin, to disturb collagen fibrils and proteoglycans, respectively. The samples were submerged in the physiological saline and tested using OCT before and after the enzyme digestion and the RI for each specimen was calculated. The RI of articular cartilage from the superficial to deep regions was 1.361 ± 0.032 (mean ± SD), 1.338 ± 0.036, and 1.371 ± 0.041 for normal specimens; 1.357 ± 0.036, 1.331 ± 0.030, and 1.392 ± 0.037 for trypsin digested specimens; and 1.361 ± 0.032, 1.336 ± 0.048, and 1.376 ± 0.043 for those treated by collagenase, respectively. Two-factor repeated measure ANOVA revealed that for all the three groups of specimens, the RI in different depths was significantly different ( p < 0.05). However, we found that the trypsin and collagenase treatments did not exert a significant effect on the RI ( p > 0.05). The results suggested that the depth dependence of articular cartilage should be taken into account when OCT is used for related measurement. [ABSTRACT FROM AUTHOR]

Do firms and households like the same cities? Can the quality of the business environment be compatible with the quality of life? We develop a new methodology based on the Rosen–Roback general equilibrium model for answering these questions and apply it to newly collected and manually matched data from Chinese cities. In order to overcome the challenges that arise when measuring the desirability of cities, we set up indexes of production amenities as well as the urban quality of life, and use wages and housing costs to estimate the implied prices of cities, i.e., the residents' and firms' willingness to pay for urban features. Our examination of the dynamic trends and influencing factors shows that firms and households differ in preference over urban features, many cities which are attractive to firms are unattractive to households, and vice versa. More specifically, in China, households prefer cities with better leisure conditions, entertainment, culture, and education resources, while firms are willing to allocate production in cities with less sunshine, more rainfall, better infrastructure, and fewer environmental restrictions. Our paper provides a unified perspective on the measurement of urban quality of life and production amenity. We also give policy suggestions to get a better grip on the functions and roles of cities; this is of practical significance for sustainable urban development. [ABSTRACT FROM AUTHOR]

Monosized strontium titanate (SrTiO3) particles with tailored morphologies have been successfully synthesized using ultrasound irradiation. Characterization techniques such as X-ray powder diffraction analysis, scanning electron microscopy, energy-dispersive analysis of X-rays, and laser particle size analysis were used to investigate the products. The results showed that all the as-prepared powders have a cubic SrTiO3 structure. Reaction conditions such as reactant concentrations, sonication time, and sonication power were found to have important effects on the morphology of SrTiO3 particles. [ABSTRACT FROM AUTHOR]

Background: Cerebellum is not only responsible for motor functions but is also involving in cognitive and emotional processes (Strick et al. 2009). Recent advances in imaging technologies allow us to examine the cerebellum in a much more systematic way including functional parcellations of cerebellum (e.g. 7-Network parcellation based on the resting state functional connectivity, Buckner et al., 2011; and task-based functional parcellation, King et al., 2019). These functional parcellations further uncover the important roles of cerebellum in nonmotor functions. In the past two decades, altered cerebellar structure and function have been observed in schizophrenia patients, with the anterior (lobules III-V) and the posterior cerebellum (lobules VI, VIIa, Crus I, and Crus II, VIII) as regions commonly reported (Bernard & Mittal 2015). Using the 7-Network taskfree parcellation, a recent multisite mega-analysis reported that patients with schizophrenia exhibited robust grey matter reduction in cerebellum (Moberget et al., 2018). The present study aimed to examine the cerebellar grey matter volumes in schizophrenia patients using anatomical, task-free connectivity-based and task-based functional parcellations. We also explored how the cerebellar volumes changes along with age in schizophrenia patients and healthy controls. Methods: Twenty-nine patients with schizophrenia (SCZ, mean age  =  22.0±2.5  years) and 55 healthy controls (HC, mean age = 23.5±3.6 years) were recruited to undertake structural magnetic resonance imaging (MRI) brain scan on a GE 750 scanner. Cerebellar volumes were measured by a high-resolution Spatially Unbiased Infratentorial (SUIT) toolbox (Diedrichsen, 2006). Regional cerebellar grey matter volumes were calculated for each participant based on anatomical (SUIT atlas) and functional atlases (7 regions of task-free parcellation; 10 regions of task-based parcellation) of the cerebellum. The group comparisons on regional cerebellar volumes were conducted in SPSS v19.0, taking total ICV as a covariate. The correlations between age and cerebellar volumes of those regions showing significant group differences were conducted. The significance threshold was set at p < 0.05. Results: Regarding the anatomical atlas, SCZ patients exhibited reduced grey matter volumes of the superior posterior cerebellum, mainly in lobules Crus II, VIIb and VIIIa. Regarding the task-free parcellation, SCZ patients exhibited smaller volumes in cerebellar regions showing functional connectivity with frontoparietal network and default mode network. Regarding the task-based parcellation, smaller volumes of cerebellar regions that activated during verbal fluency task (ROI9) was observed in SCZ patients. Correlation analyses between age and cerebellar volumes of those regions with significant group differences further reported negative correlations between age and lobule Crus II in both SCZ patients and HC (SCZ: r = -0.44, p < 0.05; HC: r = -0.43, p = 0.001). Moreover, negative correlations between age and cerebellar regions showing functional connectivity with frontoparietal network was observed in HC only (r = -0.30, p < 0.05), whereas negative correlations between age and lobules VIIb (r = -0.48, p < 0.01), VIIIa (r = -0.39, p < 0.05) and ROI9 of task-based atlas (r = -0.43, p < 0.05) were observed in SCZ patients. Discussion: Our findings showed reduced cerebellar grey matter volumes and the abnormal age-related changes of cerebellum in SCZ patients, especially in the regions related to frontoparietal network and cognitive function. These findings may highlight an important role of cerebellum underlying the mechanisms of cognitive dysfunction in mental disorders. [ABSTRACT FROM AUTHOR]

