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Diabetic kidney disease (DKD) is the main cause of chronic kidney disease (CKD) and progresses faster in males than in females. We identify sex-based differences in kidney metabolism and in the blood metabolome of male and female individuals with diabetes. Primary human proximal tubular epithelial cells (PTECs) from healthy males displayed increased mitochondrial respiration, oxidative stress, apoptosis, and greater injury when exposed to high glucose compared with PTECs from healthy females. Male human PTECs showed increased glucose and glutamine fluxes to the TCA cycle, whereas female human PTECs showed increased pyruvate content. The male human PTEC phenotype was enhanced by dihydrotestosterone and mediated by the transcription factor HNF4A and histone demethylase KDM6A. In mice where sex chromosomes either matched or did not match gonadal sex, male gonadal sex contributed to the kidney metabolism differences between males and females. A blood metabolomics analysis in a cohort of adolescents with or without diabetes showed increased TCA cycle metabolites in males. In a second cohort of adults with diabetes, females without DKD had higher serum pyruvate concentrations than did males with or without DKD. Serum pyruvate concentrations positively correlated with the estimated glomerular filtration rate, a measure of kidney function, and negatively correlated with all-cause mortality in this cohort. In a third cohort of adults with CKD, male sex and diabetes were associated with increased plasma TCA cycle metabolites, which correlated with all-cause mortality. These findings suggest that differences in male and female kidney metabolism may contribute to sex-dependent outcomes in DKD. Editor's summary: Diabetic kidney disease (DKD) progresses differently in males compared with females. Clotet-Freixas et al. report increased altered glucose and glutamine metabolism in primary human kidney proximal tubular cells from males compared with females. In mice with different combinations of sex chromosomes, the authors showed that male gonadal sex underpinned sex differences in kidney metabolism. Human kidney proximal tubular cells from females showed increased pyruvate, whereas those from males showed increased glucose and glutamine flux to the TCA cycle. In three human cohorts of different ages with or without diabetes, males showed increased serum TCA cycle metabolites, whereas females showed increased serum pyruvate that correlated with decreased all-cause mortality. These findings suggest that metabolism differences may contribute to sex differences in human DKD. —Brandon Berry [ABSTRACT FROM AUTHOR]

Objective: Running an emergency general surgery (EGS) service is challenging and requires significant personnel and institutional resources. The aim of this study was to achieve a nationwide overview of the individual EGS service organizations in public hospitals in Switzerland. Methods: All Swiss public hospitals with a surgical and emergency department were included and contacted by telephone. General surgeons were interviewed between December 2021 and January 2022 using a standardized questionnaire. Results: Seventy-two out of 79 public hospitals in Switzerland (91.1%) agreed to the survey. They employed 1,581 surgeons in 19 (26.4%) hospitals with < 100 beds, 39 (54.2%) hospitals with 100–300 beds, 7 (9.7%) with 300–600 beds, and 7 (9.7%) with > 600 beds. The median number of surgeons per hospital was 20.5 (IQR 13.0–29.0). Higher level of care (intermediate or intensive care unit) was significantly less available in small hospitals (< 100 beds). The median hour of designated emergency operating room capacity per day was 14 h (IQR 14–24) for all hospitals with < 600 beds and 24 h (IQR 14–24) for the largest hospitals (> 600 beds). With increasing hospital size, there was a significant increase in the number of surgical units where EGS and orthopedic trauma surgery were covered by two separate teams (21.1% vs. 43.6% vs. 85.7% vs. 100%, p = 0.035). The median number of surgeons on-call per hospital and per 24 h was 5.0 (IQR 3.3–6.0). Conclusion: Lack of higher level of care in small hospitals, limited emergency OR capacity and short rotations of on-call teams are major drawbacks of many current EGS systems in Switzerland. Centralization of critically ill EGS patients and reorganization of surgical on-call systems to designated acute care surgery teams should be considered. [ABSTRACT FROM AUTHOR]

