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Lipid droplets (LDs) are highly specialized energy storage organelles involved in the maintenance of lipid homoeostasis by regulating lipid flux within white adipose tissue (WAT). The physiological function of adipocytes and LDs can be compromised by mutations in several genes, leading to NEFA-induced lipotoxicity, which ultimately manifests as metabolic complications, predominantly in the form of dyslipidemia, ectopic fat accumulation, and insulin resistance. In this review, we delineate the effects of mutations and deficiencies in genes — CIDEC, PPARG, BSCL2, AGPAT2, PLIN1, LIPE, LMNA, CAV1, CEACAM1, and INSR — involved in lipid droplet metabolism and their associated pathophysiological impairments, highlighting their roles in the development of lipodystrophies and metabolic dysfunction. [ABSTRACT FROM AUTHOR]

The unique structure of [2.2]paracyclophane (PCP) with its rigidity, stability, and planar chirality has gained significant attention in polymer and material research. In this work, the incorporation of amino‐functionalized PCPs within polymers of intrinsic microporosity (PIMs) is reported for the first time. Three different PCP‐PIMs were prepared via a Tröger's base formation mechanism, and their structures characterized via solid‐state NMR, MALDI‐TOF, and SEM. Their porosity was evaluated using gas adsorption (N2 and CO2) based on theoretical calculations such as Brunauer–Emmett–Teller (BET), NLDFT pore size distribution (PSD) and ideal IAST CO2/N2 selectivity (15/85), a crucial separation when considering the capture of CO2 from flue gas. The surface areas were found to be between 200–230 m2 g−1 while the selectivity for CO2/N2 ranged from 46 to 70. [ABSTRACT FROM AUTHOR]

Purpose: The shadow economy (SE) has been a serious issue with varied dimensions in all countries that significantly affect economic growth. Therefore, all countries have made an effort to tackle the SE by pursuing several measures. This study aims to investigate the impact of financial markets (stock and bond) in reducing the SE while considering the role of country risk (political, economic and financial) in N-11 countries. Design/methodology/approach: The study employed first-generation methodological techniques, including a unit root test to identify stationarity in the series, a panel cointegration test and panel autoregressive distributive lag (ARDL) to estimate long-run and short-run relationships. Finally, the Granger causality is applied to determine the direction of the causal relationship. Findings: The study explored that country risk factors are crucial in reducing the size of the SE. Moreover, the significant moderating role of country risk factors in the financial market development and SE nexus suggests that by controlling the country's risk, financial market development can negatively affect the SE. Research limitations/implications: Due to the availability of data, the study used data, ranging from 1995 to 2015, because the tax burden data is available from 1995 while the maximum data for the SE is available till 2015, using Medina and Schneider's (2019) data estimates for the SE. Originality/value: The previous studies have focused explicitly on the role of financial institutions' development in the SE. To the best of the author's knowledge, no previous study is attempted to investigate the role of financial markets (bonds and stock) in the size of the SE. Furthermore, previous studies have ignored the important role of country risk factors in the size of the SE. This study investigates the impact of country risk on the SE and the moderating role of country risk in the development of financial markets and the SE nexus. [ABSTRACT FROM AUTHOR]

Sustainability has become the top priority for many businesses in the current era, and green marketing strategies are used to encourage the purchase of environmentally friendly goods. The research aims to analyze green marketing strategies and their impact on consumer behavior toward the environment in China. The study uses a logistic regression approach for data analysis. We found that environmental concerns and beliefs (ECB), Eco Labeling (EL), green packaging and branding (GPB), and green product, premium, and pricing (GPPP) have positive associations with consumers' attitudes and behaviors toward the environment. This study concludes that EL, ECB, EL, GBP, and GPPP are significant tools of green marketing strategies that considerably improve customers' environmental attitudes. The firm managers may adopt these green marketing strategies to achieve revenue and sustainable environmental goals. Furthermore, the government may provide incentives such as lower cooperate tax on green products industries, while private and public banks may provide subsidized loans to the green marking industries in the country. [ABSTRACT FROM AUTHOR]

Background/Objectives: Locating the mandibular foramen (MF) through imaging is clinically important for inferior alveolar nerve (IAN) anesthesia and mandibular ramus osteotomies. Although cone-beam computed tomography (CBCT) is superior in imaging the mandible, an orthopantomogram (OPG) is preferred for its ease of use and availability. Therefore, the present study aimed to evaluate the accuracy of digital OPG in localizing the MF, in a subset of the Middle Eastern population. Methods: Radiographic images (OPG and CBCT) of selected patients (adults, dentulous and no mandibular abnormalities) were used to locate the MF through digital measurements (mm) of the anteroposterior distance from the anterior border of the ramus (MF-AP) and the superoinferior position from the mandibular occlusal plane (MF-SI). Measurements were statistically compared between OPG and CBCT for accuracy. Differences in measurements between OPG and CBCT were compared against the anatomic location (right/left), age and biological sex, assuming a p-value < 0.05 as significant. Results: A total of 204 radiographic records (males: 100/females: 104/mean age: 34.65 ± 11.55 years) were evaluated. The measurements for the MF were MF-AP-OPG (right: 13.53 ± 2.44/left: 13.19 ± 2.25), MF-AP-CBCT (right: 13.61 ± 2.39/left: 13.36 ± 2.19), MF-SI-OPG (right: 5.25 ± 1.71/left: 5.41 ± 1.65) and MF-SI-CBCT (right: 5.59 ± 1.66/left: 5.52 ± 1.61). Measurements between OPG and CBCT were not significantly different, except for MF-SI (right) (p = 0.042). While the overall difference between OPG and CBCT (MF-AP/MF-SI) measurements showed a significant association (p < 0.01) with the anatomic location (right/left), a significant association (p < 0.05) with biological sex was observed only for MF-AP. Conclusions: Based on this study's outcomes, digital OPG is an accurate modality to locate the MF based on anteroposterior (MF-AP) and superoinferior (MF-SI) measurements. This would be clinically beneficial for dental and oral surgeons to achieve the optimum IAN block anesthesia based on preoperative panoramic radiographs. Similarly, it would assist maxillofacial surgeons in planning mandibular orthognathic surgeries and ramus osteotomies without complications. [ABSTRACT FROM AUTHOR]

