1. The Accuracy of Sonography in Predicting Steatosis and Fibrosis in Chronic Hepatitis C.
- Author
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Shang-Tao Lin, Chi-Chieh Yang, Chien-Long Kuo, and Chiu-Kue Nien
- Subjects
ULTRASONIC imaging ,FATTY degeneration ,FIBROSIS ,HEPATITIS C - Abstract
Abstract The accuracy and clinical significance of sonography (US) in demonstrating fatty liver and hepatic fibrosis in chronic hepatitis C (CHC) are rarely reported. US had sensitivity 71.1%, specificity 72.9%, 58.7% positive predictive value (PPV), and 82.3% negative predictive value (NPV) in demonstrating histological steatosis ≥5%. US had sensitivity 85.7%, specificity 60.4%, 13% PPV, and 98.4% NPV in demonstrating histological steatosis ≥30% with clinical significance in predicting prognosis and therapeutic response in CHC. Subjects with fatty liver on US had a greater prevalence of body mass index (BMI) ≥25 kg/m2, inflammation-necrosis grade >2, and total bilirubin r = −0.167, P = 0.083). Besides hepatic steatosis, clinicians should be alert to the possibility of advanced necrosis-inflammation grade in interpreting a report of bright liver on gray-scale US. Gray-scale US cannot replace liver biopsy as the optimal diagnostic procedure for the prediction of hepatic steatosis and fibrosis prior to initiating therapy for CHC. [ABSTRACT FROM AUTHOR]
- Published
- 2008