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We have measured the absolute doubly differential angular sputtering yield for 20 keV Kr+ impacting a polycrystalline Cu slab at an incidence angle of θi = 45° relative to the surface normal. Sputtered Cu atoms were captured using collectors mounted on a half dome above the sample, and the sputtering distribution was measured as a function of the sputtering polar, θs, and azimuthal, ϕs, angles. Absolute results of the sputtering yield were determined from the mass gain of each collector, the ion dose, and the solid angle subtended, after irradiation to a total fluence of ∼1 × 1018 ions/cm2. Our approach overcomes shortcomings of commonly used methods that only provide relative yields as a function of θs in the incidence plane (defined by the ion velocity and the surface normal). Our experimental results display an azimuthal variation that increases with increasing θs and is clearly discrepant with simulations using binary collision theory. We attribute the observed azimuthal anisotropy to ion-induced formation of micro- and nano-scale surface features that suppress the sputtering yield through shadowing and redeposition effects, neither of which are accounted for in the simulations. Our experimental results demonstrate the importance of doubly differential angular sputtering studies to probe ion sputtering processes at a fundamental level and to explore the effect of ion-beam-generated surface roughness. [ABSTRACT FROM AUTHOR]

Metasurface analogs of electromagnetically induced transparency (EIT) are attracting sustaining attention due to their ability to maintain transparency windows accompanied by extreme dispersion of propagating waves, which are important for slow light devices and highly sensitive optical sensors. In this paper, we study theoretically, numerically, and experimentally the conditions for the existence of multi-band transparency windows in the metasurface supported by the interaction of dipole modes in an asymmetric unit cell. The unit cell is composed of a single bright resonator and several dark resonators made in the form of rectangular metal patches. The manifestation of EIT is studied for different metasurface configurations by varying the number and positions of resonators used within the unit cell. To validate the slow-down effect caused by EIT, a prototype of the metasurface is fabricated and tested, providing a measurement of the group delay and bandwidth-delay product features. The obtained results clearly confirm the presence of four EIT-like transparency windows in the metasurface transmission spectra originating from the coupling between either quasi-TE or quasi-TM modes of the resonators. [ABSTRACT FROM AUTHOR]

We employ the molecular dynamics simulations to study the dynamics of acetanilide (ACN) molecules placed on a flat surface of planar multilayer hexagonal boron nitride. We demonstrate that the ACN molecules, known to be achiral in the three-dimensional space, become chiral after being placed on the substrate. Homochirality of the ACN molecules leads to stable secondary structures stabilized by hydrogen bonds between peptide groups of the molecules. By employing molecular dynamics simulations, we reveal that the structure of the resulting hydrogen-bond chains depends on the isomeric composition of the molecules. If all molecules are homochiral (i.e., with only one isomer being present), they form secondary structures (chains of hydrogen bonds in the shapes of arcs, circles, and spirals). If the molecules at the substrate form a racemic mixture, then no regular secondary structures appear, and only curvilinear chains of hydrogen bonds of random shapes emerge. A hydrogen-bond chain can form a zigzag array only if it has an alternation of isomers. Such chains can create two-dimensional (2D) regular lattices or 2D crystals. The melting scenarios of such 2D crystals depend on density of its coverage of the substrate. At 25% coverage, melting occurs continuously in the temperature interval 295–365 K. For a complete coverage, melting occurs at 415–470 K due to a shift of 11% of all molecules into the second layer of the substrate. [ABSTRACT FROM AUTHOR]

Using multinational input–output data, we analyze how the productivity of countries adjusted for participation in global value chains affects their output growth in manufacturing sectors. Based on parametric and non-parametric methods, we find that value-chain linkages are critical to the productivity–growth nexus and help to explain cross-country differences in sectoral output growth rates compared to the situation where these linkages are ignored. Our results have implications for macroeconomics, where they point to peer effects in productivity as drivers of growth, and for economic development, where they illustrate how the participation in global value chains may outweigh disadvantages in productive performance at the level of individual countries. They may also encourage future empirical tests of replicator dynamics to verify whether global value chains can explain the weak evidence of selection forces at the firm level. [ABSTRACT FROM AUTHOR]

The adiabatic connection formalism, usually based on the first-order perturbation theory, has been generalized to an arbitrary order. The generalization stems from the observation that the formalism can be derived from a properly arranged Taylor expansion. The second-order theory is developed in detail and applied to the description of two electrons in a parabolic confinement (harmonium). A significant improvement relative to the first-order theory has been obtained. [ABSTRACT FROM AUTHOR]

Protein biotherapeutics typically require expensive cold‐chain storage to maintain their fold and function. Packaging proteins in the dry state via lyophilization can reduce these cold‐chain requirements. However, formulating proteins for lyophilization often requires extensive optimization of excipients that both maintain the protein folded state during freezing and drying (i.e., "cryoprotection" and "lyoprotection"), and form a cake to carry the dehydrated protein. Here we show that sweet corn phytoglycogens, which are glucose dendrimers, can act as both a protein lyoprotectant and a cake‐forming agent. Phytoglycogen (PG) dendrimers from 16 different maize sources (PG1‐16) were extracted via ethanol precipitation. PG size was generally consistent at ~70–100 nm for all variants, whereas the colloidal stability in water, protein contaminant level, and maximum density of cytocompatibility varied for PG1‐16. 10 mg/mL PG1, 2, 9, 13, 15, and 16 maintained the activity of various proteins, including green fluorescent protein, lysozyme, β‐galactosidase, and horseradish peroxidase, over a broad range of concentrations, through multiple rounds of lyophilization. PG13 was identified as the lead excipient candidate as it demonstrated narrow dispersity, colloidal stability in phosphate‐buffered saline, low protein contaminants, and cytocompatibility up to 10 mg/mL in NIH3T3 cell cultures. All dry protein‐PG13 mixtures had a cake‐like appearance and all frozen protein‐PG13 mixtures had a Tg' of ~ −26°C. The lyoprotection and cake‐forming properties of PG13 were density‐dependent, requiring a minimum density of 5 mg/mL for maximum activity. Collectively these data establish PG dendrimers as a new class of excipient to formulate proteins in the dry state. [ABSTRACT FROM AUTHOR]