Prior studies find a positive relation between analyst forecast revisions and upcoming news, suggesting that analysts' forecast revisions are incomplete with respect to available information. In this study, we use the association between forecast revisions and upcoming news to measure forecast completeness and show that post-forecast-revision drift is higher when forecasts are incomplete. We follow Hui and Yeung's (2013) approach to separate forecast revision news into industry-wide and firm-specific components because they find that drift is primarily associated with the industry component. We find that forecast revisions are less complete for industry-wide news than for firm-specific news. Furthermore, analysts' industry-wide revisions are less complete early in the year and when the underlying news is bad, and we find stronger post-forecast-revision drift in those cases. We also show that analysts who were optimistic in prior periods tend to issue forecasts that are less complete and that generate stronger drift than forecasts by other analysts. Our findings provide an explanation for the drift that contrasts with prior studies that attribute the drift to investors' slow assimilation of the news in forecast revisions. Thus, our study sheds light on analysts' role in conveying firm-specific and industry-wide news to investors and on the implications for post-forecast-revision drift. [ABSTRACT FROM AUTHOR]

Background: Dysmenorrhea, characterized by painful menstrual cramps, significantly impacts the well-being of women globally. Despite its prevalence and adverse effects, dysmenorrhea is often underdiagnosed and inadequately treated. This study aims to validate the Arabic version of the Working ability, Location, Intensity, Days of pain, and Dysmenorrhea (WaLIDD) scale among Lebanese female university students aged 18– 45. Methods: This cross-sectional study, involving 729 participants, utilized a translated WaLIDD scale and the Depression, Anxiety, and Stress Scales (DASS-8). Results: Confirmatory Factor Analysis (CFA) confirmed the one-factor structure of the WaLIDD scale, demonstrating excellent fit indices, with good internal reliability. Concurrent validity analysis revealed significant associations between higher WaLIDD scores and elevated levels of depression, anxiety, and stress. The prevalence of dysmenorrhea in the study was estimated at 7.3%. Conclusion: The study underscores the importance of the WaLIDD scale as a reliable and valid tool for assessing dysmenorrhea among Arabic-speaking populations. The successful validation of the Arabic version facilitates its application in Lebanon and potentially other Arab regions, providing a universal tool to predict and assess dysmenorrhea and its impact. Further research is encouraged to explore the scale's applicability in clinical settings and tailor interventions for improved women's well-being. [ABSTRACT FROM AUTHOR]

Undoped, Fe, Sn doped and Fe/Sn co-doped copper oxides are prepared by precipitation synthesis. X-ray diffraction confirmed that the all synthesized powders show a monoclinic main CuO phase. The insertion of Fe or/and Sn within the CuO matrix moderately affects the preferential growth direction. Basically Fourier Transform Infrared (FTIR) confirmed about functional group and their vibrations in the CuO samples. The reflectance of the undoped sample is higher than that of the other samples. Compared to undoped CuO, the doped and co-doped NPs exhibit red-shifted gap energy. Indeed, the Fe-doped, and Sn-doped CuO NPs, exhibit a slight decrease of gap energy (1.47, 1.45 eV respectively) compared to the undoped CuO (1.49 eV), while the Fe/Sn co-doped sample has a lower gap energy of 1.06 eV. Additionally, the antibacterial efficiencies of the all-synthesized samples are tested against Staphyloccus species. Doped and undoped CuO nanopowders show important antibacterial activity on tested bacteria with MICs values ranged between 0.039 to 1.25 mg/ml. Minimum Inhibitory Concentration value of 0.039 mg/ml was obtained with Fe-doped CuO NPs (CuO:Fe NPs) against S.aureus ATCC33591, whereas the highest MIC value of 1.25 mg/ml was obtained with CuO:Sn nanopowder against the strain S. epidermidis, which was the most resistant strain. Moreover, all CuO NPs, except CuO:Fe/Sn showed important anti-adhesive and antibacterial activities against S. epidermidis when used as pellets. This was confirmed either by cell counts using the determination of CFU/ml of bacterial suspension inside the hole, or by using fluorescence microscopy. [ABSTRACT FROM AUTHOR]

This review article focuses on the impact of working fluid characteristics, geometrical parameters and the operating coefficients in thermal efficiencies of direct absorption solar collectors (DASCs). Regarding working fluid parameters, the review emphasized the importance of type of base fluid, nanoparticle properties, such as material, size, concentration and shape. Geometrical parameters, including the collector area, aspect ratio, tube diameter and collector panel design, were identified as crucial design considerations for maximizing DASC efficiency. Additionally, the review highlighted the significance of various operating parameters. Solar irradiance was identified as a critical factor, emphasizing the importance of optimizing the collector's orientation and tilt angle to maximize solar exposure. The fluid flow rate within DASCs was also recognized as a key parameter influencing heat transfer and overall performance. Increasing the thermal flow measurement of nanomaterials has been predicted to improve the heat transfer, ultimately leading to improved thermal efficiency. By carefully considering and optimizing these parameters, it is possible to maximize the efficiency and effectiveness of DASCs, thereby advancing the utilization of solar energy for sustainable and renewable power generation. [ABSTRACT FROM AUTHOR]

Purpose: To develop age-specific reference intervals for physical performance test outcomes relevant to male youth Middle Eastern football players. Methods: We analyzed mixed-longitudinal data (observations range: 1751–1943 assessments) from a sample of 441 male youth outfield football players (chronological age range: 11.7–18.4 y) as part of the Qatar Football Association and Aspire Academy development program over 14 competitive seasons. Semiparametric generalized additive models for location, scale, and shape estimated age-specific reference centiles for 10-m sprinting, 40-m sprinting, countermovement jump height, and maximal aerobic speed variables. Results: The estimated reference intervals indicated that the distribution of the physical performance test scores increased monotonically and nonlinearly with advancing chronological age for sprinting and countermovement jump outcome measures, reaching a plateau after 16 years common to each of these performance variables. The maximal aerobic speed median score increased substantially until ∼14.5 years, with the nonlinear trend flattening off toward relatively older chronological ages. Conclusions: We developed age-related reference intervals for physical performance test outcomes relevant to youth Qatari football players. Country-wide age-specific reference intervals can assist in the longitudinal tracking of the individual players' progress over time against benchmark values derived from the reference population. [ABSTRACT FROM AUTHOR]

The aim of this study is to perform analysis of nonlinear mixed convection flow of Carreau fluid due to curved stretched surface with slip condition. Furthermore, the effect of Darcy–Forchheimer and MHD is taken into consideration. The energy equation is modified by considering the variable thermal conductivity with Joule heating effect. The governing equations of the problem are highly nonlinear partial differential equations subjected to boundary conditions. Similarity transformations are used to transform nonlinear PDEs into ODEs. The numerical technique is used to solve this problem via bvp4c. The main outcomes of this research are that the impact of Forchheimer and porosity parameter tends to decrease the fluid velocity for shear thickening case. The velocity slip condition increases the fluid velocity only near the surface but the fluid velocity away from the surface does not get affected. The changing thermal conductivity raises the temperature of the fluid near the boundary. Furthermore, the impacts of various parameters on the velocity and temperature profiles are demonstrated. The values of local Nusselt number and skin friction for a different parameter are provided. [ABSTRACT FROM AUTHOR]

