1. Multifractal characterization of morphology of human red blood cells membrane skeleton.
- Author
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ŢĂLU, Ş., STACH, S., KACZMARSKA, M., FORNAL, M., GRODZICKI, T., POHORECKI, W., and BURDA, K.
- Subjects
ERYTHROCYTES ,MULTIFRACTALS ,SKELETON ,MORPHOLOGY ,MEDICAL imaging systems - Abstract
The purpose of this paper is to show applicability ofmultifractal analysis in investigations of the morphological changes of ultra-structures of red blood cells (RBCs) membrane skeleton measured using atomic force microscopy (AFM). Human RBCsobtainedfromhealthyandhypertensivedonorsas wellas healthy erythrocytes irradiated with neutrons (45 μGy) were studied. The membrane skeleton of the cells was imaged using AFMin a contactmode.Morphological characterization of the three-dimensional RBC surfaces was realized by amultifractal method. The nanometre scale study of human RBCs surface morphology revealed a multifractal geometry. The generalized dimensions D
q and the singularity spectrum f(α) provided quantitative values that characterize the local scale properties of their membrane skeleton organization. Surface characterization was made using areal ISO 25178-2: 2012 topography parameters in combination with AFM topography measurement. The surface structure of human RBCs is complex with hierarchical substructures resulting from the organization of the erythrocyte membrane skeleton. The analysed AFM images confirm a multifractal nature of the surface that could be useful in histology to quantify human RBC architectural changes associated with different disease states. In case of [ABSTRACT FROM AUTHOR]- Published
- 2016
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