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Background.Bezafibrate, a fabric acid analogue, has well-established lipid- and fibrinogen-lowering properties. Some data exist pointing towards a blood pressure-lowering effect of bezafibrate. Thus the aim of this study was to examine the acute effect of bezafibrate on blood pressure and renal haemodynamics in hypertensive and normotensive rats. [ABSTRACT FROM PUBLISHER]

Elastic recoil, neointima formation and vessel narrowing after balloon angioplasty or stent implantation were compared in 17 non-atherosclerotic New Zealand White rabbits. The implantation of a balloon-expandable Palmaz-Schatz stent was performed in one iliac artery and a balloon angioplasty alone was performed in the contralateral artery (n=34 arteries). Quantitative histomorphometry was performed by a computer-assisted analysis 1 h and 4, 10 and 24 weeks after the initial procedure. The histological appearance of the neointima was similar to that of human restenosis. The amount of the neointima was increased within sten ted vessels as compared to balloon angioplasty alone (1·0±0·1 vs 0·4±0·1 mm at 4 weeks, <0·001). However, the neointimal lumen narrowing was smaller in the stented vessels due to persistent increase in vessel perimeter as compared to balloon angio plasty alone (16·5±0·9 vs 34·7±16·5% lumen narrowing at 4 weeks, <0·05). In conclusion, stent implantation enhances neointima formation as compared to angioplasty in non-atherosclerotic rabbits. The prevention of elastic recoil after stent implantation, however, reduces the neointimal lumen narrowing. This study supports clinical observations demonstrating lower restenosis rates after stent implantation compared to standard balloon angioplasty. [ABSTRACT FROM PUBLISHER]

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Copyright of Klinische Wochenschrift is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The infusion of 0.75 mg/kg/h sodium nitroprusside (SNP) for 40 h in rabbits leads to a significant rise of the plasma thiocyanate concentration, irrespective of whether SNP was infused alone or in combination with sodium thiosulphate (ST). The iron concentration in the plasma is slightly increased, but the iron-binding capacity is not exceeded. The infusion of SNP in rabbits resulted in an elevation of the non-Hb iron in the liver in every case. About 60% of the infused SNP iron is found in the liver, whilst after FeSO infusion only about 30% of the administered iron is deposited in the liver. The higher iron content of the liver after SNP-infusion shows that SNP-iron is not taken up in free ionic form in this organ. The question of whether and to what extent the complex is broken down before being taken up remains unanswered. Slight but insignificant metabolic acidosis developed only when SNP was infused alone but not when given in combination with hydroxocobalamin (HC) or ST in the molar ratio 1∶5 (SNP : antidote). HC and ST are equally effective in preventing the development of acidosis. However, the strong colouration of the plasma after HC-infusion makes photometric determinations more difficult. [ABSTRACT FROM AUTHOR]

Copyright of Archives of Toxicology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Our clinical data enabled us to demonstrate a correlation between impaired lipid metabolism and vasculogenic impotent men. Our aim was to evaluate the effect of an impaired lipid metabolism on the smooth muscle of the corpus cavernosum. A total of 16 rabbits were given a cholesterol-enriched diet for 3 months, and 8 of these received additional thromboxane A receptor antagonist; 10 other rabbits (control) were fed a normal diet. Subsequently, cavernous tissue biopsies were taken, and tissue lipid extractions and electron microscopic evaluation were made from 3 rabbits in each group. In the untreated high-cholesterol diet group, cholesterol levels reached approx. 2.1 μg/mg body weight compared with 1.07 μg/mg b.wt. in the thromboxane A receptor antagonist-treated group and elevated levels compared with control group. Similar results were found for the triglyceride and free fatty acid levels. Lecithin tissue levels in treated rabbits were distinctly elevated against those of other 2 groups. Ultramorphological examination of the control group disclosed normal smooth muscle cell (SMC) architecture with numerous sites of intercellular contacts. These findings contrasted with those of the high-cholesterol diet groups which showed significant SMC degeneration with loss of intercellular contacts. Our data imply that impaired lipid metabolism causes cavernous SMC degeneration which plays a major role in the pathogenesis of erectile dysfunction. The thromboxane A receptor antagonist seems to produce a protective metabolic effect on the erectile tissue which may have some consequences future treatment strategies. [ABSTRACT FROM AUTHOR]

The investigation methods of the action of xenobiotics on sterol biosynthesis from C-acetate in rat hepatocyte cultures can be developed, with regard to extraction using Extrelut and the separation of the sterol pattern by thin-layer chromatography, in such a way that they are suitable for wider application, e.g., screening. Good visualisation and recognition of changes in the sterol pattern are possible using autoradiography of the thin-layer chromatogram. [ABSTRACT FROM AUTHOR]