The development of area-selective, scalable deposition methods for the anisotropic growth of transition metal dichalcogenide (TMDC) thin films with a planar morphology is essential for their practical applications in integrated electronic and optoelectronic devices. In this work, we report on the electrodeposition of layered WSe2 from a single source molecular precursor, containing both W and Se, for the first time. Using WSeCl4 in an acetonitrile (MeCN) electrolyte solution, we have employed cyclic voltammetry (CV) and electrochemical quartz crystal microbalance (EQCM) techniques to study the electrochemical behaviour of WSeCl4. A pulsed electrodeposition technique was then used to deposit WSe2 films, which possess a homogeneous composition across the whole electrode area. Characterization using scanning and transmission electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy and Raman spectroscopy confirm the electrodeposited thin films to be WSe2. As a proof-of-concept for future growth directly into 3D device architectures, we present the 2D anisotropic growth of WSe2 thin films from the edge of a 100 nm thick TiN nanoband electrode across SiO2 on microfabricated 3D structures, allowing the direct measurement of electrical characteristics. Through this work, we also demonstrate electrodeposition as an area-selective growth technique suitable for obtaining highly anisotropic WSe2 thin films which are very promising for future electronic and optoelectronic applications. [ABSTRACT FROM AUTHOR]

The present research investigates the linkage between natural resources rent and environmental quality taking into the role of the institutional and business environments. It uses a sample of 15 major oil-exporting countries throughout 2008–2020 and performs the Systems Generalized Method of Moment (SGMM) as an empirical approach. Findings confirm that natural resource rent deteriorates the environmental quality since its coefficient is found to be positively and significantly linked to the dependent variable (CO2 emissions). After dividing the sample into MENA oil-exporting countries and Non-MENA exporting countries, different results were found between these two blocs of countries. Additionally, institutional quality and the environment business are found to play an important role in mitigating the negative impact of natural resources rent on environmental quality. Many lessons could be drawn from this research and many interesting policy implications were drawn from the findings. Policymakers of these countries should work on preserving and protecting the quality of their environment. Policymakers in these countries, notably MENA oil-exporting countries, are invited to invest in clean energy. Additionally, an improvement of the institutional quality and the environment business is needed since they mitigate the negative impact of natural resources rent. [ABSTRACT FROM AUTHOR]

Breast cancer has the highest global incidence among all cancers, affecting more than 2 million individuals annually. Despite the availability of new drugs and novel treatment combinations, it is postulated that the incidence and mortality of breast cancer will rise by 40.8% and 51.9% respectively by 2040. Such dire statistics are associated with the clonal evolution of cancer cells that leads to therapeutic resistance and consequent relapse in breast cancer patients. On the other hand, the tumor microenvironment (TME) comprising of tumor cells, cancer-associated immune cells, re-programmed stromal cells, and the extracellular matrix (ECM) creates an immunosuppressive niche facilitating immune evasion. This review focuses on a critical cellular component of the tumor microenvironment, the tumor-associated macrophages (TAMs) in breast cancer immunotherapy. Macrophages are inherently plastic and can convert from an anti-tumor M1 phenotype to a pro-tumor M2 phenotype based on microenvironmental cues. Cancer cells facilitate these cues, allowing the tumor-associated macrophages to gain M2 phenotype and mediate immune evasion. Therefore, knowledge of the distinct role of tumor-associated macrophages in immune evasion can help design therapeutics such as engineered macrophages, M2 targeting drugs, and novel macrophage-mediated drug delivery strategies for long-term survival in breast cancer. [ABSTRACT FROM AUTHOR]

Introduction: While several studies have examined stroke public knowledge and awareness in individual countries within the Middle East and North Africa (MENA) region, none have provided a comprehensive cross-country assessment. Purpose: To assess public stroke knowledge and awareness among Arabic-speaking adults in seven MENA countries and identify associated factors. Materials and methods: An online cross-sectional survey was self-administered by the public population in Iraq, Lebanon, Sudan, Jordan, United Arab Emirates, Syria, and Saudi Arabia (April 2021–2023). Associations of stroke risk factors, early symptoms, and consequences with socio-demographics and medical history were analyzed using logistic regression models. Results: Of 4,090 participants (58.3% females), 42.9% identified four out of five correct answers related to general stroke knowledge. Only 25.2% identified all stroke risk factors, 24.7% recognized all symptoms, and 37.5% knew all possible consequences. Results show consistent pattern of high identification for at least one risk factor and consequences across all countries (96.3 to 99.8% and 86.2 to 100%, respectively), with varying levels of early symptom identification (56.8 to 97.9%). Females were more likely to identify a stroke risk factor, symptom, and consequence compared to males (OR = 2.525, 2.474, and 2.302, respectively, p < 0.001). Employed, urban residents, and those with higher education demonstrated better stroke awareness. Conclusion: The sample showed variable levels of stroke knowledge among the public, underscoring the pressing need for targeted community initiatives, media campaigns, and educational interventions. These efforts are paramount for improving awareness, early detection, and timely response, especially in countries with lower levels of community stroke awareness. [ABSTRACT FROM AUTHOR]

Background: The dynamic landscape of medical education demands innovative teaching methods. This study introduces virtual reality (VR) technology to anatomy courses at Qatar University, aiming to assess students’ receptiveness to virtual anatomy dissection and its potential transformative impact. Methods: The study utilized a comprehensive survey and the 3D-Organon VR anatomy software to explore students’ perceptions and acceptance of VR in comparison with traditional anatomy learning tools during practical sessions. Fisher’s exact test for independence was performed to gauge shifts in students’ attitudes and preferences towards different educational modalities. Results: The findings reveal a generally positive reception towards VR, with many students indicating a preference for VR over traditional methods. The study noted significant improvements in understanding and memorization attributed to the use of VR. Exposure to a variety of educational modalities led to notable shifts in student perceptions, particularly an increase in positive perceptions regarding the understanding of anatomy lectures and a heightened preference for VR as a learning method. Conclusions: The study underscores the evolving and adaptable attitudes of students towards VR, emphasizing the significant role that diverse learning experiences play in shaping their receptiveness. It provides valuable insights into how medical education can be reshaped through a blended approach that integrates technological innovation with traditional learning methods. These findings advocate for the strategic incorporation of VR in anatomy courses to enhance learning outcomes. [ABSTRACT FROM AUTHOR]