This article discusses the importance of the doctor-patient relationship and the decline of "bedside manner" in orthopaedic medicine. The author highlights the increasing tendency for healthcare professionals to ignore patients during procedures, emphasizing the need for effective communication and rapport between clinicians and patients. The article also addresses the challenges posed by the reliance on investigations and technology, which can diminish clinical acumen and the ability to read a patient's condition. The Hippocratic Oath is mentioned as a guide for medical doctors, emphasizing the ethical responsibilities and obligations towards patients. The article concludes by emphasizing the need for doctors and patients to advocate for standards that protect their relationship and prioritize individualized care. It also raises ethical concerns about the potential dehumanization of patient care in a future controlled by technology. [Extracted from the article]

This paper explores the journey taken by experienced psychotherapists as they embark on doctoral research, highlighting the adjustments involved in moving from being a clinician to becoming a researcher. Having touched on the complex relationship between psychotherapy and research as a whole, including how badly this has affected the development of a robust evidence base for many approaches, the paper describes the development of a post-qualifying research programme for those grafting research skills onto their clinical roles. The paper then considers how the kind of research undertaken by psychodynamic psychotherapists has shifted from being primarily focussed on single case studies – so remaining closer to the clinical writing of the past – to including both more general social science research methodologies and more precise psychoanalytic methodologies, capable of exploring in depth the processes at work in the therapeutic encounter. The main focus of the paper is on the impact on the students of undertaking their first research project. At the beginning of this process nearly all students underestimated just how much of a shift in their thinking it would involve, and the paper captures some of the key issues and powerful moments reported after their first year. They speak of the humbling impact of conducting a structured literature review and of the complexity of finding a truly researchable question and viable design, as well as the appreciation of the difference between clinical illustration and evidence. They speak of the impact of thinking about the ethical issues involved in research, and of the need to interrogate their design in order to minimise bias. One of the interesting – and to them surprising – effects is that the shift to research-mindedness feeds back into their clinical identities, in a way that is both challenging and invigorating, overall boosting their confidence as practitioners. [ABSTRACT FROM AUTHOR]

Facilitated by increased trade between Asia and Europe, handwoven shawls from the Kashmir region of the Indian subcontinent became desirable clothing for Europeans during the mid-eighteenth century. By the 1770s, European manufacturers had picked up on this trend, producing textiles that imitated Kashmiri shawls but sold at lower prices to meet a wider market. In this article, I investigate the imitation Kashmiri shawl industry of one of the most prominent European centers of shawl production—the town of Paisley, Scotland—to study the designing of its products between 1805 and 1870. I examine the training and sources used by Paisley's 'pattern drawers'—as the industry's designers were then called—to answer the question: How much did Paisley's pattern drawers rely on the patterns of their competitors—European and Asian—to produce their own work? And did all Paisley pattern drawers pirate others' work? The answer will provide insight into the intertwined nature of imitation and innovation, and moral assessments of copying from European versus Asian products. [ABSTRACT FROM AUTHOR]

Considerable research finds that male political scientists publish more research on average than do female political scientists. Yet the reasons for this difference are not entirely clear. Those findings may also overestimate the relative productivity of men because they do not account for the longer time that more men have been in the profession and thus have been publishing longer than women. For a prominent survey dataset of political scientists, we demonstrate notable cohort differences in the research productivity of both men and women across time. Our results also indicate that the overall greater productivity of men results in part from senior women scholars not generally enjoying the same benefits of long tenure on their research output as men do. [ABSTRACT FROM AUTHOR]

'The Cloth that Changed the World: India's Painted and Printed Cottons'. In the interim, the ROM's exceptional collection of Indian chintz has expanded, as has research on chintz. Royal Ontario Museum, Toronto, Canada, 12 September 2020-2 January 2022 / Cloth that Changed the World: The Art and Fashion of Indian Chintz. [Extracted from the article]

We demonstrate how men and women political scientists in PhD-granting departments perceive the professional climates there. We find remarkable differences in how men and women perceive the "cultural" climates of their departments, such as the degree to which it is sexist, but not in how they perceive strictly collegial aspects of climate. We also demonstrate that these patterns characterize the perceptions of men and women at both junior and senior ranks. Contrary to some past research, we also find that climate perceptions do not have a general effect on faculty research productivity. Further, perceptions of high departmental sexism by women scholars does not degrade their research productivity. [ABSTRACT FROM AUTHOR]

