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Venous thromboembolism (VTE) is a common complication in cancer patients. However, the magnitude of this problem in Thai hospitalized lymphoma patients has not been well studied. To identify the incidence and risk factors for VTE in those patients, retrospective and prospective cohort studies were conducted in lymphoma patients admitted to a medical school affiliated hospital. Patient profile and risk factors were recorded. Patients were followed up for 90 days after admission. A total of 469 patients were included, of which 422 patients identified from 2007 to 2011 from hospital electronic data base were in the retrospective cohort, and 47 patients enrolled during 6 months in 2012 were in the prospective cohort. Two patients in the retrospective cohort had unconfirmed VTE, and then were excluded. The incidences of VTE in the retrospective cohort and the prospective cohort were 3.6% and 8.5%, respectively (p=0.113). In the retrospective cohort, VTE rates in Non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) patients were 3.4% and 5.9%, respectively (p= 0.347). All VTEs in the prospective cohort were in NHL patients. Concerning time to VTE, all events occurred before starting or during the first 3 courses of chemotherapy. Upon multivariate analysis, the independent risk factor for VTE was being bedridden (adjusted odds ratio 6.21, 95% confidence interval 1.59 - 24.31). In conclusion, the incidence of VTE in Thai hospitalized lymphoma patients admitted for chemotherapy is high. This implies that VTE prophylaxis should be considered during the early courses of chemotherapy in bedridden lymphoma patients. [ABSTRACT FROM AUTHOR]

. Although natural anticoagulant deficiencies are the established causes of thrombosis, their roles in bleeding are not fully studied. The objective is to correlate haemostatic factors with haemorrhagic symptoms quantified by a standardized questionnaire. Adult subjects were recruited from Bangkok and nearby provinces as part of routine health surveys/checkups. The validated MCMDM-1VWD form was used to assess their bleeding symptoms. At the same time, von Willebrand factor (VWF) activity, free protein S levels and protein C activity were measured. There were 5196 individuals. The mean age was 44.3 years (range 15-99) and 41% were male subjects. The mean bleeding score was −0.28 and 95% of subjects had scores between −2 and +2. The scores were lower in female subjects than in male subjects (−0.35 vs. −0.16, P < 0.001). Bleeding scores correlated negatively with age, VWF and protein C activities (Spearman's ρ−0.258, −0.091 and −0.098, respectively, all P < 0.001), but did not significantly correlate with protein S levels. Using multivariate analysis, female gender, VWF below 100 IU dL−1, protein C below 100 IU dL−1 and protein S over 150 IU dL−1 significantly related to high (≥3) bleeding scores (adjusted odds ratio 1.95, 1.83, 1.56 and 2.84, P = 0.001, 0.001, 0.039 and 0.017, respectively). These findings may suggest interacting roles of VWF and natural anticoagulants in modifying bleeding symptoms. [ABSTRACT FROM AUTHOR]

The article discusses a research that investigates whether subcutaneous panniculitis-like T-cell non-Hodgkin lymphoma (SPTCL) demonstrates nuclear factor-activated T cells (NFAT). It states that unstained skin biopsy from 25 SPTCL patients were used in the study while immunostaining to meet World Health Organization (WHO) diagnostic criteria was conducted. Results show that NFATc1 expression is detectable in SPTCL patients' tumour cells and accessory lymphoid cells.