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Introduction: Amylase and lipase are key digestive enzymes. Amylase helps your body break down starch. Lipase helps your body digest fats. The pancreas, a glandular produces both of these enzymes. Ischemia alters the N‐terminus of lbümin reducing the ability of cobalt to bind to lbümin. The generation of ROS can transiently modify the N‐terminal region of lbümin and produce an increase in the concentration of ischemia‐modified lbümin (IMA). The aim of this study to investigate association of levels of IMA with serum amilase and lipase activities. Material and Methods: Patients (n=63) that applied to Ankara Ataturk Training and Research Hospital between 05.01.2016‐02.23.2017 were enrolled in the study. Correlation of amilase and lipase levels with IMA values were investigated by using IBM SPSS 22.0. Results: Our Result were analysed by using Pearson correlation test. There is no significant correlation between Amilase and Lipase activites with IMA values. For Amilase p>0.05; r: ‐129 and for Lipase p>0.05; r: 0.023. Discussion: Recently, introduced IMA as novel oxidative biomarker may be included some process resulting from oxidative stress. There is some reported about IMA, they have shown that IMA has a strong relation with Amilase enzyme activity. But, in our study, there is no relationship amilase and Lipase levels with IMA. This result may be due to the small number of patients included in study. [ABSTRACT FROM AUTHOR]