The work is devoted to the study of the second-harmonic generation (SHG) process as a result of random quasi-phase-matching of thulium laser radiation in ZnSe polycrystals. A linear dependence of the SHG efficiency on the nonlinear medium length has been observed in the experiment. The efficiencies of SHG in ZnSe polycrystals with average grain sizes from 35 μ m to 380 μ m were compared. The obtained results are in good agreement with the theory in the case of a Gaussian grain size distribution. [ABSTRACT FROM AUTHOR]

Background: 5-alpha reductase inhibitors (5-ARIs) change hormonal pathways and reduce prostate size. We evaluated the effects of 5-ARIs on prostatic multiparametric magnetic resonance imaging (mpMRI) suspicious findings and in the identification of prostate cancer using targeted biopsies. Methods: We conducted a retrospective study including 600 consecutive patients who, between 2017 and 2021, underwent combined transperineal fusion biopsies. Primary outcomes were Prostate Imaging Reporting and Data System version 2 (PIRADS v2) scores and the identification of clinically significant prostate cancer from suspicious lesions (targeted CSPC). Outcomes were compared between patients treated with 5-ARIs for a minimum of 6 months and the other patients. Results: Patients treated with 5-ARIs were older (p < 0.001) with higher rates of previous prostate biopsies (p = 0.004). PIRADS scores were 3, 4, and 5 in 15 (29%), 28 (54%), and 9 (17%) patients among the 5-ARI group and 130 (24%), 308 (56%), and 110 (20%) patients among the others, and the scores were not different between the groups (p = 0.69). The targeted CSPC identification rate among 5-ARI patients was 31%, not different compared to the non-5-ARI group (p = 1). Rates of targeted CSPC for each PIRADS score were not affected by 5-ARI treatment. The 5-ARI was not associated with neither PIRADS ≥ 4 score nor targeted CSPC on logistic regression analyses (OR = 0.76, 95% CI 0.4–1.4 and OR = 1.02, 95% CI 0.5–1.9, respectively). Conclusions: 5-ARI treatment is not associated with PIRADS score alterations or targeted biopsy results. Patients treated by 5-ARIs with suspicious lesions should not be addressed differently during the mpMRI-related diagnostic process. [ABSTRACT FROM AUTHOR]

Respiratory infections caused by RNA viruses are a major contributor to respiratory disease due to their ability to cause annual epidemics with profound public health implications. Influenza A virus (IAV) infection can affect a variety of host signaling pathways that initiate tissue regeneration with hyperplastic and/or dysplastic changes in the lungs. Although these changes are involved in lung recovery after IAV infection, in some cases, they can lead to serious respiratory failure. Despite being ubiquitously observed, there are limited data on the regulation of long-term recovery from IAV infection leading to normal or dysplastic repair represented by inflammation-to-metaplasia transition in mice or humans. To address this knowledge gap, we used integrative bioinformatics analysis with further verification in vivo to elucidate the dynamic molecular changes in IAV-infected murine lung tissue and identified the core genes (Birc5, Cdca3, Plk1, Tpx2, Prc1. Rrm2, Nusap1, Spag5, Top2a, Mcm5) and transcription factors (E2F1, E2F4, NF-YA, NF-YB, NF-YC) involved in persistent lung injury and regeneration processes, which may serve as gene signatures reflecting the long-term effects of IAV proliferation on the lung. Further analysis of the identified core genes revealed their involvement not only in IAV infection but also in COVID-19 and lung neoplasm development, suggesting their potential role as biomarkers of severe lung disease and its complications represented by abnormal epithelial proliferation and oncotransformation. [ABSTRACT FROM AUTHOR]

The invasive wasp-mimicking Tiger Longicorn Beetle, Xylotrechus chinensis, a potentially lethal pest of mulberry trees (Moraceae: Morus spp.), was first reported in Europe in 2018. In Catalonia its spread has been impressive: one district, four towns, 44 km2 in February 2018; four districts, 12 towns, 378 km2 in July 2020; seven districts, 65 towns, 1134 km2 in December 2023. It is likely the infestation will spread further in the future, in particular along the Mediterranean coast from Spain to Greece. The flight period of this beetle in Mediterranean countries is expanding on both ends (from the end of April to mid-October), probably due to increasing temperatures because of climate change, although this should be further proved. The adult beetle life span is 18–23 days in insectaria, likely somewhat shorter in the wild since they do not feed and spend more energy flying outside. The single treatment with abamectin carried out in a Catalonian town in June 2022 on a sample of 24 trees (12 treated, 12 untreated) has been effective in reducing the infestation of this beetle in relation to untreated trees. But the reduction was not complete since new exit holes appeared during the summer of the following year. Therefore, an additional treatment carried out during the first ten days of October should be tested to achieve a better control of this pest. It would also be worthwhile trying a single treatment of abamectin in mid-July since it should be able to kill larvae hatching before the treatment and still have sufficient residual activity for larvae hatching after the treatment, and thus cover the entire activity period. Also, to get satisfactory mulberry tree protection, it is likely that treatments might have to be repeated for a few consecutive years. Yearly re-infestations from untreated public and/or private mulberry trees are also a concern and make short-term control of this pest difficult, no doubt accounting for the rapid spread of this beetle. [ABSTRACT FROM AUTHOR]