Meta-analytic results have revealed a significant influence of stress on a wide array of psychological and behavioral markers, underscoring its considerable clinical importance. Providing a simple and cost-effective tool assessing stress for the Arabic-speaking population would be immensely beneficial. Therefore, our research objective was to examine the psychometric properties of an Arabic version of the Stress Numerical Rating Scale-11 (Arabic SNRS-11), including its reliability, and construct validity. 763 adolescents were recruited during November 2023. An anonymous self-administered Google Forms link was distributed via social media networks. The results of the EFA revealed two factors, which explained 66.43% of the common variance. When adding the SNRS-11, Bartlett’s test of sphericity, χ2(55) = 4127.1, p < 0.001, and KMO (0.88) remained adequate. The two-factor solution obtained explained 63.28% of the variance. The same structure was obtained in both males and females separately. McDonald’s ω and Cronbach’s α were very good for all models. Both PSS and Arabic SNRS-11 scores correlated significantly and positively with each other, as well as with higher depression, anxiety and stress scores. Finally, no significant difference was found between males and females in terms of PSS (27.08 ± 6.43 vs. 27.72 ± 6.06; p = 0.163; Cohen’s d = 0.102) and Arabic SNRS-11 (4.68 ± 2.56 vs. 4.97 ± 2.52; p = 0.125; Cohen’s d = 0.113) scores. The findings indicate that the Arabic SNRS-11 is a cost-effective, valid, and reliable tool for assessing stress. Therefore, it is recommended to use this single item to assess momentary or day-to-day stress among Arabic-speaking adolescents in Arab clinical and research settings. To evaluate the practical effectiveness of the Arabic SNRS-11 and to further enhance the data on its construct validity, future studies should assess the measure in diverse contexts and among specific populations. [ABSTRACT FROM AUTHOR]

Megameatus intact prepuce (MIP) presents with diverse phenotypes that complicate the management of this rare but complex hypospadias variant. Current data on optimal treatment methods and patient outcomes are sparse, unintegrated, and therefore challenging to implement clinically. A comprehensive systematic review of the existing literature on MIP was conducted according to PRISMA guidelines. Electronic databases including PubMed, Embase, and Scopus were searched for relevant articles published up to [2024]. Key aims were to assess the safety and efficacy of different surgical interventions, and synthesize corresponding outcomes reported in the literature. The search yielded 18 articles meeting the inclusion criteria, representing a total of 524 enrolled patients across multiple geographic regions. Diagnosis of MIP typically involves clinical examination, imaging studies, and urological evaluation. Surgical management options included preputial reconstruction, urethroplasty, and meatal advancement with glanuloplasty. Reported outcomes varied, with success rates ranging from [77.1–100%]. Long-term follow-up data on functional and cosmetic outcomes were limited. Megameatus intact prepuce presents diagnostic and management challenges due to low prevalence and variable presentation. This systematic review presents a current understanding of MIP diagnosis, surgical techniques, and patient outcomes. Future studies should assess the long-term functional outcomes of different surgical approaches, and investigate the underlying genetic and environmental factors contributing to the diverse clinical manifestations of MIP. [ABSTRACT FROM AUTHOR]

Background: Over 768 million cases of COVID‐19 infection have been reported worldwide, with pregnant women being the most vulnerable members of society during such an infectious disease outbreak. In the United Arab Emirates, there are limited studies explaining the effects of COVID‐19 on pregnant women and their fetuses. In this study, the maternal and fetal outcomes in pregnant women with COVID‐19 in a tertiary maternal hospital, United Arab Emirates, were examined. Materials and Methods: A descriptive study was conducted in a tertiary hospital for Obstetrics and Gynecology in Ras Al Khaimah, UAE. The study included all pregnant women who tested positive for COVID‐19 infection from April 2020 to September 2021. Results: The study revealed that a higher number of COVID‐19‐infected pregnant patients presented in their third trimester (69.1%). The comorbidity of body mass index (BMI) had the most effect on the severity/hospitalization status of the patients (p = 0.018). In the nonhospitalized group, fever was the most common symptom (26%), whereas in the hospitalized group, cough was the most common symptom (94%). Emergency cesarean delivery was found to be significant (p = 0.0007) in hospitalized patients. COVID‐19 pneumonia was the prevailing adverse maternal outcome. NICU admission and prematurity were the most frequent neonatal outcomes. Conclusions: In conclusion, our findings show that adverse maternal outcomes, obesity, and mode of delivery were related to COVID‐19 severity in pregnant patients. However, there was no effect generally on the adverse fetal outcomes except for jaundice and birth weight. [ABSTRACT FROM AUTHOR]

Introduction: Premature rupture of membranes (PROM) before 37 weeks of gestation is a common obstetrical event, whose pathophysiology is still poorly understood. Our objective was to study the mechanical strength of fetal membranes in women with a clinical risk factor for preterm premature rupture of membranes (PPROM). Methods: We included, in a prospective, descriptive, single-center study, patients scheduled for cesarean section at term (≥ 37 weeks of gestation). For each patient, we performed uniaxial tensile tests on fetal membranes with a universal testing machine equipped with a force sensor (EZ20®, Lloyds), allowing the recording of an applied force/time curve. We collected maximum force (Fmax), maximum stress (σMax), and Young's modulus of elasticity. The thickness of each membrane sample was also measured. We compared the values obtained according to certain clinical risk factors for PPROM such as age, body mass index, gravidity, parity, a history of PPROM or preterm birth, smoking, gestational diabetes, geographic origin, and socioeconomic level. Results: We analyzed 31 patients and found no association between the studied risk factors and σMax. Fmax was lower in primiparous patients (p = 0.02) but increased with patient parity (p = 0.005). Gestational diabetes was associated with a higher Fmax (p = 0.033) and sub-Saharan geographical origin with a greater thickness (p = 0.0043). As membrane thickness increased, σMax (p = 0.009) and Young's modulus decreased (p = 0.037). Conclusion: Primiparous patients have lower membrane mechanical strength than patients who have had one or more deliveries. Mechanically, the thicker membranes are less rigid and less resistant. [ABSTRACT FROM AUTHOR]