The dominance of safener can unite with herbicides acquiring the efficient protection of crop and qualifying control of weeds in agricultural fields. In order to solve the crop toxicity problem and exploit the novel potential safener for fenoxaprop-P-ethyl herbicide, a series of trichloromethyl dichlorobenzene triazole derivatives were designed and synthesized by the principle of active subunit combination. A total of 21 novel substituted trichloromethyl dichlorobenzene triazole compounds were synthesized by substituted aminophenol and amino alcohol derivatives as the starting materials, using cyclization and acylation. All the compounds were unambiguously characterized by IR, 1H-NMR, 13C-NMR, and HRMS. A greenhouse bioassay indicated that most of the title compounds could protect wheat from injury caused by fenoxaprop-P-ethyl at varying degrees, in which compound 5o exhibited excellent safener activity at a concentration of 10 μmol/L and was superior to the commercialized compound fenchlorazole. A structure–activity relationship for the novel compounds was determined, which demonstrated that those compounds containing benzoxazine groups showed better activity than that of oxazole-substituted compounds. Introducing a benzoxazine fragment and electron-donating group to specific positions could improve or maintain the safener activity for wheat against attack by the herbicide fenoxaprop-P-ethyl. A molecular docking model suggested that a potential mechanism between 5o and fenoxaprop-P-ethyl is associated with the detoxication of the herbicide. Results from the present work revealed that compound 5o exhibited good crop safener activities toward wheat and could be a promising candidate structure for further research on wheat protection. [ABSTRACT FROM AUTHOR]

In load predication, point-based forecasting methods have been widely applied. However, uncertainties arising in load predication bring significant challenges for such methods. This therefore drives the development of new methods amongst which interval predication is one of the most effective. In this study, a deep belief network-based lower–upper bound estimation (LUBE) approach is proposed, and a genetic algorithm is applied to reinforce the search ability of the LUBE method, instead of simulated an annealing algorithm. The approach is applied to the short-term load prediction on some realistic electricity load data. To demonstrate the effectiveness and efficiency of the proposed method, it is compared with three state-of-the-art methods. Experimental results show that the proposed approach can significantly improve the predication accuracy. [ABSTRACT FROM AUTHOR]

Metal organic chemical vapor deposition (MOCVD) growth systems are one of the main types of equipment used for growing single crystal materials, such as GaN. To obtain film epitaxial materials with uniform performance, the flow field and temperature field in a GaN-MOCVD reactor are investigated by modeling and simulating. To make the simulation results more consistent with the actual situation, the gases in the reactor are considered to be compressible, making it possible to investigate the distributions of gas density and pressure in the reactor. The computational fluid dynamics method is used to study the effects of inlet gas flow velocity, pressure in the reactor, rotational speed of graphite susceptor, and gases used in the growth, which has great guiding significance for the growth of GaN film materials. [ABSTRACT FROM AUTHOR]