Background/Objectives: Neutrophils have recently gained significant attention due to their heterogeneity in tumor settings. The gene expression profiles of neutrophils from different tumor types are of great interest. Murine splenic neutrophils reflect the immune status of the organism and could be a source of tumor-associated neutrophils in tumor-bearing mice. However, information about appropriate reference genes for RT-qPCR analysis of murine neutrophils in the literature is lacking. The aim of this study was to identify stably expressed reference genes in murine splenic neutrophils. Methods: Bone marrow- and spleen-derived neutrophils were isolated from healthy C57Bl/6 and CBA/LacSto mice. Spleen-derived neutrophils were isolated from mice with Lewis lung carcinoma (LLC) and drug-resistant lymphosarcoma (RLS40). RNA was isolated and used for RT-qPCR analysis of 10 selected reference genes. Analysis of reference gene stability was performed using four different algorithms (BestKeeper, NormFinder, geNorm, ΔCt method), and comprehensive ranking was constructed using RefFinder. Results: The Ct values for the reference genes were in the range of 16.73–30.83 with the highest expression levels observed for B2m and the lowest for Sdha. Differences in the stability ranking performed by different algorithms were observed; however, the overall ranking of the studied reference genes was as follows, from most to least stably expressed: Tbp, Hprt1, Ywhaz, B2m, Gapdh, Actb, Sdha, Eef2, Rack1, and Rpl13a. Using Tbp or Rpl13a for RT-qPCR data normalization significantly affected the interpretation of target gene expression. Conclusions: Tbp and Hprt1 are recommended reference genes for murine splenic neutrophils regardless of their activation status. [ABSTRACT FROM AUTHOR]

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This paper studies some results on solutions associated with interval-valued optimal control problems driven by generalized invariant convex (for short, invex) functionals. Necessary conditions of optimality are stated for the considered optimization problem. Also, the sufficiency of the necessary optimality conditions is investigated. Moreover, various duality relationships between the dual models and the primal optimization problem are deliberated. [ABSTRACT FROM AUTHOR]

The observation of the gate-controlled supercurrent (GCS) effect in superconducting nanostructures increased the hopes for realizing a superconducting equivalent of semiconductor field-effect transistors. However, recent works attribute this effect to various leakage-based scenarios, giving rise to a debate on its origin. A proper understanding of the microscopic process underlying the GCS effect and the relevant time scales would be beneficial to evaluate the possible applications. In this work, we observed gate-induced two-level fluctuations between the superconducting state and normal state in Al/InAs nanowires (NWs). Noise correlation measurements show a strong correlation with leakage current fluctuations. The time-domain measurements show that these fluctuations have Poissonian statistics. Our detailed analysis of the leakage current measurements reveals that it is consistent with the stress-induced leakage current (SILC), in which inelastic tunneling with phonon generation is the predominant transport mechanism. Our findings shed light on the microscopic origin of the GCS effect and give deeper insight into the switching dynamics of the superconducting NW under the influence of the strong gate voltage. It was recently shown that a voltage could be used to control a supercurrent in superconducting nanostructures, much like a transistor, however, the exact origin of this effect has been debated. Here Elalaily et al. show via noise measurements that the suppression of the supercurrent in the superconducting device arises due to excitation emission by inelastic tunneling of the electrons through the trap states created by stressing the oxide layer between the gate and the NW under a high electric field. [ABSTRACT FROM AUTHOR]

In this paper, we investigate constraint qualifications and optimality conditions for multiobjective mathematical programming problems with vanishing constraints (MOMPVC) on Hadamard manifolds. The MOMPVC-tailored generalized Guignard constraint qualification (MOMPVC-GGCQ) for MOMPVC is introduced in the setting of Hadamard manifolds. By employing MOMPVC-GGCQ and the intrinsic properties of Hadamard manifolds, we establish Karush–Kuhn–Tucker (KKT)-type necessary Pareto efficiency criteria for MOMPVC. Moreover, we introduce several MOMPVC-tailored constraint qualifications and develop interrelations among them. In particular, we establish that the MOMPVC-tailored constraint qualifications introduced in this paper turn out to be sufficient conditions for MOMPVC-GGCQ. Suitable illustrative examples are furnished in the framework of well-known Hadamard manifolds to validate and demonstrate the importance and significance of the derived results. To the best of our knowledge, this is the first time that constraint qualifications, their interrelations, and optimality criteria for MOMPVC have been explored in the framework of Hadamard manifolds. [ABSTRACT FROM AUTHOR]

An inertial navigation system (INS) utilizes three orthogonal accelerometers and gyroscopes to determine platform position, velocity, and orientation. There are countless applications for INS, including robotics, autonomous platforms, and the internet of things. Recent research explores the integration of data-driven methods with INS, highlighting significant innovations, improving accuracy and efficiency. Despite the growing interest in this field and the availability of INS datasets, no datasets are available for gyro-free INS (GFINS) and multiple inertial measurement unit (MIMU) architectures. To fill this gap and to stimulate further research in this field, we designed and recorded GFINS and MIMU datasets using 54 inertial sensors grouped in nine inertial measurement units. These sensors can be used to define and evaluate different types of MIMU and GFINS architectures. The inertial sensors were arranged in three different sensor configurations and mounted on a mobile robot, a passenger car and a turntable. In total, the dataset contains 45 hours of inertial data and corresponding ground truth trajectories. The data is freely accessible through our figshare repository. [ABSTRACT FROM AUTHOR]