Pioglitazone, an anti-diabetic drug, has been previously shown to ameliorate kidney damage through anti-inflammatory and antioxidant effects. In this study, we employed an integrative bioinformatics approach to study the possible mechanisms involved in the mitigative effect of pioglitazone against colistin-induced nephrotoxicity. Next, we validated the results obtained from the bioinformatics study by pre-treating human kidney-2 (HK-2) cell line with pioglitazone 100 μM for 30 minutes and then treating the cells with colistin sulfate 1200 μM for 24 hours. Inflammatory signaling by cytokines and the nuclear factor erythroid 2 related factor 2 (Nrf2) signaling pathways were predicted to be involved in the ameliorative effect of pioglitazone against colistin-induced nephrotoxicity. The nuclear factor kappa B subunit p65 (NF-κB p65) and Nrf2 were among the predicted transcription factors regulating the hub genes. Moreover, miR-24, miR-16, and miR-21 were identified as potential pathogenic miRNAs regulating the hub genes. In contrast, miR-17, miR-27a, and miR-146a were identified as potential protective miRNAs. The in vitro study indicated that pioglitazone pre-treatment increased cell viability in HK-2 cells exposed to colistin. Pioglitazone pre-treatment reduced the expression of pro-inflammatory cytokine genes (IL6 and TNF). Moreover, pioglitazone reduced the protein expression of NF-κB p65 and increased the protein expression of Nrf2. The protective effect of pioglitazone against colistin-induced toxicity in HK-2 cells is related to its anti-inflammatory and antioxidant activity through modulating NF-κB-mediated inflammatory signaling and Nrf2-mediated antioxidative stress signaling. [ABSTRACT FROM AUTHOR]

The low sensitivity of liquid‐state nuclear magnetic resonance (NMR) can be overcome by hyperpolarizing nuclear spins by dissolution dynamic nuclear polarization (dDNP). It consists of transferring the near‐unity polarization of unpaired electron spins of stable radicals to the nuclear spins of interest at liquid helium temperatures, below 2 K, before melting the sample in view of hyperpolarized liquid‐state magnetic resonance experiments. Reaching such a temperature is challenging and requires complex instrumentation, which impedes the deployment of dDNP. Here, we propose organic conductive polymers such as polyaniline (PANI) as a new class of polarizing matrices and report 1H polarizations of up to 5 %. We also show that 13C spins of a host solution impregnated in porous conductive polymers can be hyperpolarized by relayed DNP. Such conductive polymers can be synthesized as chiral and display current induced spin selectivity leading to electron spin hyperpolarization close to unity without the need for low temperatures nor high magnetic fields. Our results show the feasibility of solid‐state DNP in conductive polymers that are known to exhibit chirality‐induced spin selectivity. [ABSTRACT FROM AUTHOR]

The low sensitivity of liquid‐state nuclear magnetic resonance (NMR) can be overcome by hyperpolarizing nuclear spins by dissolution dynamic nuclear polarization (dDNP). It consists of transferring the near‐unity polarization of unpaired electron spins of stable radicals to the nuclear spins of interest at liquid helium temperatures, below 2 K, before melting the sample in view of hyperpolarized liquid‐state magnetic resonance experiments. Reaching such a temperature is challenging and requires complex instrumentation, which impedes the deployment of dDNP. Here, we propose organic conductive polymers such as polyaniline (PANI) as a new class of polarizing matrices and report 1H polarizations of up to 5 %. We also show that 13C spins of a host solution impregnated in porous conductive polymers can be hyperpolarized by relayed DNP. Such conductive polymers can be synthesized as chiral and display current induced spin selectivity leading to electron spin hyperpolarization close to unity without the need for low temperatures nor high magnetic fields. Our results show the feasibility of solid‐state DNP in conductive polymers that are known to exhibit chirality‐induced spin selectivity. [ABSTRACT FROM AUTHOR]

Cardiovascular disorders (CVDs) are a major global health concern, but their underlying molecular mechanisms are not fully understood. Recent research highlights the role of long noncoding RNAs (lncRNAs), particularly ANRIL, in cardiovascular development and disease. ANRIL, located in the human genome's 9p21 region, significantly regulates cardiovascular pathogenesis. It controls nearby tumor suppressor genes CDKN2A/B through epigenetic pathways, influencing cell growth and senescence. ANRIL interacts with epigenetic modifiers, leading to altered histone modifications and gene expression changes. It also acts as a transcriptional regulator, impacting key genes in CVD development. ANRIL's involvement in cardiovascular epigenetic regulation suggests potential therapeutic strategies. Manipulating ANRIL and its associated epigenetic modifiers could offer new approaches to managing CVDs and preventing their progression. Dysregulation of ANRIL has been linked to various cardiovascular conditions, including coronary artery disease, atherosclerosis, ischemic stroke, and myocardial infarction. This abstract provides insights from recent research, emphasizing ANRIL's significance in the epigenetic landscape of cardiovascular disorders. By shedding light on ANRIL's role in cellular processes and disease development, the abstract highlights its potential as a therapeutic target for addressing CVDs. [ABSTRACT FROM AUTHOR]

This study presents a rare comparative analysis of the factors influencing environmental quality through greenhouse gas (GHG) emissions in the European Union member states' largest economies, i.e., France and Germany. By considering the unique economic, energy, and environmental characteristics of both countries, the finding unveils a novel perspective in the literature. The research utilizes a recently developed wavelet local multiple correlation (WLMC) technique with quarterly dataset spanning from 1990/Q1 to 2020/Q4. The results demonstrate that environmental-related information and communication technologies innovations, energy transition, and financial development play significant roles in limiting the growth of GHGs emission, particularly in the medium and long term. The wavelet-based Granger causality analysis reveals evidence of feedback causality among the variables in both countries in the medium and long term. Moreover, there are slight differences in the short-term relationships given that the observations are generally similar in later period. Overall, the findings offer a deeper understanding and policy insights regarding the time and frequency dynamics of GHG drivers in France and Germany. [ABSTRACT FROM AUTHOR]

Forensic chemists frequently employ statistical profiling approaches to assess the degree of similarity between samples of illicit drugs. Such profiling information can help reveal connections between nodes in distribution networks and manufacturing laboratories. For amphetamine, the routine method of comparing a pair of samples includes the use of a dissimilarity measure based on the Pearson correlation coefficient calculated between their chemical profiles obtained through gas chromatography–mass spectrometry. This simple measure of (dis)similarity has been shown distinguish pairs sharing a common origin (e.g., same production batch) to a reasonable level of accuracy. However, Pearson correlation fails to capture all the relevant notions of similarity between chemical profiles of amphetamine. We present a new statistical method for forensic drug comparison that uses a more sophisticated statistical modelling approach to determine similarity between samples. We show that this leads to improved performance over the correlation‐based approach. The proposed method is easily extendable and has an intuitive interpretation both from chemistry and forensic perspectives, which supports wide applicability to illicit drug profiling in practice. [ABSTRACT FROM AUTHOR]