Objective: To determine factors associated with completion of recommended outpatient follow-up visits in children with complex chronic conditions (CCCs) following hospital discharge. Methods: We retrospectively identified children aged 1 to 17 years diagnosed with a CCC who were discharged from our rural tertiary care children's hospital between 2017 and 2018 with a diagnosis meeting published CCC criteria. Patients discharged from the neonatal intensive care unit and patients enrolled in a care coordination program for technology-dependent children were excluded. Results: Of 113 eligible patients, 77 (68%) had outpatient follow-up consistent with discharge instructions. Intensive care unit (ICU) admission (P =.020) and prolonged length of stay (P =.004) were associated with decreased likelihood of completing recommended follow-up. Conclusions: Among children with CCCs who were not already enrolled in a care coordination program, ICU admission was associated with increased risk of not completing recommended outpatient follow-up. This population could be targeted for expanded care coordination efforts. [ABSTRACT FROM AUTHOR]

Considerable work assesses research productivity in political science. Yet, the latter work has not explicated how research careers can differ across time and individuals and neither has it considered such careers in teaching institutions. This article presents an empirically validated typology for research career paths for political scientists who began their career in a teaching institution. The typology demonstrates that many scholars follow paths different from the most conventional expectations, and research "success" by measures of publications and citations is associated with only some of those paths. Thus, existing research on aggregate publications and citations likely addresses only a subset of the career paths described here. Understanding research activities in our profession requires accounting for various career paths, their motivations, and their place in our research community. [ABSTRACT FROM AUTHOR]

Purpose: Preserving and increasing the health care workforce in rural areas has become imperative due to the shortage of health care workers serving rural populations. However, limited data are available on long‐term patterns of employment in rural settings among health care workers. Methods: We analyzed the National Longitudinal Survey of Youth, which enrolled a nationally representative sample of adolescents in 1979 and tracked their career outcomes through 2016. Using the US Census Bureau occupation codes, we identified participants who worked in health care occupations, and we classified their employment in rural versus urban areas. Findings: Of the 1,007 respondents (including 109 doctoral health professionals), 70% worked only in urban locations, 13% worked only in rural locations, and 17% worked in both rural and urban locations during their health care career. Rural upbringing, White race, and female gender were associated with rural employment. Among nondoctoral health professionals, lower educational attainment was associated with increased likelihood of working only in rural settings. Conclusion: Our study indicates the rural workforce is split between workers who are only employed in rural settings, and those who are intermittently employed in rural and urban settings. Therefore, retention of health care workers in rural settings and recruitment of workers from urban settings to practice in rural areas are important strategies for addressing the rural health care worker shortage. Rural upbringing, previously described as predictive of physician practice in rural locations, appears the strongest predictor of rural employment for both doctoral health professionals and nondoctoral health professionals. [ABSTRACT FROM AUTHOR]

Considerable research assesses research success in political science. Yet this work has not considered widespread findings that scholars can follow various career research paths that complicate how we envision scholarly success. Further, we have no systematic information on these career paths in any scientific discipline. I present an empirically validated research career-path typology for political scientists who began their career in a research institution. The typology demonstrates that many scholars follow paths different from the most conventional expectations, and research success by measures of publications and citations is associated with only some of these paths. Thus, existing research on aggregate publications and citations likely addresses only a subset of the career paths revealed in this article. Understanding research activities in our profession requires consideration of the various career paths, their motivation, and their place in our research community. [ABSTRACT FROM AUTHOR]

The citations Citations (referencing), in which one paper refers to earlier works, are the standard means by which authors acknowledge the source of their methods, ideas and findings, and are often used as a rough measure of a paper's importance. There is an argument of whether citation analysis that is measuring the numbers (count and density) of citations should be considered as a significant influence on what constitutes a classic paper [[16], [29]]. It allows for the relative impact of an article regardless of year of publication; however, although a recently published article may have a high citation density because of its newness it usually takes a few years to acquire classic status [[16]]. These include the types of publications, the time of publication, the size and field of the study, the journal in which the article is published, and the novelty of a subspecialty. [Extracted from the article]