Managing a portfolio whose value closely tracks an index by trading only in a subset of the index constituents involves an NP-hard optimisation problem. In the prior literature, it has been suggested that this problem be solved using sequential Monte Carlo (SMC, also known as particle filter) methods. However, this literature does not take transaction costs into account, although transaction costs are the primary motivation for attempting to replicate the index by trading in a subset, rather than the full set of index constituents. This paper modifies the SMC approach to index tracking to allow for proportional transaction costs and implements this extended method on empirical data for a variety stock indices. In addition to providing a more practically useful tracking strategy by allowing for transaction costs, we find that including a penalty for transaction costs in the optimisation objective can actually lead to better tracking performance. [ABSTRACT FROM AUTHOR]

Ultralow temperature crystals of the helium isotopes 3 He and 4 He are intriguing quantum systems. Deciphering the complex features of these unusual materials has been made possible in large part by Alexander Andreev's groundbreaking research. In 1978, Andreev and Alexander Parshin predicted the existence of melting/freezing waves at the surface of a solid 4 He crystal, which was subsequently promptly detected. Successively, for the fermionic 3 He superfluid/solid interface, even more intricate crystallization waves were anticipated, although they have not been observed experimentally so far. In this work, we provide preliminary results on 3 He crystals at the temperature T = 0.41 mK, supporting the existence of spin supercurrents in the melting/freezing waves on the crystal surface below the antiferromagnetic ordering temperature T N = 0.93 mK, as predicted by Andreev. The spin currents that accompany such a melting-freezing wave make it a unique object, in which the inertial mass is distinctly different from the gravitational mass. [ABSTRACT FROM AUTHOR]

The primary emphasis of the present study is to introduce some novel characterizations of the interval-valued (I. V) right symmetric quantum derivative and antiderivative operators relying on generalized Hukuhara difference. To continue the study, we start with the concept of symmetric differentiability in the interval-valued sense and explore some important properties. Furthermore, through the utilization of the (I. V) symmetric derivative operator, we develop the right-sided (I. V) integral operator and explore its key properties. Also, we establish various (I. V) trapezium-like inequalities by considering the newly proposed operators and support line. Later on, we deliver another proof of the trapezium inequality through an analytical approach. Also, we present the numerical and visual analysis for the verification of our results. [ABSTRACT FROM AUTHOR]

The article explores passive systems for regulating microclimates in residential settings, with a focus on modular constructions. It investigates the use of the trombe wall system for passive ventilation to ensure comfort and hygiene. The study examines building designs that enable effective air circulation without using mechanical systems. Furthermore, the effectiveness of the passive system of using solar energy with the trombe wall as a ventilation device in modular houses has been experimentally confirmed. Although the research confirms the effectiveness of this solar system in modular homes, there is limited documentation regarding its overall efficiency, particularly concerning the impact of the surface pressure coefficient on ventilation. The study establishes the correlations governing the thermosiphon collector's effectiveness at varying air layer thicknesses. Optimal parameters, such as maximum air consumption (L = 120 m3h−1), are identified at an air layer thickness (δ) of 100 mm and outlet openings area (F) of 0.056 m2. These findings pave the way for improving passive systems aimed at maintaining optimal thermal and air conditions in modern homes. The findings suggest the potential for more efficient and sustainable housing solutions. Further research is essential to understand how factors like building design and wind speed affect ventilation system efficacy. [ABSTRACT FROM AUTHOR]

This study examines the influence of the reinforced-concrete frame topology and crack opening effects on the structural behavior under a column removal scenario. For this purpose, a variant of discretization of the finite element model has been proposed, which takes into account additional rotations during the formation of discrete cracks. As a criterion of the bearing capacity of structures, the equilibrium point at the force-displacement curve was adopted. Verification of the proposed method has been performed using experimental data for a U-shaped frame. The paper provides a comparative analysis of the calculation results for 3-story, 5-story and 9-story reinforced-concrete frames using structural elements and the proposed method. It is found that accounting for the discrete nature of cracks had practically no effect on the magnitudes of axial forces in the elements. However, for bending moments, the proposed method showed a decrease compared to the traditional approach. The increase of axial tensile forces in the support sections of the beam above the zone of local failure has been detected for reinforced-concrete frames with 3 - 5 stories, which can lead to an increase in the influence of buckling for the columns to which such a beam is adjacent. [ABSTRACT FROM AUTHOR]

Background: Preoperative identification of the bowel on imaging is essential in planning renal access during percutaneous nephrolithotomy (PCNL) and avoiding colonic injury. We aimed this study to assess which noncontrast computed tomography (NCCT) window setting provides the optimal colonic identification for PCNL preoperative planning. Methods: Ten urologic surgeons (four seniors, six residents) reviewed 22 images of NCCT scans in both abdomen and lung window settings in a randomized blinded order. Colonic area delineation in each image was performed using a dedicated, commercially available area calculator software. A comparison of the marked colonic area between the abdomen and lung window settings was performed. Results: Overall, the mean marked colonic area was greater in the lung window compared with the abdomen window (8.82 cm2 vs 7.4 cm2, respectively, p < 0.001). Switching the CT window from abdomen to lung increased the identified colonic area in 50 cases (50%). Intraclass correlation showed good agreement between the senior readers and among all readers (0.92 and 0.87, respectively). Similar measurements of the colonic area in both abdomen and lung windows were observed in 26/44 (60%) of the seniors cases and in 7/66 (10%) of the resident cases (p = 0.002). Conclusion: Lung window solely or in combination with abdomen window appears to provide the most accurate colonic identification for preoperative planning of PCNL access and potentially reduce the risk of colonic injury. This pattern is more evident among young urologists, and we propose to introduce it as a standard sequence in PCNL preplanning. [ABSTRACT FROM AUTHOR]