For the time being, there is a growing endeavor towards supporting energy-saving technologies, most significantly heat exchanger systems, by improving the performance of the heat transfer process. The study model employed is a double-pipe heat exchanger (DPHEX), which is served in an actual project at the Low-Density Polyethylene (LDPE) unit of the State Company for Petrochemical Industries in Basra, Iraq. The prominent goals of this study are to gain a deeper comprehension of the exchanger's performance under advanced operating conditions and to maximize the efficiency of heat transfer between the two fluids in the DPHEX system. The current work applies a distinctive connection of SOLIDWORKS with ANSYS FLUENT software to conduct a simulation design and computational fluid dynamics (CFD) analysis of a heat transfer system in DPHEX. Thermal analysis of exchangers is challenging since many parameters, such as the geometry of the heat exchangers and the varying flow regimes influence the overall heat transfer coefficient. As a result, a Genetic Algorithm (GA) was employed to investigate the optimal design and operating conditions of DPHEX, using a COM server to provide flexible communication between the MATLAB GA toolbox and Aspen HYSYS® software. The preliminary findings from ANSYS FLUENT simulations and GA optimizations demonstrated significant improvements. Specifically, the heat transfer rate rose by 24% and 28%, respectively, also there made up an elevate in the overall heat transfer coefficient to 675 W/m²·K and 751 W/m²·K, correspondingly, from 440 W/m²·K in the as-built heat exchanger. Notably, these results were observed while the outgoing temperature of the chilled ethylene gas was at 49, and the efficiency accounted for 87.7%. The study exhibited the feasibility of reducing the cooling water quantity from the traditional mass flow rate of 73.860 kg/hr to 50.400 kg/hr while maintaining a reasonable efficiency of 83% at the LDPE unit. These results were achieved with the leaving temperature of ethylene gas and cooling water set at 50 and 34, respectively. Hence, minimizing water consumption in heat exchangers brings about environmental, economic, and operational advantages. Generally, the study results have reinforced the importance of simulation tools and their direct contribution to achieving efficient and eco-friendly energy systems. [ABSTRACT FROM AUTHOR]

There is increasing interest in using specialized circuits based on emerging technologies to develop a new generation of smart devices. The process and device variability exhibited by such materials, however, can present substantial challenges for designing circuits. Three models are considered here: a physical compact model, an empirical look‐up table, and an empirical surrogate model based on a multilayer perceptron (MLP) regression. Each one is fit to measurements of discrete organic thin film transistors in the low voltage regime. It is shown that the models provide consistent results when designing artificial neuron circuits, but that the MLP regression provides the highest accuracy and is much simpler to fit compared to the compact model. The targeted technology exhibits non‐ideal behavior such as variable threshold voltage and hysteresis. Using the MLP regression model, the effect of such variability on the performance of an artificial neuron circuit is compared. It is found that these effects alter the neuron firing rate and change the time spent in the on/off states but do not change the basic operation. [ABSTRACT FROM AUTHOR]

During January and February 2022, a huge spike in the cases of COVID-19 was recorded in the Khyber Pakhtunkhwa (KP) province of Pakistan prompting the civil administration to institute new restrictions. To investigate the underlying causes of this surge, the regional Public Health Reference Lab (PHRL) launched a screening effort throughout the Province's remote and urban areas. Herein, we present our survey results during the peak months of the pandemic. The data indicated the prevalence of highly transmissible delta- and Omicron-like virus variants, which may explain the rise in positive cases. Phylogenetic analysis revealed the genetic association between the sequences from this study and those found in Pakistan as well as from geographically distant countries, suggesting a complex evolutionary history. For screening, we deployed an easy-to-use single primer-based polymerase chain reaction (PCR) assay to identify the circulation of SARS-CoV-2. The assay was validated using clinical swabs of COVID-19 patients and obtained consistent results with Sanger sequencing. Our survey identified a patient simultaneously infected with two variants of concern, indicating the presence of the Deltacron variant, although we cannot discount the possibility of sequencing errors. We recommend that SARS-CoV-2 be continuously monitored to detect single nucleotide polymorphisms (SNPs) that are causally linked to the emergence of new lineages. Our method provides a rapid and cost-effective detection assay for SARS-CoV-2 in a resource-constrained setting. [ABSTRACT FROM AUTHOR]

Purpose: The concept of interposing double dorsal preputial flaps to cover the urethroplasty was introduced in 2005 to reduce the risk of urethrocutaneous fistula (UCF). Our study aims to compare the postoperative outcomes of urethroplasty for distal hypospadias between two groups: one receiving single preputial flap coverage and another receiving double flap coverage. Materials and methods: We conducted a retrospective analysis study of boys with primary distal hypospadias who underwent surgery by the same experienced surgeon, at our department between 2010 and 2021. The study population was divided into two groups: Group A, which underwent urethroplasty coverage with single dorsal preputial flap, and Group B, which underwent coverage with double flap. Postoperative complications were compared between the two groups. Results: We collected 105 cases, comprising 51 in Group A and 54 cases in Group B. The mean age at surgery was 29 months in Group A and 24 months in Group B. Post‐operative follow‐up period ranged from 6 months to 8 years. Functional and cosmetic outcomes were judged excellent in 88.7%. Only 10 boys experienced complications requiring reoperation. UCF occurred in 5 patients from Group A, while no cases were reported in Group B (p = 0.024). Meatal stenosis was identified in three patients in Group A and in two patients in Group B (p = 1). No other complications, such as glans dehiscence or penile torsion, were noted. Conclusion: Double dorsal dartos flap is an effective method for covering the new urethra and can be recommended in the treatment of patients with virgin distal hypospadias. [ABSTRACT FROM AUTHOR]

Sulfonated poly (ether ether ketone) (SPEEK) has received substantial attention for its potential to improve the electrochemical behavior and thermomechanical capabilities of direct methanol fuel cells. This study examines how the integration by solution casting of microcrystalline cellulose (MCC) and 2,3-dialdehyde cellulose (DAC) onto highly sulfonated PEEK (with a sulfonation degree of 80%) affects its physicochemical properties and morphological structures. The mechanical attributes and proton conductivity of the polymer matrix are impacted by MCC and DAC inclusion into SPEEK membrane. The maximum proton conductivity was seen in the SPEEK/MCC membranes at 70 °C (up to 0.1 S cm−1). The proton conductivity in methanol vapor was increased by SPEEK/DAC membranes at high temperatures as opposed to pristine SPEEK and SPEEK/MCC membranes. [ABSTRACT FROM AUTHOR]