Research on the determinants of scholarly productivity is flourishing, driven both by long-standing curiosity about its wide variation, and by recent concern over race and gender inequalities. Beyond standard structural and demographic determinants of research output, some studies point to the role of individual psychology. We contribute to scholarship on personality and productivity by showing not only that personality matters, but when and for whom. Using an original, representative study of faculty from one discipline, political science, we propose and test several hypotheses about the "Big Five" personality determinants of productivity, as gauged through counts of publications, H-index scores, and citations. Controlling for a large number of familiar determinants (e.g., race, gender, rank, and institutional incentives), we find that conscientiousness predicts productivity, but that its effects are conditioned by openness to experience. More precisely, we discover that these two personality traits have compensatory effects, such that openness to experience and conscientiousness each matter most in the absence of the other. In addition, personality has heterogeneous impacts on productivity across different contexts; conscientiousness more strongly affects scholarly output in research-oriented institutions, while collaboration reduces the penalty associated with lack of conscientiousness. [ABSTRACT FROM AUTHOR]

The virus crisis affects Orthopaedic surgery and scientific activities worldwide The operating theatres are transformed into intensive care units (ICU) and reserved for ventilation and respiratory management of these patients. Many trauma patients in the present pandemia are also potential or confirmed COVID-19 patients; this makes the treating orthopaedic surgeons the front-line treating physicians. The World Healh Organisation (WHO) and the global surgical community should develop tools and protocols to help evaluate the surgical capacities of hospitals and assist in the management of trauma patients in crisis. [Extracted from the article]

A growing body of research investigates the factors that enhance the research productivity and creativity of political scientists. This work provides a foundation for future research, but it has not addressed some of the most promising causal hypotheses in the general scientific literature on this topic. This article explicates the latter hypotheses, a typology of scientific career paths that distinguishes how scientific careers vary over time with respect to creative ambitions and achievements, and a research agenda based on the preceding components for investigation of the publication success of political scientists. [ABSTRACT FROM AUTHOR]

Highlights from the article: How to evaluate reviewers - the international orthopedics reviewers score (INOR-RS) Peer-review (refereeing) is the process of subjecting an author's work to the scrutiny of others who are experts in the same field. Authors' suggested reviewers produce reviews of similar quality to editor-chosen reviewers [[8], [12]]; however, the former are more likely to recommend acceptance [[7], [12]]. To evaluate who are the best reviewers and to determine if there are any characteristics that would tend to predict the quality of their peer-reviews, we routinely review the peer-reviews performed in our journal by the reviewers included in the journal's reviewers' panel.

Cauda equina syndrome is a devastating condition often following an innocent pathology in the form of a disc prolapse. The effect on sufferers, however, can be lifelong. It is necessary to make a diagnosis as expeditiously as possible via adequate history, clinical examination and appropriate imaging to offer treatment, in the form of decompressive surgery within 48 hours. It is extremely important to communicate adequately with the patient and their family recording all the relevant details including those of expected outcome. National guidelines are likely to be of value to clinicians and patients. [ABSTRACT FROM AUTHOR]

Copyright of Operative Orthopädie und Traumatologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Peer-review is the core of the editorial process and the basis of the publication system. Although being a peer-reviewer is sometimes frustrating, communication between authors, editors and reviewers in the peer-review process determines the eventual success of the publication; this communication should be formal, constructive, honest and polite [[1]]. Peer-review is considered a biased process with identified defects [[3]-[11]]; some peer-reviewers are too young with limited experience, not all are equally skilled in the peer-review process, and very few have had a formal training and assessment methods for peer-review [[1], [12]]. Retrospective analysis of the quality of reports by author-suggested and non-author-suggested reviewers in journals operating on open or single-blind peer review models. [Extracted from the article]