Barley development from seedling to flowering involves both external and internal changes, the latter requiring microscopic observation. Internal changes allow for the classification of preflowering development into three phases: vegetative, early reproductive, and late reproductive. Genetic and environmental factors influence the duration of these phases, impacting grain yield. Photoperiod-sensitivity genes PPD-H1 play amajor role in flowering time, affecting adaptation; however, the effect might also be direct (beyond affecting phenology). In this paper, we aimed to assess how PPD-H1 alleles affect barley development, including the progression of growth phases, leaf emergence, tillering dynamics, and spikelet development. Two experiments (field and controlled conditions) were conducted with a factorial combination of (i) four near-isogenic lines (NILs) for PPD-H1 alleles (ppd-H1 or Ppd-H1) under two contrasting PHYC genetic backgrounds (PhyC-l and PhyC-e) and (ii) two photoperiod conditions (short and long days). As expected, longer photoperiods led to a shorter growth cycle. All subphases of time to flowering, final leaf number, and phyllochron were affected by photoperiod. The effects of PPD-H1 on flowering time depended on the PHYC genetic backgrounds and photoperiod conditions. PPD-H1 effects on flowering time were associated with leaf number and phyllochron; the interplay between leaf number and phyllochron affected mainly the late reproductive phase. We also found that although PPD-H1 did not affect the phyllochron of the first six leaves, the phyllochron of leaves appearing later, when grown under a short photoperiod, was consistently increased in lines carrying the ppd-H1 allele. Tillering dynamics exhibited variability, but PPD-H1 did not affect the final spike number under a 24-h photoperiod. [ABSTRACT FROM AUTHOR]

In the current study, we compute some upper bounds for the remainder term of Boole's quadrature rule involving convex mappings. First, we build a new identity for first-order differentiable mapping, an auxiliary result to establish our required estimates. We provide several upper bounds by utilizing the identity, convexity property, and bounded property of mappings and some well-known inequalities. Moreover, based on our primary findings, we deliver applications to the means, quadrature rule, special mappings, and non-linear analysis by developing a novel iterative scheme with cubic order of convergence. To the best of our knowledge, the current study is the first attempt to derive upper bounds for Boole's scheme involving convex mappings. [ABSTRACT FROM AUTHOR]

In this article, we explore the construction of Hamiltonians with long‐range interactions and their corrections using the short‐range behavior of the wave function. A key aspect of our investigation is the examination of the one‐particle potential, kept constant in our previous work, and the effects of its optimization on the adiabatic connection. Our methodology involves the use of a parameter‐dependent potential dependent on a single parameter to facilitate practical computations. We analyze the energy errors and densities in a two‐electron system (harmonium) under various conditions, employing different confinement potentials and interaction parameters. The study reveals that while the mean‐field potential improves the expectation value of the physical Hamiltonian, it does not necessarily improve the energy of the system within the bounds of chemical accuracy. We also delve into the impact of density variations in adiabatic connections, challenging the common assumption that a mean field improves results. Our findings indicate that as long as energy errors remain within chemical accuracy, the mean field does not significantly outperform a bare potential. This observation is attributed to the effectiveness of corrections based on the short‐range behavior of the wave function, a universal characteristic that diminishes the distinction between using a mean field or not. [ABSTRACT FROM AUTHOR]

Urinary incontinence after robotic-assisted radical prostatectomy (RARP) has been associated with older age, a longer operative time, a higher BMI, a short membranous urethral length and preoperative erectile function. The authors sought to assess the association between the neuromuscular characteristics and postoperative urinary incontinence. Methods: RARP specimens from 29 men who underwent bilateral nerve sparing were reanalyzed. Urinary incontinence was evaluated using the International Consultation on Incontinence Questionnaire—Short Form (ICIQ-SF) at 6 weeks post surgery and last follow-up. Linear and logistic regression analyses were performed to assess neuromuscular characteristics and incontinence. Results: At the 1-year follow-up, 11 patients (38%) reported severe incontinence (>12 ICIQ-SF score). The median number of peripheral nerves observed at the base and apex in the specimens was 52 (IQR 13–139) and 59 (IQR: 28–129), respectively. Ganglia were present in 19 patients (65%) at the base and 12 patients (41%) at the apex. Additionally, the median proportional area of detrusor smooth muscle fibers at the base was 0.54 (IQR 0.31–1), while the median proportional area of striated muscle fibers at the apex was 0.13 (IQR 0.08–0.24). No statistically significant associations were found. Conclusions: Histologic neuromuscular characteristics were not associated with postoperative urinary incontinence. Enhanced intraoperative evaluation and larger-scale studies may prove useful for the prediction of postprostatectomy incontinence. [ABSTRACT FROM AUTHOR]