Alzheimer's disease (AD), a brain disorder, is the leading cause of dementia among older adults. Taurine, an amino acid abundantly present in the brain, and shows potential neuroprotective properties. Therefore, we investigated the effects of taurine on Matrix Metalloproteinase-9 (MMP-9) levels and the expression changes of miRNA-21 and miRNA-146a in the SH-SY5Y cell line. Taurine's impact on the SH-SY5Y cell line was evaluated via the 2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. MMP-9 levels were measured using an enzyme-linked immunosorbent assay (ELISA) kit, while the expression of miRNA-21 and miRNA-146a genes was assessed through Real-Time PCR analysis. The MTT assay revealed no toxic effects on SH-SY5Y cells with increasing concentrations of taurine. Analysis of gene expression indicated a rise in miRNA-21 expression and a decline in miRNA-146 expression with increasing taurine concentration, with the most notable change observed at 1 mg/mL taurine (p<0.001). ELISA results demonstrated a significant increase in MMP-9 levels in the SH-SY5Y cell line treated with 1 mg/mL taurine compared to the untreated group (p<0.001). Our study revealed that taurine can alter the expression of miRNA-146a and miRNA-21. In conclusion, taurine therapy presents promising therapeutic avenues for treating AD or mitigating severe symptoms. Nonetheless, further research is necessary to comprehensively grasp the precise mechanisms at play. [ABSTRACT FROM AUTHOR]

This study uses machine learning techniques to investigate the bond strength between steel and concrete under various elevated temperature scenarios. Five distinct machine learning algorithms, including Random Forest (RF), XGBoost, AdaBoost, Decision Tree, Linear Regression, and hyperparameteric optimisations, were used to predict changes in bond strength. The models underwent rigorous optimisation using GridSearchCV to achieve optimal performance. In this study, we evaluated several metrics such as Mean Squared Error, Root Mean Squared Error, Mean Absolute Error, and coefficient of determination (R2) Score to compare and assess the models' prediction capabilities. After optimisation, results indicate that the RF model exhibited exceptional performance in estimating bond strength across different temperature conditions, demonstrating minimal errors and a high R2 Score. Visual comparisons of actual and predicted values further confirmed the efficacy of the RF model in capturing complex fluctuations in bond strength. The findings of this study underscore the potential of machine learning models, particularly the optimized RF method, in accurately predicting bond strength under varying thermal conditions, with promising implications for engineering and construction practices. [ABSTRACT FROM AUTHOR]

This article shows how the market valuation of start-up companies and the corporate-designed creation of human capital reveal some of the material and more intangible ways in which the economisation of the urban field plays out in the contemporary knowledge economy. The proposed analysis seeks to make visible how both direct and indirect state action enables the different dimensions of the urban field to come together, become valuable and jointly constitute what Michael Hardt and Antonio Negri have called the 'metropolis'. In so doing, the article underlines that the different dimensions of the urban field figure prominently albeit differently partake in processes of extraction of knowledge value in monetised or sociocultural form. At the conceptual level, we critically engage with the existing literature on emergent forms of state capitalism by putting forward a governmental analytic on state power in contemporary urbanised knowledge capitalism. Empirically, we develop our arguments through two case studies. First, we examine the start-up unicorn Wolt, often considered as one of the national champion start-ups in Finland (together with a handful of mobile game developers). Second, we scrutinise the arrival of the Apple software developer Academy in Naples, a widely celebrated state-capital interaction in an economically struggling urban context in southern Italy. These cases are among the many that motivate one to re-think the entanglement of urban space, state governmentality and value extraction as it unfolds today in urbanised knowledge economies. [ABSTRACT FROM AUTHOR]

Lead sulfide quantum dots (PbS QDs) are promising candidates for high-performance solar cells due to their tunable bandgaps and low-cost solution processing. However, low carrier mobility and numerous surface defects restrict the performance of the fabricated solar cells. Herein, we report the synthesis of novel PbS-perovskite core-shell QDs to solve the low carrier mobility problem of PbS QDs via a facile hot injection method. CsPbI2Br shell enabled strain-free epitaxial growth on the surface of PbS QDs because of 98% lattice match. Our results demonstrate a significant improvement in the photoluminescence and stability of the synthesized PbS-CsPbI2Br QDs upon shell formation, attributed to the effective suppression of surface defects by the epitaxial shell of CsPbI2Br. As a result, the obtained solar cell based on PbS-CsPbI2Br core-shell QD exhibits a power conversion efficiency (PCE) of 8.43%, two times higher than that of pristine PbS QDs. Overall, the construction of PbS-CsPbI2Br core-shell structures represent a promising strategy for advancing the performance of PbS QDs-based optoelectronic devices. [ABSTRACT FROM AUTHOR]

The present research investigation utilizes nano-sized graphite (Gr) and silicon carbide (SiC) as secondary fillers incorporated into a primary aluminium alloy (Al6061) matrix using a two-step stir casting method. Investigate the impact of this advanced two-step stir technology on the microstructure of the hybrid composite using a scanning electron microscope equipped with a tungsten-heated cathode electrode. This study assesses the effects of Gr and SiC on the porosity, density, tensile properties (yield strength, ultimate strength, and elongation), microhardness, and impact toughness of the hybrid nanocomposite at room temperature with a relative humidity of 60 %. The homogenous structure of the Al6061/5 wt% Gr/9 wt% SiC hybrid nanocomposite exhibits superior mechanical properties compared to other compositions. Specifically, the two-step stir casting technique has demonstrated the ability to reduce the porosity level to less than 1 %, resulting in enhanced yield strength (124±4 MPa), tensile strength (153±3 MPa), and microhardness (92±2 HV). [ABSTRACT FROM AUTHOR]

In this research, we investigate mixed convection transport of mass and heat transfer in the unsteady boundary layer flow of the Eyring‐Powell fluid around a rotating cone in the presence of Brownian and thermophoresis effects. Rotating cones are widely used in conical diffusers, medical devices, Aerospace Engineering and a variety of rheometric and viscosimetry applications. Specifically, we focus on the flow of the Eyring‐Powell fluid around the cone in the presence of magnetohydrodynamics and nanofluid. The modeled momentum, energy, and concentration equations of the problem are transformed into nonlinear dimensionless, nonlinear ordinary equations by utilizing the similarity variables. These nonlinear coupled ordinary differential equations are solved numerically via Bvp4c, and the outcomes for important physical parameters on momentum, energy, and concentration equations are presented graphically. The computational outcomes of physical parameters for skin friction coefficient, local Nusselt number, and Sherwood are also presented in tabular form. [ABSTRACT FROM AUTHOR]

