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The Kern Family Foundation’s nearly $88 million investment in the Medical College of Wisconsin enhanced the effectiveness of the partnership through a charter of principles to ensure alignment of values and expectations. Their charter describes a commitment to shared values, including character, caring, and practical wisdom, as well as freedom of expression, principled innovation, merit, and inclusive excellence. This article describes how creating a charter of principles shared by funder and grantee can establish a common language and understanding of the key priorities and principles guiding the funded work. This article shares insights into the process of developing this charter, its key elements and benefits, and lessons learned. [ABSTRACT FROM AUTHOR]