The pathogenic strategy of Escherichia coli and many other gramnegative pathogens relies on the translocation of a specific set of proteins, called effectors, into the eukaryotic host cell during infection. These effectors act in concert to modulate host cell processes in favor of the invading pathogen. Injected by the type III secretion system (T3SS), the effector arsenal of enterohemorrhagic E. coli (EHEC) O157:H7 features at least eight individual NleG effectors, which are also found across diverse attaching and effacing pathogens. NleG effectors share a conserved C-terminal U-box E3 ubiquitin ligase domain that engages with host ubiquitination machinery. However, their specific functions and ubiquitination targets have remained uncharacterized. Here, we identify host proteins targeted for ubiquitination-mediated degradation by two EHEC NleG family members, NleG5-1 and NleG2-3. NleG5-1 localizes to the host cell nucleus and targets the MED15 subunit of the Mediator complex, while NleG2-3 resides in the host cytosol and triggers degradation of Hexokinase-2 and SNAP29. Our structural studies of NleG5-1 reveal a distinct N-terminal α/β domain that is responsible for interacting with host protein targets. The core of this domain is conserved across the NleG family, suggesting this domain is present in functionally distinct NleG effectors, which evolved diversified surface residues to interact with specific host proteins. This is a demonstration of the functional diversification and the range of host proteins targeted by the most expanded effector family in the pathogenic arsenal of E. coli. [ABSTRACT FROM AUTHOR]

The galectin family of secreted lectins have emerged as important regulators of immune cell function; however, their role in B-cell responses is poorly understood. Here we identify IgM-BCR as a ligand for galectin-9. Furthermore, we show enhanced BCR microcluster formation and signaling in galectin-9-deficient B cells. Notably, treatment with exogenous recombinant galectin-9 nearly completely abolishes BCR signaling. We investigated the molecular mechanism for galectin-9-mediated inhibition of BCR signaling using superresolution imaging and single-particle tracking. We show that galectin-9 merges pre-existing nanoclusters of IgM-BCR, immobilizes IgM-BCR, and relocalizes IgM-BCR together with the inhibitory molecules CD45 and CD22. In resting naive cells, we use dual-color superresolution imaging to demonstrate that galectin-9 mediates the close association of IgM and CD22, and propose that the loss of this association provides a mechanism for enhanced activation of galectin-9-deficient B cells. [ABSTRACT FROM AUTHOR]

Legionella pneumophila translocates the largest known arsenal of over 330 pathogenic factors, called ,,effectors,'' into host cells during infection, enabling L. pneumophila to establish a replicative niche inside diverse amebas and human macrophages. Here, we reveal that the L. pneumophila effectors MavC (Lpg2147) and MvcA (Lpg2148) are structural homologs of cycle inhibiting factor (Cif) effectors and that the adjacent gene, lpg2149, produces a protein that directly inhibits their activity. In contrast to canonical Cifs, both MavC and MvcA contain an insertion domain and deamidate the residue Gln40 of ubiquitin but not Gln40 of NEDD8. MavC and MvcA are functionally diverse, with only MavC interacting with the human E2-conjugating enzyme UBE2N (Ubc13). MavC deamidates the UBE2N~Ub conjugate, disrupting Lys63 ubiquitination and dampening NF-κB signaling. Combined, our data reveal a molecular mechanism of host manipulation by pathogenic bacteria and highlight the complex regulatory mechanisms integral to L. pneumophila's pathogenic strategy. [ABSTRACT FROM AUTHOR]

Scientific misconduct (fraud) in medical writing is an important and not infrequent problem for the scientific community. Although noteworthy examples of fraud surface occasionally in the media, detection of fraud in medical publishing is generally not as straightforward as one might think. National bodies on ethics in science, strict selection criteria, a robust peer-review process, careful statistical validation, and anti-plagiarism and image-fraud detection software contribute to the production of high-quality manuscripts. This article reviews the various types of fraud in medical writing, discusses the related literature, and describes tools journals implement to unmask fraud. [Orthopedics. 2018; 41(2):e176–e183]. [ABSTRACT FROM AUTHOR]