Logopenic variant primary progressive aphasia (lvPPA) is characterized by word-finding deficits and phonologic errors in fluent speech. Transcranial direct current stimulation (tDCS) targeting either left temporoparietal junction (TPJ) or left inferior frontal gyrus (IFG) show evidence of improving language function in lvPPA. The present case study evaluated the effects of two separate rounds of high definition tDCS (HD-tDCS) (4 mA; 30 sessions) on language and functional neuroimaging in a 57-year-old woman with lvPPA. Stimulation was centred on two different regions across rounds: (1) left TPJ, and (2) left (IFG). Results showed an improved proportion of content to floorholder words during a naturalistic speech task through both rounds as well as change in confrontation naming after TPJ (improvement) and IFG (worsened) stimulation. fMRI connectivity during task showed left lateralized positive correlations following round 1 and anti-correlations with components of the default mode network following round 2. Resting state segregation of a language-associated functional network increased following both rounds, and task-based segregation of the same network increased following IFG stimulation. These results suggest that stimulation to both regions using HD-tDCS may improve language function in lvPPA, while simultaneously eliciting widespread changes beyond the targeted area in neuronal activity and functional connectivity. [ABSTRACT FROM AUTHOR]

Trigeminal neuralgia (TN) is a severe facial pain disease of uncertain pathophysiology and unclear genetic background. Although recent research has reported a more important role of genetic factors in TN pathogenesis, few candidate genes have been proposed to date. The present study aimed to identify independent genetic variants in the protein-coding genes associated with TN. We focused on genes previously linked to TN based on the results of four proteomic studies conducted by our research team. The goal was to validate these findings on the genetic level to enhance our understanding of the role of genetics in TN. The study is based on the participants from UK Biobank cohort. Following quality control, 175 independent single nucleotide polymorphisms (SNPs) in 17 genes were selected. The study sample comprised of diagnosed TN cases (N = 555) and randomly matched controls (N = 6245) based on specific criteria. Two SNPs corresponding to C8B rs706484 [odds ratio (OR) (95% confidence interval (CI)): 1.357 (1.158–1.590); p: 0.00016] and MFG-E8 rs2015495 [OR (95% CI): 1.313 (1.134–1.521); p: 0.00028] showed significant positive association with TN, indicating a positive effect of the SNP alleles on gene expression and disease risk. Interestingly, both SNPs are Expression Quantitative Trait Loci (eQTLs), and are associated with changes in the expression activity of their corresponding gene. Our findings suggest novel genetic associations between C8B, a key component of the complement system, and MFG-E8, which plays a role in regulating neuroinflammation, in relation to TN. The identified genetic variations may help explain why some individuals develop TN while others do not, indicating a potential genetic predisposition to the condition. [ABSTRACT FROM AUTHOR]

Maraging steels are used in industries that require high precision due to their exceptional mechanical properties. This paper presents the impact of ten process parameters on the mechanical properties of maraging steel produced via electron beam melting (EBM). The parameters studied here include printing orientation, scanning speed, beam power, beam diameter, line offset, layer thickness, scan strategy, number of contours, preheating temperature, and post-processing. The mechanical properties evaluated are tensile strength, strain at fracture, elongation at failure, energy density, material hardness, porosity, and surface morphology. The results showed a significant correlation between these mechanical properties and the EBM parameters. The highest ultimate tensile stress, determined from the tensile test, was recorded at 1491.51 MPa, corresponding to an energy density of 64.28 J/mm3. The optimal parameters were identified as a line offset of 0.1 mm, a layer thickness of 50 μm, a scanning speed of 2800 mm/s, and a beam power of 15 mA. The energy density during EBM in turn affected microstructure, porosity, and mechanical properties. Furthermore, the study revealed that aging heat treatment had a considerable impact on the mechanical properties, with the highest tensile strength observed for a sample that had undergone aging at 460 °C for 8 h. The results show the critical role of process parameters and aging heat treatment in achieving optimal mechanical properties in EBM-produced maraging steel M789. These findings contribute to the optimization of this manufacturing technique for industrial applications. [ABSTRACT FROM AUTHOR]

Purpose: Incisional hernias (IH) rates after diverting loop ileostomy reversal (DLI-R) have been reported up to 24%. We aimed to characterize the incidence rate and risk factors associated with DLI-R site IH formation within 1-year in a large patient cohort. Methods: A retrospective review at a single quaternary referral center hospital of adult patients who underwent DLI-R over a 5-year period and abdominal computerized tomography (CT) imaging performed within 1-year for any indication postoperatively was conducted. All CTs scans were independently reviewed by staff surgeons to determine the presence of a fascial defect at the DLI-R site. Results: 2,196 patients underwent DLI-R; of these, 569 (25.9%) underwent CT imaging for any indication. Mean patient age, 54.8 (± 14.9), BMI 27.6 kg/m2. 87 (15%) patients had a parastomal hernia at time of DLI-R. After median follow-up of 10 months, 203 patients (35.7%) had IH at the DLI-R site. Age (p = 0.14), sex (p = 0.39), race (p = 0.75), and smoking status (p = 0.82) weren't associated with IH after DLI-R. Comorbidities weren't significantly associated with IH following DLI-R. In univariate analysis, increased BMI (p < 0.001), presence of a parastomal hernia (p = 0.008), and suture type (p = 0.01) were associated with IH development. On multivariate analysis, BMI remained significant, and polyglyconate compared to polydioxanone suture were associated with higher rates of IH (p < 0.001). Conclusion: We observed that the rate of incisional hernias within 1-year of diverting ileostomy reversal was indeed common at 36%. Granted, a high percentage of the population was excluded due to heterogeneity in radiographic evaluation that could be mitigated in future prospective studies. Our study suggests that IH preventative strategies include weight loss for overweight and obese patients prior to DLI-R and that the optimal suture for DLI-R is polydioxanone. [ABSTRACT FROM AUTHOR]

The sustainable development of waste-recycled polymer matrix composites found a wide range of applications due to their superior specific properties, reliability, and economics. The prime aim of this research is to enhance the structural stability of Kevlar fiber–reinforced polypropylene composite by the additions (0, 3, 6, 9, and 12wt%) of cotton stalk powder and (0, 1, 3, 5, and 7wt%) granite particles through injection mould technique. The interface quality of synthesized composites is analyzed via an FTIR and scanning electron microscope. It reveals good particle distribution with a strong interface. Based on ASTM D790, D256-04, and D5023 standards, the flexural strength, impact strength, and dynamic mechanical analysis behavior of the composite studied and found that sample 4 is maximum flexural strength (158.29 ± 1.09 MPa), impact strength (29.87 ± 0.75 J), and sample 5 found stable on high dynamic load without failure (42.06 ± 0.43GPa). The thermal decompose performance of the composite is analyzed by 27° to 700° through thermogravimetric analysis, and sample 5 offered good thermal stability at 278°C. [ABSTRACT FROM AUTHOR]