Claviceps purpurea (Fries) Tulasne is a valuable source of many bioactive metabolites (ergot alkaloids) for the pharmaceutical industry. Selection and cultivation of pharmaceutical ergot Claviceps purpurea needs quick qualitative and quantitative analyses for alkaloid identification and chemotaxonomic strain passportisation; however, express methods can be uninformative for some conditions. We used an alternative method of reversed-phase HPLC-UV (based on formic acid elution) for the identification and determination of concentrations for ergot alkaloids in sclerotias from parasitic cultures of 3 strains of pharmaceutical Claviceps purpurea. Two different types of standard solutions of ergocriptine—sum of the α+β isomers and the ergotoxine mixture (ergocornine +α+β ergocriptine with a known ratio)—allowed us to clearly identify each peak in the analysis of standard solutions and sclerotia samples of parasitic ergot. Parameters of retention time and concentrations were determined for ergotamine (25.4 ± 0.11 min, 0.57 ± 0.04 g/100 g respectively), ergometrine (7.67 ± 0.01 min, 0.02 ± 0.004 g/100 g), ergocristine (27.83 ± 0.01 min, 0.62 ± 0.05 g/100 g), ergocornine (25.61 ± 0.11 min, 0.27 ± 0.04 g/100 g), and α- and β-isomers of ergocriptine (α-ergocriptine – 27.19 ± 0.01 min, 0.17 ± 0.01 g/100 g; β-ergocriptine – 27.42 ± 0.01 min, 0.061 ± 0.05 g/100 g). Ergotamine, ergometrine, ergocristine, ergocornine, α- and β-isomers of ergocriptine were identified and quantitatively determined in sclerotias from different strains of pharmaceutical ergot Claviceps purpurea. [ABSTRACT FROM AUTHOR]

The frequency dependence of the complex refractive index of an InAs/GaSb superlattice where plastic relaxation is suppressed by interface compensation of strains and the fundamental absorption edge falls in the far-infrared range is experimentally determined for the first time at temperatures of 77–300 K. The energy structure of the superlattice minibands and its variation with temperature are discussed. [ABSTRACT FROM AUTHOR]

In this paper, we investigate and characterize a family of optimization problems introduced by interval-valued functionals that are determined by curvilinear integrals. To this end, we first state the path independence and (strictly) L U convexity properties of the considered functionals. Thereafter, we formulate the corresponding controlled variational inequalities. The main results of this paper provide some connections for the above-mentioned variational models. Since the objective functionals have a physical importance, an illustrative application is considered and studied by using the theoretical elements obtained in this study. [ABSTRACT FROM AUTHOR]

In this paper, we introduce and study a new class of minimization models driven by multiple integrals as cost functionals. Concretely, we formulate and establish some sufficient efficiency criteria for a feasible point in the considered optimization problem. To this end, we introduce and define the concepts of (Γ , ψ) -invexity and generalized (Γ , ψ) -invexity for the involved real-valued controlled multiple integral-type functionals. More precisely, we extend the notion of (generalized) (Γ , ψ) -invexity to the multiple objective control models driven by multiple integral functionals. In addition, innovative proofs are considered for the principal results derived in the paper. [ABSTRACT FROM AUTHOR]

Computed tomography (CT) is known for its non-invasiveness, fast procedure, and also for providing detailed diagnostic information to physicians. It also utilises low-dose-rate ionising radiation (X-rays) as a source for imaging. Multidetector computed tomography (MDCT) is an advanced system that uses iodinated contrast media for more accurate diagnostic results. Studies suggest using these contrasts will lead to greater radiation adsorption with significant DNA damage. No studies have been taken comparing the physical dose with the biological effect. The present study sheds light on the same by assessing the biological effect of CT with and without contrast intervention. The present study is timebound; thus, 21 participants attending for CT thorax and abdomen with no history of any cancer were included. The same participants underwent both pre-contrast and post-contrast studies. The blood sample was taken before the procedure and used as a control. Physical parameters like DLP and CTDI obtained from the instrument were compared with the MN frequency obtained (CBMN Assay). The study showed a significant increase (p-value < 0.05) in the Physical and MN frequency in the Post-Contrast group compared to the pre-contrast group. Although a positive correlation was observed between pre and post-contrast groups, the results were not found to be statistically significant (p-value < 0.05). The study confirms increased physical dose and MN frequency upon contrast intervention. This study recommends the judicial use of MDCT in disease diagnostics. [ABSTRACT FROM AUTHOR]

Introduction: Current guidelines endorse the use of perioperative chemotherapy (POC) in muscle-invasive bladder cancer (MIBC) to enhance the long-term overall survival (OS) compared to radical cystectomy (RC) alone. This study aims to assess the impact of POC on the OS in frail and morbid (F-M) patients undergoing RC. Methods: A retrospective multicenter study of 291 patients who underwent RC between 2015 and 2019 was performed. Patients with both a Charlson comorbidity index ≥ 4 and Modified Frailty Index ≥ 2 were classified as the F-M cohort. We compared the clinical and pathological characteristics and outcomes of the F-M patients who received POC to those who underwent RC alone. Univariable and multivariable analyses were performed to identify the predictors of the OS. Results: The F-M cohort included 102 patients. POC was administered to 44% of these patients: neoadjuvant (NAC) to 31%, adjuvant (AC) to 19%, and both to 6 (6%). The OS was significantly lower in the F-M cohort compared to in the healthier patients (median OS 42 months, p = 0.02). The F-M patients who received POC were younger, less morbid and had better renal function. Although POC was marginally associated with improved OS in the univariable analysis (p = 0.06), this was not significant in the multivariable analysis (p = 0.50). NAC was associated with improved OS in the univariable analysis (p = 0.004) but not after adjustment for competing factors (p = 1.00). AC was not associated with the OS. Conclusions: POC does not improve the OS in F-M patients undergoing RC. Personalized treatment strategies and further prospective studies are needed to optimize care in this unique vulnerable population. [ABSTRACT FROM AUTHOR]

