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In the last decade Open Science principles have been successfully advocated for and are being slowly adopted in different research communities. In response to the COVID-19 pandemic many publishers and researchers have sped up their adoption of Open Science practices, sometimes embracing them fully and sometimes partially or in a sub-optimal manner. In this article, we express concerns about the violation of some of the Open Science principles and its potential impact on the quality of research output. We provide evidence of the misuses of these principles at different stages of the scientific process. We call for a wider adoption of Open Science practices in the hope that this work will encourage a broader endorsement of Open Science principles and serve as a reminder that science should always be a rigorous process, reliable and transparent, especially in the context of a pandemic where research findings are being translated into practice even more rapidly. We provide all data and scripts at https://osf.io/renxy/ . [ABSTRACT FROM AUTHOR]

In biomedical research, various longitudinal markers measuring different quantities are often collected over time. For example, repeated measures of psychometric scores are very informative about the degradation process toward dementia. These trajectories are generally nonlinear with an acceleration of the decline a few years before the diagnosis and a large heterogeneity between psychometric tests depending on the underlying cognitive function to be evaluated and the metrological properties of the test. Comparing the times of acceleration of the decline before diagnosis between cognitive tests is useful to better understand the natural history of the disease. Our objective is to propose a bivariate random changepoint model that allows for the comparison of the mean time of change between two markers. A frequentist approach is proposed that gives validated statistical tests to assess the temporal order of the changepoints. Using a spline transformation function, the model is designed to handle non-Gaussian data, that are common for cognitive scores which frequently exhibit a strong ceiling effect. The procedure is assessed through a simulation study and applied to a French cohort of elderly to identify the order of the decline of several cognitive scores. The whole methodology has been implemented in a R package freely available. [ABSTRACT FROM AUTHOR]

In biomedical research, random changepoint mixed models are used to take into account an individual breakpoint in a biomarker trajectory. This may be observed in the cognitive decline measured by psychometric tests in the prediagnosis phase of Alzheimer's disease. The existence, intensity and duration of this accelerated decline can depend on individual characteristics. The main objective of our work is to propose inferential methods to assess the existence of this phase of accelerated decline, ie, the existence of a random changepoint. To do so, we use a mixed model with two linear phases and test the nullity of the parameter measuring the difference of slopes between the two phases. Because we face the issue of nuisance parameters being unidentifiable under the null hypothesis, the supremum of the classic score test statistic on these parameters is used. The asymptotic distribution of the supremum under the null is approached with a perturbation method based on the multiplier bootstrap. The performance of our testing procedure is assessed via simulations and the test is applied to the French cohort PAQUID of elderly subjects to study the shape of the prediagnosis decline according to educational level. The test is significant for both educational levels and the estimated trajectories confirmed that educational level is a good marker for cognitive reserve. [ABSTRACT FROM AUTHOR]

Besides, the vaccination status of a population does not capture the population immunisation status, by excluding previously infected individuals. Vaccination rates and COVID-19 cases The authors have specified that they included "68 countries that met the following criteria: had second dose vaccine data available; had COVID-19 case data available; had population data available; and the last update of data was within 3 days prior to or on September 3, 2021.". [Extracted from the article]