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Aim: Although blood group antigens were initially identified as erythrocyte surface antigens and their significance was mainly ascribed to serology, it soon became evident that these antigens are widely distributed in human tissues such as platelets. Immunthrombocytopenia (ITP) is a common autoimmune disorder characterized by a low platelet count. In our study, we investigated the relationship between ABO and Rhesus (Rh) blood groups and primary ITP. Material and Methods: A retrospective study was conducted at our center with 304 patients diagnosed with primary ITP and 491 blood donors. Results: ABO phenotype in patients group A, B, O, AB were 42.8%, 14.1%, 34.9%, 8.2%, respectively and 51.6%, 8.1%, 27.9%, 12.4% in the control group, respectively. Rh phenotype in patients group positive or negative 87.5%, 12.5 % respectively and 88.8%, 11.2% in the control group, respectively. A total of 304 patients with primary ITP, consisting of 203 (66.8%) females, and 101(33,2%) males were included in this study. The mean age was 49,5 ±18 years. There was no significant difference in the distribution of ABO blood types and Rh factor by gender (respectively p=0.176, p= 0.195). Conclusion: In our study, no significant difference was found between the blood group distribution in the population and the blood group distribution of patients diagnosed with primary ITP. [ABSTRACT FROM AUTHOR]

Aim: Depression, vitamin D deficiency, and anemia are significant global public health issues. Depression, loss of interest, and a lack of enjoyment are the main warning indicators. In this study, we aimed to compare the results of the Beck depression test before and after replacement therapy in patients with iron deficiency anemia and vitamin D deficiency and to show the relationship between iron deficiency anemia (IDA), vitamin D deficiency anemia and depression in patients. Material and Methods: 139 patients with vitamin D deficiency and/or IDA who applied to the internal medicine outpatient clinics of Dışkapı Hospital between March 2017 and September 2017 participated in the study. Patients with vitamin D deficiency and/or IDA were included in the study, and the Beck depression test (BDI) questionnaire was applied to these patients before and after their treatment. Then, the scores on these two questionnaires were compared. Statistical analyzes were performed using SPSS version 20.0 (Armonk, NY: IBM Corp.). Results: All patients had Vitamin D deficiency, 59% (n=82) had both IDA and Vitamin D deficiency, and 41% had only Vitamin D deficiency. The mean follow-up time of the patients after treatment was 64.2±23.4 days. There was a significant decrease in BDI scores in both male patients (p=0.025) and female patients (p<0.001) after treatment compared to before. Conclusion: In our study, it was shown that the risk of depression is high in patients with vitamin D deficiency and/or IDA, and depressive symptoms decreased after short-term replacement therapy with vitamin D and iron. [ABSTRACT FROM AUTHOR]

Acquired hemophilia A (AHA) is a rare disease caused by autoantibodies inhibiting factor VIII (FVIII) activity. Although the conditionis usually idiopathic, there may be other underlying diseases. Treatment consists of two steps: treatment of acute bleeding and immunosuppression. In this multicenter study, we aimed to demonstrate the clinical characteristics, management details, and survival of AHA patients in Turkey. Data was collected from eleven centers in Turkey. aPTT, FVIII, FVIII inhibitor, and hemoglobin (HB) levels, mixing test results, and demographics at diagnosis, treatment information, adverse events, bleeding episodes during follow-up, relapses, and outcome were analyzed. Twenty-nine patients were analyzed (58.6% female). No underlying disorder could be detected in 14 patients. The most prevalent etiologies were pregnancy, malignancy and infections. The median FVIII activity and FVIII inhibitor titer at diagnosis were 0.7% (0.0–29.4%) and 32.6 BU (0.6–135.6 BU) respectively. Bleeding was severe in 44.8% of patients. The HB value was significantly lower in patients with severe bleeding. Most of the patients (n = 25, 86.2%) had only one bleeding episode without relapse, three patients (10.3%) had two bleeding episodes, and one patient had more than three bleedings. 21 (75%) patients received hemostatic therapy. The use of recombinant FVIIa was slightly higher than activated prothrombin complex concentrate (15 versus 10 patients). Immunosuppressive treatment was initiated in 26 (93%) patients. Regimens containing steroid, cyclophosphamide, and rituximab in different combinations were the most preferred. The median follow-up period was 13 months (2–156 months). Median overall survival was 154.97 months. Four and six-year survival were 90.9 ± 0.8% and 77.9 ± 14.1% respectively. This is a unique study that investigated the demographic characteristics, treatment approaches, and patient survival of AHA in Turkey. [ABSTRACT FROM AUTHOR]

The article focuses on Bradyrhizobium enterica in cord colitis syndrome which was first described as an agent by Herrera et al. Cord colitis syndrome defined as chronic active colitis and granulomatous inflammation that responds to antibiotics, with late-onset diarrhea after umbilical cord blood transplantation without known infectious agents or graft-versus-host disease (GvHD).

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