Introduction: International Orthopaedics was founded in 1977. Within the 40 volumes and 247 issues since its launch, 5462 scientific articles have been published. This article identifies, analyses and categorises the best cited articles published by the journal to date.Methods: We searched Elsevier Scopus database for citations of all papers published in International Orthopaedics since its foundation. Source title was selected, and the journal's title was introduced in the search engine. The identified articles were sorted based on their total number of received citations, forming a descending list from 1 to 100. Total citations and self-citations of all co-authors were recorded. Year of publication, number of co-authors, number of pages, country and institution of origin and study type were identified.Results: The best 100 papers and their citations correspond approximately to 2% of all the journal's publications. Total citations ranged from 62 to 272; 26 papers had >100 citations, of which self-citations accounted for <4%. Mean authorship number per paper was four and mean page number 6.5. United States, Japan and Germany ranked the top three countries of origin. The most common study type was case series, and most common topics were adult reconstruction, sports medicine and trauma.Conclusions: This article identifies topics, authors and institutions that contributed with their high-quality work in the journal's development over time. International Orthopaedics remains faithful to its authors and readers by publishing topical, well-written articles in excellent English. [ABSTRACT FROM AUTHOR]

Spinal infections represent a difficult challenge to treating clinicians. Infections in the presence of implants are even more so. In this review the literature appears to reflect a change of practice in which the aim is to retain implants if possible. The newer spinal procedures such as disc replacements pose different problems largely due to the more difficult access. The situation in the spine is more difficult than in general orthopaedics when dealing with infection due to the requirement for stability and to protect neurological function. The main thrust of management, therefore, is early diagnosis and a high index of suspicion followed by adequate if not radical management in a multidisciplinary setting. In the event prevention is better than cure and therefore consideration of the various mechanisms to avoid infection must be taken. There are some 'novel' considerations for the avoidance of infection alongside the tried and tested techniques. There are also new procedures for wound closure and the elimination of dead space. [ABSTRACT FROM AUTHOR]

Pathogens deliver complex arsenals of translocated effector proteins to host cells during infection, but the extent to which these proteins are regulated once inside the eukaryotic cell remains poorly defined. Among all bacterial pathogens, Legionella pneumophila maintains the largest known set of translocated substrates, delivering over 300 proteins to the host cell via its Type IVB, Icm/Dot translocation system. Backed by a few notable examples of effector-effector regulation in L. pneumophila, we sought to define the extent of this phenomenon through a systematic analysis of effector-effector functional interaction. We used Saccharomyces cerevisiae, an established proxy for the eukaryotic host, to query > 108,000 pairwise genetic interactions between two compatible expression libraries of ~330 L. pneumophila-translocated substrates. While capturing all known examples of effector- effector suppression, we identify fourteen novel translocated substrates that suppress the activity of other bacterial effectors and one pair with synergistic activities. In at least nine instances, this regulation is direct--a hallmark of an emerging class of proteins called metaeffectors, or "effectors of effectors". Through detailed structural and functional analysis, we show that metaeffector activity derives from a diverse range of mechanisms, shapes evolution, and can be used to reveal important aspects of each cognate effector’s function. Metaeffectors, along with other, indirect, forms of effector-effector modulation, may be a common feature of many intracellular pathogens--with unrealized potential to inform our understanding of how pathogens regulate their interactions with the host cell. [ABSTRACT FROM AUTHOR]

The article reports that "International Orthopaedics" a journal on orthopaedics completed 40 years since its first issue was launched. The article also provides information on the past Editor-in-Chief's of the magazine including names like Kjeld Skou Andersen, Jean-Pierre Courpied, and Marko Pećina.

Political science is falling behind a broad movement in the United States that seeks to reform the teaching of scientific literacy in undergraduate education. Indeed, political science is far behind that movement because the discipline does not have a collective commitment to science education at the undergraduate level. This article discusses prominent efforts in this reform movement and assesses the state of science education in our discipline. The authors propose an agenda for action on this issue in political science as well as fundamental educational benchmarks for undergraduate political science literacy. [ABSTRACT FROM AUTHOR]

