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Background: Fluoxetine is a serotonin-specific reuptake inhibitor antidepressant and is the only approved pharmacological treatment for major depressive disorder (MDD) in children and adolescent. Methods: We searched the published randomized controlled-trials to review fluoxetine efficacy and tolerability using the databases PubMed, EudraCT, ClinicalTrials.gov, and Cochrane Central Register of Controlled Trials for fluoxetine role in managing MDD in children and adolescents. A meta-analysis was conducted using the identified 7 clinical trials to assess efficacy using the outcomes: Children's Depression Rating Scale–Revised (CDRS-R), Clinical Global Impressions–Severity of Illness (CGI-S) and Clinical Global Impressions–Improvement (CGI-I) response rate. The risk of discontinuation due to adverse effects and common side effects were examined. Results: The mean difference in change from baseline for CDRS-R was −2.72 (95% confidence interval [CI], −3.96, −1.48) favoring fluoxetine treatment (P <.001). Similarly, mean difference for CGI-S was −0.21 (95% CI, −0.36, −0.06). The risk ratio (RR) of discontinuing due to adverse events was 0.98 (95% CI, 0.54, 1.83), with RR for headache side effects 1.34 (95% CI, 1.03, 1.74) and rash 2.6 (95% CI, 1.32, 5.14). Conclusion: Fluoxetine demonstrates significant improvements in symptom intensity control in young patients suffering from MDD and is considered well tolerated with similar rates of trials discontinuation; however, fluoxetine was associated with a higher risk of headache and rash side effects. These findings will guide psychiatrists and pharmacists in their clinical role for supporting the care of young mental health patients. [ABSTRACT FROM AUTHOR]

Bruxism as a side‐effect of psychotropic medications could result in significant consequences for oral health such as tooth structure destruction and irreversible harm to the temporomandibular joint. The review findings uncovered by these authors can assist in understanding the aetiology of bruxism, establishing an appropriate management plan, while supporting psychiatrists and dentists to detect temporomandibular dysfunctions such as bruxism. [ABSTRACT FROM AUTHOR]

Cariprazine is a new atypical antipsychotic for management of schizophrenia and bipolar disorder. This article examines the role of cariprazine, a partial D2 and D3 receptor agonist (with a higher affinity for the D3 receptor), in the management of psychiatric conditions. Cariprazine leads to significant improvements in scores on psychiatric scales such as the Positive and Negative Syndrome scale, the Clinical Global Impressions scale, and the Young Mania Rating scale, but it is also associated with side effects such as akathisia, restlessness, and insomnia. These findings can help guide psychiatrists and pharmacists in their clinical role of supporting their psychiatric patients. [ABSTRACT FROM AUTHOR]

Non‐pharmacological management remains the initial approach for behavioural and psychological symptoms of dementia (BPSD). However, pharmacological management has a role in specific situations. Here, the authors examine the pharmacological management of elderly patients with dementia and challenging behaviour and aim to raise awareness of the risk of complications associated with first‐ and second‐generation antipsychotic medications. [ABSTRACT FROM AUTHOR]

This is a case report of a man in his 60s who presented to an English hospital following a significant lithium overdose. He was monitored for 24 hours, and then renal replacement therapy was initiated after assessment by the renal team. As soon as the lithium level returned to normal therapeutic levels (from 4.7 mEq/L to 0.67 mEq/L), lithium was restarted by the medical team. At this point, the patient developed new slurred speech and later catatonia. In this case report, we discuss the factors that could determine which patients are at risk of neurotoxicity following lithium overdose and the appropriate decision regarding when and how to consider initiation of renal replacement therapy and restarting of lithium. [ABSTRACT FROM AUTHOR]