Distal radioulnar joint (DRUJ) instability is a complex condition that can severely affect forearm function, causing pain, limited range of motion, and reduced strength. This review aims to consolidate current knowledge on the diagnosis and management of DRUJ instability, emphasizing a new classification system that we propose. The review synthesizes anatomical and biomechanical factors essential for DRUJ stability, focusing on the interrelationship between the bones and surrounding soft tissues. Our methodology involved a thorough examination of recent studies, incorporating clinical assessments and advanced imaging techniques such as MRI, ultrasound, and dynamic CT. This approach allowed us to develop a classification system that categorizes DRUJ injuries into three distinct grades. This system is intended to be practical for both clinical and radiological evaluations, offering clear guidance for treatment based on injury severity. The review discusses a range of treatment options, from conservative measures like splinting and physiotherapy to surgical procedures, including arthroscopy and DRUJ arthroplasty. The proposed classification system enhances the accuracy of diagnosis and supports more effective decision making in clinical practice. In summary, our findings suggest that the integration of advanced imaging techniques with minimally invasive surgical interventions can lead to better outcomes for patients. This review serves as a valuable resource for clinicians, providing a structured approach to managing DRUJ instability and improving patient care through the implementation of our new classification system. [ABSTRACT FROM AUTHOR]

Photoluminescence imaging (PLI) is a widely accepted, fast, and contactless method for detecting crystal defects in crystalline silicon solar cells and solar‐grade silicon wafers. However, it is less known by semiconductor wafer manufacturers despite the similarities between photovoltaic (PV) and semiconductor wafers. This study focuses on the detection of microcracks by PLI during high‐quality Czochralski silicon (Cz‐Si) wafer manufacturing. The results show that in case of low resistivity (<25 mΩ cm) wafers, microcracks can be detected at any stage of the processing—even after diamond‐wire slicing. When resistivity increases, visibility of microcracks reduces in process steps that produce uneven surfaces. Nevertheless, they can still be detected after slurry‐wire slicing, lapping, alkaline etching, and polishing. According to the results, unlike resistivity, other material parameters such as dopant species, crystal orientation, and wafer thickness have no similar impact on visibility of microcracks in PLI. Furthermore, all wafers produce a decent photoluminescence (PL) signal without a need for separate sample preparation. Based on these results, general recommendations for the in‐line detection of microcracks for Cz‐Si wafer manufactures are provided. While this study focuses on microcracks, the results and discussion include broader perspectives on the defect characterization in Cz‐Si wafer manufacturing via PLI. [ABSTRACT FROM AUTHOR]

Since not every problem in optimization theory involves convex functionals, in this study, we introduced new classes of generalized convex functionals. More precisely, under generalized hypotheses, we stated new efficiency conditions associated with a class of multiple-objective optimal control models. To this end, we first defined the Gθ-Fritz John problem and, by considering it, we established a link between the solutions of Gθ-Fritz John problem and efficient solutions of the considered model (P). In addition, we formulated the Gθ-necessary efficiency conditions for a feasible solution in (P). After that, we established a connection between the newly defined concept of Gθ − KT points to (P) and the efficient solutions of (P). Finally, we turned our attention to the Gθ-sufficient efficiency conditions for a feasible solution to (P). More precisely, we established that any feasible solution to (P) will be an efficient solution if the assumption of Gθ-convexity (and/or Gθ-quasiconvexity, Gθ-strictly quasiconvexity, Gθ-monotonic quasiconvexity) is imposed on the involved functionals [ABSTRACT FROM AUTHOR]

The Pacific oyster (Crassostrea gigas Thunberg, 1795) is a crucial species in global aquaculture; however, optimizing larval survival rates and ensuring high-quality seed production continue to pose significant challenges. Probiotics have been investigated as a potential solution throughout various stages of the production process. This study assessed strains of lactic acid bacteria (LAB) and pathogenic strains isolated from oysters. Notably, several LAB strains, particularly Lactobacillus plantarum 69Cr, demonstrated probiotic potential by inhibiting the growth of pathogens such as Vibrio proteolyticus. In Pacific oyster larvae, the L. plantarum 69Cr strain significantly improved survival, with an increase of over 80% compared to those exposed to the pathogen Staphylococcus pasteuri. These findings highlight the effectiveness of the L. plantarum 69Cr strain as a promising probiotic for protecting oyster larvae from pathogenic threats. [ABSTRACT FROM AUTHOR]

U.S. K–12 school districts that traditionally utilized ongoing "formative" assessments of student progress increasingly rely on additional "interim" assessments to predict student performance on standardized tests. Moreover, some districts are experimenting with merit-based teacher bonuses tied to standardized test scores. We examine the relationship between interim assessments and teacher bonuses using a two-period principal–agent model. The school district (principal), operating under a limited budget, decides whether to implement interim assessments and how much merit pay to offer, and teachers (agents) choose how much effort to exert in each period. We use two-state (proficient versus not proficient) Markovian dynamics to describe the evolution of student test readiness, in which the transition probability in a given period depends on both teachers' effort decisions and the starting state. Our results indicate that, despite the popularity of interim assessments, their usefulness is far from guaranteed. In particular, the accuracy promised by these assessments is a double-edged sword: positive midyear results can make it easier to incentivize second period teacher effort, but negative results can have a demotivating effect. Moreover, even when an interim assessment does result in a higher probability of the school ending the year in the proficient state, the resulting higher expected costs of merit-based bonuses for the district may exceed the available budget. Thus, even a free interim assessment might be too expensive for the school district. This paper was accepted by Charles Corbett, operations management. Funding: This research was supported by the Risk Management Center Russell Ackoff Doctoral Student Fellowship and the Fishman-Davidson Center for Service and Operations Management, both at The Wharton School, University of Pennsylvania, Philadelphia, Pennsylvania. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2020.01547. [ABSTRACT FROM AUTHOR]