Background: Inhalative nanocarriers for local or systemic therapy are promising. Gold nanoparticles (AuNP) have been widely considered as candidate material. Knowledge about their interaction with the lungs is required, foremost their uptake by surface macrophages and epithelial cells. Diseased lungs are of specific interest, since these are the main recipients of inhalation therapy. We, therefore, used Scnn1b-transgenic (Tg) mice as a model of chronic obstructive pulmonary disease (COPD) and compared uptake and localization of inhaled AuNP in surface macrophages and lung tissue to wild-type (Wt) mice. Methods: Scnn1b-Tg and Wt mice inhaled a 21-nm AuNP aerosol for 2 h. Immediately (0 h) or 24 h thereafter, bronchoalveolar lavage (BAL) macrophages and whole lungs were prepared for stereological analysis of AuNP by electron microscopy. Results: AuNP were mainly found as singlets or small agglomerates of ⩽ 100 nm diameter, at the epithelial surface and within lung-surface structures. Macrophages contained also large AuNP agglomerates (> 100 nm). At 0 h after aerosol inhalation, 69.2±4.9% AuNP were luminal, i.e. attached to the epithelial surface and 24.0±5.9% in macrophages in Scnn1b-Tg mice. In Wt mice, 35.3±32.2% AuNP were on the epithelium and 58.3±41.4% in macrophages. The percentage of luminal AuNP decreased from 0 h to 24 h in both groups. At 24 h, 15.5±4.8% AuNP were luminal, 21.4±14.2% within epithelial cells and 63.0±18.9% in macrophages in Scnn1b-Tg mice. In Wt mice, 9.5±5.0% AuNP were luminal, 2.2±1.6% within epithelial cells and 82.8±0.2% in macrophages. BAL-macrophage analysis revealed enhanced AuNP uptake in Wt animals at 0 h and in Scnn1b-Tg mice at 24 h, confirming less efficient macrophage uptake and delayed clearance of AuNP in Scnn1b-Tg mice. Conclusions: Inhaled AuNP rapidly bound to the alveolar epithelium in both Wt and Scnn1b-Tg mice. Scnn1b-Tg mice showed less efficient AuNP uptake by surface macrophages and concomitant higher particle internalization by alveolar type I epithelial cells compared to Wt mice. This likely promotes AuNP depth translocation in Scnn1b-Tg mice, including enhanced epithelial targeting. These results suggest AuNP nanocarrier delivery as successful strategy for therapeutic targeting of alveolar epithelial cells and macrophages in COPD. [ABSTRACT FROM AUTHOR]

Within the medical and physical sciences journals evidence suggests that problems of authorship ethics and journal management bedevil the editors of these journals. Although anecdotal evidence suggests that similar problems persist in political science, the extent of these problems within political science is not well established. Here we report the results of a survey of political science journal editors' perceptions of ethical and managerial issues associated with their journals. We find that unlike ethical publication concerns in the clinical and natural sciences fields, these issues are not of significant concern among our sample. Ethical problems are of low concern and editors report high levels of confidence to address these problems. Managerial problems, such as the adequacy of reviewer pools, are of higher concern to our sample. [ABSTRACT FROM AUTHOR]

Most subfields of research in political science are today at an intellectual plateau well short of general theory. Many have been at that plateau since about 1980. Several reasons might account for this situation, including the challenge of constructing general theory. I argue, however, that some of our must common educational and research practices also retard theoretical progress. I describe those practices and their unfortunate consequences, but also explicate a series of research strategies that would help advance our theoretical work. As a foundation for the preceding arguments, I characterize the theory-building ambitions of the discipline, our progress toward general theory, and how advances toward such theory can be mapped for any science. [ABSTRACT FROM PUBLISHER]

Spinal infections represent a difficult challenge to treating clinicians. Infections in the presence of implants are even more so. In this review the literature appears to reflect a change of practice in which the aim is to retain implants if possible. The newer spinal procedures such as disc replacements pose different problems largely due to the more difficult access. The situation in the spine is more difficult than in general orthopaedics when dealing with infection due to the requirement for stability and to protect neurological function. The main thrust of management, therefore, is early diagnosis and a high index of suspicion followed by adequate if not radical management in a multidisciplinary setting. In the event prevention is better than cure and therefore consideration of the various mechanisms to avoid infection must be taken. There are some 'novel' considerations for the avoidance of infection alongside the tried and tested techniques. There are also new procedures for wound closure and the elimination of dead space. [ABSTRACT FROM AUTHOR]