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Objective:To compare detectability of simulated ground-glass nodules (GGNs) on chest digital tomosynthesis (CDT) among 12 images obtained at 6 radiation doses using 2 reconstruction algorithms and to analyze its association with nodular size and density.Methods:74 simulated GGNs [5, 8 and 10 mm in diameter/−630 and −800 Hounsfield units (HU) in density] were placed in a chest phantom in 14 nodular distribution patterns. 12 sets of coronal images were obtained using CDT at 6 radiation doses: 120 kV–10 mA/20 mA/80 mA/160 mA, 100 kV–80 mA and 80 kV–320 mA with and without iterative reconstruction (IR). 10 radiologists recorded GGN presence and locations by continuously distributed rating. GGN detectability was compared by receiver operating characteristic analysis among 12 images and detection sensitivities (DS) were compared among 12 images in subgroups classified by nodular diameters and densities.Results:GGN detectability at 120 kV–160 mA with IR was similar to that at 120 kV–80 mA with IR (0.614 mSv), as area under receiver operating characteristic curve was 0.798 ± 0.024 and 0.788 ± 0.025, respectively, and higher than six images acquired at 120 kV (p  < 0.05). For nodules of −630 HU/8 mm, DS at 120 kV–10 mA without IR was 73.5 ± 6.0% and was similar to that by the other 11 data acquisition methods (p = 0.157). For nodules of −800 HU/10 mm, DS both at 120 kV–80 mA and 120 kV–160 mA without IR was improved by IR (56.3 ± 11.9%) (p  < 0.05).Conclusion:CDT demonstrated sufficient detectability for larger more-attenuated GGNs (>8 mm) even in the lowest radiation dose (0.17 mSv) and improved detectability for less-attenuated GGNs with the diameter of 10 mm at submillisievert with IR. [ABSTRACT FROM AUTHOR]