No-till (NT) alleviates adverse effects of agricultural production on environmental quality, improves soil health, and reduces greenhouse gas emissions, yet this has not been demonstrated in humid subtropical Mississippi. Research objectives were to evaluate nutrient and C dynamics and soil quality via Soil Management Assessment Framework (SMAF) following 15 years of continuous management under corn (Zea mays L.) (2008–2018) and soybean [Glycine max (L.) Merr.] (2019–2022) on a Dundee silt loam soil. After 15 years, soil organic carbon (SOC) stocks (0- to 30-cm depth) under NT were 25% higher than conventional tillage (CT). Between 2020 and 2022, SOC stocks increased 3 Mg ha−1 under NT and decreased 2 Mg ha−1 under CT. Increased SOC retention under NT could represent an opportunity for increasing the systems’ profitability as C markets expand. Greater SOC and aggregation scores improved SMAF soil quality index (SQI) under NT (71%), compared to CT (66%), underscoring the critical role of organic matter in soil functioning in managed agrosystems. Soybean yields were not linked to SMAF SQI (p > 0.05), suggesting that crop yields are mostly affected by non-edaphic factors (e.g., climate extremes). SMAF illustrated positive impacts of NT on SOC sequestration and soil health, which may foster its adoption as a conservation practice in the Lower Mississippi River basin. As such, NT stands as a climate-smart management practice that allows for sustainable intensification in humid subtropical regions. [ABSTRACT FROM AUTHOR]

A spatial problem of elasticity theory is solved for a layer located on two bearings embedded in it. The bearings are represented as thick-walled pipes embedded in the layer parallel to its boundaries. The pipes are rigidly connected to the layer, and contact-type conditions (normal displacements and tangential stresses) are specified on the insides of the pipes. Stresses are set on the flat surfaces of the layer. The objective of this study is to obtain the stress–strain state of the body of the layer under different geometric characteristics of the model. The solution to the problem is presented in the form of the Lamé equation, whose terms are written in different coordinate systems. The generalized Fourier method is used to transfer the basic solutions between coordinate systems. By satisfying the boundary and conjugation conditions, the problem is reduced to a system of infinite linear algebraic equations of the second kind, to which the reduction method is applied. After finding the unknowns, using the generalized Fourier method, it is possible to find the stress–strain state at any point of the body. The numerical study of the stress state showed high convergence of the approximate solutions to the exact one. The stress–strain state of the composite body was analyzed for different geometric parameters and different pipe materials. The results obtained can be used for the preliminary determination of the geometric parameters of the model and the materials of the joints. The proposed solution method can be used not only to calculate the stress state of bearing joints, but also of bushings (under specified conditions of rigid contact without friction on the internal surfaces). [ABSTRACT FROM AUTHOR]

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Aim: The value of post‐operative pelvic drain placement after robot‐assisted radical prostatectomy (RARP) for the purpose of diagnosing post‐operative complications is undetermined. The aim of this study was to assess the yield of pelvic drain outputs in predicting post‐operative early‐onset urinary leaks from a vesicourethral anastomosis. Methods: We conducted a retrospective analysis of 204 consecutive patients who underwent RARP in our institution between 2018 and 2022. The daily outputs of the drain and the urinary catheter were measured, and patients with early‐onset anastomotic urinary leak were compared with those who were free of any leak. The association between post‐operative drain output and the presence of urinary leak was investigated by regression analyses. Results: Post‐operative early‐onset leak was present in six patients (3.4%) whose baseline characteristics were not different from those of patients with no leak. The median pelvic drain output on post‐operative day 1 (D‐POD1) was 80 mL (interquartile range [IQR] 51–150 mL) and 122 mL (IQR 62–200 mL) on D‐POD2. The median D‐POD1 of patients with a leak was significantly higher than those without one (250 mL vs 80 mL, respectively; P <.001). The threshold to predict an anastomotic urinary leak was 227 mL on D‐POD1 (area under the curve 0.88; P <.001), and an association between D‐POD1 >227 mL and the presence of urinary leak (odds ratio 35; P <.001) was found. Conclusions: Pelvic drain output on POD1 can predict early‐onset urinary leak. Given the relatively low rate of this complication via a robotic approach, however, we consider that, unless otherwise indicated, the routine placement of a pelvic drain may be safely avoided. [ABSTRACT FROM AUTHOR]

This paper deals with a weighting technique for a class of multiple cost optimization problems with interval values. More specifically, we introduce a multiobjective interval-valued controlled model and investigate it by applying the weighting method. In this regard, several characterization theorems are derived. Moreover, a numerical example is formulated. Based on the provided illustrative example and performing a comparative analysis of the results obtained using the weighting technique versus traditional optimization methods, we can easily conclude the effectiveness of the weighting technique in solving multiple cost optimization problems, that is, the conversion of a vector problem to a scalar one. [ABSTRACT FROM AUTHOR]

The wettability of black silicon (BSi) layers fabricated by reactive ion etching (RIE), metal‐assisted chemical etching (MACE), and laser‐induced etching (LIE) techniques is studied. The contact angles of wetting on the samples with deionized water and methylammonium iodide‐based perovskite solutions are determined. It is found that the element composition and the enlargement area factor of BSi layers have a significant effect on their wettability. When tested with water, the RIE and MACE BSi layers exhibit hydrophobic properties, while the LIE BSi layer demonstrates hydrophilic properties due to the SiOx‐rich surface structures. It is also shown that aging leads to a decrease in the water contact angle. Upon exposure to perovskite solution droplets, BSi layers become highly lyophilic. Based on the Wenzel and Cassie–Baxter models, the mechanisms responsible for the wetting states of the fabricated samples are identified. In the results obtained, valuable insights are provided into the potential of using these layers in tandem perovskite/silicon solar cells. [ABSTRACT FROM AUTHOR]