Search

Chirp- and random-based coded excitation methods have been proposed to reduce standing wave formation and improve focusing of transcranial ultrasound. However, no clear evidence has been shown to support the benefits of these ultrasonic excitation sequences in vivo. This study evaluates the chirp and periodic selection of random frequency (PSRF) coded-excitation methods for opening the blood-brain barrier (BBB) in mice. Three groups of mice (n  =  15) were injected with polydisperse microbubbles and sonicated in the caudate putamen using the chirp/PSRF coded (bandwidth: 1.5–1.9 MHz, peak negative pressure: 0.52 MPa, duration: 30 s) or standard ultrasound (frequency: 1.5 MHz, pressure: 0.52 MPa, burst duration: 20 ms, duration: 5 min) sequences. T1-weighted contrast-enhanced MRI scans were performed to quantitatively analyze focused ultrasound induced BBB opening. The mean opening volumes evaluated from the MRI were mm3, mm3and mm3 for the chirp, random and regular sonications, respectively. The mean cavitation levels were V.s, V.s and V.s for the chirp, random and regular sonications, respectively. The chirp and PSRF coded pulsing sequences improved the BBB opening localization by inducing lower cavitation levels and smaller opening volumes compared to results of the regular sonication technique. Larger bandwidths were associated with more focused targeting but were limited by the frequency response of the transducer, the skull attenuation and the microbubbles optimal frequency range. The coded methods could therefore facilitate highly localized drug delivery as well as benefit other transcranial ultrasound techniques that use higher pressure levels and higher precision to induce the necessary bioeffects in a brain region while avoiding damage to the surrounding healthy tissue. [ABSTRACT FROM AUTHOR]

Piezoelectric polymers are highly desirable for ultrasound applications since their low acoustic impedance is much closer to the impedances of air and water than those of traditional piezoceramics. However, the piezoelectric effect observed in these poled polymers is limited to a few dozen picocoulombs per newton and requires very low-noise amplification. A different class of polymeric material known as piezoelectrets, presents piezoelectric effect in the same order of magnitude as those found on piezoceramics. This new class of materials has been explored in a wide range of applications such as flexible keyboards and airborne ultrasound transducers. Based on these polymers, we present here a new transducer for vibro-acoustography (VA), which is an ultrasonic image technique employed in medical diagnosis or material analysis based on ultrasound scattered by a target object. A calibration was carried out using a standard hydrophone, which is normally employed in VA. The average sensitivity of the transducer in the continuous wave mode was 1.712 mV Pa−1(−182.7 dB re 1 V Pa−1) with a maximum sensitivity of 18.25 mV Pa−1 (−154.8 dB re 1 V Pa−1) at its resonance frequency around 40 kHz. Subsequently, measurements in the burst mode and of directional sensitivity were taken and are presented here together with VA images obtained from a chicken bone and a metal sphere. [ABSTRACT FROM AUTHOR]